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公开(公告)号:US07960544B2
公开(公告)日:2011-06-14
申请号:US12097616
申请日:2006-12-18
申请人: Wilmin Bartolini , Brian M. Cali , Barbara Chen , Yueh-Tyng Chien , Mark G. Currie , G. Todd Milne , James Philip Pearson , John Jeffrey Talley , Jane Yang , Craig Zimmerman , Charles Kim , Kevin Sprott , Timothy Barden , Regina Lundigran , Ara Mermerian
发明人: Wilmin Bartolini , Brian M. Cali , Barbara Chen , Yueh-Tyng Chien , Mark G. Currie , G. Todd Milne , James Philip Pearson , John Jeffrey Talley , Jane Yang , Craig Zimmerman , Charles Kim , Kevin Sprott , Timothy Barden , Regina Lundigran , Ara Mermerian
IPC分类号: C07D403/06 , C07D239/26 , C07D471/04 , C07D401/06 , C07D271/06 , C07D271/10 , C07D417/06 , C07D413/06 , C07D263/32 , C07D261/08
CPC分类号: C07D209/42 , C07D209/30 , C07D401/06 , C07D409/06 , C07D417/06
摘要: Indoles that have activity as inhibitors of FAAH are described as are indoles and indole derivatives that have activity as inhibitors of DAO.
摘要翻译: 具有作为FAAH抑制剂的活性的吲哚被描述为具有作为DAO抑制剂的活性的吲哚和吲哚衍生物。
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公开(公告)号:US20090264653A1
公开(公告)日:2009-10-22
申请号:US12097616
申请日:2006-12-18
申请人: Wilmin Bartolini , Brian M Cali , Barbara Chen , Yueh-Tyng Chien , Mark G. Currie , G. Todd Milne , James Philip Pearson , John Jeffrey Talley , Jane Yang , Craig Zimmerman , Charles Kim , Kevin Sprott , Timothy Barden , Regina Lundigran , Ara Mermerian
发明人: Wilmin Bartolini , Brian M Cali , Barbara Chen , Yueh-Tyng Chien , Mark G. Currie , G. Todd Milne , James Philip Pearson , John Jeffrey Talley , Jane Yang , Craig Zimmerman , Charles Kim , Kevin Sprott , Timothy Barden , Regina Lundigran , Ara Mermerian
IPC分类号: C07D413/14 , C07D209/04 , C07D235/00 , C07D403/04 , C07D215/02 , C07D471/02
CPC分类号: C07D209/42 , C07D209/30 , C07D401/06 , C07D409/06 , C07D417/06
摘要: Indoles that have activity as inhibitors of FAAH are described as are indoles and indole derivatives that have activity as inhibitors of DAO.
摘要翻译: 具有作为FAAH抑制剂活性的吲哚被描述为具有作为DAO抑制剂的活性的吲哚和吲哚衍生物。
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公开(公告)号:US08884020B2
公开(公告)日:2014-11-11
申请号:US12309993
申请日:2007-08-07
申请人: John Jeffrey Talley , Kevin Sprott , James Philip Pearson , G. Todd Milne , Wayne Schairer , Jane Yang , Charles Kim , Timothy Barden , Regina Lundrigan , Ara Mermerian , Mark G. Currie
发明人: John Jeffrey Talley , Kevin Sprott , James Philip Pearson , G. Todd Milne , Wayne Schairer , Jane Yang , Charles Kim , Timothy Barden , Regina Lundrigan , Ara Mermerian , Mark G. Currie
IPC分类号: C07D209/18 , C07D209/22 , C07D401/06
CPC分类号: C07D209/18 , C07D209/22 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/14 , C07D413/06 , C07D413/14 , C07D417/14 , C07D498/04
摘要: Indole derivatives that are useful for treating pain, inflammation and other conditions are described. Certain of the compounds are benzyl derivatives and others are benzoyl derivatives. The compounds are substituted at least at the 3 position of the indole.
摘要翻译: 描述了可用于治疗疼痛,炎症和其它病症的吲哚衍生物。 某些化合物是苄基衍生物,而其它化合物是苯甲酰基衍生物。 该化合物至少在吲哚的3位被取代。
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公开(公告)号:US20100197708A1
公开(公告)日:2010-08-05
申请号:US12309993
申请日:2007-08-07
申请人: John Jeffrey Talley , Kevin Sprott , James Philip Pearson , G. Todd Milne , Wayne Schairer , Jane Yang , Charles Kim , Timothy Barden , Regina Lundrigan , Ara Mermerian , Mark G. Currie
发明人: John Jeffrey Talley , Kevin Sprott , James Philip Pearson , G. Todd Milne , Wayne Schairer , Jane Yang , Charles Kim , Timothy Barden , Regina Lundrigan , Ara Mermerian , Mark G. Currie
IPC分类号: A61K31/506 , C07D401/12 , A61K31/4439 , C07D209/22 , A61K31/4045 , C07D403/12 , A61P3/04 , A61P25/06 , A61P29/00 , A61P25/22 , A61P27/06 , A61P37/08 , A61P11/06
CPC分类号: C07D209/18 , C07D209/22 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/14 , C07D413/06 , C07D413/14 , C07D417/14 , C07D498/04
摘要: Indole derivatives that are useful for treating pain, inflammation and other conditions are described. Certain of the compounds are benzyl derivatives and others are benzoyl derivatives. The compounds are substituted at least at the 3 position of the indole.
摘要翻译: 描述了可用于治疗疼痛,炎症和其它病症的吲哚衍生物。 某些化合物是苄基衍生物,而其它化合物是苯甲酰基衍生物。 该化合物至少在吲哚的3位被取代。
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公开(公告)号:US20130259830A1
公开(公告)日:2013-10-03
申请号:US13809548
申请日:2011-06-24
申请人: Timothy Barden , Colleen Hudson , James Jia , Charles Kim , Regina Graul , Ara Mermerian , Joel Moore , Kevin Sprott , Yueh-tyng Chien
发明人: Timothy Barden , Colleen Hudson , James Jia , Charles Kim , Regina Graul , Ara Mermerian , Joel Moore , Kevin Sprott , Yueh-tyng Chien
IPC分类号: C07D209/14 , A61K31/4439 , C07D409/06 , A61K31/405 , A61K45/06 , A61K31/496 , C07D209/30 , C07D471/04 , A61K31/437 , A61K31/5377 , C07D401/06 , C07D491/052
CPC分类号: C07D209/14 , A61K31/404 , A61K31/405 , A61K31/437 , A61K31/4439 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D209/10 , C07D209/30 , C07D401/06 , C07D403/06 , C07D409/06 , C07D471/04 , C07D491/052 , C07D493/04
摘要: Modulators of CRTH2, particularly antagonists of CRTH2, that are useful for treating various disorders, including asthma and respiratory disorders are disclosed. The compounds fall within a genus described by Formula I:
摘要翻译: 公开了可用于治疗各种疾病(包括哮喘和呼吸系统疾病)的CRTH2调节剂,特别是CRTH2拮抗剂。 化合物属于由式I描述的属:
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公开(公告)号:US20110150834A1
公开(公告)日:2011-06-23
申请号:US12969840
申请日:2010-12-16
申请人: Ara MERMERIAN , Bo Peng , Colleen Hudson , Charles Kim , Joel Moore , Jason Rohde , Kevin Sprott , Regina Graul , Takashi Nakai , James Jia , Wilmin Bartolini
发明人: Ara MERMERIAN , Bo Peng , Colleen Hudson , Charles Kim , Joel Moore , Jason Rohde , Kevin Sprott , Regina Graul , Takashi Nakai , James Jia , Wilmin Bartolini
IPC分类号: A61K31/4025 , C07D403/12 , C07D401/04 , A61K31/4439 , C07D413/12 , A61K31/5377 , A61K31/56 , A61K38/21 , A61K31/7028 , A61K31/606 , A61K38/22 , A61P29/00 , A61P11/00 , A61P37/08 , A61P11/06 , A61P19/02 , A61P1/00 , A61P37/06 , A61P3/10 , A61P25/00 , A61P35/02 , A61P1/04 , A61P17/00
CPC分类号: C07D403/12 , C07D207/325 , C07D401/04 , C07D413/14
摘要: Modulators of CRTH2, particularly antagonists of CRTH2, that are useful for treating various disorders, including asthma and respiratory disorders are disclosed. The compounds fall within a genus described by formula I:
摘要翻译: 公开了可用于治疗各种疾病(包括哮喘和呼吸系统疾病)的CRTH2调节剂,特别是CRTH2拮抗剂。 化合物属于式I所述的一类:
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公开(公告)号:US08674115B2
公开(公告)日:2014-03-18
申请号:US12969840
申请日:2010-12-16
申请人: Ara Mermerian , Bo Peng , Colleen Hudson , Charles Kim , Joel Moore , Jason Rohde , Kevin Sprott , Regina Graul , Takashi Nakai , James Jia , Wilmin Bartolini
发明人: Ara Mermerian , Bo Peng , Colleen Hudson , Charles Kim , Joel Moore , Jason Rohde , Kevin Sprott , Regina Graul , Takashi Nakai , James Jia , Wilmin Bartolini
IPC分类号: C07D207/30 , A61K31/40
CPC分类号: C07D403/12 , C07D207/325 , C07D401/04 , C07D413/14
摘要: Modulators of CRTH2, particularly antagonists of CRTH2, that are useful for treating various disorders, including asthma and respiratory disorders are disclosed. The compounds fall within a genus described by formula I:
摘要翻译: 公开了可用于治疗各种疾病(包括哮喘和呼吸系统疾病)的CRTH2调节剂,特别是CRTH2拮抗剂。 化合物属于式I所述的一类:
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公开(公告)号:US20110312945A1
公开(公告)日:2011-12-22
申请号:US13121669
申请日:2009-10-01
申请人: James Jia , Ara Mermerian , Charles Kim , Regina Graul , Joel Moore
发明人: James Jia , Ara Mermerian , Charles Kim , Regina Graul , Joel Moore
IPC分类号: A61K31/55 , C07D209/12 , C07D403/12 , C07D401/12 , C07D413/14 , C07D409/12 , A61K31/5377 , A61K31/403 , A61K31/496 , A61K31/454 , A61P11/06 , A61P29/00 , A61P37/08 , A61P11/00 , A61P11/02 , A61P19/02 , A61P19/08 , A61P17/06 , A61P17/02 , A61P3/10 , A61P1/00 , C07D413/12
CPC分类号: C07D209/10 , C07D403/12
摘要: Modulators of CRTH2, particularly antagonists of CRTH2, that are useful for treating various disorders, including asthma and respiratory disorders are disclosed. The compounds fall within a genus described by formula I
摘要翻译: 公开了可用于治疗各种疾病(包括哮喘和呼吸系统疾病)的CRTH2调节剂,特别是CRTH2拮抗剂。 化合物属于式I所述的一类
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公开(公告)号:US08748442B2
公开(公告)日:2014-06-10
申请号:US13174676
申请日:2011-06-30
申请人: Charles Kim , Takashi Nakai , Thomas Wai-Ho Lee , Joel Moore , Nicholas Robert Perl , Jason Rohde , Rajesh R Iyengar , Ara Mermerian , Angelika Fretzen
发明人: Charles Kim , Takashi Nakai , Thomas Wai-Ho Lee , Joel Moore , Nicholas Robert Perl , Jason Rohde , Rajesh R Iyengar , Ara Mermerian , Angelika Fretzen
IPC分类号: A01N43/54 , A61K31/505 , A01N43/40 , A61K31/44 , C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00
CPC分类号: C07D401/04 , A61K31/4155 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/522 , A61K31/5365 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D473/34 , C07D491/048 , C07D498/04 , A61K2300/00
摘要: Compounds of Formula I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.
摘要翻译: 描述式I化合物。 它们作为sGC的刺激剂是有用的,特别是NO不依赖于血红素依赖性刺激物。 这些化合物可用于治疗,预防或治疗本文公开的各种疾病。
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公开(公告)号:US20120184516A1
公开(公告)日:2012-07-19
申请号:US13174676
申请日:2011-06-30
申请人: Charles Kim , Takashi Nakai , Thomas Wai-Ho Lee , Joel Moore , Nicholas Robert Perl , Jason Rohde , Rajesh R. Iyengar , Ara Mermerian
发明人: Charles Kim , Takashi Nakai , Thomas Wai-Ho Lee , Joel Moore , Nicholas Robert Perl , Jason Rohde , Rajesh R. Iyengar , Ara Mermerian
IPC分类号: A61K31/56 , A61K31/444 , C07D403/04 , A61K31/506 , C07D401/04 , A61K31/4439 , C07D409/14 , C07D403/14 , C07D417/14 , C07D491/048 , A61K31/497 , C07D413/14 , C07D405/14 , C07D473/34 , A61K31/52 , A61K31/522 , C07D498/04 , A61K31/5365 , A61K31/5377 , A61P9/00 , A61P9/12 , A61P7/02 , A61P11/00 , A61P7/00 , A61P19/04 , A61P11/08 , A61P9/10 , A61P13/12 , A61P9/04 , A61P9/06 , A61P29/00 , A61P1/16 , A61P15/00 , A61P13/00 , A61P13/08 , A61P3/06 , A61P11/06 , A61P37/06 , A61P3/10 , C07D401/14
CPC分类号: C07D401/04 , A61K31/4155 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/522 , A61K31/5365 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D473/34 , C07D491/048 , C07D498/04 , A61K2300/00
摘要: Compounds of Formula I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.
摘要翻译: 描述式I化合物。 它们作为sGC的刺激剂是有用的,特别是NO不依赖于血红素依赖性刺激物。 这些化合物可用于治疗,预防或治疗本文公开的各种疾病。
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