公开(公告)号：US09321742B2

公开(公告)日：2016-04-26

申请号：US14237546

申请日：2012-08-08

申请人： Sung Wuk Kim ,  Chang Hee Min ,  Se Hwan Park ,  Duck Kim ,  Ji Sun Lee ,  Yong Eun Kim ,  Ju Hoon Oh

发明人： Sung Wuk Kim ,  Chang Hee Min ,  Se Hwan Park ,  Duck Kim ,  Ji Sun Lee ,  Yong Eun Kim ,  Ju Hoon Oh

IPC分类号： C07C279/26 ,  C07C29/16 ,  C07D205/04 ,  C07D213/40 ,  C07D295/215 ,  C07D333/20 ,  C07D307/52

CPC分类号： C07D295/215 ,  C07D205/04 ,  C07D213/40 ,  C07D307/52 ,  C07D333/20

摘要： A N1-cyclic amine-N5-substituted biguanide derivative of Formula 1 or a pharmaceutically acceptable salt thereof, a method of manufacturing the same, and a pharmaceutical composition including the biguanide derivative or the pharmaceutically acceptable salt thereof as an active ingredient are provided. The biguanide derivatives have an effect of inhibiting cancer cell proliferation and also exhibit anticancer activity including inhibition of cancer metastasis and cancer recurrence, because they are effective in activating AMPK, which is associated with the control of energy metabolism, even when administered in a small dose compared with conventional drugs. Also, the biguanide derivatives are highly effective at lowering blood glucose and lipid concentration by AMPK activation, thus they may be effectively used to treat diabetes mellitus, obesity, hyperlipemia, hypercholesterolemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovary syndrome and metabolic syndrome.

摘要翻译： 提供式1的N 1 - 环胺-N 5 - 取代双胍衍生物或其药学上可接受的盐，其制备方法和包含双胍衍生物或其药学上可接受的盐作为活性成分的药物组合物。 双胍衍生物具有抑制癌细胞增殖的作用，并且还表现出抗肿瘤活性，包括抑制癌症转移和癌症复发，因为即使以小剂量施用也能有效地激活与能量代谢控制有关的AMPK 与常规药物相比。 此外，双胍衍生物通过AMPK活化降低血糖和脂质浓度高度有效，因此可有效用于治疗糖尿病，肥胖症，高脂血症，高胆固醇血症，脂肪肝，冠状动脉疾病，骨质疏松症，多囊卵巢综合征和代谢 综合征

公开(公告)号：US20140179661A1

公开(公告)日：2014-06-26

申请号：US14237546

申请日：2012-04-08

申请人： Sung Wuk Kim ,  Chang Hee Min ,  Se Hwan Park ,  Duck Kim ,  Ji Sun Lee ,  Yong Eun Kim ,  Ju Hoon Oh

发明人： Sung Wuk Kim ,  Chang Hee Min ,  Se Hwan Park ,  Duck Kim ,  Ji Sun Lee ,  Yong Eun Kim ,  Ju Hoon Oh

IPC分类号： C07D295/215 ,  C07D205/04 ,  C07D333/20 ,  C07D213/40 ,  C07D307/52

CPC分类号： C07D295/215 ,  C07D205/04 ,  C07D213/40 ,  C07D307/52 ,  C07D333/20

摘要： A N1-cyclic amine-N5-substituted biguanide derivative of Formula 1 or a pharmaceutically acceptable salt thereof, a method of manufacturing the same, and a pharmaceutical composition including the biguanide derivative or the pharmaceutically acceptable salt thereof as an active ingredient are provided. The biguanide derivatives have an effect of inhibiting cancer cell proliferation and also exhibit anticancer activity including inhibition of cancer metastasis and cancer recurrence, because they are effective in activating AMPK, which is associated with the control of energy metabolism, even when administered in a small dose compared with conventional drugs. Also, the biguanide derivatives are highly effective at lowering blood glucose and lipid concentration by AMPK activation, thus they may be effectively used to treat diabetes mellitus, obesity, hyperlipemia, hypercholesterolemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovary syndrome and metabolic syndrome.

摘要翻译： 提供式1的N 1 - 环胺-N 5 - 取代双胍衍生物或其药学上可接受的盐，其制备方法和包含双胍衍生物或其药学上可接受的盐作为活性成分的药物组合物。 双胍衍生物具有抑制癌细胞增殖的作用，并且还表现出抗肿瘤活性，包括抑制癌症转移和癌症复发，因为即使以小剂量施用也能有效地激活与能量代谢控制有关的AMPK 与常规药物相比。 此外，双胍衍生物通过AMPK活化降低血糖和脂质浓度高度有效，因此可有效用于治疗糖尿病，肥胖症，高脂血症，高胆固醇血症，脂肪肝，冠状动脉疾病，骨质疏松症，多囊卵巢综合征和代谢 综合征

公开(公告)号：US08141622B2

公开(公告)日：2012-03-27

申请号：US11663564

申请日：2005-09-23

申请人： Seong-Ho Kang ,  Yong Eun Seo ,  Sang-Chul Byon ,  Yong Sang Kim

发明人： Seong-Ho Kang ,  Yong Eun Seo ,  Sang-Chul Byon ,  Yong Sang Kim

IPC分类号： B60H1/00

CPC分类号： B60H1/00007 ,  B60H1/00021 ,  B60H1/00564 ,  B60H1/243 ,  B60H1/246 ,  B60H2001/00192

摘要： A console air conditioner includes an evaporator, a heater, a face vent, a floor vent, and a vent door for controlling the opening degrees of the face vent and the floor vent and is installed in the console space between front seats of a vehicle. Both sides of the air mixing zone where a cool air passageway meets a warm air passageway in the console air conditioner are connected to a pillar duct extending toward the middle pillar of the vehicle. A temperature control door controls the opening degrees of a cool air passageway and a warm air passageway of the air conditioner case and is installed such that rotational trace of the temperature control door is overlapped with a pillar vent area that is defined between the pillar ducts.

摘要翻译： 控制台空调包括蒸发器，加热器，面孔，地板通风口和通风门，用于控制面孔和地板通风口的开度，并安装在车辆前座之间的控制台空间中。 冷空气通道与控制台空气调节器中的暖风通道相连的空气混合区两侧连接到朝向车辆中柱延伸的支柱管道。 温度控制门控制冷气通道和空调机壳的暖风通道的开度，并且安装成使温度控制门的旋转轨迹与限定在支柱管道之间的立柱通气区域重叠。

公开(公告)号：US08025096B2

公开(公告)日：2011-09-27

申请号：US11703273

申请日：2007-02-07

申请人： Sung Ho Kang ,  Sang Chul Byon ,  Yong Eun Seo ,  Yong Sang Kim ,  Yun Cheol Park

发明人： Sung Ho Kang ,  Sang Chul Byon ,  Yong Eun Seo ,  Yong Sang Kim ,  Yun Cheol Park

IPC分类号： B60H1/00

CPC分类号： B60H1/0065 ,  B60H1/00857 ,  G05G7/02 ,  Y10T16/5448

摘要： A door actuating device for an air conditioner of a vehicle can efficiently prevent separation of a link member after the link member is coupled to a rotating member when operating two doors simultaneously by using one door actuator, and the rotating member has a simple structure, thereby increasing facility of fabrication and reducing the fabricating cost.

摘要翻译： 用于车辆空调的门致动装置可以通过使用一个门致动器同时操作两个门之后，在连杆构件联接到旋转构件之后有效地防止连杆构件的分离，并且旋转构件具有简单的结构，由此 增加制造设备并降低制造成本。

公开(公告)号：US07726391B2

公开(公告)日：2010-06-01

申请号：US11340566

申请日：2006-01-27

申请人： Yong-Eun Seo ,  Sang-Chul Byun ,  Sung-Ho Kang ,  Seong-Seok Han ,  Yong-Sang Kim

发明人： Yong-Eun Seo ,  Sang-Chul Byun ,  Sung-Ho Kang ,  Seong-Seok Han ,  Yong-Sang Kim

IPC分类号： B60H1/00 ,  B60H3/00

CPC分类号： B60H1/00064 ,  B60H1/00514 ,  B60H2001/00107 ,  B60H2001/002

摘要： A vehicle air conditioner casing has defrost, face, and front seat floor vents variably communicating with a mixing chamber. Air passageways in the casing include an evaporator and heater core. A rear seat console vent communicates with a warm air passageway including the heater core and a cool air passageway through a console side cool air bypass passageway on the casing bottom surface, under the heater core. A front seat temperature adjusting door adjusts variably opens cool air passageway outlets and the warm air passageway with respect to the mixing chamber. A rear seat main temperature adjusting door variably opens warm air passageway inlets and the console side cool air bypass passageway. A rear seat auxiliary temperature variably adjusts the openings of warm air passageway outlets and the console cool air bypass passageway with respect to the rear seat console vent.

摘要翻译： 车辆空调器壳体具有与混合室可变地连通的除霜，面部和前座椅地板通风口。 壳体中的空气通道包括蒸发器和加热器芯。 后座控制台排气口与包括加热器芯的暖空气通道和冷空气通道通过加热器芯下的壳体底表面上的控制台侧冷气旁路通道连通。 前座温度调节门可相对于混合室可变地打开冷空气通道出口和暖空气通道。 后座主温度调节门可以可变地打开暖空气通道入口和控制台侧的冷气旁路通道。 后座辅助温度相对于后座椅控制台排气口可变地调节暖空气通道出口和控制台冷气旁路通道的开口。

公开(公告)号：US20090185096A1

公开(公告)日：2009-07-23

申请号：US12196306

申请日：2008-08-22

申请人： Yong-Eun PARK

发明人： Yong-Eun PARK

IPC分类号： H05K1/16 ,  B23K1/00 ,  G02F1/1333

CPC分类号： H05K1/111 ,  H05K1/0269 ,  H05K1/0295 ,  H05K3/3421 ,  H05K3/3452 ,  H05K2201/09381 ,  H05K2201/09954 ,  H05K2201/10651 ,  Y02P70/611 ,  Y02P70/613

摘要： A printed circuit board includes; first and second pads spaced apart from each other; and a dielectric region which surrounds the first and second pads, wherein each of the first and second pads includes a main region and an expansion region which extends from the main region, and wherein the main regions of the first and second pads are configured to have a first surface mount device mounted thereon, wherein the expansion regions and portions of the main regions which directly adjoin the expansion regions of the first and second pads are configured to have a second surface mount device mounted thereon, and wherein the first and second surface mount devices have different sizes.

摘要翻译： 印刷电路板包括： 第一和第二垫彼此间隔开; 以及围绕所述第一和第二焊盘的电介质区域，其中所述第一和第二焊盘中的每一个包括主区域和从所述主区域延伸的扩展区域，并且其中所述第一和第二焊盘的主区域被配置为具有 安装在其上的第一表面安装装置，其中所述扩展区域和与所述第一和第二焊盘的所述扩展区域直接相邻的所述主要区域的部分被配置为具有安装在其上的第二表面安装装置，并且其中所述第一和第二表面安装 设备具有不同的尺寸。

公开(公告)号：US20090073100A1

公开(公告)日：2009-03-19

申请号：US12019468

申请日：2008-01-24

申请人： Sang-Soo Kim ,  Choong-Seob Oh ,  Jin-Hyeok Park ,  Jin-Ho Park ,  Dong-Gyu Kim ,  Yong-Eun Park ,  Nam-Soo Kang ,  Gyu-Su Lee ,  Sin-Gu Kang

发明人： Sang-Soo Kim ,  Choong-Seob Oh ,  Jin-Hyeok Park ,  Jin-Ho Park ,  Dong-Gyu Kim ,  Yong-Eun Park ,  Nam-Soo Kang ,  Gyu-Su Lee ,  Sin-Gu Kang

IPC分类号： G09G3/36

CPC分类号： G02F1/13452 ,  H05K1/189 ,  H05K3/361

摘要： A liquid crystal display of compact size is disclosed. The liquid crystal display has a signal transmission film and a single integrated PCB for processing a gate driving signal and data driving signal. The signal transmission film includes a base substrate, a gate driver IC formed on said base substrate, an input pattern formed on said base substrate that applies gate driving signals input from an external device to the gate driver IC, a first output pattern formed on said base substrate that outputs a first gate driving signal processed in said gate driver IC, and a second output pattern formed on said base substrate, that outputs a second gate driving signal bypassing the gate driver IC among the gate driving signals.

摘要翻译： 公开了一种紧凑尺寸的液晶显示器。 液晶显示器具有用于处理栅极驱动信号和数据驱动信号的信号传输膜和单个集成PCB。 信号传输膜包括基底基板，形成在所述基底基板上的栅极驱动器IC，形成在所述基底基板上的输入图案，其将从外部装置输入的栅极驱动信号施加到栅极驱动器IC，形成在所述栅极驱动器IC上的第一输出图案 输出在所述栅极驱动器IC中处理的第一栅极驱动信号的基极基板，以及形成在所述基板上的第二输出图案，其在所述栅极驱动信号中输出旁路栅极驱动器IC的第二栅极驱动信号。

公开(公告)号：US07392663B2

公开(公告)日：2008-07-01

申请号：US11312647

申请日：2005-12-21

申请人： Sung-Ho Kang ,  Yong-Eun Seo

发明人： Sung-Ho Kang ,  Yong-Eun Seo

IPC分类号： F25D21/14

CPC分类号： B60H1/3233 ,  B60H1/00514

摘要： A two layer type air conditioner for vehicles facilitates drainage of water induced into a blower through an outside air intake to a condensed water outlet and prevents backflow of water to the blower. A blower has an intake duct for inhaling inside air and outside air. A double suction type scroll case mounted on the intake duct is divided into two passages by a partition plate. A blower fan is rotatably mounted in the two passages. A motor turns the blower fan. A case for the air conditioner includes an evaporator for cooling the air blown from the blower and a condensed water outlet for draining condensed water generated from the evaporator. The case is divided into two passages corresponding to those of the scroll case. A drain drains water induced into the blower to the condensed water outlet.

摘要翻译： 用于车辆的双层型空调器有助于将通过外部空气入口引入鼓风机的水排出到冷凝水出口，并防止水回送到鼓风机。 鼓风机具有用于吸入空气和外部空气的进气管道。 安装在进气管上的双吸式涡旋箱被隔板分成两个通道。 鼓风机可旋转地安装在两个通道中。 电机转动鼓风机。 空调器的壳体包括用于冷却从鼓风机吹出的空气的蒸发器和用于排出从蒸发器产生的冷凝水的冷凝水出口。 这种情况分为对应于涡卷箱的两个通道。 排水口将引入鼓风机的水排入冷凝水出口。

公开(公告)号：US5768046A

公开(公告)日：1998-06-16

申请号：US820163

申请日：1997-03-19

申请人： Kwang-Ryeol Lee ,  Kwang-Yong Eun ,  Keun-Mo Kim

发明人： Kwang-Ryeol Lee ,  Kwang-Yong Eun ,  Keun-Mo Kim

IPC分类号： G11B5/53 ,  B81C99/00 ,  C23C16/26 ,  C23C16/27 ,  C23C16/458 ,  C23C16/50 ,  C23C16/509 ,  G11B15/18 ,  G11B15/61 ,  G11B15/62 ,  G11B23/50 ,  G11B5/40 ,  C23C16/00

CPC分类号： C23C16/509 ,  C23C16/26 ,  C23C16/458 ,  C23C16/5093 ,  G11B15/61 ,  G11B15/1808 ,  G11B15/62 ,  G11B23/502

摘要： A head drum is coated with double films, each having different characteristics, by forming a first diamond-like hard carbon film of high degree of hardness and then forming a second diamond-like hard carbon film of a lower degree of hardness thereon. The degree of hardness of the second film is lower than that of the first film. The double coating is performed by means of a synthesizing apparatus which comprises a reactor consisting of a power supply electrode, a workpiece support and an annular ground electrode spaced from the stacked head drums by a predetermined distance.

摘要翻译： 通过形成高硬度的第一金刚石状硬质碳膜，然后形成硬度较低的第二类金刚石状硬质碳膜，头鼓通过双层膜涂覆，每层具有不同的特性。 第二膜的硬度低于第一膜的硬度。 双层涂层通过合成装置进行，该合成装置包括由电源电极，工件支撑件和与叠置的磁头鼓隔开预定距离的环形接地电极组成的电抗器。

公开(公告)号：US20100325377A1

公开(公告)日：2010-12-23

申请号：US12870324

申请日：2010-08-27

申请人： Jason Ansel Lango ,  Yong Eun Cho ,  Paul Christopher Eastham ,  Ling Zheng ,  Stephen L. Manley ,  John K. Edwards ,  Robert M. English ,  Emmanuel Ackaouy

发明人： Jason Ansel Lango ,  Yong Eun Cho ,  Paul Christopher Eastham ,  Ling Zheng ,  Stephen L. Manley ,  John K. Edwards ,  Robert M. English ,  Emmanuel Ackaouy

IPC分类号： G06F12/16

CPC分类号： G06F16/10

摘要： A technique is disclosed for restoring data of sparse volumes, where one or more block pointers within the file system structure are marked as ABSENT, and fetching the appropriate data from an alternate location on demand. Client data access requests to the local storage system initiate a restoration of the data from a backing store as required. A demand generator can also be used to restore the data as a background process by walking through the sparse volume and restoring the data of absent blocks. A pump module is also disclosed to regulate the access of the demand generator. Once all the data has been restored, the volume contains all data locally, and is no longer a sparse volume.

摘要翻译： 公开了一种用于恢复稀疏卷的数据的技术，其中文件系统结构中的一个或多个块指针被标记为ABSENT，并且根据需要从备用位置获取适当的数据。 对本地存储系统的客户端数据访问请求根据需要启动从后台存储器恢复数据。 还可以使用需求生成器通过遍历稀疏卷并恢复缺席块的数据来将数据恢复为后台进程。 还公开了一种泵模块来调节需求发生器的通路。 一旦所有数据都已恢复，卷将包含本地的所有数据，并且不再是稀疏卷。