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1.发明申请DEVICE AND METHODS FOR COLLECTION OF BIOLOGICAL FLUID SAMPLE AND TREATMENT OF SELECTED COMPONENTS 有权用于收集生物流体样品和处理选定组分的装置和方法公开(公告)号：US20110091990A1
公开(公告)日：2011-04-21
申请号：US12773525
申请日：2010-05-04
IPC分类号： G01N1/18
CPC分类号： B01L3/50825 , A61B5/15003 , A61B5/150236 , A61B5/150251 , A61B5/150351 , A61B5/150755 , A61B5/154 , A61B5/417 , A61B10/0045 , B01F13/002 , B01F15/00512 , B01L3/50215 , B01L2200/16 , B01L2300/042 , B01L2300/047 , B01L2300/0609 , B01L2400/0683 , G01N33/491 , Y10T428/13 , Y10T436/25375 , Y10T436/255
摘要： A collection device and a method for collecting a biological sample, particularly whole blood, includes a separating member to separate the whole blood into its components, and at least reagent positioned to selectively interact with a component of the separated sample. The reagent is able to selectively interact with the plasma/serum, and is prevented from contacting or interacting with the whole blood.
摘要翻译： 收集装置和用于收集生物样品，特别是全血的收集装置和方法包括分离构件，以将全血分离成其组分，并且至少包含试剂，定位成选择性地与分离的样品的组分相互作用。 试剂能够选择性地与血浆/血清相互作用，并且被阻止与全血接触或相互作用。
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2.发明申请Device and methods for collection of biological fluid sample and treatment of selected components 有权用于收集生物流体样品和处理所选组分的装置和方法公开(公告)号：US20050059163A1
公开(公告)日：2005-03-17
申请号：US10912263
申请日：2004-08-05
CPC分类号： B01L3/50825 , A61B5/15003 , A61B5/150236 , A61B5/150251 , A61B5/150351 , A61B5/150755 , A61B5/154 , A61B5/417 , A61B10/0045 , B01F13/002 , B01F15/00512 , B01L3/50215 , B01L2200/16 , B01L2300/042 , B01L2300/047 , B01L2300/0609 , B01L2400/0683 , G01N33/491 , Y10T428/13 , Y10T436/25375 , Y10T436/255
摘要： A collection device and a method for collecting a biological sample, particularly whole blood, includes a separating member to separate the whole blood into its components, and at least reagent positioned to selectively interact with a component of the separated sample. The reagent is able to selectively interact with the plasma/serum, and is prevented from contacting or interacting with the whole blood.
摘要翻译： 收集装置和用于收集生物样品，特别是全血的收集装置和方法包括分离构件，以将全血分离成其组分，并且至少包含试剂，定位成选择性地与分离的样品的组分相互作用。 试剂能够选择性地与血浆/血清相互作用，并且被阻止与全血接触或相互作用。
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3.发明授权Device and methods for collection of biological fluid sample and treatment of selected components 有权用于收集生物流体样品和处理所选组分的装置和方法公开(公告)号：US08632740B2
公开(公告)日：2014-01-21
申请号：US12773525
申请日：2010-05-04
IPC分类号： B01L3/14
CPC分类号： B01L3/50825 , A61B5/15003 , A61B5/150236 , A61B5/150251 , A61B5/150351 , A61B5/150755 , A61B5/154 , A61B5/417 , A61B10/0045 , B01F13/002 , B01F15/00512 , B01L3/50215 , B01L2200/16 , B01L2300/042 , B01L2300/047 , B01L2300/0609 , B01L2400/0683 , G01N33/491 , Y10T428/13 , Y10T436/25375 , Y10T436/255
摘要： A collection device and a method for collecting a biological sample, particularly whole blood, includes a separating member to separate the whole blood into its components, and at least reagent positioned to selectively interact with a component of the separated sample. The reagent is able to selectively interact with the plasma/serum, and is prevented from contacting or interacting with the whole blood.
摘要翻译： 收集装置和用于收集生物样品，特别是全血的收集装置和方法包括分离构件，以将全血分离成其组分，并且至少包含试剂，其定位成选择性地与分离的样品的组分相互作用。 试剂能够选择性地与血浆/血清相互作用，并且被阻止与全血接触或相互作用。
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公开(公告)号：US20080241001A1
公开(公告)日：2008-10-02
申请号：US11937954
申请日：2007-11-09
申请人： Bruce Haywood , Ajit Dastane , Fu-Chung Lin
发明人： Bruce Haywood , Ajit Dastane , Fu-Chung Lin
IPC分类号： B01L3/02
CPC分类号： A61B5/417 , A61B5/15003 , A61B5/150221 , A61B5/150236 , A61B5/150244 , A61B5/150274 , A61B5/150351 , A61B5/150366 , A61B5/150389 , A61B5/150503 , A61B5/150755 , A61B5/150893 , A61B5/154 , A61J1/05 , A61J1/12 , A61J7/00 , A61J7/0053 , B01L3/02 , B01L3/50 , B01L3/5082 , B01L2200/16 , B01L2300/0609 , C12M23/12 , C12M33/04 , G01N35/1095 , Y10T436/2525 , Y10T436/25375
摘要： A collection container and a method for collecting a biological sample, particularly whole blood, includes at least one stabilizing agent in an amount effective to stabilize and inhibit protein degradation and/or fragmentation. The stabilizing agent is able to stabilize proteases in the biological sample, particularly at the point of collection, by inhibiting protein degradation and/or fragmentation in the sample when the sample is stored. The stabilizing agent comprises or consists of one or more protease inhibitors.
摘要翻译： 收集容器和收集生物样品，特别是全血的方法包括至少一种有效稳定和抑制蛋白质降解和/或破碎的稳定剂。 当储存样品时，稳定剂能够通过抑制样品中的蛋白质降解和/或碎裂来稳定生物样品中的蛋白酶，特别是在收集点。 稳定剂包含或由一种或多种蛋白酶抑制剂组成。
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公开(公告)号：US09295416B2
公开(公告)日：2016-03-29
申请号：US12398777
申请日：2009-03-05
CPC分类号： A61B5/150343 , A61B5/1405 , A61B5/1438 , A61B5/150022 , A61B5/150061 , A61B5/150259 , A61B5/150267 , A61B5/150351 , A61B5/153 , A61B5/154 , A61B10/0096 , B01L3/5021 , B01L2200/026 , B01L2300/042 , B01L2300/047 , B01L2300/0609 , B01L2300/0672 , B01L2300/0838 , B01L2300/087 , B01L2400/0409
摘要： A container assembly is disclosed including an outer container, a hollow inner member, and a closure. The outer container has a closed bottom, an open top, and a sidewall extending therebetween. The hollow inner member is disposed within the outer container and has an inner surface defining at least one capillary channel. The inner member includes a first end adjacent to the open top of the outer container and has an outer periphery seated against the sidewall of the outer container. The closure has a proximal end and a distal end. The closure proximal end is seated at least partially within the first end of the inner member to seal the outer container and inner member and define a fluid collection chamber. The closure distal end defines a recessed area shaped to direct fluid under capillary action to the at least one capillary channel in the inner member.
摘要翻译： 公开了一种容器组件，其包括外部容器，中空内部构件和封闭件。 外部容器具有封闭的底部，敞开的顶部和在其间延伸的侧壁。 中空的内部构件设置在外部容器内并且具有限定至少一个毛细通道的内表面。 内部构件包括与外部容器的开口顶部相邻的第一端部，并且具有抵靠外部容器的侧壁的外周。 封闭件具有近端和远端。 封闭件近端至少部分地位于内部构件的第一端内以密封外部容器和内部构件并限定流体收集室。 闭合件远端限定凹形区域，其形状以将毛细作用下的流体引导到内部构件中的至少一个毛细管通道。
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公开(公告)号：US20090259145A1
公开(公告)日：2009-10-15
申请号：US12398777
申请日：2009-03-05
IPC分类号： A61B5/151
CPC分类号： A61B5/150343 , A61B5/1405 , A61B5/1438 , A61B5/150022 , A61B5/150061 , A61B5/150259 , A61B5/150267 , A61B5/150351 , A61B5/153 , A61B5/154 , A61B10/0096 , B01L3/5021 , B01L2200/026 , B01L2300/042 , B01L2300/047 , B01L2300/0609 , B01L2300/0672 , B01L2300/0838 , B01L2300/087 , B01L2400/0409
摘要： A container assembly is disclosed including an outer container, a hollow inner member, and a closure. The outer container has a closed bottom, an open top, and a sidewall extending therebetween. The hollow inner member is disposed within the outer container and has an inner surface defining at least one capillary channel. The inner member includes a first end adjacent to the open top of the outer container and has an outer periphery seated against the sidewall of the outer container. The closure has a proximal end and a distal end. The closure proximal end is seated at least partially within the first end of the inner member to seal the outer container and inner member and define a fluid collection chamber. The closure distal end defines a recessed area shaped to direct fluid under capillary action to the at least one capillary channel in the inner member.
摘要翻译： 公开了一种容器组件，其包括外部容器，中空内部构件和封闭件。 外部容器具有封闭的底部，敞开的顶部和在其间延伸的侧壁。 中空的内部构件设置在外部容器内并且具有限定至少一个毛细通道的内表面。 内部构件包括与外部容器的开口顶部相邻的第一端部，并且具有抵靠外部容器的侧壁的外周。 封闭件具有近端和远端。 封闭件近端至少部分地位于内部构件的第一端内以密封外部容器和内部构件并限定流体收集室。 闭合件远端限定凹形区域，其形状以将毛细作用下的流体引导到内部构件中的至少一个毛细管通道。
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公开(公告)号：US07985387B2
公开(公告)日：2011-07-26
申请号：US12629158
申请日：2009-12-02
申请人： Bruce Haywood , Ajit Dastane , Fu-Chung Lin
发明人： Bruce Haywood , Ajit Dastane , Fu-Chung Lin
IPC分类号： B01L3/00
CPC分类号： A61B5/417 , A61B5/15003 , A61B5/150221 , A61B5/150236 , A61B5/150244 , A61B5/150274 , A61B5/150351 , A61B5/150366 , A61B5/150389 , A61B5/150503 , A61B5/150755 , A61B5/150893 , A61B5/154 , A61J1/05 , A61J1/12 , A61J7/00 , A61J7/0053 , B01L3/02 , B01L3/50 , B01L3/5082 , B01L2200/16 , B01L2300/0609 , C12M23/12 , C12M33/04 , G01N35/1095 , Y10T436/2525 , Y10T436/25375
摘要： A collection container and a method for collecting a biological sample, particularly whole blood, includes at least one stabilizing agent in an amount effective to stabilize and inhibit protein degradation and/or fragmentation. The stabilizing agent is able to stabilize proteases in the biological sample, particularly at the point of collection, by inhibiting protein degradation and/or fragmentation in the sample when the sample is stored. The stabilizing agent includes one or more protease inhibitors.
摘要翻译： 收集容器和收集生物样品，特别是全血的方法包括至少一种有效稳定和抑制蛋白质降解和/或破碎的稳定剂。 当储存样品时，稳定剂能够通过抑制样品中的蛋白质降解和/或碎裂来稳定生物样品中的蛋白酶，特别是在收集点。 稳定剂包括一种或多种蛋白酶抑制剂。
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公开(公告)号：US20100280414A1
公开(公告)日：2010-11-04
申请号：US12629158
申请日：2009-12-02
申请人： Bruce Haywood , Ajit Dastane , Fu-Chung Lin
发明人： Bruce Haywood , Ajit Dastane , Fu-Chung Lin
CPC分类号： A61B5/417 , A61B5/15003 , A61B5/150221 , A61B5/150236 , A61B5/150244 , A61B5/150274 , A61B5/150351 , A61B5/150366 , A61B5/150389 , A61B5/150503 , A61B5/150755 , A61B5/150893 , A61B5/154 , A61J1/05 , A61J1/12 , A61J7/00 , A61J7/0053 , B01L3/02 , B01L3/50 , B01L3/5082 , B01L2200/16 , B01L2300/0609 , C12M23/12 , C12M33/04 , G01N35/1095 , Y10T436/2525 , Y10T436/25375
摘要： A collection container and a method for collecting a biological sample, particularly whole blood, includes at least one stabilizing agent in an amount effective to stabilize and inhibit protein degradation and/or fragmentation. The stabilizing agent is able to stabilize proteases in the biological sample, particularly at the point of collection, by inhibiting protein degradation and/or fragmentation in the sample when the sample is stored. The stabilizing agent comprises or consists of one or more protease inhibitors.
摘要翻译： 收集容器和收集生物样品，特别是全血的方法包括至少一种有效稳定和抑制蛋白质降解和/或破碎的稳定剂。 当储存样品时，稳定剂能够通过抑制样品中的蛋白质降解和/或碎裂来稳定生物样品中的蛋白酶，特别是在收集点。 稳定剂包含一种或多种蛋白酶抑制剂或由一种或多种蛋白酶抑制剂组成。
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公开(公告)号：US07645425B2
公开(公告)日：2010-01-12
申请号：US11937954
申请日：2007-11-09
申请人： Bruce Haywood , Ajit Dastane , Fu-Chung Lin
发明人： Bruce Haywood , Ajit Dastane , Fu-Chung Lin
IPC分类号： B01L3/00
CPC分类号： A61B5/417 , A61B5/15003 , A61B5/150221 , A61B5/150236 , A61B5/150244 , A61B5/150274 , A61B5/150351 , A61B5/150366 , A61B5/150389 , A61B5/150503 , A61B5/150755 , A61B5/150893 , A61B5/154 , A61J1/05 , A61J1/12 , A61J7/00 , A61J7/0053 , B01L3/02 , B01L3/50 , B01L3/5082 , B01L2200/16 , B01L2300/0609 , C12M23/12 , C12M33/04 , G01N35/1095 , Y10T436/2525 , Y10T436/25375
摘要： A collection container and a method for collecting a biological sample, particularly whole blood, includes at least one stabilizing agent in an amount effective to stabilize and inhibit protein degradation and/or fragmentation. The stabilizing agent is able to stabilize proteases in the biological sample, particularly at the point of collection, by inhibiting protein degradation and/or fragmentation in the sample when the sample is stored. The stabilizing agent includes one or more protease inhibitors.
摘要翻译： 收集容器和收集生物样品，特别是全血的方法包括至少一种有效稳定和抑制蛋白质降解和/或破碎的稳定剂。 当储存样品时，稳定剂能够通过抑制样品中的蛋白质降解和/或碎裂来稳定生物样品中的蛋白酶，特别是在收集点。 稳定剂包括一种或多种蛋白酶抑制剂。
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公开(公告)号：US07309468B2
公开(公告)日：2007-12-18
申请号：US10436263
申请日：2003-05-13
申请人： Timothy Stevens , Bruce Haywood , Ajit Dastane , Fu-Chung Lin
发明人： Timothy Stevens , Bruce Haywood , Ajit Dastane , Fu-Chung Lin
IPC分类号： B01L3/00
CPC分类号： A61B5/417 , A61B5/15003 , A61B5/150221 , A61B5/150236 , A61B5/150244 , A61B5/150274 , A61B5/150351 , A61B5/150366 , A61B5/150389 , A61B5/150503 , A61B5/150755 , A61B5/150893 , A61B5/154 , A61J1/05 , A61J1/12 , A61J7/00 , A61J7/0053 , B01L3/02 , B01L3/50 , B01L3/5082 , B01L2200/16 , B01L2300/0609 , C12M23/12 , C12M33/04 , G01N35/1095 , Y10T436/2525 , Y10T436/25375
摘要： A collection container and a method for collecting a biological sample, particularly whole blood, that includes at least one stabilizing agent in an amount effective to stabilize and inhibit protein degradation and/or fragmentation. The stabilizing agent is able to stabilize proteases in the biological sample, particularly at the point of collection, by inhibiting protein degradation and/or fragmentation in the sample when the sample is stored. The stabilizing agent includes one or more protease inhibitors.
摘要翻译： 收集容器和收集生物样品，特别是全血的方法，其包含至少一种有效稳定和抑制蛋白质降解和/或破碎的量的稳定剂。 当储存样品时，稳定剂能够通过抑制样品中的蛋白质降解和/或碎裂来稳定生物样品中的蛋白酶，特别是在收集点。 稳定剂包括一种或多种蛋白酶抑制剂。
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