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公开(公告)号：US08268565B2
公开(公告)日：2012-09-18
申请号：US12326800
申请日：2008-12-02
申请人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Stephen A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence B. Blyn , Thomas A. Hall , Yun Jiang , James C. Hannis , Neill White , Vivek Samant , Mark W. Eshoo , Jared J. Drader
发明人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Stephen A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence B. Blyn , Thomas A. Hall , Yun Jiang , James C. Hannis , Neill White , Vivek Samant , Mark W. Eshoo , Jared J. Drader
CPC分类号： C12Q1/686 , C12Q1/6806 , C12Q1/6844 , C12Q1/6858 , C12Q1/6872 , C12Q1/6888 , C12Q1/689 , C12Q2600/156 , G01N2333/28 , G01N2333/32 , G01N2333/35 , G01N2333/36 , C12Q2563/167 , C12Q2545/101 , C12Q2531/113 , C12Q2565/627 , C12Q2545/113
摘要： The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.
摘要翻译： 本发明提供线粒体DNA的快速法医分析方法和线粒体DNA异质性表征的方法，可用于评估线粒体疾病的进展。
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公开(公告)号：US20090239224A1
公开(公告)日：2009-09-24
申请号：US12326800
申请日：2008-12-02
申请人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence B. Blyn , Thomas A. Hall , Yun Jiang , James C. Hannis , Neill White , Vivek Samant , Mark W. Eshoo , Jared J. Drader
发明人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence B. Blyn , Thomas A. Hall , Yun Jiang , James C. Hannis , Neill White , Vivek Samant , Mark W. Eshoo , Jared J. Drader
IPC分类号： C12Q1/68
CPC分类号： C12Q1/686 , C12Q1/6806 , C12Q1/6844 , C12Q1/6858 , C12Q1/6872 , C12Q1/6888 , C12Q1/689 , C12Q2600/156 , G01N2333/28 , G01N2333/32 , G01N2333/35 , G01N2333/36 , C12Q2563/167 , C12Q2545/101 , C12Q2531/113 , C12Q2565/627 , C12Q2545/113
摘要： The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.
摘要翻译： 本发明提供线粒体DNA的快速法医分析方法和线粒体DNA异质性表征的方法，可用于评估线粒体疾病的进展。
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3.发明申请Systems for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy 审中-公开线粒体DNA的快速法医分析系统和线粒体DNA异质性的表征公开(公告)号：US20100145626A1
公开(公告)日：2010-06-10
申请号：US12605628
申请日：2009-10-26
申请人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence B. Blyn , Thomas A. Hall , Yun Jiang , James C. Hannis , Neill White , Vivek Samant , Mark W. Eshoo , Jared J. Drader
发明人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence B. Blyn , Thomas A. Hall , Yun Jiang , James C. Hannis , Neill White , Vivek Samant , Mark W. Eshoo , Jared J. Drader
CPC分类号： C12Q1/686 , C12Q1/6806 , C12Q1/6844 , C12Q1/6858 , C12Q1/6872 , C12Q1/6888 , C12Q1/689 , C12Q2600/156 , G01N2333/28 , G01N2333/32 , G01N2333/35 , G01N2333/36 , C12Q2563/167 , C12Q2545/101 , C12Q2531/113 , C12Q2565/627 , C12Q2545/113
摘要： The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.
摘要翻译： 本发明提供线粒体DNA的快速法医分析方法和线粒体DNA异质性表征的方法，可用于评估线粒体疾病的进展。
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4.发明授权Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy 有权线粒体DNA快速法医分析方法及线粒体DNA异质性表征公开(公告)号：US07666588B2
公开(公告)日：2010-02-23
申请号：US10660998
申请日：2003-09-12
申请人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence B. Blyn , Thomas A. Hall , Yun Jiang , James C. Hannis , Neil White , Vivek Samant , Mark W. Eshoo , Jared J. Drader
发明人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence B. Blyn , Thomas A. Hall , Yun Jiang , James C. Hannis , Neil White , Vivek Samant , Mark W. Eshoo , Jared J. Drader
CPC分类号： C12Q1/686 , C12Q1/6806 , C12Q1/6844 , C12Q1/6858 , C12Q1/6872 , C12Q1/6888 , C12Q1/689 , C12Q2600/156 , G01N2333/28 , G01N2333/32 , G01N2333/35 , G01N2333/36 , C12Q2563/167 , C12Q2545/101 , C12Q2531/113 , C12Q2565/627 , C12Q2545/113
摘要： The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.
摘要翻译： 本发明提供线粒体DNA的快速法医分析方法和线粒体DNA异质性表征的方法，可用于评估线粒体疾病的进展。
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公开(公告)号：US20120115213A1
公开(公告)日：2012-05-10
申请号：US12837191
申请日：2010-07-15
申请人： Steven A. Hofstadler , Jose R. Gutierrez , James C. Hannis , Jared J. Drader , Rex O. Bare , Jeffrey C. Smith , Paul J. Gleason , Jared H. Nathanson , Ronald K. Bergold , Robert D. Miller , Kevin S. Oberkramer
发明人： Steven A. Hofstadler , Jose R. Gutierrez , James C. Hannis , Jared J. Drader , Rex O. Bare , Jeffrey C. Smith , Paul J. Gleason , Jared H. Nathanson , Ronald K. Bergold , Robert D. Miller , Kevin S. Oberkramer
CPC分类号： C12Q1/686 , B01L7/52 , C12Q1/6806 , G01N27/72 , G01N35/00871 , G01N35/0092 , G01N35/0095 , G01N35/0098 , G01N35/025 , G01N35/026 , G01N2035/00534
摘要： The present invention provides systems and methods for analysis of samples, particularly biological and environmental sample to detect biomolecules of interest contained therein. A variety of system components are described herein, including, but not limited to, components for sample handling, mixing of materials, sample processing, transfer of materials, and analysis of materials. The invention further provides mechanisms for combining and integrating the different components and for housing, moving, and storing system components or the system as a whole. The systems may include any one or more or all of these components. The system finds particular use when employed for analysis of nucleic acid molecule using mass spectrometry, however, the invention is not limited such specific uses.
摘要翻译： 本发明提供用于分析样品，特别是生物和环境样品以检测其中所含感兴趣的生物分子的系统和方法。 本文描述了各种系统组件，包括但不限于用于样品处理，材料混合，样品处理，材料转移和材料分析的组件。 本发明还提供了用于组合和集成不同部件并且用于整体地容纳，移动和存储系统部件或系统的机构。 这些系统可以包括这些组件中的任何一个或多个或全部。 当使用质谱法分析核酸分子时，该系统特别有用，但本发明不限于此。
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公开(公告)号：US08158936B2
公开(公告)日：2012-04-17
申请号：US12705352
申请日：2010-02-12
申请人： Steven A. Hofstadler , Jose R. Gutierrez , James C. Hannis , Jared J. Drader , Rex O. Bare , Jeffrey C. Smith , Paul J. Gleason , Jared Nathanson
发明人： Steven A. Hofstadler , Jose R. Gutierrez , James C. Hannis , Jared J. Drader , Rex O. Bare , Jeffrey C. Smith , Paul J. Gleason , Jared Nathanson
CPC分类号： H01J49/165 , C12Q1/6872 , G01N23/00 , G01R31/2812 , G01R31/2848 , G01R31/2853 , H01J27/02 , H01J49/0422 , H01J49/0431 , H01J49/0468
摘要： The invention relates generally to sample ionization, and provides ionization probe assemblies, systems, computer program products, and methods useful for this purpose.
摘要翻译： 本发明一般涉及样品离子化，并且提供电离探针组件，系统，计算机程序产品和用于此目的的方法。
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公开(公告)号：US09217132B2
公开(公告)日：2015-12-22
申请号：US13355261
申请日：2012-01-20
申请人： Mark W. Eshoo , Jose R. Gutierrez , Jared J. Drader , John Picuri , Karl M. Cabrera , Stanley Motley , Thomas N. Chiesl
发明人： Mark W. Eshoo , Jose R. Gutierrez , Jared J. Drader , John Picuri , Karl M. Cabrera , Stanley Motley , Thomas N. Chiesl
CPC分类号： G01N1/31 , B01L3/502715 , B01L2200/027 , B01L2300/06 , B01L2300/0816 , C12M47/06 , C12N1/066 , C12N13/00 , C12Q1/6806 , G01N1/30 , Y10T436/25
摘要： Provided herein are apparatuses and methods for fragmenting nucleic acids or disrupting cells. For example, some embodiments provide a disposable microfluidic device designed to position a sample to be in direct contact with a high frequency vibrating element that emits an ultrasonic frequency into the sample such that the vibrational energy transduced into the sample results in fragmenting nucleic acids or disrupting cells.
摘要翻译： 本文提供了用于分裂核酸或破坏细胞的装置和方法。 例如，一些实施例提供了一次性微流体装置，其被设计成将样品定位成与向样品中发射超声频率的高频振动元件直接接触，使得转导到样品中的振动能导致碎裂的核酸或破坏 细胞。
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公开(公告)号：US08796617B2
公开(公告)日：2014-08-05
申请号：US13342760
申请日：2012-01-03
申请人： Steven A. Hofstadler , Jose R. Gutierrez , James C. Hannis , Jared J. Drader , Rex O. Bare , Jeffrey C. Smith , Paul J. Gleason , Jared Nathanson
发明人： Steven A. Hofstadler , Jose R. Gutierrez , James C. Hannis , Jared J. Drader , Rex O. Bare , Jeffrey C. Smith , Paul J. Gleason , Jared Nathanson
CPC分类号： H01J49/165 , C12Q1/6872 , G01N23/00 , G01R31/2812 , G01R31/2848 , G01R31/2853 , H01J27/02 , H01J49/0422 , H01J49/0431 , H01J49/0468
摘要： The invention relates generally to sample ionization, and provides ionization probe assemblies, systems, computer program products, and methods useful for this purpose.
摘要翻译： 本发明一般涉及样品离子化，并且提供电离探针组件，系统，计算机程序产品和用于此目的的方法。
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公开(公告)号：US20120097846A1
公开(公告)日：2012-04-26
申请号：US13342760
申请日：2012-01-03
申请人： Steven A. Hofstadler , Jose R. Gutierrez , James C. Hannis , Jared J. Drader , Rex O. Bare , Jeffrey C. Smith , Paul J. Gleason , Jared Nathanson
发明人： Steven A. Hofstadler , Jose R. Gutierrez , James C. Hannis , Jared J. Drader , Rex O. Bare , Jeffrey C. Smith , Paul J. Gleason , Jared Nathanson
CPC分类号： H01J49/165 , C12Q1/6872 , G01N23/00 , G01R31/2812 , G01R31/2848 , G01R31/2853 , H01J27/02 , H01J49/0422 , H01J49/0431 , H01J49/0468
摘要： The invention relates generally to sample ionization, and provides ionization probe assemblies, systems, computer program products, and methods useful for this purpose.
摘要翻译： 本发明一般涉及样品离子化，并且提供电离探针组件，系统，计算机程序产品和用于此目的的方法。
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公开(公告)号：US20100219336A1
公开(公告)日：2010-09-02
申请号：US12705352
申请日：2010-02-12
申请人： Steven A. Hofstadler , Jose R. Gutierrez , James C. Hannis , Jared J. Drader , Rex O. Bare , Jeffrey C. Smith , Paul J. Gleason , Jared Nathanson
发明人： Steven A. Hofstadler , Jose R. Gutierrez , James C. Hannis , Jared J. Drader , Rex O. Bare , Jeffrey C. Smith , Paul J. Gleason , Jared Nathanson
CPC分类号： H01J49/165 , C12Q1/6872 , G01N23/00 , G01R31/2812 , G01R31/2848 , G01R31/2853 , H01J27/02 , H01J49/0422 , H01J49/0431 , H01J49/0468
摘要： The invention relates generally to sample ionization, and provides ionization probe assemblies, systems, computer program products, and methods useful for this purpose.
摘要翻译： 本发明一般涉及样品离子化，并且提供电离探针组件，系统，计算机程序产品和用于此目的的方法。
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