公开(公告)号：US10406175B2

公开(公告)日：2019-09-10

申请号：US15308725

申请日：2015-05-15

Applicant: Agency for Science, Technology and Research

Inventor： Motoichi Kurisawa ,  Fan Lee

IPC: A61K47/48 ,  A61K31/353 ,  A61K31/728 ,  C08B37/00 ,  C08L5/08 ,  C08B37/08 ,  A61K9/00 ,  A61K47/61

Abstract: There is provided a polymer-flavonoid conjugate, or a pharmaceutically acceptable salt thereof, uses thereof, and methods of making thereof. The disclosed polymer-flavonoid conjugates may be useful in the therapeutic and/or prophylactic treatment of a joint condition in a subject.

公开(公告)号：US09439886B2

公开(公告)日：2016-09-13

申请号：US14697565

申请日：2015-04-27

Applicant: Agency for Science, Technology and Research

Inventor： Motoichi Kurisawa ,  Fan Lee ,  Joo Eun Chung ,  Pui Yik Peggy Chan

IPC: A61F2/02 ,  A61K31/353 ,  A61K31/015 ,  A61K31/05 ,  C12P17/06 ,  A61K9/00 ,  A61L27/54 ,  A61K47/48 ,  C08J3/075 ,  A61K31/738 ,  C12P19/26

CPC classification number: A61K31/353 ,  A61K9/0024 ,  A61K31/015 ,  A61K31/05 ,  A61K31/738 ,  A61K47/61 ,  A61K47/6903 ,  A61L27/54 ,  C08J3/075 ,  C08J2397/00 ,  C12P17/06 ,  C12P19/26

Abstract: There is provided methods for producing a hydrogel comprising conjugates of a hydrogel forming agent and a flavonoid including a method for producing a hydrogel that is capable of adhesion of cells and which comprises enzymatically cross-linked conjugates of a hydrogel forming agent and a flavonoid. There is also provided a method for producing a hydrogel comprising conjugates of a hydrogel forming agent and a flavonoid without the addition of an exogenous peroxide or peroxidase or without the addition of an exogenous peroxide. Hydrogels produced by such methods and methods of using the hydrogels are also described herein.

Abstract translation: 提供了包含水凝胶形成剂和类黄酮的缀合物的水凝胶的方法，包括能够粘附细胞的水凝胶的制造方法，其包含水凝胶形成剂和类黄酮的酶交联的缀合物。 还提供了一种制备水凝胶的方法，其包括水凝胶形成剂和类黄酮的缀合物，而不加入外源性过氧化物酶或过氧化物酶或不加入外源过氧化物。 本文还描述了通过这些使用水凝胶的方法和方法生产的水凝胶。

公开(公告)号：US10052389B2

公开(公告)日：2018-08-21

申请号：US14767784

申请日：2014-02-13

Applicant: Agency for Science, Technology and Research

Inventor： Motoichi Kurisawa ,  Ki Hyun Bae ,  Fan Lee

IPC: A61K47/61 ,  A61K47/69 ,  A61K47/48 ,  A61L27/20 ,  A61L27/22 ,  A61L27/48 ,  A61L27/52 ,  A61L27/54 ,  A61L31/04 ,  A61L31/12 ,  A61L31/14 ,  A61L31/16 ,  A61L15/44 ,  A61L15/60 ,  A61K9/00 ,  A61K47/10 ,  A61K47/36 ,  A61K38/21 ,  A61K38/28 ,  A61K38/38 ,  C08B37/02 ,  C08L5/02 ,  A61K47/60

CPC classification number: A61K47/61 ,  A61K9/0019 ,  A61K9/0024 ,  A61K38/21 ,  A61K38/212 ,  A61K38/28 ,  A61K38/385 ,  A61K47/10 ,  A61K47/36 ,  A61K47/60 ,  A61K47/6903 ,  A61L15/44 ,  A61L15/60 ,  A61L27/20 ,  A61L27/22 ,  A61L27/48 ,  A61L27/52 ,  A61L27/54 ,  A61L31/042 ,  A61L31/043 ,  A61L31/129 ,  A61L31/145 ,  A61L31/16 ,  A61L2300/622 ,  A61L2400/06 ,  C08B37/0021 ,  C08L5/02 ,  C08L89/00 ,  C08L5/00 ,  C08L71/02

Abstract: The present disclosure relates to a polymeric system for release of an active agent, comprising a first polymeric phase containing the active agent, the first polymeric phase forming discrete regions of a set size range and being dispersed within a second polymeric phase comprising a cross-linked polymer-phenol conjugate for release of the active agent therein. The present disclosure further provides an injectable hydrogel comprising the disclosed polymeric system, a carrier for delivering a biologically active substance or a drug comprising the injectable hydrogel, and a method for producing the disclosed polymeric system.

公开(公告)号：US20150374838A1

公开(公告)日：2015-12-31

申请号：US14767784

申请日：2014-02-13

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Motoichi Kurisawa ,  Ki Hyun Bae ,  Fan Lee

IPC: A61K47/48 ,  A61K38/21 ,  A61K9/00 ,  A61K38/38 ,  A61K38/28

CPC classification number: A61K47/61 ,  A61K9/0019 ,  A61K9/0024 ,  A61K38/21 ,  A61K38/212 ,  A61K38/28 ,  A61K38/385 ,  A61K47/10 ,  A61K47/36 ,  A61K47/60 ,  A61K47/6903 ,  A61L15/44 ,  A61L15/60 ,  A61L27/20 ,  A61L27/22 ,  A61L27/48 ,  A61L27/52 ,  A61L27/54 ,  A61L31/042 ,  A61L31/043 ,  A61L31/129 ,  A61L31/145 ,  A61L31/16 ,  A61L2300/622 ,  A61L2400/06 ,  C08B37/0021 ,  C08L5/02 ,  C08L89/00 ,  C08L5/00 ,  C08L71/02

Abstract: The present disclosure relates to a polymeric system for release of an active agent, comprising a first polymeric phase containing the active agent, the first polymeric phase forming discrete regions of a set size range and being dispersed within a second polymeric phase comprising a cross-linked polymer-phenol conjugate for release of the active agent therein. The present disclosure further provides an injectable hydrogel comprising the disclosed polymeric system, a carrier for delivering a biologically active substance or a drug comprising the injectable hydrogel, and a method for producing the disclosed polymeric system.

Abstract translation: 本公开涉及一种用于释放活性剂的聚合物体系，其包含含有活性剂的第一聚合物相，所述第一聚合物相形成一定大小范围的离散区域并分散在包含交联的第二聚合物相 聚合物 - 苯酚共轭物用于其中活性剂的释放。 本公开进一步提供了包含所公开的聚合物体系的可注射水凝胶，用于递送生物活性物质的载体或包含可注射水凝胶的药物，以及用于制备所公开的聚合物体系的方法。

公开(公告)号：US20150313869A1

公开(公告)日：2015-11-05

申请号：US14697565

申请日：2015-04-27

Applicant: Agency for Science, Technology and Research

Inventor： Motoichi Kurisawa ,  Fan Lee ,  Joo Eun Chung ,  Pui Yik Peggy Chan

IPC: A61K31/353 ,  C12P17/06 ,  A61K31/738

CPC classification number: A61K31/353 ,  A61K9/0024 ,  A61K31/015 ,  A61K31/05 ,  A61K31/738 ,  A61K47/61 ,  A61K47/6903 ,  A61L27/54 ,  C08J3/075 ,  C08J2397/00 ,  C12P17/06 ,  C12P19/26

Abstract: There is provided methods for producing a hydrogel comprising conjugates of a hydrogel forming agent and a flavonoid including a method for producing a hydrogel that is capable of adhesion of cells and which comprises enzymatically cross-linked conjugates of a hydrogel forming agent and a flavonoid. There is also provided a method for producing a hydrogel comprising conjugates of a hydrogel forming agent and a flavonoid without the addition of an exogenous peroxide or peroxidase or without the addition of an exogenous peroxide. Hydrogels produced by such methods and methods of using the hydrogels are also described herein.

Abstract translation: 提供了包含水凝胶形成剂和类黄酮的缀合物的水凝胶的方法，包括能够粘附细胞的水凝胶的制造方法，其包含水凝胶形成剂和类黄酮的酶交联的缀合物。 还提供了一种制备水凝胶的方法，其包括水凝胶形成剂和类黄酮的缀合物，而不加入外源性过氧化物酶或过氧化物酶或不加入外源过氧化物。 本文还描述了通过这些使用水凝胶的方法和方法生产的水凝胶。

公开(公告)号：US20130338101A1

公开(公告)日：2013-12-19

申请号：US13970432

申请日：2013-08-19

Applicant: Agency for Science, Technology and Research

Inventor： Motoichi Kurisawa ,  Fan Lee ,  Joo Eun Chung ,  Pui Yik Peggy Chan

IPC: A61K31/353 ,  C12P19/26 ,  A61K31/738

CPC classification number: A61K31/353 ,  A61K9/0024 ,  A61K31/015 ,  A61K31/05 ,  A61K31/738 ,  A61K47/61 ,  A61K47/6903 ,  A61L27/54 ,  C08J3/075 ,  C08J2397/00 ,  C12P17/06 ,  C12P19/26

Abstract: There are provided methods for producing a hydrogel that is capable of adhesion of cells and which comprises enzymatically cross-linked conjugates of a hydrogel forming agent and a flavonoid, formed from a reaction using peroxide and peroxidase. Hydrogels produced by such methods and methods of using the hydrogels are also provided.

Abstract translation: 提供了能够产生能够粘附细胞的水凝胶的方法，其包括由使用过氧化物和过氧化物酶的反应形成的水凝胶形成剂和类黄酮的酶交联的缀合物。 还提供了通过使用水凝胶的方法和方法制备的水凝胶。

公开(公告)号：US09034364B2

公开(公告)日：2015-05-19

申请号：US13970432

申请日：2013-08-19

Applicant: Agency for Science, Technology and Research

Inventor： Motoichi Kurisawa ,  Fan Lee ,  Joo Eun Chung ,  Pui Yik Peggy Chan

IPC: A61F2/02 ,  A61K31/353 ,  A61K31/015 ,  A61K31/05 ,  A61K47/48 ,  C08J3/075 ,  A61K31/738 ,  C12P19/26

CPC classification number: A61K31/353 ,  A61K9/0024 ,  A61K31/015 ,  A61K31/05 ,  A61K31/738 ,  A61K47/61 ,  A61K47/6903 ,  A61L27/54 ,  C08J3/075 ,  C08J2397/00 ,  C12P17/06 ,  C12P19/26

Abstract: There are provided methods for producing a hydrogel that is capable of adhesion of cells and which comprises enzymatically cross-linked conjugates of a hydrogel forming agent and a flavonoid, formed from a reaction using peroxide and peroxidase. Hydrogels produced by such methods and methods of using the hydrogels are also provided.

Abstract translation: 提供了能够产生能够粘附细胞的水凝胶的方法，其包括由使用过氧化物和过氧化物酶的反应形成的水凝胶形成剂和类黄酮的酶交联的缀合物。 还提供了通过使用水凝胶的方法和方法制备的水凝胶。