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    Carboxamide compounds and methods for using the same
    4.
    发明授权
    Carboxamide compounds and methods for using the same 有权
    羧甲酰胺化合物及其使用方法

    公开(公告)号：US08846600B2

    公开(公告)日：2014-09-30

    申请号：US13728374

    申请日：2012-12-27

    申请人： Ihab S. Darwish ,  Hui Hong ,  Rajinder Singh ,  Xiang Xu

    发明人： Ihab S. Darwish ,  Hui Hong ,  Rajinder Singh ,  Xiang Xu

    IPC分类号： A01N61/00 ,  A61K31/00 ,  A61K31/497 ,  C07D401/14 ,  C07D401/12

    CPC分类号： C07D401/12 ,  C07D401/14

    摘要： Disclosed are carboxamide compounds as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure in which R1, R2, R3, R4, T, p, q, w and x are as described herein. In certain embodiments, a compound disclosed herein activates the AMPK pathway, and can be used to treat metabolism-related disorders and conditions.

    摘要翻译： 公开了羧酰胺化合物以及药物组合物和使用方法。 一个实施方案是具有其中R 1，R 2，R 3，R 4，T，p，q，w和x如本文所述的结构的化合物。 在某些实施方案中，本文公开的化合物激活AMPK途径，并且可用于治疗与代谢有关的病症和病症。

    NOVEL GERMINAL KINASE PROTEINS, COMPOSITIONS AND METHODS OF USE
    8.
    发明申请
    NOVEL GERMINAL KINASE PROTEINS, COMPOSITIONS AND METHODS OF USE 审中-公开
    新型端粒激酶蛋白，组合物和使用方法

    公开(公告)号：US20080108098A1

    公开(公告)日：2008-05-08

    申请号：US11867504

    申请日：2007-10-04

    申请人： Cindy Leo ,  Ying Luo ,  Xiang Xu ,  Simon Yu

    发明人： Cindy Leo ,  Ying Luo ,  Xiang Xu ,  Simon Yu

    IPC分类号： C12Q1/48

    CPC分类号： C12N9/1205 ,  C12Q1/485 ,  G01N33/5041 ,  G01N2500/02

    摘要： The present invention provides compositions and methods for modulating cell proliferation, survival, morphology, and migration. Nucleic acids encoding proteins, and proteins so encoded which are capable of modulating proliferation, survival, morphology, and migration in mammalian cells are provided. Compositions and methods for the treatment of disorders related to cell proliferation, survival, morphology and migration are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions are methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating proliferation, survival, morphology, and migration in mammalian cells.

    摘要翻译： 本发明提供调节细胞增殖，存活，形态和迁移的组合物和方法。 提供了编码蛋白质的核酸和如此编码的能够调节哺乳动物细胞中增殖，存活，形态和迁移的蛋白质。 还提供了用于治疗与细胞增殖，存活，形态和迁移相关的病症的组合物和方法。 还提供了预防和预防这种疾病的方法。 还提供组合物是用于诊断和预测这些疾病的方法。 进一步提供了用于鉴定能够调节哺乳动物细胞中增殖，存活，形态和迁移的生物活性剂的测定。

    Electrical terminal
    9.
    发明授权
    Electrical terminal 有权
    电气端子

    公开(公告)号：US07351121B2

    公开(公告)日：2008-04-01

    申请号：US10579324

    申请日：2004-11-19

    申请人： Xiang Xu

    发明人： Xiang Xu

    IPC分类号： H01R11/09

    CPC分类号： H01R13/2421

    摘要： An electrical terminal includes first and second contact members having outer pressure contacting end portions for pressure engaging a pair of spaced electrical devices. The contact members have enlarged inner end portions. A sleeve includes a through hole for slidably receiving the inner end portions of the contact members at opposite ends thereof. The through hole has opposite open ends through which the pressure contacting end portions of the contact members project. Restricted stops are formed at the open ends of the through holes for abutting the enlarged inner ends of the contact members to define outer limit positions of the pressure contacting end portions of the contact members. A biasing member is disposed in the through hole to resiliently bias the contact members in opposite directions. The invention contemplates that an outside diameter of the sleeve at a first end thereof be smaller than an outside diameter of the sleeve at a second end thereof. Thereby, the smaller diameter end is easily formed into a restricted stop, and the larger diameter end of the sleeve can be used for clamping and disassembling the terminal from an electrical device without damaging the sleeve.

    摘要翻译： 电端子包括第一和第二接触构件，其具有用于压力接合一对间隔开的电气装置的外部压力接触端部。 接触构件具有扩大的内端部。 套筒包括用于在其相对端可滑动地容纳接触构件的内端部的通孔。 通孔具有相对的开口端，接触构件的压力接触端部通过该开口端突出。 在通孔的开口端处形成有限制的止动件，用于抵靠接触构件的扩大的内端，以限定接触构件的压力接触端部的外部极限位置。 偏置构件设置在通孔中以沿相反的方向弹性地偏置接触构件。 本发明设想在其第一端处的套筒的外径小于在其第二端处的套筒的外径。 因此，较小直径的端部容易地形成为限制止动件，并且套筒的较大直径端可用于将端子与电气装置夹紧和拆卸而不损坏套筒。

    Spring Loaded Electrical Terminal
    10.
    发明申请
    Spring Loaded Electrical Terminal 审中-公开
    弹簧式电气端子

    公开(公告)号：US20080003852A1

    公开(公告)日：2008-01-03

    申请号：US10579488

    申请日：2004-11-19

    申请人： Xiang Xu

    发明人： Xiang Xu

    IPC分类号： H01R13/24

    CPC分类号： H01R13/2421 ,  H01R2201/02

    摘要： An electrical terminal (30) includes first (32) and second (34) contact members having outer pressure contacting end portions (32a, 34a) for pressure engaging a pair of electrical devices and enlarged inner end portions (32b, 34b). A sleeve (36) includes a through hole (44) for slidably receiving the inner end portions of the contact members. The through hole has opposite open ends (46, 48) through which the pressure contacting end portions of the contact members project for engaging the spaced electrical devices. A biasing member (38) is disposed in the through hole to resiliently bias the contact members in opposite directions. The biasing member is in a relaxed condition when the pressure contacting end portions of the contact members are out of pressure engagement with the electrical devices. Thereby, one of the contact members can be retracted substantially into the through hole to thereby reduce the distance between distal ends of the pressure contacting end portions of the contact members.

    摘要翻译： 电气端子（30）包括第一（32）和第二（34）接触构件，其具有用于压力接合一对电气装置和扩大的内端部（32b，34b）的外部压力接触端部 ）。 套筒（36）包括用于可滑动地容纳接触构件的内端部的通孔（44）。 通孔具有相对的开口端（46,48），接触构件的压力接触端部通过该端部突出以接合间隔开的电气装置。 偏置构件（38）设置在通孔中以使接触构件沿相反方向弹性偏置。 当接触构件的压力接触端部与电气装置脱离压力时，偏置构件处于松弛状态。 因此，接触构件中的一个可以基本上缩回到通孔中，从而减小接触构件的压力接触端部的远端之间的距离。