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    Compound having phosphorylcholine group, polymer thereof and process for producing the same
    1.
    发明授权
    Compound having phosphorylcholine group, polymer thereof and process for producing the same 有权
    具有磷酸胆碱基的化合物，其聚合物及其制备方法

    公开(公告)号：US07378538B2

    公开(公告)日：2008-05-27

    申请号：US10518462

    申请日：2004-02-18

    申请人： Yu Nagase ,  Masataka Oku ,  Kazuhiko Ishihara ,  Yasuhiko Iwasaki

    发明人： Yu Nagase ,  Masataka Oku ,  Kazuhiko Ishihara ,  Yasuhiko Iwasaki

    IPC分类号： C07F9/02

    CPC分类号： C07F9/65742 ,  C07F9/091 ,  C08G18/3206 ,  C08G18/3889 ,  C08G18/7657 ,  C08G61/10 ,  C08G63/6924

    摘要： A compound of the invention is a specific compound having a phosphorylcholine group, and a polymer of the invention comprises at least 1 mol % of repeating units with a phosphorylcholine group and has a number-average molecular weight of 1,000 or more, the repeating units with a phosphorylcholine group being represented by the formula (II): wherein A is a bond selected from a single bond, —O—, —COO—, —OOC—, —CONH—, —NH—, —NHCO—, —NR2— and —CH2O— where R2 is an alkyl group having 1 to 6 carbon atoms; and m is an integer of 1 to 12.

    摘要翻译： 本发明的化合物是具有磷酸胆碱基团的具体化合物，本发明的聚合物含有至少1摩尔％的具有磷酸胆碱基的重复单元，数均分子量为1,000以上，重复单元与 磷酸胆碱基团由式（II）表示：其中A是选自单键，-O - ， - COO - ， - OOC - ， - CONH - ， - NH - ， - NHCO-， 其中R 2是具有1至6个碳原子的烷基;其中R 2是具有1至6个碳原子的烷基; m为1〜12的整数。

    Compound having phosphorylcholine group, polymer thereof and process for producing the same
    2.
    发明申请
    Compound having phosphorylcholine group, polymer thereof and process for producing the same 有权
    具有磷酸胆碱基的化合物，其聚合物及其制备方法

    公开(公告)号：US20060041160A1

    公开(公告)日：2006-02-23

    申请号：US10518462

    申请日：2004-02-18

    申请人： Yu Nagase ,  Masataka Oku ,  Kazuhiko Ishihara ,  Yasuhiko Iwasaki

    发明人： Yu Nagase ,  Masataka Oku ,  Kazuhiko Ishihara ,  Yasuhiko Iwasaki

    IPC分类号： C07F9/10

    CPC分类号： C07F9/65742 ,  C07F9/091 ,  C08G18/3206 ,  C08G18/3889 ,  C08G18/7657 ,  C08G61/10 ,  C08G63/6924

    摘要： A compound of the invention is a specific compound having a phosphorylcholine group, and a polymer of the invention comprises at least 1 mol % of repeating units with a phosphorylcholine group and has a number-average molecular weight of 1,000 or more, the repeating units with a phosphorylcholine group being represented by the formula (II): wherein A is a bond selected from a single bond, —O—, —COO—, —OOC—, —CONH—, —NH—, —NHCO—, —NR2— and —CH2O— where R2 is an alkyl group having 1 to 6 carbon atoms; and m is an integer of 1 to 12.

    摘要翻译： 本发明的化合物是具有磷酸胆碱基团的具体化合物，本发明的聚合物含有至少1摩尔％的具有磷酸胆碱基的重复单元，数均分子量为1,000以上，重复单元与 磷酸胆碱基团由式（II）表示：其中A是选自单键，-O - ， - COO - ， - OOC - ， - CONH - ， - NH - ， - NHCO-， 其中R 2是具有1至6个碳原子的烷基;其中R 2是具有1至6个碳原子的烷基; m为1〜12的整数。

    Diamine compound having phosphorylcholine group, polymer thereof, and process for producing the polymer
    3.
    发明授权
    Diamine compound having phosphorylcholine group, polymer thereof, and process for producing the polymer 有权
    具有磷酸胆碱基团的二胺化合物，其聚合物，以及聚合物的制造方法

    公开(公告)号：US08063238B2

    公开(公告)日：2011-11-22

    申请号：US12439192

    申请日：2007-08-31

    申请人： Yu Nagase ,  Naoya Shimoyamada ,  Yasuhiko Iwasaki ,  Kazuhiko Ishihara

    发明人： Yu Nagase ,  Naoya Shimoyamada ,  Yasuhiko Iwasaki ,  Kazuhiko Ishihara

    IPC分类号： C07F9/02 ,  C08G18/70

    CPC分类号： C08G73/1046 ,  C07F9/091 ,  C08G18/10 ,  C08G18/3206 ,  C08G69/26 ,  C08G73/105 ,  C08G18/4854 ,  C08G18/3889

    摘要： Highly polymerizable diamine compounds having a phosphorylcholine group are disclosed. High-molecular weight polymers are obtained from the highly polymerizable diamine compound having a phosphorylcholine group as a monomer, and the polymers have improved mechanical strength, water resistance and heat resistance while maintaining excellent biocompatibility and processability of MPC polymers. Processes for producing the polymers are disclosed. The diamine compounds having a phosphorylcholine group are represented by Formula (I). The polymers contain at least 1 mol % of a specific structural unit with a phosphorylcholine group represented by Formula (II) and have a number average molecular weight of not less than 5,000. In the processes, the diamine compound is used as a monomer.

    摘要翻译： 公开了具有磷酸胆碱基团的高度可聚合的二胺化合物。 从具有磷酸胆碱基团的高度可聚合的二胺化合物作为单体获得高分子量聚合物，并且聚合物具有改善的机械强度，耐水性和耐热性，同时保持MPC聚合物优异的生物相容性和加工性。 公开了制备聚合物的方法。 具有磷酸胆碱基团的二胺化合物由式（I）表示。 聚合物含有至少1摩尔％的具有由式（II）表示的磷酸胆碱基团并且数均分子量不小于5,000的特定结构单元。 在该方法中，二胺化合物用作单体。

    Diamine Compound Having Phosphorylcholine Group, Polymer Thereof, and Process for Producing the Polymer
    4.
    发明申请
    Diamine Compound Having Phosphorylcholine Group, Polymer Thereof, and Process for Producing the Polymer 有权
    具有磷酰胆碱基团的二胺化合物，其聚合物以及聚合物的制备方法

    公开(公告)号：US20100036081A1

    公开(公告)日：2010-02-11

    申请号：US12439192

    申请日：2007-08-31

    申请人： Yu Nagase ,  Naoya Shimoyamada ,  Yasuhiko Iwasaki ,  Kazuhiko Ishihara

    发明人： Yu Nagase ,  Naoya Shimoyamada ,  Yasuhiko Iwasaki ,  Kazuhiko Ishihara

    IPC分类号： C07F9/09 ,  C08G73/00

    CPC分类号： C08G73/1046 ,  C07F9/091 ,  C08G18/10 ,  C08G18/3206 ,  C08G69/26 ,  C08G73/105 ,  C08G18/4854 ,  C08G18/3889

    摘要： Highly polymerizable diamine compounds having a phosphorylcholine group are disclosed. High-molecular weight polymers are obtained from the highly polymerizable diamine compound having a phosphorylcholine group as a monomer, and the polymers have improved mechanical strength, water resistance and heat resistance while maintaining excellent biocompatibility and processability of MPC polymers. Processes for producing the polymers are disclosed. The diamine compounds having a phosphorylcholine group are represented by Formula (I). The polymers contain at least 1 mol % of a specific structural unit with a phosphorylcholine group represented by Formula (II) and have a number average molecular weight of not less than 5,000. In the processes, the diamine compound is used as a monomer.

    摘要翻译： 公开了具有磷酸胆碱基团的高度可聚合的二胺化合物。 从具有磷酸胆碱基团的高度可聚合的二胺化合物作为单体获得高分子量聚合物，并且聚合物具有改善的机械强度，耐水性和耐热性，同时保持MPC聚合物优异的生物相容性和加工性。 公开了制备聚合物的方法。 具有磷酸胆碱基团的二胺化合物由式（I）表示。 聚合物含有至少1摩尔％的具有由式（II）表示的磷酸胆碱基团并且数均分子量不小于5,000的特定结构单元。 在该方法中，二胺化合物用作单体。

    BIOABSORBABLE BLEND FOR TEMPORARY SCAFFOLDING OF THE BLOOD VESSEL WALL
    8.
    发明申请
    BIOABSORBABLE BLEND FOR TEMPORARY SCAFFOLDING OF THE BLOOD VESSEL WALL 有权
    生物可溶性混合物用于血管壁的临时消毒

    公开(公告)号：US20110178594A1

    公开(公告)日：2011-07-21

    申请号：US13120507

    申请日：2008-11-07

    申请人： Hyung Il Kim ,  Kazuhiko Ishihara

    发明人： Hyung Il Kim ,  Kazuhiko Ishihara

    IPC分类号： A61F2/82 ,  A61L27/26 ,  A61F2/06 ,  B29D7/00

    CPC分类号： A61L31/041 ,  A61F2/82 ,  A61F2210/0004 ,  A61L27/14 ,  A61L27/26 ,  A61L27/507 ,  A61L31/148 ,  A61L2300/80 ,  C08L101/02 ,  C08L67/04

    摘要： A bioabsorbable blend comprising poly(L-lactide) (PLLA) and a phosphorylcholine group-containing copolymer (PPCP) capable of enduring the mechanical strength of blood vessel walls and applicable for fabricating cardiovascular devices was developed. The blend acts as a scaffold to support blood vessel walls during vascular healing and undergoes biodegradation in vivo after vascular healing is complete. Furthermore, the blend can prevent the formation and adsorption of thrombi.

    摘要翻译： 开发了能够耐受血管壁的机械强度并适用于制造心血管装置的包含聚（L-丙交酯）（PLLA）和含磷酸胆碱基团的共聚物（PPCP）的生物可吸收混合物。 混合物作为支架，用于在血管愈合期间支持血管壁，并且在血管愈合完成后在体内经历生物降解。 此外，共混物可以防止血栓的形成和吸附。

    MATERIAL FOR PREVENTING TISSUE ADHESION AND MATERIAL FOR PREVENTING JOINT CONTRACTURE
    9.
    发明申请
    MATERIAL FOR PREVENTING TISSUE ADHESION AND MATERIAL FOR PREVENTING JOINT CONTRACTURE 审中-公开
    防止组织粘合的材料和预防联合合同的材料

    公开(公告)号：US20110059176A1

    公开(公告)日：2011-03-10

    申请号：US12744251

    申请日：2008-11-14

    申请人： Toru Moro ,  Kozo Nakamura ,  Hiroshi Kawaguchi ,  Noriyuki Ishiyama ,  Kazuhiko Ishihara ,  Tomohiro Konno ,  Tadashi Ohyama ,  Mizuna Yoshikawa

    发明人： Toru Moro ,  Kozo Nakamura ,  Hiroshi Kawaguchi ,  Noriyuki Ishiyama ,  Kazuhiko Ishihara ,  Tomohiro Konno ,  Tadashi Ohyama ,  Mizuna Yoshikawa

    IPC分类号： A61K9/14 ,  A61P41/00 ,  A61K31/785

    CPC分类号： A61K31/715 ,  A61K31/765 ,  A61K31/80

    摘要： The present invention provides a tissue adhesion prevention material preparable at an affected area at the time of surgical procedure by producing a three-dimensional polymeric structure having a flexible structure and high solute permeability in a medium comprising water as the main component under mild conditions appropriate for body tissue components (i.e., at ordinary temperature and pressure) without conducting a chemical reaction or employing a physical procedure such as heating or light or radiation irradiation. This makes it possible to provide a tissue adhesion prevention material and a joint contracture prevention materials, which can effectively prevent postoperative adhesion of a tissue in the affected area to the surrounding tissue and contracture of the movable part of a joint.The tissue adhesion prevention material and/or the joint contracture prevention material of the present invention comprise, as the main component, a composition comprising a compound having a polyvalent hydroxyl group and a polymer containing phosphorylcholine groups and phenylboronic acid groups.

    摘要翻译： 本发明提供了一种在外科手术时可以在患病区域制备的组织粘附防止材料，通过在适于温和条件的温和条件下，在包含水作为主要成分的介质中制备具有柔性结构和高溶质渗透性的三维聚合物结构 身体组织成分（即，在常温和常压下）而不进行化学反应或采用诸如加热或光或辐射照射的物理过程。 这使得可以提供能够有效地防止受影响的区域中的组织对周围组织的术后粘附和关节的可动部的挛缩的组织粘合防止材料和接合挛缩防止材料。 本发明的组织粘附防止材料和/或接合挛缩防止材料以包含具有多价羟基的化合物和含有磷酸胆碱基团的聚合物和苯基硼酸基的组成为主要成分。

    MEDICAL DEVICE AND METHOD FOR PRODUCING THE SAME
    10.
    发明申请
    MEDICAL DEVICE AND METHOD FOR PRODUCING THE SAME 有权
    医疗装置及其制造方法

    公开(公告)号：US20110027757A1

    公开(公告)日：2011-02-03

    申请号：US12809690

    申请日：2008-12-19

    申请人： Masayuki Kyomoto ,  Kazuhiko Ishihara ,  Kozo Nakamura ,  Yoshio Takatori ,  Hiroshi Kawaguchi ,  Toru Moro

    发明人： Masayuki Kyomoto ,  Kazuhiko Ishihara ,  Kozo Nakamura ,  Yoshio Takatori ,  Hiroshi Kawaguchi ,  Toru Moro

    IPC分类号： A61C8/00 ,  B32B3/00 ,  B32B13/12 ,  B05D1/18 ,  B05D3/06

    CPC分类号： A61L33/0076 ,  A61K6/033 ,  A61K6/04 ,  A61L27/34 ,  A61L31/10 ,  Y10T428/31667 ,  A61K6/0023 ,  C08L33/08 ,  C08L33/10

    摘要： An object is to provide a medical device having excellent antithrombotic and sliding characteristics, which can exert a cell adhesion inhibitory effect. A medical device comprising: a substrate capable of forming hydroxyl groups; and a biocompatible material layer laminated on the substrate at an appropriate position, wherein the hydroxyl groups are formed on a surface of the substrate at least at a required position by a surface treatment, while the biocompatible material layer is formed from a polymer containing phosphorylcholine groups, and wherein the substrate and the biocompatible material layer are joined via a binder layer formed from silica being covalently bonded with the hydroxyl groups and the biocompatible material, respectively.

    摘要翻译： 本发明的目的是提供具有优异的抗血栓形成和滑动特性的医疗装置，其能够发挥细胞粘附抑制作用。 一种医疗装置，包括：能够形成羟基的基材; 以及在适当位置层叠在基材上的生物相容性材料层，其中通过表面处理在至少所需位置上在基材的表面上形成羟基，同时生物相容性材料层由含有磷酸胆碱基团的聚合物形成 ，并且其中所述基材和所述生物相容性材料层通过分别与所述羟基和所述生物相容性材料共价键合的由二氧化硅形成的粘合剂层连接。