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公开(公告)号：US12071411B2
公开(公告)日：2024-08-27
申请号：US18050557
申请日：2022-10-28
发明人： Joel Worley Beatty , Samuel Lawrie Drew , Matthew Epplin , Jeremy Fournier , Balint Gal , Clayton Hardman , Artur Karenovich Mailyan , Kenneth Victor Lawson , Manmohan Reddy Leleti , Dongdong Liu , Guillaume Mata , Ma{hacek over (s)}a Podunavac , Jay Patrick Powers , Brandon Reid Rosen , Kai Yu
IPC分类号： C07D231/56 , C07D405/04 , C07D405/06 , C07D409/04 , C07D409/06 , C07D413/06
CPC分类号： C07D231/56 , C07D405/04 , C07D405/06 , C07D409/04 , C07D409/06 , C07D413/06
摘要： The present disclosure is directed to compounds that are inhibitors of HIF-2α having a structure according to Formula I, and compositions containing those compounds. Methods of using the compounds for the treatment of diseases, disorders, or conditions are also described.
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公开(公告)号：US11787762B2
公开(公告)日：2023-10-17
申请号：US17835559
申请日：2022-06-08
发明人： Joel Worley Beatty , Samuel Lawrie Drew , Matthew Epplin , Jeremy Thomas Andre Fournier , Balint Gal , Tezcan Guney , Karl T. Haelsig , Clayton Hardman , Steven Donald Jacob , Jenna Leigh Jeffrey , Jaroslaw Kalisiak , Kenneth Victor Lawson , Manmohan Reddy Leleti , Erick Allen Lindsey , Artur Karenovich Mailyan , Debashis Mandal , Guillaume Mata , Hyunyoung Moon , Jay Patrick Powers , Brandon Reid Rosen , Yongli Su , Anh Thu Tran , Zhang Wang , Xuelei Yan , Kai Yu
IPC分类号： C07C317/32 , A61K31/10 , A61K31/277 , A61K31/343 , A61K31/353 , A61K31/365 , A61K31/381 , A61K31/404 , A61K31/415 , A61K31/416 , A61K31/4174 , A61K31/4192 , A61K31/4196 , A61K31/421 , A61K31/423 , A61K31/426 , A61K31/428 , A61K31/437 , A61K31/44 , A61K31/4412 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/4965 , A61K31/50 , A61K31/5025 , A61K31/505 , A61K31/519 , A61K31/538 , A61K39/395 , A61K45/06 , C07C255/53 , C07C317/22 , C07C317/36 , C07D209/34 , C07D211/86 , C07D213/57 , C07D213/71 , C07D213/73 , C07D213/74 , C07D213/84 , C07D215/48 , C07D217/04 , C07D231/12 , C07D231/56 , C07D233/64 , C07D237/20 , C07D239/42 , C07D241/12 , C07D249/06 , C07D249/08 , C07D263/32 , C07D263/57 , C07D265/36 , C07D277/30 , C07D277/56 , C07D277/64 , C07D307/83 , C07D311/22 , C07D333/64 , C07D401/04 , C07D401/10 , C07D409/10 , C07D413/10 , C07D471/04 , C07D487/04
CPC分类号： C07C317/32 , A61K31/10 , A61K31/277 , A61K31/343 , A61K31/353 , A61K31/365 , A61K31/381 , A61K31/404 , A61K31/415 , A61K31/416 , A61K31/4174 , A61K31/4192 , A61K31/4196 , A61K31/421 , A61K31/423 , A61K31/426 , A61K31/428 , A61K31/437 , A61K31/44 , A61K31/4412 , A61K31/47 , A61K31/472 , A61K31/4709 , A61K31/4965 , A61K31/50 , A61K31/505 , A61K31/5025 , A61K31/519 , A61K31/538 , A61K39/3955 , A61K45/06 , C07C255/53 , C07C317/22 , C07C317/36 , C07D209/34 , C07D211/86 , C07D213/57 , C07D213/71 , C07D213/73 , C07D213/74 , C07D213/84 , C07D215/48 , C07D217/04 , C07D231/12 , C07D231/56 , C07D233/64 , C07D237/20 , C07D239/42 , C07D241/12 , C07D249/06 , C07D249/08 , C07D263/32 , C07D263/57 , C07D265/36 , C07D277/30 , C07D277/56 , C07D277/64 , C07D307/83 , C07D311/22 , C07D333/64 , C07D401/04 , C07D401/10 , C07D409/10 , C07D413/10 , C07D471/04 , C07D487/04 , C07C2602/08 , C07C2602/10
摘要： Compounds that inhibit HIF-2α, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2α.
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公开(公告)号：US11633416B1
公开(公告)日：2023-04-25
申请号：US17193473
申请日：2021-03-05
IPC分类号： A61K31/70 , A01N43/04 , A61K31/7064 , A61K47/24 , A61K9/00
摘要： Oral formulations comprising a compound of Formula (I) and a chelating agent are provided, wherein compounds of Formula (I) have the structure: wherein, W, X, Y, Z, Ra, Rc, and each Rg are as defined herein. Also provided are methods of preparation, methods of use, and specific dosage forms.
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公开(公告)号：US12103907B2
公开(公告)日：2024-10-01
申请号：US18239892
申请日：2023-08-30
发明人： Joel Worley Beatty , Samuel Lawrie Drew , Matthew Epplin , Jeremy Thomas Andre Fournier , Balint Gal , Tezcan Guney , Karl T. Haelsig , Clayton Hardman , Steven Donald Jacob , Jenna Leigh Jeffrey , Jaroslaw Kalisiak , Kenneth Victor Lawson , Manmohan Reddy Leleti , Erick Allen Lindsey , Artur Karenovich Mailyan , Debashis Mandal , Guillaume Mata , Hyunyoung Moon , Jay Patrick Powers , Brandon Reid Rosen , Yongli Su , Anh Thu Tran , Zhang Wang , Xuelei Yan , Kai Yu
IPC分类号： C07C317/32 , A61K31/10 , A61K31/277 , A61K31/343 , A61K31/353 , A61K31/365 , A61K31/381 , A61K31/404 , A61K31/415 , A61K31/416 , A61K31/4174 , A61K31/4192 , A61K31/4196 , A61K31/421 , A61K31/423 , A61K31/426 , A61K31/428 , A61K31/437 , A61K31/44 , A61K31/4412 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/4965 , A61K31/50 , A61K31/5025 , A61K31/505 , A61K31/519 , A61K31/538 , A61K39/395 , A61K45/06 , C07C255/53 , C07C317/22 , C07C317/36 , C07D209/34 , C07D211/86 , C07D213/57 , C07D213/71 , C07D213/73 , C07D213/74 , C07D213/84 , C07D215/48 , C07D217/04 , C07D231/12 , C07D231/56 , C07D233/64 , C07D237/20 , C07D239/42 , C07D241/12 , C07D249/06 , C07D249/08 , C07D263/32 , C07D263/57 , C07D265/36 , C07D277/30 , C07D277/56 , C07D277/64 , C07D307/83 , C07D311/22 , C07D333/64 , C07D401/04 , C07D401/10 , C07D409/10 , C07D413/10 , C07D471/04 , C07D487/04
CPC分类号： C07C317/32 , A61K31/10 , A61K31/277 , A61K31/343 , A61K31/353 , A61K31/365 , A61K31/381 , A61K31/404 , A61K31/415 , A61K31/416 , A61K31/4174 , A61K31/4192 , A61K31/4196 , A61K31/421 , A61K31/423 , A61K31/426 , A61K31/428 , A61K31/437 , A61K31/44 , A61K31/4412 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/4965 , A61K31/50 , A61K31/5025 , A61K31/505 , A61K31/519 , A61K31/538 , A61K39/3955 , A61K45/06 , C07C255/53 , C07C317/22 , C07C317/36 , C07D209/34 , C07D211/86 , C07D213/57 , C07D213/71 , C07D213/73 , C07D213/74 , C07D213/84 , C07D215/48 , C07D217/04 , C07D231/12 , C07D231/56 , C07D233/64 , C07D237/20 , C07D239/42 , C07D241/12 , C07D249/06 , C07D249/08 , C07D263/32 , C07D263/57 , C07D265/36 , C07D277/30 , C07D277/56 , C07D277/64 , C07D307/83 , C07D311/22 , C07D333/64 , C07D401/04 , C07D401/10 , C07D409/10 , C07D413/10 , C07D471/04 , C07D487/04 , C07C2602/08 , C07C2602/10
摘要： Compounds that inhibit HIF-2α, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2α.
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公开(公告)号：US11407712B2
公开(公告)日：2022-08-09
申请号：US17205273
申请日：2021-03-18
发明人： Joel Worley Beatty , Samuel Lawrie Drew , Matthew Epplin , Jeremy Thomas Andre Fournier , Balint Gal , Tezcan Guney , Karl T. Haelsig , Clayton Hardman , Steven Donald Jacob , Jenna Leigh Jeffrey , Jaroslaw Kalisiak , Kenneth Victor Lawson , Manmohan Reddy Leleti , Erick Allen Lindsey , Artur Karenovich Mailyan , Debashis Mandal , Guillaume Mata , Hyunyoung Moon , Jay Patrick Powers , Brandon Reid Rosen , Yongli Su , Anh Thu Tran , Zhang Wang , Xuelei Yan , Kai Yu
IPC分类号： C07C317/32 , A61K31/10 , A61K31/277 , A61K31/343 , A61K31/353 , A61K31/365 , A61K31/381 , A61K31/404 , A61K31/415 , A61K31/416 , A61K31/4174 , A61K31/4192 , A61K31/4196 , A61K31/421 , A61K31/423 , A61K31/426 , A61K31/428 , A61K31/437 , A61K31/44 , A61K31/4412 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/4965 , A61K31/50 , A61K31/5025 , A61K31/505 , A61K31/519 , A61K31/538 , A61K39/395 , A61K45/06 , C07C255/53 , C07C317/22 , C07C317/36 , C07D209/34 , C07D211/86 , C07D213/57 , C07D213/71 , C07D213/73 , C07D213/74 , C07D213/84 , C07D215/48 , C07D217/04 , C07D231/12 , C07D231/56 , C07D233/64 , C07D237/20 , C07D239/42 , C07D241/12 , C07D249/06 , C07D249/08 , C07D263/32 , C07D263/57 , C07D265/36 , C07D277/30 , C07D277/56 , C07D277/64 , C07D307/83 , C07D311/22 , C07D333/64 , C07D401/04 , C07D401/10 , C07D409/10 , C07D413/10 , C07D471/04 , C07D487/04
摘要： Compounds that inhibit HIF-2α, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2α.
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