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    Surgical Instrument
    2.
    发明申请
    Surgical Instrument 审中-公开
    手术器械

    公开(公告)号：US20090254075A1

    公开(公告)日：2009-10-08

    申请号：US11989104

    申请日：2006-07-26

    申请人： Adrian Paz ,  Roni Shabat

    发明人： Adrian Paz ,  Roni Shabat

    IPC分类号： A61B18/04

    CPC分类号： A61B17/3203 ,  A61B2018/046

    摘要： A surgical instrument suitable for endoscopic operations having a gripping handle, tubular body and an operational tip. Jetting outlets laterally disposed at the operational tip provides for jetting pressurized liquid delivered by the tubular body. The jetting outlets are configured as to emit converging jets. Two or more jets converge at a convergence point laterally displaced at a predefined distance from the surface of the operational tip. The operational tip includes a heating member having an active face for contact heating a bleeding tissue. A rotating mechanism provides for independently rotating the jetting outlets and the active surface of the heating member relative to the gripping handle. A method for regulating the operating temperature of the heating member is provided.

    摘要翻译： 适于内窥镜操作的手术器械具有握柄，管体和操作尖端。 横向设置在操作尖端处的喷射出口提供喷射由管状体输送的加压液体。 喷射出口配置为发射会聚喷嘴。 两个或更多个射流在与操作尖端的表面预定距离横向移位的会聚点处会聚。 操作尖端包括具有用于接触加热出血组织的主动面的加热构件。 旋转机构提供相对于把手独立地旋转加热构件的喷射出口和活动表面。 提供了一种用于调节加热部件的工作温度的方法。

    System and Method for thermally Treating Tissues
    3.
    发明申请
    System and Method for thermally Treating Tissues 审中-公开
    用于热处理组织的系统和方法

    公开(公告)号：US20090069876A1

    公开(公告)日：2009-03-12

    申请号：US12087469

    申请日：2007-01-09

    申请人： Shaul Shohat ,  Roni Shabat ,  Elazar Segal ,  Adrian Paz

    发明人： Shaul Shohat ,  Roni Shabat ,  Elazar Segal ,  Adrian Paz

    IPC分类号： A61F7/12

    CPC分类号： A61B18/04 ,  A61B2017/00274 ,  A61B2018/00547 ,  A61B2018/046

    摘要： A system and method are provided for thermally treating tissues in percutaneous surgery or endoluminal treatments. The system consists of at least one catheter for thermally treating a tissue, hydraulic unit for circulating fluids through the catheters and a control station by which an operator is displayed with, and inputs and/or modifies, working parameters of the system. The catheters have an operational face, which is optionally expandable and encloses a lumen through which the fluids are circulated. The method disclosed implements cooling of the targeted tissue prior to its heating. For heating and or cooling the tissues, the operational face of a catheter is pressed against a surface of the targeted tissue while heat emitted from or conducted to the tissue is respectively transferred into or from the circulated fluids.

    摘要翻译： 提供用于经皮手术或腔内治疗中热处理组织的系统和方法。 该系统包括用于热处理组织的至少一个导管，用于使流体通过导管循环的液压单元和操作者通过该控制站显示并输入和/或修改系统的工作参数。 导管具有可操作的面，其可任选地可膨胀并且包围流体通过其流通的内腔。 所公开的方法在加热之前对目标组织进行冷却。 为了加热和/或冷却组织，将导管的操作面压在目标组织的表面上，同时从组织发出或传导到组织的热量分别转移到循环流体中或从循环流体转移。

    Extracting Device for Surgical Fasteners
    4.
    发明申请
    Extracting Device for Surgical Fasteners 有权
    外科紧固件提取装置

    公开(公告)号：US20090264900A1

    公开(公告)日：2009-10-22

    申请号：US12084317

    申请日：2006-11-02

    申请人： Adrian Paz ,  Gilad Heftman ,  Eitan Hod

    发明人： Adrian Paz ,  Gilad Heftman ,  Eitan Hod

    IPC分类号： A61B17/10 ,  A61B17/08

    CPC分类号： A61B17/076

    摘要： The application provides a device (2) for extracting from a body tissue surgical fasteners (20) having a crown, a baseplate and prongs extending from the crown to the baseplate. The device includes a shaft having a lumen with a cross-sectional shape and dimensions to allow the crown to enter the lumen while preventing the baseplate from entering the lumen.

    摘要翻译： 本申请提供了一种用于从身体组织提取外科紧固件（20）的装置（2），所述外科紧固件（20）具有冠部，底板和从冠部延伸到基板的尖头。 该装置包括轴，其具有具有横截面形状和尺寸的内腔，以允许牙冠进入内腔，同时防止基板进入管腔。

    Surgical Fasteners and Devices for Surgical Fasteners
    5.
    发明申请
    Surgical Fasteners and Devices for Surgical Fasteners 审中-公开
    手术紧固件和外科紧固件的装置

    公开(公告)号：US20090030434A1

    公开(公告)日：2009-01-29

    申请号：US11990262

    申请日：2006-08-09

    申请人： Adrian Paz ,  Gilad Heftman ,  Eitan Hod

    发明人： Adrian Paz ,  Gilad Heftman ,  Eitan Hod

    IPC分类号： A61B17/03

    CPC分类号： A61B17/064 ,  A61B17/0401 ,  A61B17/0682 ,  A61B2017/0412 ,  A61B2017/0422 ,  A61B2017/0427 ,  A61B2017/0445 ,  A61B2017/0464 ,  A61B2017/0641 ,  A61F2/0063

    摘要： The invention provides fasteners for surgical fastening. The surgical fastener of the invention has a crown from which extend two or more prongs. The prongs are parallel to the axis of the crown and each prong is provided with one or more barbs. The invention also provides a system for surgical fastening device configured to deploy one or more surgical fasteners of the invention and one or more surgical fasteners of the invention.

    摘要翻译： 本发明提供了用于手术紧固的紧固件。 本发明的外科紧固件具有冠部，从其延伸两个或更多个插脚。 尖头平行于表冠的轴线，每个插脚设有一个或多个倒钩。 本发明还提供了一种用于外科紧固装置的系统，其被配置为展开本发明的一个或多个手术紧固件和本发明的一个或多个手术紧固件。

    Anastomosis device and system
    6.
    发明申请
    Anastomosis device and system 审中-公开
    吻合装置及系统

    公开(公告)号：US20100130993A1

    公开(公告)日：2010-05-27

    申请号：US11989242

    申请日：2006-07-25

    申请人： Adrian Paz ,  Gilad Heftman ,  Eitan Hod

    发明人： Adrian Paz ,  Gilad Heftman ,  Eitan Hod

    IPC分类号： A61B17/11 ,  A61M29/00

    CPC分类号： A61B17/11 ,  A61B17/1114 ,  A61B2017/1103 ,  A61B2017/1107 ,  A61B2017/1135

    摘要： An anastomosis device for forming two lumen-comprising body structures having an un-deployed and a deployed state and switchable from the former to the latter, comprising: a body with an overall cylindrical shape defining a proximal-distal extending axis of and comprising an external essentially cylindrical body part with a lumen and an internal body part at least a portion thereof being deployed within the lumen of the external body part and axially displacable with respect thereto in the switch between the un-deployed and the deployed states; said internal body part having an internal duct extending axially therethrough whereby in the deployed state there is a fluid communication between the distal and the proximal ends of the body; and two tissue-engaging units axially displaced from one another along said axis; at least one of the two units can change its state from a closed state in the un-deployed state of the device to an opened, tissue-engaging state in the deployed state of the device in which said first unit extends in an overall radial direction and is adapted in this state for tight association with internal walls of one of the body structures, such that the combined tissue-engaging action of the two unit holds the two structures together.

    摘要翻译： 一种吻合装置，用于形成具有未部署状态和展开状态的两个含腔体的主体结构，并且可从前者向后延伸，包括：主体，其整体圆柱形形状限定近端 - 远侧延伸轴线并且包括外部 基本上圆柱形的主体部分具有内腔和内部主体部分，其至少一部分展开在外部主体部分的内腔内，并且在未展开状态和展开状态之间的开关中可相对于其移动; 所述内部主体部分具有轴向延伸穿过的内部管道，由此在展开状态下，主体的远端和近端之间存在流体连通; 和两个沿着所述轴线彼此轴向移位的组织接合单元; 两个单元中的至少一个可以在装置的未展开状态下将其状态从关闭状态改变到处于展开状态的打开的组织接合状态，其中所述第一单元沿总体径向延伸 并且在该状态下适应于与身体结构之一的内壁紧密联系，使得两个单元的组合的组织接合动作将两个结构保持在一起。

    Extracting device for surgical fasteners
    7.
    发明授权
    Extracting device for surgical fasteners 有权
    外科紧固件提取装置

    公开(公告)号：US08747420B2

    公开(公告)日：2014-06-10

    申请号：US12084317

    申请日：2006-11-02

    申请人： Adrian Paz ,  Gilad Heftman ,  Eitan Hod

    发明人： Adrian Paz ,  Gilad Heftman ,  Eitan Hod

    IPC分类号： A61B17/10

    CPC分类号： A61B17/076

    摘要： The application provides a device (2) for extracting from a body tissue surgical fasteners (20) having a crown, a baseplate and prongs extending from the crown to the baseplate. The device includes a shaft having a lumen with a cross-sectional shape and dimensions to allow the crown to enter the lumen while preventing the baseplate from entering the lumen.

    摘要翻译： 本申请提供了一种用于从身体组织提取外科紧固件（20）的装置（2），所述外科紧固件（20）具有冠部，底板和从冠部延伸到基板的尖头。 该装置包括轴，其具有具有横截面形状和尺寸的内腔，以允许牙冠进入内腔，同时防止基板进入内腔。

    Tumor associated antigen peptides and use of same as anti-tumor vaccines
    8.
    发明授权
    Tumor associated antigen peptides and use of same as anti-tumor vaccines 失效
    肿瘤相关抗原肽及其与抗肿瘤疫苗的使用

    公开(公告)号：US07960507B2

    公开(公告)日：2011-06-14

    申请号：US12844663

    申请日：2010-07-27

    申请人： Lea Eisenbach ,  Boaz Tirosh ,  Erez Bar-Haim ,  Adrian Paz ,  Matityahu Fridkin ,  Cheryl Fitzer-Attas ,  Arthur Machlenkin ,  Esther Tzehoval

    发明人： Lea Eisenbach ,  Boaz Tirosh ,  Erez Bar-Haim ,  Adrian Paz ,  Matityahu Fridkin ,  Cheryl Fitzer-Attas ,  Arthur Machlenkin ,  Esther Tzehoval

    IPC分类号： C07K16/00

    CPC分类号： C12N9/6445 ,  A61K39/00 ,  A61K48/00 ,  C07K14/47 ,  C07K14/4727 ,  C07K14/705 ,  C12N9/16

    摘要： The present invention relates to tumor associated antigen (TAA) peptides and to use of same, of polynucleotides encoding same and of cells presenting same as anti-tumor vaccines. More particularly, the present invention relates to tumor associated antigen peptides derived from Uroplakin Ia, Ib, II and III, Prostate specific antigen (PSA), Prostate acid phosphatase (PAP) and Prostate specific membrane antigen (PSMA), BA-46 (Lactadherin), Mucin (MUC-1), and Teratocarcinoma-derived growth factor (CRIPTO-1) and the use of same as anti-tumor vaccines to prevent or cure bladder, prostate, breast or other cancers, carcinomas in particular. Most particularly, the present invention relates to tumor associated antigen peptides which are presentable to the immune system by HLA-A2 molecules.

    摘要翻译： 本发明涉及肿瘤相关抗原（TAA）肽及其使用方法，其编码相同的多核苷酸和与抗肿瘤疫苗相同的细胞。 更具体地说，本发明涉及衍生自Uroplatinin Ia，Ib，II和III，前列腺特异性抗原（PSA），前列腺酸性磷酸酶（PAP）和前列腺特异性膜抗原（PSMA），BA-46（Lactadherin ），粘蛋白（MUC-1）和细胞因子来源的生长因子（CRIPTO-1），以及其与抗肿瘤疫苗的用途预防或治愈膀胱，前列腺，乳腺癌或其他癌症，特别是癌症。 最特别地，本发明涉及可由HLA-A2分子呈递给免疫系统的肿瘤相关抗原肽。

    Implantable Device For Obesity Prevention
    9.
    发明申请
    Implantable Device For Obesity Prevention 审中-公开
    用于肥胖预防的植入式装置

    公开(公告)号：US20080208240A1

    公开(公告)日：2008-08-28

    申请号：US12063134

    申请日：2006-08-13

    申请人： Adrian Paz

    发明人： Adrian Paz

    IPC分类号： A61M29/02

    CPC分类号： A61F5/003 ,  A61F5/004 ,  A61F5/0043 ,  A61F5/0073

    摘要： A device for controlling the expansion of a hollow internal organ, comprising an inflatable balloon, which is inserted in an uninflated state into the desired position close to the organ using minimally invasive procedures. After insertion, the balloon is inflated to its required size and shape. The invention is useful for restricting the expansion of the stomach during meals, thus inducing a feeling of satiety and preventing over-eating. Inflation may be performed through a catheter connected to a readily accessible inflation port. In the case of the gastric embodiment, the balloon may be positioned pro-peritoneally, such that the procedure is surgically simple. One or more sensors located close to the organ to be controlled, may monitor a physiological effect relating to the organ, and the output of the sensor used to control the level of inflation of the balloon in order to correct the condition being monitored.

    摘要翻译： 一种用于控制中空内脏的膨胀的装置，包括可膨胀的气球，其以未充气状态插入到使用微创程序的器官附近的期望位置。 插入后，气球膨胀至所需尺寸和形状。 本发明对于限制饭食期间的胃膨胀是有用的，因此引起饱腹感和防止过度食用。 可以通过连接到容易接近的充气口的导管进行充气。 在胃实施例的情况下，气囊可以被腹膜定位，使得手术简单。 靠近待控制的器官的一个或多个传感器可以监测与器官有关的生理效应，以及用于控制气囊膨胀水平的传感器的输出，以便校正被监测的状况。