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公开(公告)号：US11667662B2
公开(公告)日：2023-06-06
申请号：US17206896
申请日：2021-03-19
发明人： Laurent Pierre Paul Debien , Juan Carlos Jaen , Jaroslaw Kalisiak , Kenneth V. Lawson , Manmohan Reddy Leleti , Erick Allen Lindsey , Dillon Harding Miles , Eric Newcomb , Jay Patrick Powers , Brandon Reid Rosen , Ehesan Ui Sharif
IPC分类号： A01N43/04 , A61K31/70 , C07H19/23 , A61K31/7076 , C07H19/16 , C07H19/20 , C07H19/207 , C07F9/6561 , C07H19/04 , A61K31/706 , A61K45/06 , A61K31/7052 , A61K31/7064 , C07H19/14
CPC分类号： C07H19/23 , A61K31/70 , A61K31/706 , A61K31/7052 , A61K31/7064 , A61K31/7076 , A61K45/06 , C07F9/6561 , C07F9/65616 , C07H19/04 , C07H19/14 , C07H19/16 , C07H19/20 , C07H19/207 , A61K31/7076 , A61K2300/00 , A61K31/7064 , A61K2300/00 , A61K31/706 , A61K2300/00
摘要： Compounds that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.
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公开(公告)号：US11058704B2
公开(公告)日：2021-07-13
申请号：US16338975
申请日：2017-10-02
发明人： Laurent Pierre Paul Debien , Jaroslaw Kalisiak , Kenneth V. Lawson , Manmohan Reddy Leleti , Erick Allen Lindsey , Dillon Harding Miles , Eric Newcomb , Jay Patrick Powers , Brandon Reid Rosen , Ehesan Ul Sharif
IPC分类号： A01N43/04 , A61K31/70 , A61K31/7076 , A61K31/706 , A61K31/7064 , A61K39/395 , C07H19/20 , C07H19/207 , C07H19/23
摘要： Compounds that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.
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公开(公告)号：US10239912B2
公开(公告)日：2019-03-26
申请号：US15400748
申请日：2017-01-06
发明人： Laurent Pierre Paul Debien , Juan Carlos Jaen , Jaroslaw Kalisiak , Kenneth V. Lawson , Manmohan Reddy Leleti , Erick Allen Lindsey , Dillon Harding Miles , Eric Newcomb , Jay Patrick Powers , Brandon Reid Rosen , Ehesan Ul Sharif
IPC分类号： A61K31/70 , A01N43/04 , C07H19/23 , A61K31/7052 , A61K31/7076 , C07H19/16 , C07H19/20 , C07H19/207 , A61K31/7064 , C07H19/14 , C07F9/6561 , C07H19/04
摘要： Compounds that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.
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公开(公告)号：US12071411B2
公开(公告)日：2024-08-27
申请号：US18050557
申请日：2022-10-28
发明人： Joel Worley Beatty , Samuel Lawrie Drew , Matthew Epplin , Jeremy Fournier , Balint Gal , Clayton Hardman , Artur Karenovich Mailyan , Kenneth Victor Lawson , Manmohan Reddy Leleti , Dongdong Liu , Guillaume Mata , Ma{hacek over (s)}a Podunavac , Jay Patrick Powers , Brandon Reid Rosen , Kai Yu
IPC分类号： C07D231/56 , C07D405/04 , C07D405/06 , C07D409/04 , C07D409/06 , C07D413/06
CPC分类号： C07D231/56 , C07D405/04 , C07D405/06 , C07D409/04 , C07D409/06 , C07D413/06
摘要： The present disclosure is directed to compounds that are inhibitors of HIF-2α having a structure according to Formula I, and compositions containing those compounds. Methods of using the compounds for the treatment of diseases, disorders, or conditions are also described.
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公开(公告)号：US11787762B2
公开(公告)日：2023-10-17
申请号：US17835559
申请日：2022-06-08
发明人： Joel Worley Beatty , Samuel Lawrie Drew , Matthew Epplin , Jeremy Thomas Andre Fournier , Balint Gal , Tezcan Guney , Karl T. Haelsig , Clayton Hardman , Steven Donald Jacob , Jenna Leigh Jeffrey , Jaroslaw Kalisiak , Kenneth Victor Lawson , Manmohan Reddy Leleti , Erick Allen Lindsey , Artur Karenovich Mailyan , Debashis Mandal , Guillaume Mata , Hyunyoung Moon , Jay Patrick Powers , Brandon Reid Rosen , Yongli Su , Anh Thu Tran , Zhang Wang , Xuelei Yan , Kai Yu
IPC分类号： C07C317/32 , A61K31/10 , A61K31/277 , A61K31/343 , A61K31/353 , A61K31/365 , A61K31/381 , A61K31/404 , A61K31/415 , A61K31/416 , A61K31/4174 , A61K31/4192 , A61K31/4196 , A61K31/421 , A61K31/423 , A61K31/426 , A61K31/428 , A61K31/437 , A61K31/44 , A61K31/4412 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/4965 , A61K31/50 , A61K31/5025 , A61K31/505 , A61K31/519 , A61K31/538 , A61K39/395 , A61K45/06 , C07C255/53 , C07C317/22 , C07C317/36 , C07D209/34 , C07D211/86 , C07D213/57 , C07D213/71 , C07D213/73 , C07D213/74 , C07D213/84 , C07D215/48 , C07D217/04 , C07D231/12 , C07D231/56 , C07D233/64 , C07D237/20 , C07D239/42 , C07D241/12 , C07D249/06 , C07D249/08 , C07D263/32 , C07D263/57 , C07D265/36 , C07D277/30 , C07D277/56 , C07D277/64 , C07D307/83 , C07D311/22 , C07D333/64 , C07D401/04 , C07D401/10 , C07D409/10 , C07D413/10 , C07D471/04 , C07D487/04
CPC分类号： C07C317/32 , A61K31/10 , A61K31/277 , A61K31/343 , A61K31/353 , A61K31/365 , A61K31/381 , A61K31/404 , A61K31/415 , A61K31/416 , A61K31/4174 , A61K31/4192 , A61K31/4196 , A61K31/421 , A61K31/423 , A61K31/426 , A61K31/428 , A61K31/437 , A61K31/44 , A61K31/4412 , A61K31/47 , A61K31/472 , A61K31/4709 , A61K31/4965 , A61K31/50 , A61K31/505 , A61K31/5025 , A61K31/519 , A61K31/538 , A61K39/3955 , A61K45/06 , C07C255/53 , C07C317/22 , C07C317/36 , C07D209/34 , C07D211/86 , C07D213/57 , C07D213/71 , C07D213/73 , C07D213/74 , C07D213/84 , C07D215/48 , C07D217/04 , C07D231/12 , C07D231/56 , C07D233/64 , C07D237/20 , C07D239/42 , C07D241/12 , C07D249/06 , C07D249/08 , C07D263/32 , C07D263/57 , C07D265/36 , C07D277/30 , C07D277/56 , C07D277/64 , C07D307/83 , C07D311/22 , C07D333/64 , C07D401/04 , C07D401/10 , C07D409/10 , C07D413/10 , C07D471/04 , C07D487/04 , C07C2602/08 , C07C2602/10
摘要： Compounds that inhibit HIF-2α, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2α.
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公开(公告)号：US11045472B2
公开(公告)日：2021-06-29
申请号：US16610812
申请日：2018-05-03
发明人： Manmohan Reddy Leleti , Dillon Harding Miles , Jay Patrick Powers , Brandon Reid Rosen , Ehesan Ul Sharif , Rhiannon Thomas-Tran
IPC分类号： C07D401/14 , C07D405/14 , A61K31/517 , A61K33/243 , A61K31/4709 , A61K31/704 , A61K39/395 , A61K45/06
摘要： Compounds of Formula I that inhibit at least one of the A2A and A2B adenosine receptors, and compositions containing compounds of Formula I and methods for synthesizing compounds of Formula I, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by the adenosine A2A receptor and/or the adenosine A2B receptor.
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公开(公告)号：US11001603B2
公开(公告)日：2021-05-11
申请号：US17009590
申请日：2020-09-01
发明人： Laurent Pierre Paul Debien , Juan Carlos Jaen , Jaroslaw Kalisiak , Kenneth V. Lawson , Manmohan Reddy Leleti , Erick Allen Lindsey , Dillon Harding Miles , Eric Newcomb , Jay Patrick Powers , Brandon Reid Rosen , Ehesan Ul Sharif
IPC分类号： A01N43/04 , A61K31/70 , C07H19/23 , A61K31/7076 , C07H19/16 , C07H19/20 , C07H19/207 , C07F9/6561 , C07H19/04 , A61K31/706 , A61K45/06 , A61K31/7052 , A61K31/7064 , C07H19/14
摘要： Compounds that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.
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公开(公告)号：US20240285665A1
公开(公告)日：2024-08-29
申请号：US18629820
申请日：2024-04-08
发明人： Laurent Pierre Paul DEBIEN , Jaroslaw Kalisiak , Kenneth V. Lawson , Manmohan Reddy Leleti , Erick Allen Lindsey , Dillon Harding Miles , Eric Newcomb , Jay Patrick Powers , Brandon Reid Rosen , Ehesan UI Sharif
IPC分类号： A61K31/7076 , A61K31/706 , A61K31/7064 , A61K39/395 , C07H19/20 , C07H19/207 , C07H19/23
CPC分类号： A61K31/7076 , A61K31/706 , A61K31/7064 , A61K39/3955 , C07H19/20 , C07H19/207 , C07H19/23
摘要： Compounds that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.
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公开(公告)号：US11220492B2
公开(公告)日：2022-01-11
申请号：US16614063
申请日：2018-05-16
发明人： Manmohan Reddy Leleti , Dillon Harding Miles , Jay Patrick Powers , Brandon Reid Rosen , Ehesan Ul Sharif
IPC分类号： C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14
摘要： A compound that is an inhibitor of at least one of the A2A and A2B adenosine receptors having Formula (I) and compositions containing the compound and methods for synthesizing the compound, are described herein. The use of such compound and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by the adenosine A2A receptor and/or the adenosine A2B receptor.
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公开(公告)号：US20190309010A1
公开(公告)日：2019-10-10
申请号：US16273843
申请日：2019-02-12
发明人： Laurent Pierre Paul DEBIEN , Juan Carlos Jaen , Jaroslaw Kalisiak , Kenneth V. Lawson , Manmohan Reddy Leleti , Erick Allen Lindsey , Dillon Harding Miles , Eric Newcomb , Jay Patrick Powers , Brandon Reid Rosen , Ehesan Ul Sharif
IPC分类号： C07H19/23 , A61K31/706 , A61K45/06 , C07H19/207 , C07H19/20 , C07H19/16 , A61K31/7076 , A61K31/70 , C07F9/6561 , C07H19/14 , A61K31/7064 , A61K31/7052 , C07H19/04
摘要： Compounds that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.
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