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23 条记录 (耗时 0.018 秒)

    Flavone compounds
    1.
    发明授权
    Flavone compounds 失效
    黄酮化合物

    公开(公告)号：US5889003A

    公开(公告)日：1999-03-30

    申请号：US968837

    申请日：1997-09-26

    申请人： Alain Dhainaut ,  Guy Lewin ,  Emmanuel Canet ,  Michel Lonchampt ,  Yves Rolland

    发明人： Alain Dhainaut ,  Guy Lewin ,  Emmanuel Canet ,  Michel Lonchampt ,  Yves Rolland

    IPC分类号： A61K31/35 ,  A61K31/352 ,  A61P11/00 ,  A61P29/00 ,  A61P43/00 ,  C07D311/30 ,  C07D405/12

    CPC分类号： C07D405/12 ,  C07D311/30

    摘要： A compound of general formula (I): ##STR1## in which: R.sub.1 represents alkyl,X represents oxygen, --CHR'-- or --CR'.dbd.,R' is chosen from hydrogen and alkyl,R.sub.2 represents optionally substituted alkyl as is defined in the description, cycloalkyl or polycycloalkyl as are defined in the description,R.sub.3 represents hydrogen or hydroxyl,Alk represents alkylene, andY is as defined in the description,and medicinal products containing the same are useful as PDE IV inhibitors.

    摘要翻译： 通式（I）的化合物：其中：R 1表示烷基，X表示氧，-CHR'-或-CR'=，R'选自氢和烷基，R 2表示任选取代的烷基 如描述中定义的环烷基或多环烷基，如说明书中所定义，R 3表示氢或羟基，Alk表示亚烷基，Y如说明书中所定义，并且含有该化合物的药物可用作PDE IV抑制剂。

    Benzopyrrolidinone compounds as bronchospastic agents
    4.
    发明授权
    Benzopyrrolidinone compounds as bronchospastic agents 失效
    苯并吡咯烷酮化合物作为支气管痉挛剂

    公开(公告)号：US4968705A

    公开(公告)日：1990-11-06

    申请号：US391936

    申请日：1989-08-10

    申请人： Gilbert Regnier ,  Alain Dhainaut ,  Jacques Duhault ,  Michel Lonchampt

    发明人： Gilbert Regnier ,  Alain Dhainaut ,  Jacques Duhault ,  Michel Lonchampt

    IPC分类号： C07D491/056 ,  A61K31/4427 ,  A61K31/445 ,  A61P11/00 ,  A61P29/00 ,  A61P37/08 ,  C07D401/06

    CPC分类号： C07D401/06

    摘要： New benzopyrrolidinone compounds, which can be used as medicaments and correspond to the formula ##STR1## in which: either: R.sub.1 and R.sub.2 together represent, with the bond of the etherocycle to which they are attached, an optionally substituted benzene nucleus and, simultaneously, R.sub.3 and R.sub.4 are hydrogen, (C.sub.1 -C.sub.4)alkyl or (C.sub.5 -C.sub.6)cycloalkyl;or:R.sub.1 is hydrogen, R.sub.4 is a single bond and R.sub.2 and R.sub.3 together represent, with the bond of the heterocycle to which they are bonded, an optionally substituted benzene nucleus; andA is a straight or branched hydrocarbon chain having from 2 to 6 carbon atoms that is optionally substituted by hydroxy;X is a single bond, oxygen or sulphur; andY is hydrogen, halogen or (C.sub.1 -C.sub.5)alkyl or alkoxy.These new compounds and the physiologically tolerable salts thereof can be used therapeutically, especially in the treatment of bronchospastic disorders and inflammations in the ENT area.

    摘要翻译： 新的苯并吡咯烷酮化合物，其可以用作药物并且对应于式“IMAGE”，其中：R 1和R 2一起表示与它们所连接的醚基的键，任选取代的苯核， R3和R4是氢，（C1-C4）烷基或（C5-C6）环烷基; 或：R 1是氢，R 4是单键，并且R 2和R 3一起表示与它们所键合的杂环的键，任选取代的苯核; 并且A是具有2-6个碳原子的直链或支链烃链，任选被羟基取代; X是单键，氧或硫; 和Y是氢，卤素或（C 1 -C 5）烷基或烷氧基。 这些新化合物及其生理上可耐受的盐可用于治疗，特别是在ENT区域的支气管痉挛性障碍和炎症的治疗中。

    Disubstituted polymethylene imines
    8.
    发明授权
    Disubstituted polymethylene imines 失效
    二取代聚亚甲基亚胺

    公开(公告)号：US4514398A

    公开(公告)日：1985-04-30

    申请号：US478715

    申请日：1983-03-25

    申请人： Gilbert Regnier ,  Alain Dhainaut ,  Michel Laubie ,  Jacques Duhault

    发明人： Gilbert Regnier ,  Alain Dhainaut ,  Michel Laubie ,  Jacques Duhault

    IPC分类号： A61K31/505 ,  A61K31/53 ,  A61P7/06 ,  A61P9/00 ,  C07D211/46 ,  C07D211/58 ,  C07D401/04 ,  C07D403/04 ,  C07D405/14 ,  C07D409/14

    CPC分类号： C07D401/04 ,  C07D211/46 ,  C07D211/58 ,  C07D403/04 ,  C07D405/14 ,  C07D409/14

    摘要： Polymethylene-imines of the formula: ##STR1## in which: A is a hydrocarbon radical from C.sub.3 to C.sub.5 in a straight or branched chain possibly containing one or two double bonds and possibly substituted by one or more hydroxy radicals;X is CH or nitrogen;n is zero, one or two;Y is oxygen or N--R.sub.1 in which R.sub.1 is hydrogen, alkyl from C.sub.1 to C.sub.5, alkenyl from C.sub.2 to C.sub.5, cycloalkyl or cycloalkenyl from C.sub.3 to C.sub.7, or acetyl;R is hydrogen, alkyl from C.sub.1 to C.sub.5, cycloalkyl from C.sub.5 to C.sub.7 or phenyl optionally substituted by one or more fluorine or chlorine; andB is hydrogen, alkyl from C.sub.1 to C.sub.5, alkenyl from C.sub.2 to C.sub.5, or phenyl, naphthyl, benzofuranyl, benzothienyl, benzodioxolyl, benzodioxanyl, benzodioxinyl, .DELTA.3-chromanyl, thiochromenyl or chromanyl, each optionally substituted by fluorine, chlorine, alkyl or alkoxy from C.sub.1 to C.sub.5 ; ora radical of the formula: ##STR2## in which: R.sub.2, R.sub.3 and R.sub.4 which may be the same or different, each represent hydrogen, or phenyl optionally substituted by fluorine or chlorine.These compounds and physiologically tolerable acid addition salts thereof may be used as medicines especially in the treatment of all kinds of tissular hypoxia.

    摘要翻译： 具有下式的聚亚甲基亚胺：其中：A是直链或支链中C3至C5的烃基，可能含有一个或两个双键并且可能被一个或多个羟基取代; X是CH或氮; n为零，一或二; Y是氧或N-R1，其中R1是氢，C1至C5的烷基，C2至C5的烯基，C3至C7的环烷基或环烯基，或乙酰基; R是氢，C1至C5的烷基，C5至C7的环烷基或任选被一个或多个氟或氯取代的苯基; B为氢，C1至C5的烷基，C2至C5的烯基，或苯基，萘基，苯并呋喃基，苯并噻吩基，苯并二氧杂环戊烯基，苯并二氧杂环戊烷基，苯并二氧杂环戊烯基，三苯甲基苯并二氢吡喃基，硫代色烯基或色满基，各自任选被氟取代， 或C1至C5的烷氧基; 或下式的基团：其中：可以相同或不同的R 2，R 3和R 4各自表示氢或任选被氟或氯取代的苯基。 这些化合物和其生理上可耐受的酸加成盐可以用作药物，特别是用于治疗各种组织缺氧。

    Piperidylbenzimidazolinone derivatives
    9.
    发明授权
    Piperidylbenzimidazolinone derivatives 失效
    哌啶基苯并咪唑啉酮衍生物

    公开(公告)号：US4338323A

    公开(公告)日：1982-07-06

    申请号：US205725

    申请日：1980-11-10

    申请人： Gilbert Regnier ,  Alain Dhainaut ,  Jacques Duhault ,  Michelle Boulanger

    发明人： Gilbert Regnier ,  Alain Dhainaut ,  Jacques Duhault ,  Michelle Boulanger

    IPC分类号： C07D409/14 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  A61K31/445 ,  C07D211/58

    CPC分类号： C07D401/04 ,  C07D401/14 ,  Y10S514/826

    摘要： Piperidylbenzimidazolinone derivatives of the formula: ##STR1## in which: R.sub.1 is lower alkyl, phenyl, halophenyl, lower alkylphenyl, lower alkoxyphenyl, methylenedioxyphenyl, ethylenedioxyphenyl, thienyl, furyl or pyridyl.R.sub.2 is R'.sub.1 COO-- or R'.sub.1 --COO--CH.sub.2 -- in which R'.sub.1 has the same meanings as R.sub.1, R.sub.1 and R'.sub.1 being the same or different, or R.sub.3 NH-- in which R.sub.3 is formyl, acetyl mesyl, carbamoyl, sulfamoyl or ethoxalyl.Z is hydrogen, lower-alkyl or lower alkenyl, andT is hydrogen, lower alkyl or lower alkoxy.These compounds and physiologically tolerable acid addition salts thereof may be used as medicines especially in the treatment of autoimmune, allergic and antiinflammatory diseases and in the treatment of dyspnea especially asthmatic and bronchial dyspnea.

    摘要翻译： 下式的哌啶基苯并咪唑啉酮衍生物：其中：R1是低级烷基，苯基，卤代苯基，低级烷基苯基，低级烷氧基苯基，亚甲二氧基苯基，亚乙二氧基苯基，噻吩基，呋喃基或吡啶基。 R2是R'1COO-或R'1-COO-CH2-，其中R'1具有与R1相同的含义，R1和R'1相同或不同，或R3NH-，其中R3是甲酰基，乙酰基甲磺酰基， 氨基甲酰基，氨磺酰基或乙氧基。 Z是氢，低级烷基或低级烯基，T是氢，低级烷基或低级烷氧基。 这些化合物和其生理上可耐受的酸加成盐可以用作药物，特别是用于治疗自身免疫性，过敏性和抗炎性疾病以及治疗呼吸困难，特别是哮喘和支气管呼吸困难。

    Azabicyclic compounds, a process for their preparation and pharmaceutical compositions containing them
    10.
    发明授权
    Azabicyclic compounds, a process for their preparation and pharmaceutical compositions containing them 失效
    氮杂双环化合物，其制备方法和含有它们的药物组合物

    公开(公告)号：US07576120B2

    公开(公告)日：2009-08-18

    申请号：US10589831

    申请日：2005-02-20

    申请人： Patrick Casara ,  Anne-Marie Chollet ,  Alain Dhainaut ,  Lionel Bert ,  Pierre Lestage ,  Brian Lockhart

    发明人： Patrick Casara ,  Anne-Marie Chollet ,  Alain Dhainaut ,  Lionel Bert ,  Pierre Lestage ,  Brian Lockhart

    IPC分类号： A61K31/40 ,  C07D209/44

    CPC分类号： C07D209/52 ,  C07D403/12

    摘要： A compound selected from those of formula (I): wherein m and n, which may be identical or different, each represent an integer from 0 to 2 inclusive, with the sum of the two integers being from 2 to 3 inclusive, p and q, which may be identical or different, each represent an integer from 0 to 2 inclusive, Alk represents an alkylene, alkenylene or alkynylene chain, X represents an oxygen atom, a sulphur atom or an —N(R)— group wherein R represents a hydrogen atom or an alkyl group, Y, Y′ and W are as defined in the description, its enantiomers, diastereoisomers, and addition salts thereof with one or more pharmaceutically acceptable acid or base. Medicinal products containing the same which are useful for treating conditions associated with central histaminergic systems.

    摘要翻译： 选自式（I）的化合物：其中m和n可以相同或不同，各自表示0至2的整数，其中两个整数的和包括2和3，其中p和q 可以相同或不同，各自表示0〜2的整数，Alk表示亚烷基，亚烯基或亚炔基链，X表示氧原子，硫原子或-N（R） - 基，其中R表示 氢原子或烷基，Y，Y'和W如说明书中所定义，其对映体，非对映异构体及其与一种或多种药学上可接受的酸或碱的加成盐。 含有该药物的药物可用于治疗与中枢组胺能系统相关的病症。