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公开(公告)号：US20060266543A1
公开(公告)日：2006-11-30
申请号：US11474775
申请日：2006-06-26
Applicant: Alexis Clare , Wesley King , William LaCourse , Howard Liebermann , James O'Keefe
Inventor： Alexis Clare , Wesley King , William LaCourse , Howard Liebermann , James O'Keefe
CPC classification number: G06K19/06018 , G06K19/06187 , Y10T29/49117 , Y10T29/49194
Abstract: A drawn glass-coated metallic member has a thermal contraction coefficient differential such that the thermal contraction coefficient of the glass is less than that of the metallic member. The thermal contraction coefficient differential is maintained within a predetermined range during drawing. Drawn glass is placed under residual compression, interfacial bonding between said glass and said wire is substantially uniform, and surface cracking and bond breaks between metal and glass are substantially prevented. Optical properties of the glass coated microwire provide a basis for enabling multi-bit encoding capability. Advantageously data encoding is achieved optically, magneto-optically or using a combined magnetic and optical encoding mechanism. The duplex material constitution of the glass coated microwire permits imparting of data thereon by selection and processing of the glass. Data implantation is readily achieved in-line, during an initial drawing operation, or as a separate post-draw process. Reading of data on optically encoded glass coated microwire is readily accomplished by optical or magnetic methodology, or a combination thereof.
Abstract translation: 拉制的玻璃涂覆的金属构件具有热收缩系数差，使得玻璃的热收缩系数小于金属构件的热收缩系数。 在拉伸期间，热收缩系数差保持在预定范围内。 拉制玻璃被置于残余压缩之下，所述玻璃和所述丝之间的界面结合基本上是均匀的，并且基本上防止了金属和玻璃之间的表面开裂和结合断裂。 玻璃涂层微丝的光学性质为实现多位编码能力提供了基础。 有利地，光学，磁光学或使用组合的磁和光编码机构实现数据编码。 玻璃涂布的微线的双面材料构成允许通过玻璃的选择和处理在其上赋予数据。 在初始绘图操作期间，或者作为单独的后绘制过程，数据注入很容易在线实现。 通过光学或磁性方法或其组合容易地实现对光学编码的玻璃包覆微丝的数据的读取。
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公开(公告)号：US5721049A
公开(公告)日：1998-02-24
申请号：US463009
申请日：1995-06-05
Applicant: Michele S. Marcolongo , Paul Ducheyne , Frank Ko , William LaCourse
Inventor： Michele S. Marcolongo , Paul Ducheyne , Frank Ko , William LaCourse
IPC: A61F2/00 , A61F2/30 , A61F2/36 , A61L27/02 , A61L27/10 , A61L27/42 , A61L27/44 , C03C13/00 , D03D15/00 , C04B33/24 , B32B17/04 , C03C3/076
CPC classification number: A61F2/30965 , A61F2/367 , A61L27/025 , A61L27/10 , A61L27/422 , A61L27/443 , A61L27/446 , C03C13/00 , D03D15/00 , D03D15/0011 , D03D15/0027 , D03D9/00 , A61F2/3094 , A61F2002/30289 , A61F2002/3082 , A61F2230/0091 , C03C2213/02 , D10B2101/06 , D10B2101/08 , D10B2101/12 , D10B2331/021 , D10B2401/041 , D10B2401/061 , D10B2401/063 , D10B2509/00 , Y10T428/249949 , Y10T428/29 , Y10T428/2907 , Y10T428/2924 , Y10T428/2929 , Y10T428/2931 , Y10T428/31504
Abstract: Composite materials formed from bone bioactive glass or ceramic fibers and structural fibers are disclosed. In preferred embodiments, a braid or mesh of interwoven bone bioactive glass or ceramic fibers and structural fibers is impregnated with a polymeric material to provide a composite of suitable biocompatibility and structural integrity. Most preferably, the mesh or braid is designed so that the bioactive fibers are concentrated at the surface of the implant to create a surface comprised of at least 30% bioactive material, thereby providing enhanced bone ingrowth. The interweaving between the bone bioactive glass or ceramic fibers and the core of structural fibers overcomes the problems found in prior composite systems where the bioactive material delaminates from the polymer. Preferred bioactive materials include calcium phosphate ceramics and preferred structural fibers include carbon fibers. Further preferred bioactive materials include aluminum oxide at greater than 0.2%, by mole. Improved prosthetic implants and methods of affixing an implant are thus also disclosed.
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公开(公告)号：US20050221365A1
公开(公告)日：2005-10-06
申请号：US11098052
申请日：2005-04-04
Applicant: Alan Goldstein , William LaCourse , Howard Liebermann
Inventor： Alan Goldstein , William LaCourse , Howard Liebermann
CPC classification number: B01L7/52 , A61B2017/008 , B01L3/502707 , B01L3/502715 , B01L3/50851 , B01L3/561 , B01L2200/12 , B01L2200/16 , B01L2300/0838 , B01L2300/0845 , B01L2300/16 , B01L2300/1827 , C12Q1/686 , Y10T428/2933 , Y10T428/294 , Y10T428/2958
Abstract: A metallic glass-coated microwire has controllable surface porosity. The porosity is achieved by etching the metallic glass-coated microwire or other shapes of glass-coated bodies with acid after annealing to produce a multi-phase glass coating. Porous metallic glass-coated microwires are found to make superior PCR machines, which find use in a variety of in vivo, biochemical, and chemical sensors. Advantageously, the PCR apparatus is smaller, less expensive to construct than conventional units. It readily carries out in vivo passive or active operations.
Abstract translation: 金属玻璃涂层微丝具有可控的表面孔隙度。 通过在退火之后用酸蚀刻金属玻璃包覆的微丝或其它形状的玻璃涂覆体以产生多相玻璃涂层来实现孔隙率。 发现多孔金属玻璃涂层微丝可以制造出优异的PCR机器，可用于各种体内，生物化学和化学传感器。 有利地，PCR装置比常规单元更小，更便宜。 它容易进行体内被动或主动操作。
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公开(公告)号：US5468544A
公开(公告)日：1995-11-21
申请号：US152962
申请日：1993-11-15
Applicant: Michele S. Marcolongo , Paul Ducheyne , Frank Ko , William LaCourse
Inventor： Michele S. Marcolongo , Paul Ducheyne , Frank Ko , William LaCourse
IPC: A61L27/00 , A61F2/00 , A61F2/30 , A61F2/32 , A61F2/36 , A61L27/02 , A61L27/10 , A61L27/42 , A61L27/44 , A61L31/00 , A61L31/12 , C03C4/00 , C03C13/00 , C08J5/04 , D03D1/00 , D03D15/00 , D04C1/02 , D04H13/00 , B32B18/00 , B32B27/00 , B32B33/00
CPC classification number: C03C4/0007 , A61F2/30965 , A61F2/367 , A61L27/025 , A61L27/10 , A61L27/422 , A61L27/443 , A61L27/446 , C03C13/00 , D03D15/00 , D03D15/0011 , D03D15/0027 , D03D9/00 , A61F2/3094 , A61F2002/30289 , A61F2002/3082 , A61F2230/0091 , C03C2213/02 , D10B2101/06 , D10B2101/08 , D10B2101/12 , D10B2331/021 , D10B2401/041 , D10B2401/061 , D10B2401/063 , D10B2509/00 , Y10T428/29 , Y10T428/2929 , Y10T428/2931 , Y10T428/2964 , Y10T428/2965 , Y10T428/2967 , Y10T428/2969 , Y10T428/2973 , Y10T428/2978 , Y10T428/30 , Y10T442/3049 , Y10T442/3236
Abstract: Composite materials formed from bone bioactive glass or ceramic fibers and structural fibers are disclosed. In preferred embodiments, a braid or mesh of interwoven bone bioactive glass or ceramic fibers and structural fibers is impregnated with a polymeric material to provide a composite of suitable biocompatibility and structural integrity. Most preferably, the mesh or braid is designed so that the bioactive fibers are concentrated at the surface of the implant to create a surface comprised of at least 30% bioactive material, thereby providing enhanced bone ingrowth. The interweaving between the bone bioactive glass or ceramic fibers and the core of structural fibers overcomes the problems found in prior composite systems where the bioactive material delaminates from the polymer. Preferred bioactive materials include calcium phosphate ceramics and preferred structural fibers include carbon fibers. Improved prosthetic implants and methods of affixing an implant are thus also disclosed.
Abstract translation: 公开了由骨生物活性玻璃或陶瓷纤维和结构纤维形成的复合材料。 在优选的实施方案中，用聚合物材料浸渍交织的骨生物活性玻璃或陶瓷纤维和结构纤维的编织物或网，以提供合适的生物相容性和结构完整性的复合材料。 最优选地，网或编织物被设计成使得生物活性纤维集中在植入物的表面以产生由至少30％的生物活性材料组成的表面，从而提供增强的骨向内生长。 骨生物活性玻璃或陶瓷纤维与结构纤维芯之间的交织克服了现有复合体系中发现的问题，其中生物活性材料从聚合物分层。 优选的生物活性材料包括磷酸钙陶瓷，优选的结构纤维包括碳纤维。 因此，还公开了改进的假体植入物和固定植入物的方法。
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公开(公告)号：US20050000599A1
公开(公告)日：2005-01-06
申请号：US10881760
申请日：2004-06-30
Applicant: Howard Liebermann , William LaCourse
Inventor： Howard Liebermann , William LaCourse
IPC: B32B15/02 , B32B15/04 , C03B37/026 , C03C20060101 , H01F1/01
CPC classification number: C03B37/026 , H01F1/15333 , H01F1/15391 , Y10T428/294
Abstract: A drawn glass-coated metallic member has a thermal contraction coefficient differential such that the thermal contraction coefficient of the glass is less than that of the metallic member. The thermal contraction coefficient differential is maintained within a predetermined range during drawing. The glass is placed under residual compression, interfacial bonding between said glass and said wire is substantially uniform, and surface cracking and bond breaks between metal and glass are substantially prevented. A dynamic balance is maintained between the surface tension of the molten alloy and the resistance to high temperature deformation by the glass vessel in which it is contained, enabling the production of glass-coated amorphous or nanocrystalline alloy members having predefined cross-sectional shapes.
Abstract translation: 拉制的玻璃涂覆的金属构件具有热收缩系数差，使得玻璃的热收缩系数小于金属构件的热收缩系数。 在拉伸期间，热收缩系数差保持在预定范围内。 将玻璃置于残余压缩之下，所述玻璃与所述丝之间的界面结合基本上是均匀的，并且基本上防止了金属和玻璃之间的表面裂纹和结合断裂。 熔融合金的表面张力与容纳玻璃容器的耐高温变形性之间保持动态平衡，能够生产具有预定横截面形状的玻璃涂覆的非晶或纳米晶合金构件。
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Patent Agency Ranking
公开(公告)号：US6121172A
公开(公告)日：2000-09-19
申请号：US461109
申请日：1995-06-05
Applicant: Michele S. Marcolongo , Paul Ducheyne , Frank Ko , William LaCourse
Inventor： Michele S. Marcolongo , Paul Ducheyne , Frank Ko , William LaCourse
IPC: A61F2/00 , A61F2/30 , A61F2/36 , A61L27/02 , A61L27/10 , A61L27/42 , A61L27/44 , C03C13/00 , D03D15/00 , B32B18/00 , C04B33/24
CPC classification number: D03D15/00 , A61F2/30965 , A61F2/367 , A61L27/025 , A61L27/10 , A61L27/422 , A61L27/443 , A61L27/446 , C03C13/00 , D03D15/0011 , D03D15/0027 , D03D9/00 , A61F2/3094 , A61F2002/30289 , A61F2002/3082 , A61F2230/0091 , C03C2213/02 , D10B2101/06 , D10B2101/08 , D10B2101/12 , D10B2331/021 , D10B2401/041 , D10B2401/061 , D10B2401/063 , D10B2509/00
Abstract: Composite materials formed from bone bioactive glass or ceramic fibers and structural fibers are disclosed. In preferred embodiments, a braid or mesh of interwoven bone bioactive glass or ceramic fibers and structural fibers is impregnated with a polymeric material to provide a composite of suitable biocompatibility and structural integrity. Most preferably, the mesh or braid is designed so that the bioactive fibers are concentrated at the surface of the implant to create a surface comprised of at least 30% bioactive material, thereby providing enhanced bone ingrowth. The interweaving between the bone bioactive glass or ceramic fibers and the core of structural fibers overcomes the problems found in prior composite systems where the bioactive material delaminates from the polymer. Preferred bioactive materials include calcium phosphate ceramics and preferred structural fibers include carbon fibers. Further preferred bioactive materials include aluminum oxide at greater than 0.2%, by mole. Improved prosthetic implants and methods of affixing an implant are thus also disclosed.
Abstract translation: 公开了由骨生物活性玻璃或陶瓷纤维和结构纤维形成的复合材料。 在优选的实施方案中，用聚合物材料浸渍交织的骨生物活性玻璃或陶瓷纤维和结构纤维的编织物或网，以提供合适的生物相容性和结构完整性的复合材料。 最优选地，网或编织物被设计成使得生物活性纤维集中在植入物的表面以产生由至少30％的生物活性材料组成的表面，从而提供增强的骨向内生长。 骨生物活性玻璃或陶瓷纤维与结构纤维芯之间的交织克服了现有复合体系中发现的问题，其中生物活性材料从聚合物分层。 优选的生物活性材料包括磷酸钙陶瓷，优选的结构纤维包括碳纤维。 进一步优选的生物活性材料包括大于0.2％（摩尔）的氧化铝。 因此，还公开了改进的假体植入物和固定植入物的方法。
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公开(公告)号：US20070292958A1
公开(公告)日：2007-12-20
申请号：US11708047
申请日：2007-02-20
Applicant: William Lacourse , Swati Modi
Inventor： William Lacourse , Swati Modi
CPC classification number: C12Q1/00 , C12Q1/34 , Y10T436/11
Abstract: The present invention relates to apparatuses and methods for analyzing enzyme reactions, including, large, industrial-scale reactions. The methods allow for enzymatic reaction to be followed on-line in real-time, without the need for sample removal and without contamination. Furthermore, the methods provide for quantitative analysis of analytes of enzymatic reactions.
Abstract translation: 本发明涉及用于分析酶反应的装置和方法，包括大的工业规模反应。 该方法允许在线实时地进行酶反应，而不需要去除样品并且没有污染。 此外，该方法提供了酶反应分析物的定量分析。
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公开(公告)号：US20060019400A1
公开(公告)日：2006-01-26
申请号：US11186993
申请日：2005-07-22
Applicant: William LaCourse , Romina Kaushik , Ronita Marple
Inventor： William LaCourse , Romina Kaushik , Ronita Marple
IPC: G01N33/00
CPC classification number: G01N30/64 , G01N30/84 , G01N2030/8435 , Y10T436/142222
Abstract: The present invention provides methods and kits for the detection of glucuronide metabolites of various drugs, alcohols and other compounds using a combination of High Performance Liquid Chromatography coupled with Pulsed Electrochemical Detection. Detection of a drug and its glucuronide metabolite(s) has applications in interpretive forensic and clinical toxicology. The ability to estimate metabolite/drug ratios enables the assessment of route, dose and time of exposure. In instances where the parent drug is biotransformed quickly and can only found in low levels in biological fluids, the detection of metabolites allows for the identification of parent drugs. Furthermore, metabolite determination enables the differentiation between recent and chronic drug use.
Abstract translation: 本发明提供用于使用高效液相色谱与脉冲电化学检测结合来检测各种药物，醇和其它化合物的葡糖苷酸代谢物的方法和试剂盒。 检测药物及其葡糖苷酸代谢物在解释性法医和临床毒理学中有应用。 估计代谢物/药物比例的能力可以评估路线，剂量和暴露时间。 在母体药物快速生物转化并且只能在生物液体中发现低水平的情况下，代谢物的检测允许鉴定母体药物。 此外，代谢物测定使得能够区分近期和慢性药物使用。
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公开(公告)号：US20050109435A1
公开(公告)日：2005-05-26
申请号：US10935258
申请日：2004-09-07
Applicant: Howard Liebermann , William LaCourse , Alexis Clare , Wesley King , James O'Keefe
Inventor： Howard Liebermann , William LaCourse , Alexis Clare , Wesley King , James O'Keefe
IPC: G06K20060101 , G06K19/06 , H01F1/09 , H01F1/38
CPC classification number: G06K19/06018 , G06K19/06046 , G06K19/06187 , G06K19/06196 , Y10T428/12465 , Y10T428/2935 , Y10T428/2938 , Y10T428/2949
Abstract: A glass-coated amorphous metallic microwire is encoded with multi-bit digital information. Encoding is achieved magnetically, optically or through a combination of magnetic and optical encoding processes. Magnetic encoding is carried out by modifying the constituent magnetic domain structure through selective relief of interfacial stress between the glass coating and the amorphous metallic alloy core. It is also achieved by selective surface crystallization of the amorphous metallic core in order to produce a controlled magnetic bias field. Optical encoding is associated with the glass coating. It is readily achieved by fluorescent element deposition, patterned removal of fluorescent element coating, Bragg grating, and thermally activated pattern deposition. The magnetic and optical multi-bit encoding approaches for glass-coated amorphous metallic microwire can be used individually or collectively in either a redundant or a complementary manner. Encoded microwire of the instant invention can be assembled into tags for electronic article surveillance and into numerous other structures as well.
Abstract translation: 用多位数字信息编码玻璃涂层的非晶态金属微丝。 编码是通过磁学，光学或通过磁和光编码过程的组合实现的。 通过选择性地避免玻璃涂层和非晶金属合金芯之间的界面应力来改变构成磁畴结构来进行磁编码。 也可以通过非晶金属芯的选择性表面结晶来实现，以产生受控的磁偏置场。 光学编码与玻璃涂层有关。 通过荧光元件沉积，荧光元件涂层的图案化去除，布拉格光栅和热激活图案沉积容易实现。 用于玻璃涂覆的非晶金属微丝的磁和光多位编码方法可以单独使用或以多余或互补的方式共同使用。 本发明的编码微线可以组装成用于电子物品监视的标签以及许多其它结构。
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公开(公告)号：US20060086528A1
公开(公告)日：2006-04-27
申请号：US10972549
申请日：2004-10-25
Applicant: Alexis Clare , Wesley King , William LaCourse , Howard Liebermann , James O' Keefe
Inventor： Alexis Clare , Wesley King , William LaCourse , Howard Liebermann , James O' Keefe
IPC: H01B7/00
CPC classification number: G06K19/06018 , G06K19/06187 , Y10T29/49117 , Y10T29/49194
Abstract: A drawn glass-coated metallic member has a thermal contraction coefficient differential such that the thermal contraction coefficient of the glass is less than that of the metallic member. The thermal contraction coefficient differential is maintained within a predetermined range during drawing. Drawn glass is placed under residual compression, interfacial bonding between said glass and said wire is substantially uniform, and surface cracking and bond breaks between metal and glass are substantially prevented. Optical properties of the glass coated microwire provide a basis for enabling multi-bit encoding capability. Advantageously data encoding is achieved optically, magneto-optically or using a combined magnetic and optical encoding mechanism. The duplex material constitution of the glass coated microwire permits imparting of data thereon by selection and processing of the glass. Data implantation is readily achieved in-line, during an initial drawing operation, or as a separate post-draw process. Reading of data on optically encoded glass coated microwire is readily accomplished by optical or magnetic methodology, or a combination thereof.
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