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133 条记录 (耗时 0.031 秒)

    Traceable card holder
    2.
    发明授权
    Traceable card holder 有权

    公开(公告)号：US11896098B2

    公开(公告)日：2024-02-13

    申请号：US17512697

    申请日：2021-10-28

    申请人： Xiangyang Zhang ,  Yi Xiao

    发明人： Xiangyang Zhang ,  Yi Xiao

    IPC分类号： A45C1/06 ,  A45C11/18 ,  A45C13/18

    CPC分类号： A45C1/06 ,  A45C11/182 ,  A45C13/185 ,  A45C2001/065 ,  A45C2001/067

    摘要： The invention discloses a traceable card holder, comprising a first clamp plate, a second clamp plate, an elastic band, top cover components, bottom cover components, a tracker and an elastic clamp; the first clamp plate is arranged oppositely to the second clamp plate, the elastic band is connected respectively with the first clamp plate and the second clamp plate, and the elastic band is used to drive the first clamp plate and the second clamp plate to move towards each other for clamping; the top cover components are detachably mounted on one side of the first clamp plate which is away from the second clamp plate, and the tracker is detachably mounted on the top cover components.

    APTAMER-BASED SENSORS FOR DETECTION OF FENTANYL OPIOIDS
    4.
    发明申请
    APTAMER-BASED SENSORS FOR DETECTION OF FENTANYL OPIOIDS 有权

    公开(公告)号：US20210396706A1

    公开(公告)日：2021-12-23

    申请号：US17354342

    申请日：2021-06-22

    申请人： Yi XIAO ,  Juan CANOURA

    发明人： Yi XIAO ,  Juan CANOURA

    IPC分类号： G01N27/327 ,  C12N15/115 ,  G01N21/64

    摘要： The subject invention provides materials and methods for single-step fluorescence and electrochemical detection of small molecules, e.g., fentanyl and its analogs, in a sample. The subjection invention provides nucleic acids materials, e.g., aptamers (nucleic acid oligonucleotides) that can bind to fentanyl and its analogs with nanomolar affinity and high specificity against illicit drugs, adulterants, and cutting agents commonly existing in seized samples. The method for detecting fentanyl and/or its analogs in a sample comprises contacting the sample with an aptamer-based sensor selective for fentanyl and its analogs, and sensitively, specifically, and rapidly detecting fentanyl and/or its analogs in the sample.

    Aptamers that bind to natural and synthetic cannabinoids
    5.
    发明授权
    Aptamers that bind to natural and synthetic cannabinoids 有权

    公开(公告)号：US10907163B1

    公开(公告)日：2021-02-02

    申请号：US16901723

    申请日：2020-06-15

    申请人： Yi Xiao ,  Haixiang Yu

    发明人： Yi Xiao ,  Haixiang Yu

    IPC分类号： C12N15/11 ,  C12N15/115 ,  G01N33/94 ,  G01N21/64

    摘要： The subject invention provides materials and methods for single-step detection of small molecules, e.g., natural and synthetic cannabinoids, in a sample. The subjection invention provides nucleic acids materials, e.g., aptamers (nucleic acid oligonucleotides) that can bind to natural and/or synthetic cannabinoids. The method for detecting a natural or synthetic cannabinoid in a sample comprises contacting the sample with an aptamer-based sensor selective for the natural or synthetic cannabinoid, and sensitively and rapidly detecting the natural or synthetic cannabinoid in the sample. The aptamer-based sensor comprises aptamers that can specifically binds to natural and/or synthetic cannabinoids with nanomolar dissociation constant.

    MATERIALS AND METHODS FOR RAPID AND SENSITIVE DETECTION OF SMALL-MOLECULE TARGETS
    6.
    发明申请
    MATERIALS AND METHODS FOR RAPID AND SENSITIVE DETECTION OF SMALL-MOLECULE TARGETS 审中-公开

    公开(公告)号：US20190309296A1

    公开(公告)日：2019-10-10

    申请号：US15947315

    申请日：2018-04-06

    申请人： YI XIAO ,  HAIXIANG YU

    发明人： YI XIAO ,  HAIXIANG YU

    IPC分类号： C12N15/115 ,  G01N33/92 ,  G01N33/94

    摘要： The subject invention provides methods, assays and products for detecting small-molecules in a sample, in particular, in both clinical and field settings. The method for detecting a small-molecule target in a sample comprises providing a sample, contacting the sample with an aptamer-based sensor selective for the small-molecule target, and sensitively and rapidly detecting the small-molecule target in the sample. Specifically, the method utilizes EATR-amplified small-molecule sensors based on cooperative binding split aptamers (CBSAs).

    MATERIALS AND METHODS FOR RAPID AND SPECIFIC DETECTION OF COCAINE
    9.
    发明申请
    MATERIALS AND METHODS FOR RAPID AND SPECIFIC DETECTION OF COCAINE 有权
    用于快速和特异性检测COCAINE的材料和方法

    公开(公告)号：US20160131668A1

    公开(公告)日：2016-05-12

    申请号：US14930242

    申请日：2015-11-02

    申请人： Daniel RONCANCIO ,  Haixiang YU ,  Xiaowen XU ,  Yi XIAO

    发明人： Daniel RONCANCIO ,  Haixiang YU ,  Xiaowen XU ,  Yi XIAO

    IPC分类号： G01N33/94 ,  C12N15/115

    CPC分类号： G01N33/946 ,  C12N15/115 ,  C12N2310/16 ,  C12N2320/10

    摘要： The invention pertains to a rapid and specific aptamer-based method for one-step cocaine detection with minimal reagent requirements based on an aptamer sensor that reports the presence of cocaine via the displacement and unquenching of a bound fluorophore molecule. In certain embodiments, the invention provides novel aptamers, which have reduced background fluorescence, bind a fluorophore molecule tightly, and show an increased signal gain in the presence of cocaine.

    摘要翻译： 本发明涉及用于一步可卡因检测的快速和特异性基于适体的方法，其基于适配体传感器具有最小的试剂需求，所述适体传感器通过结合的荧光团分子的置换和消除来报告可卡因的存在。 在某些实施方案中，本发明提供新颖的适体，其具有降低的背景荧光，紧密结合荧光团分子，并且在可卡因存在下显示增加的信号增益。