公开(公告)号：US06976963B2

公开(公告)日：2005-12-20

申请号：US10261169

申请日：2002-09-30

Applicant: Vaughan L. Clift

Inventor： Vaughan L. Clift

IPC: A61B5/00 ,  A61B5/0205 ,  A61B5/021 ,  A61B5/024 ,  A61B5/08 ,  A61B5/083 ,  A61B5/02

CPC classification number: A61B5/0205 ,  A61B5/021 ,  A61B5/02125 ,  A61B5/024 ,  A61B5/0809 ,  A61B5/0836 ,  A61B5/1455

Abstract: Apparatus and techniques are provided for precise measuring and monitoring of certain vital signs of patients that have been difficult to measure especially in emergency situations. Sensor may be used for detecting contraction and expansion in the vascular bed of the lining tissue of the external auditory canal during a cardiac cycle to obtain a better indication of certain physiological parameters. Such a signal generally may be superimposed with an additional signal that is primarily due to breathing activity of the patient. Based on various scenarios different sensors may be used to determine the signal due to breathing activity and thus the physiological parameter of interest may be derived. The signal corresponding to the physiological parameter of interest, for example, blood pressure may then be used to monitor the vital signs or control other medical equipment.

Abstract translation: 提供仪器和技术，用于精确测量和监测特别是在紧急情况下难以测量的患者的某些生命体征。 传感器可用于检测在心脏周期期间外耳道衬里组织的血管床中的收缩和扩张，以获得某些生理参数的更好指示。 这样的信号通常可以与主要由于患者的呼吸活动引起的附加信号叠加。 基于各种情况，可以使用不同的传感器来确定由于呼吸活动引起的信号，因此可以导出感兴趣的生理参数。 然后可以使用与感兴趣的生理参数（例如血压）相对应的信号来监测生命体征或控制其他医疗设备。

公开(公告)号：US6110730A

公开(公告)日：2000-08-29

申请号：US678361

申请日：1996-06-26

Applicant: Clarence F. Sams ,  Vaughan L. Clift ,  Kelly E. McDonald

Inventor： Clarence F. Sams ,  Vaughan L. Clift ,  Kelly E. McDonald

IPC: B01L3/00 ,  G01N1/31 ,  G01N33/50 ,  G01N33/53 ,  G01N33/569 ,  C12M1/00

CPC classification number: B01L3/505 ,  G01N1/31 ,  G01N33/5094 ,  G01N33/5302 ,  G01N33/56972

Abstract: An apparatus and method for using the apparatus for staining particular cell markers is disclosed. The apparatus includes a flexible tube that is reversibly pinched into compartments with one or more clamps. Each compartment of the tube contains a separate reagent and is in selective fluid communication with adjoining compartments.

Abstract translation: 公开了一种用于染色特定细胞标记物的装置和方法。 该装置包括柔性管，其可逆地夹入具有一个或多个夹具的隔室中。 管的每个隔室含有单独的试剂，并且与相邻的隔室选择性地流体连通。

公开(公告)号：US5866007A

公开(公告)日：1999-02-02

申请号：US813570

申请日：1997-03-07

Applicant: Peggy A. Whitson ,  Vaughan L. Clift

Inventor： Peggy A. Whitson ,  Vaughan L. Clift

IPC: B01L3/00 ,  G01N33/483 ,  B01D37/00 ,  B01D61/00

CPC classification number: B01L3/50853 ,  B01L2400/0406 ,  Y10T436/25375 ,  Y10T436/255

Abstract: The present invention provides a method and apparatus for separating a blood sample having a volume of up to about 20 milliliters into cellular and acellular fractions. The apparatus includes a housing divided by a fibrous filter into a blood sample collection chamber having a volume of at least about 1 milliliter and a serum sample collection chamber. The fibrous filter has a pore size of less than about 3 microns, and is coated with a mixture including between about 1-40 wt/vol % mannitol and between about 0.1-15 wt/vol % of plasma fraction protein (or an animal or vegetable equivalent thereof). The coating causes the cellular fraction to be trapped by the small pores, leaving the cellular fraction intact on the fibrous filter while the acellular fraction passes through the filter for collection in unaltered form from the serum sample collection chamber.

Abstract translation: 本发明提供了一种用于将具有高达约20毫升的体积的血液样品分离成细胞和无细胞级分的方法和装置。 该装置包括由纤维过滤器分成具有至少约1毫升体积的血液样品收集室的壳体和血清样品收集室。 纤维过滤器具有小于约3微米的孔径，并且涂覆有包含约1-40重量/体积％甘露糖醇和约0.1-15重量/体积％血浆级分蛋白质（或动物或 蔬菜当量）。 涂层导致细胞部分被小孔捕获，使细胞部分完整地保留在纤维过滤器上，而无细胞部分通过过滤器以从血清样品收集室以未改变的形式收集。

公开(公告)号：US08980641B2

公开(公告)日：2015-03-17

申请号：US12309704

申请日：2007-07-25

Applicant: Vaughan L. Clift ,  Kristin L. Harriman ,  Richard L. Pettys ,  David M. Headley ,  Tiffany M. Conerly

Inventor： Vaughan L. Clift ,  Kristin L. Harriman ,  Richard L. Pettys ,  David M. Headley ,  Tiffany M. Conerly

IPC: G01N21/75 ,  G01N21/78 ,  G01N21/94 ,  G01N21/01 ,  G01N35/00 ,  C12Q1/04 ,  G01N21/77

CPC classification number: G01N21/78 ,  C12Q1/04 ,  G01N21/01 ,  G01N21/94 ,  G01N33/227 ,  G01N35/00029 ,  G01N2035/00148

Abstract: A method of rapidly detecting trace materials including biohazards, toxins, radioactive materials, and narcotics in situ is disclosed. A corresponding apparatus is disclosed. A trace of the material is collected on a pad of the card component, collected by swiping the pad on suspected surface or exposure to the suspected air volume. A novel card component is disclosed that when inserted in a chemical detection unit (CDU), releases reaction chemicals from flexible walled capsules in desired sequence. The exposed pad containing trace material and chemicals are heated in the chemical detection unit to produce a spectral pattern that is analyzed by the optical electronics in the CDU and results are displayed, stored and/or transmitted over a communications network.

Abstract translation: 公开了一种快速检测包括生物危害物，毒素，放射性物质和麻醉剂在内的痕量物质的方法。 公开了相应的装置。 将材料的痕迹收集在卡组件的垫上，通过在可疑表面上滑动垫或暴露于可疑的气体体积来收集。 公开了一种新颖的卡片组件，当插入化学检测单元（CDU）时，以期望的顺序从柔性壁胶囊释放反应化学物质。 包含微量材料和化学物质的暴露的焊盘在化学检测单元中被加热以产生由CDU中的光学电子器件分析的光谱图，并且通过通信网络显示，存储和/或传输结果。

公开(公告)号：US20090325300A1

公开(公告)日：2009-12-31

申请号：US12309704

申请日：2007-07-25

Applicant: Vaughan L. Clift ,  Kristin L. Harriman ,  Richard L. Pettys ,  David M. Headley ,  Tiffany M. Conerly

Inventor： Vaughan L. Clift ,  Kristin L. Harriman ,  Richard L. Pettys ,  David M. Headley ,  Tiffany M. Conerly

IPC: G01N23/00 ,  G01N21/03 ,  G01N33/00 ,  G01N30/00

CPC classification number: G01N21/78 ,  C12Q1/04 ,  G01N21/01 ,  G01N21/94 ,  G01N33/227 ,  G01N35/00029 ,  G01N2035/00148

Abstract: A method of rapidly detecting trace materials including biohazards, toxins, radioactive materials, and narcotics in situ is disclosed. A corresponding apparatus is disclosed. A trace of the material is collected on a pad of the card component, collected by swiping the pad on suspected surface or exposure to the suspected air volume. A novel card component is disclosed that when inserted in a chemical detection unit (CDU), releases reaction chemicals from flexible walled capsules in desired sequence. The exposed pad containing trace material and chemicals are heated in the chemical detection unit to produce a spectral pattern that is analyzed by the optical electronics in the CDU and results are displayed, stored and/or transmitted over a communications network.

Abstract translation: 公开了一种快速检测包括生物危害物，毒素，放射性物质和麻醉剂在内的痕量物质的方法。 公开了相应的装置。 将材料的痕迹收集在卡组件的垫上，通过在可疑表面上滑动垫或暴露于可疑的气体体积来收集。 公开了一种新颖的卡片组件，当插入化学检测单元（CDU）时，以期望的顺序从柔性壁胶囊释放反应化学物质。 包含微量材料和化学物质的暴露的焊盘在化学检测单元中被加热以产生由CDU中的光学电子器件分析的光谱图，并且通过通信网络显示，存储和/或传输结果。

公开(公告)号：US06454718B1

公开(公告)日：2002-09-24

申请号：US09554044

申请日：2000-05-09

Applicant: Vaughan L. Clift

Inventor： Vaughan L. Clift

IPC: A61B502

CPC classification number: A61B5/6817 ,  A61B5/0205 ,  A61B5/021 ,  A61B5/02427 ,  A61B5/04008 ,  A61B5/14552

Abstract: An intra aural probe for monitoring multiple physiological parameters simultaneously. The probe includes a pressure sensor, a temperature sensor and a light sensor. The probe is dimensioned to fit snugly and sealingly within the outer aural cavity. The probe measures blood pressure and pulse rate and volume of blood by detecting contraction and expansion in the vascular bed of the lining tissue of the external auditory canal during the cardiac cycle. The probe also measures respiratory rate and respiratory volume by detecting pressure changes across the tympanic membrane or movement of the tympanic membrane induced by corresponding pressure changes in the naso-pharynx and trachea during respiration. In addition, the probe measures temperature in the auditory canal, measures electroencephalographic voltages or electrocardiographic voltages by measuring small potential differences between the external auditory canal region and a suitable reference position, measures electroencephalographic currents by measuring magnetic flux, and measures changes in oxygen saturation of the haemoglobin traveling in the capillary bed lining the external auditory canal.

Abstract translation: 用于同时监测多种生理参数的耳内探测器。 探头包括压力传感器，温度传感器和光传感器。 探头的尺寸适合紧密地密封在外耳道腔内。 探测器通过检测心脏周期内外耳道内膜组织血管床的收缩和膨胀来测量血压，血压和血量。 通过检测鼓膜上的压力变化或由呼吸期间鼻咽和气管中的相应压力变化引起的鼓膜运动，探头也测量呼吸频率和呼吸量。 此外，探头测量耳道的温度，通过测量外耳道区域和合适的参考位置之间的小电位差来测量脑电压或心电图电压，通过测量磁通量测量脑电流，并测量氧饱和度的变化 血红蛋白在毛细血管床中行进，衬在外耳道内。

公开(公告)号：US5665238A

公开(公告)日：1997-09-09

申请号：US605300

申请日：1996-01-26

Applicant: Peggy A. Whitson ,  Vaughan L. Clift

Inventor： Peggy A. Whitson ,  Vaughan L. Clift

IPC: B01L3/00 ,  G01N33/483 ,  G01N33/49 ,  G01N33/50 ,  B01D37/00 ,  B01D61/00

CPC classification number: B01L3/5023 ,  B01L3/50853 ,  G01N33/491 ,  G01N33/5002 ,  B01L2300/0681 ,  B01L2400/0487 ,  Y10T436/25375 ,  Y10T436/255

Abstract: The present invention provides an apparatus for separating a relatively large volume of blood into cellular and acellular fractions without the need for centrifugation. The apparatus comprises a housing divided by a fibrous filter into a blood sample collection chamber having a volume of at least about 1 milliliter and a serum sample collection chamber. The fibrous filter has a pore size of less than about 3 microns, and is coated with a mixture of mannitol and plasma fraction protein (or an animal or vegetable equivalent thereof). The coating causes the cellular fraction to be trapped by the small pores, leaving the cellular fraction intact on the fibrous filter while the acellular fraction passes through the filter for collection in unaltered form from the serum sample collection chamber.

Abstract translation: 本发明提供了一种用于将相对较大体积的血液分离成细胞和无细胞级分而不需要离心的装置。 该装置包括由纤维过滤器分成具有至少约1毫升体积的血液样品收集室的壳体和血清样品收集室。 纤维过滤器的孔径小于约3微米，并且用甘露糖醇和血浆级分蛋白（或其动物或植物当量）的混合物包被。 涂层导致细胞部分被小孔捕获，使细胞部分完整地保留在纤维过滤器上，而无细胞部分通过过滤器以从血清样品收集室以未改变的形式收集。