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    Composition for oral cavity
    1.
    发明申请
    Composition for oral cavity 审中-公开
    口腔成分

    公开(公告)号：US20050244346A1

    公开(公告)日：2005-11-03

    申请号：US10517053

    申请日：2002-06-07

    申请人： Akira Nakao ,  Toru Saito

    发明人： Akira Nakao ,  Toru Saito

    IPC分类号： A61K8/39 ,  A61K8/41 ,  A61K8/43 ,  A61K8/44 ,  A61K8/49 ,  A61K8/60 ,  A61K8/73 ,  A61Q11/00 ,  A61K7/22

    CPC分类号： A61K8/442 ,  A61K8/39 ,  A61K8/416 ,  A61K8/43 ,  A61K8/4926 ,  A61K8/60 ,  A61K8/604 ,  A61K8/731 ,  A61K2800/412 ,  A61K2800/5422 ,  A61Q11/00

    摘要： The present invention provides an oral composition comprising crystalline cellulose, and one or more surface active agents selected from the group consisting of alkyl glycoside, polyglycerin fatty acid ester, sucrose fatty acid ester and betaine, which has an excellent shape-holding ability and dispersibility in an oral cavity, does not change a taste of juice after teeth brushing, in addition, has excellent stability with time not causing solid-liquid separation. Moreover, the present invention provides an oral composition comprising a cationic bactericide and crystalline cellulose, which can effectively prevent an oral cavity disease such as a periodontal disease, dental caries and the like by enhancing an ability of the cationic bactericide to reside on a tooth surface.

    摘要翻译： 本发明提供了包含结晶纤维素和一种或多种选自烷基糖苷，聚甘油脂肪酸酯，蔗糖脂肪酸酯和甜菜碱的表面活性剂的口服组合物，其具有优异的形状保持能力和分散性 口腔不会改变牙齿刷牙后果汁的味道，此外，具有优异的稳定性随时间而不会导致固液分离。 此外，本发明提供了包含阳离子杀菌剂和结晶纤维素的口腔用组合物，其可以通过增强阳离子杀菌剂驻留在牙齿表面上的能力来有效地防止口腔疾病如牙周病，龋齿等 。

    OPTICAL DISC DRIVE DEVICE AND TILT CORRECTION DEVICE
    3.
    发明申请
    OPTICAL DISC DRIVE DEVICE AND TILT CORRECTION DEVICE 有权
    光盘驱动装置和倾斜校正装置

    公开(公告)号：US20090161504A1

    公开(公告)日：2009-06-25

    申请号：US12337033

    申请日：2008-12-17

    申请人： Takashi Inoue ,  Hiroshi Shimada ,  Akira Nakao ,  Yasuhiro Hayashi

    发明人： Takashi Inoue ,  Hiroshi Shimada ,  Akira Nakao ,  Yasuhiro Hayashi

    IPC分类号： G11B7/00

    CPC分类号： G11B7/0941 ,  G11B7/0901 ,  G11B7/0956

    摘要： An optical disc drive device has an FE signal generator which generates a focus error signal, a TE signal generator which generates a tracking error signal, a return beam detector which detects a return beam reflected by an optical disc after irradiated by an optical pickup to generate a return beam level signal, a return beam gain setting part which sets amplitude adjustment amount of the return beam level signal so that a signal level of the return beam level signal generated by the return beam detector coincides with a predetermined reference level, an FE gain setting part which sets amplitude adjustment amount of the focus error signal in accordance with the signal level of the return beam level signal adjusted by the return beam gain setting part so that a signal amplitude of the focus error signal is constant, and a TE gain setting part which sets amplitude adjustment amount of the tracking error signal in accordance with the signal level of the return beam level signal adjusted by the return beam gain adjustment part so that a signal amplitude of the tracking error signal is constant.

    摘要翻译： 光盘驱动装置具有产生聚焦误差信号的FE信号发生器，产生跟踪误差信号的TE信号发生器，检测由光拾取器照射后由光盘反射的返回光束的返回光束检测器， 返回光束电平信号，返回光束增益设置部分，其设置返回光束电平信号的幅度调整量，使得由返回光束检测器产生的返回光束电平信号的信号电平与预定参考电平相符，FE增益 设置部分，其根据由返回光束增益设置部分调整的返回光束电平信号的信号电平设置聚焦误差信号的幅度调整量，使得聚焦误差信号的信号幅度恒定，并且TE增益设置 根据调整的返回光束电平信号的信号电平设定跟踪误差信号的幅度调整量的部分 通过返回光束增益调整部分，使得跟踪误差信号的信号幅度恒定。

    Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses
    5.
    发明申请
    Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses 审中-公开
    杂芳基取代的吡咯衍生物，其制备及其治疗用途

    公开(公告)号：US20050283006A1

    公开(公告)日：2005-12-22

    申请号：US10411061

    申请日：2003-04-10

    申请人： Tomio Kimura ,  Kazumasa Aoki ,  Akira Nakao ,  Shigeru Ushiyama ,  Takaichi Shimozato ,  Nobuyuki Ohkawa ,  Takayoshi Nagasaki ,  Takanori Yamazaki

    发明人： Tomio Kimura ,  Kazumasa Aoki ,  Akira Nakao ,  Shigeru Ushiyama ,  Takaichi Shimozato ,  Nobuyuki Ohkawa ,  Takayoshi Nagasaki ,  Takanori Yamazaki

    IPC分类号： C07D401/04 ,  C07D401/14 ,  C07D451/02 ,  C07D453/02 ,  C07D455/02 ,  C07D471/04 ,  C07D487/04 ,  C07D491/20 ,  C07D41/14 ,  C07D43/02

    CPC分类号： C07D451/02 ,  C07D401/04 ,  C07D401/14 ,  C07D453/02 ,  C07D455/02 ,  C07D471/04 ,  C07D487/04

    摘要： Compounds having activity against production of inflammatory cytokines of formula (I)′: A′ is pyrrole; R1′ is aryl or heteroaryl; R2′ is heteroaryl having at least one nitrogen atom; R3′ is (IIa)′, (IIb)′ or (IIc)′: m′ is 1 or 2; one of D′ and E′ is nitrogen and the other is >C(R5′)—, R5′ is hydrogen, Substituent α′ or Substituent β′; B′ is nitrogen-containing 4- to 7-membered heterocyclic; R4′ is 1 to 3 substituents from Substituent α′, Substituent β′ and Substituent γ′; R1′ and R3′ are bonded to two atoms of the pyrrole adjacent to the pyrrole atom bonded to R2′; Substituent α′: hydroxyl, nitro, cyano, halogen, alkoxy, halogeno alkoxy, alkylthio, halogeno alkylthio or —NRa′Rb′; Ra′ and Rb′ are hydrogen, alkyl, alkenyl, alkynyl, aralkyl or alkylsulfonyl, or Ra′ and Rb′ with the nitrogen atom form a heterocyclyl; Substituent β′: alkyl, alkenyl, alkynyl, aralkyl or cycloalkyl; Substituent γ′: oxo, hydroxyimino, alkoxyimino, alkylene, alkylenedioxy, alkylsulfinyl, alkylsulfonyl, aryl, aryloxy, alkylidenyl or aralkylidenyl.

    摘要翻译： 具有抗式产生式（I）的炎性细胞因子的化合物的化合物：A'是吡咯; R 1是芳基或杂芳基; R 2是具有至少一个氮原子的杂芳基; （IIa）'，（IIb）'或（IIc）'：m'为1或2; D'和E'之一是氮，另一个是> C（R 5'） - ，R 5'是氢，取代基α'或取代基β'; B'是含氮的4-至7-元杂环; R 4'是1至3个取代基α'，取代基β'和取代基γ'的取代基; R 1'和R 3'连接到与R 2'连接的吡咯原子相邻的吡咯的两个原子上; 取代基α'：羟基，硝基，氰基，卤素，烷氧基，卤代烷氧基，烷硫基，卤代烷硫基或-NR a R b b。 R a，O和R b'是氢，烷基，烯基，炔基，芳烷基或烷基磺酰基，或者R a'和R“ b'与氮原子形成杂环基; 取代基β'：烷基，烯基，炔基，芳烷基或环烷基; 取代基γ'：氧代，羟基亚氨基，烷氧基亚氨基，亚烷基，亚烷基二氧基，烷基亚磺酰基，烷基磺酰基，芳基，芳氧基，亚烷基或芳烷基。

    Bicyclic unsaturated tertiary amine compounds
    6.
    发明申请
    Bicyclic unsaturated tertiary amine compounds 审中-公开
    双环不饱和叔胺化合物

    公开(公告)号：US20050159444A1

    公开(公告)日：2005-07-21

    申请号：US11039423

    申请日：2005-01-19

    申请人： Tomio Kimura ,  Nobuyuki Ohkawa ,  Kazumasa Aoki ,  Akira Nakao ,  Takayoshi Nagasaki

    发明人： Tomio Kimura ,  Nobuyuki Ohkawa ,  Kazumasa Aoki ,  Akira Nakao ,  Takayoshi Nagasaki

    IPC分类号： A61K31/4745 ,  C07D455/02

    CPC分类号： A61K31/4745 ,  C07D455/02

    摘要： A bicyclic unsaturated tertiary amine compound capable of inhibiting the production of inflammatory cytokines. The compound has the following formula (I): wherein A represents pyrrole or pyrazole, R1 represents an aryl group or a heteroaryl group which may be substituted, R2 represents a heteroaryl group which may be substituted, and R3 represents an indolizine group, or a pharmacologically acceptable salt thereof, a pharmacologically acceptable ester thereof or a pharmacologically acceptable derivative thereof.

    摘要翻译： 能够抑制炎性细胞因子产生的双环不饱和叔胺化合物。 化合物具有下式（I）：其中A表示吡咯或吡唑，R 1表示可被取代的芳基或杂芳基，R 2表示 可以被取代的杂芳基，R 3表示中氮茚基，或其药理学上可接受的盐，其药理学上可接受的酯或其药理学上可接受的衍生物。

    Apparatus and method for folding sheet-form material
    8.
    发明授权
    Apparatus and method for folding sheet-form material 失效
    用于折叠片材的装置和方法

    公开(公告)号：US5300168A

    公开(公告)日：1994-04-05

    申请号：US978208

    申请日：1992-11-19

    申请人： Akira Nakao ,  Toyofusa Endo ,  Takeshi Ikeda

    发明人： Akira Nakao ,  Toyofusa Endo ,  Takeshi Ikeda

    IPC分类号： B65H45/12 ,  B32B31/00 ,  B44C1/22 ,  C23F1/00

    CPC分类号： B65H45/12 ,  Y10T156/1015 ,  Y10T156/1026 ,  Y10T156/1049

    摘要： Apparatus for folding a sheet-form material in a zigzag fashion. Lower and upper guide members are provided in opposed relation in a frame. Sheet-form material is placed under tension between the upper and lower guide members. Plural lower up-and-down movable members are arranged at regular intervals on the lower guide member. Plural upper up-and-down movable members are arranged on the upper guide member at regular intervals and at positions alternate with the lower up-and-down movable members. Fold imparting members are arranged respectively at upper ends of lower up-and-down movable members and at lower ends of upper up-and-down movable members. Upper and lower up-and-down movable members are driven to move toward each other, sequentially from one end side of the upper and lower guide members and toward the other end side, to give folds to the sheet-form material.

    摘要翻译： 用于以锯齿形折叠片状材料的装置。 下引导构件和上引导构件在框架中以相对的关系提供。 片状材料被放置在上部和下部引导构件之间的张力下。 多个较低的上下可动构件以规则的间隔布置在下引导构件上。 多个上部上下可动构件以规则的间隔布置在上引导构件上，并且与下部上下可动构件交替的位置。 折叠赋予构件分别布置在上下可动构件的上端和上上下可动构件的下端。 驱动上下上下可动构件，从上下导向构件的一端侧向另一端侧依次移动，向片状材料折叠。