公开(公告)号：US08795740B2

公开(公告)日：2014-08-05

申请号：US10576862

申请日：2004-10-20

申请人： Steven Kritzler ,  Alex Sava

发明人： Steven Kritzler ,  Alex Sava

IPC分类号： A01N59/14 ,  A01N59/00 ,  C02F3/00 ,  C02F1/00 ,  C02F1/68 ,  C11D9/16

CPC分类号： F24F13/22 ,  A01N63/02 ,  A61L2/23 ,  C02F1/50 ,  C02F3/34 ,  C02F2305/14 ,  F24F2003/1678 ,  F24F2013/227 ,  A01N59/14 ,  A01N35/08 ,  A01N25/34 ,  A01N2300/00

摘要： A tablet for use in a drip tray including an excipient selected so that the tablet will not fully dissolve in water at ambient temperature for a period of at least one month, more preferably up to 12 months, a biocide, at least one enzyme, preferably a proteolytic or hydrolase enzyme, and enzyme preserving means, such as a boron compound for maintaining enzyme activity in a moist environment. The excipient may be for example poly vinyl alcohols, high molecular weight polyethylene glycols, high molecular weight polypropylene glycols, esters or partial esters of polyethylene glycols or of polypropylene glycols, and high molecular weight thermoplastic surfactants. The invention also relates to methods for inhibiting the growth of biofilm in an drip tray or the like, including the step of adding to the tray a tablet according to the invention.

摘要翻译： 一种用于包括赋形剂的滴液盘的片剂，其选择为使得片剂在环境温度下不会完全溶解在水中至少一个月，更优选至多12个月的时间，杀生物剂，至少一种酶，优选地 蛋白水解酶或水解酶，以及酶保存装置，例如在潮湿环境中保持酶活性的硼化合物。 赋形剂可以是例如聚乙烯醇，高分子量聚乙二醇，高分子量聚丙二醇，聚乙二醇或聚丙二醇的酯或偏酯，以及高分子量热塑性表面活性剂。 本发明还涉及抑制滴落盘等中生物膜生长的方法，包括向托盘中加入根据本发明的片剂的步骤。

公开(公告)号：US20080260716A1

公开(公告)日：2008-10-23

申请号：US11631904

申请日：2005-07-05

申请人： Steven Kritzler ,  Alex Sava

发明人： Steven Kritzler ,  Alex Sava

IPC分类号： A01N63/00 ,  A01N33/12 ,  A01N33/00 ,  A01N59/14 ,  A01N59/24 ,  A01P1/00 ,  A61L2/025 ,  A61L2/08 ,  A61L2/10 ,  A61L2/03 ,  A61L2/18 ,  A01N43/40 ,  A01N59/12 ,  A01N59/00 ,  A01N37/00

CPC分类号： A61L2/186 ,  A01N33/12 ,  A01N39/00 ,  A61L2/04 ,  A61L2202/24 ,  A01N25/00 ,  A01N2300/00

摘要： Methods and compositions for high level disinfection (as herein defined) of a surface. Methods include treating the surface with a composition including a quaternary ammonium compound in a concentration which exceeds 1% w/w and the temperature of treatment is in the range of from 30° C. to 80° C. A log (6) reduction in Mycobacterium terrae is achieved on the surface in less than 10 minutes. The temperature may be produced by a physical chaotrope, a chemical chaotrope (such as) boron or a boron compound or complex or a combination of chaotropic agents. Sequestering agents and enzymes maybe added.

摘要翻译： 用于表面高水平消毒（如本文定义）的方法和组合物。 方法包括用包含超过1％w / w的浓度的季铵化合物的组合物处理表面，并且处理温度在30℃至80℃的范围内。log（6）还原 在不到10分钟的时间内在表面上实现分枝杆菌。 温度可以通过物理离液剂，化学离液剂（如硼）或硼化合物或络合物或离液剂的组合产生。 可加入螯合剂和酶。

公开(公告)号：US20070207135A1

公开(公告)日：2007-09-06

申请号：US10576862

申请日：2004-10-20

申请人： Steven Kritzler ,  Alex Sava

发明人： Steven Kritzler ,  Alex Sava

IPC分类号： A61K38/43

CPC分类号： F24F13/22 ,  A01N63/02 ,  A61L2/23 ,  C02F1/50 ,  C02F3/34 ,  C02F2305/14 ,  F24F2003/1678 ,  F24F2013/227 ,  A01N59/14 ,  A01N35/08 ,  A01N25/34 ,  A01N2300/00

摘要： A tablet for use in a drip tray including an excipient selected so that the tablet will not fully dissolve in water at ambient temperature for a period of at least one month, more preferably up to 12 months, a biocide, at least one enzyme, preferably a proteolytic or hydrolase enzyme, and enzyme preserving means, such as a boron compound for maintaining enzyme activity in a moist environment. The excipient may be for example poly vinyl alcohols, high molecular weight polyethylene glycols, high molecular weight polypropylene glycols, esters or partial esters of polyethylene glycols or of polypropylene glycols, and high molecular weight thermoplastic surfactants. The invention also relates to methods for inhibiting the growth of biofilm in an drip tray or the like, including the step of adding to the tray a tablet according to the invention.

摘要翻译： 一种用于包括赋形剂的滴液盘的片剂，其选择为使得片剂在环境温度下不会完全溶解在水中至少一个月，更优选至多12个月的时间，杀生物剂，至少一种酶，优选地 蛋白水解酶或水解酶，以及酶保存装置，例如在潮湿环境中保持酶活性的硼化合物。 赋形剂可以是例如聚乙烯醇，高分子量聚乙二醇，高分子量聚丙二醇，聚乙二醇或聚丙二醇的酯或偏酯，以及高分子量热塑性表面活性剂。 本发明还涉及抑制滴落盘等中生物膜生长的方法，包括向托盘中加入根据本发明的片剂的步骤。

公开(公告)号：US07244554B2

公开(公告)日：2007-07-17

申请号：US10311861

申请日：2001-06-20

申请人： Steven Kritzler ,  Alex Sava

发明人： Steven Kritzler ,  Alex Sava

IPC分类号： C12Q1/00

CPC分类号： C12Q1/00

摘要： A unitary single use analytic device for detecting an enzyme in a liquid. The device comprises a support structure for manual manipulation and a composition associated therewith which is responsive to the enzyme in such a way as to cause a change in appearance of the device. The device may be adapted for detecting an enzymes from a plurality of classes by having compositions selectively responsive to an enzyme of one class, each responding in such a way as to cause a change in appearance of the device indicative of the presence of an enzyme of a respective class. Also disclosed is a method for estimating the activity of an enzyme in a liquid comprising the steps of inserting a test strip of the present invention into the liquid and measuring the time taken from the moment of insertion until a predetermined change in appearance of the test strip is observed, or noting the appearance of the strip after predetermined time.

摘要翻译： 一种用于检测液体中酶的单一用途分析装置。 该装置包括用于手动操作的支撑结构和与其相关联的组合物，其以使得该装置的外观改变的方式响应于酶。 该装置可以适于通过使组成选择性地响应于一类的酶来检测来自多个类的酶，每种酶以使得指示酶的存在的装置的外观改变的方式进行响应 相应的班级。 还公开了一种用于估计酶在液体中的活性的方法，包括以下步骤：将本发明的测试条插入液体中并测量从插入时刻到测试条的预定改变的时间 或者在预定时间之后注意到条的外观。

公开(公告)号：US20110123508A1

公开(公告)日：2011-05-26

申请号：US12991842

申请日：2009-05-06

申请人： Steven Kritzler ,  Alex Sava

发明人： Steven Kritzler ,  Alex Sava

IPC分类号： A01N63/02 ,  A01P1/00

CPC分类号： C11D3/48 ,  A01N39/00 ,  A01N63/02 ,  C11D3/2058 ,  C11D3/38618 ,  A01N59/14 ,  A01N2300/00

摘要： A composition or concentrate for cleaning medical or dental instruments comprising in combination a protease and a biostatically effective phenoxy alcohol such as phenoxyethanol selected such that at a working solution dilution of the combination, the phenoxy alcohol is at a concentration below the MIC of the selected phenoxy alcohol against Pseudomonas aeruginosa (ATCC 15442), and wherein the combination is nevertheless effective to reduce a 6 log concentration of Pseudomonas aeruginosa (ATCC 15442) by at least a 1 log concentration within 4 hours. The composition or concentrate may further include or more hydrolases and or boron or a boron compound. The composition may be used in methods for cleaning a soiled medical or dental instrument, for example in an ultrasonic bath.

摘要翻译： 用于清洁医疗或牙科器械的组合物或浓缩物，其包含蛋白酶和生物降解有效的苯氧基醇如苯氧基乙醇的组合，其选择为使得在组合的工作溶液稀释下，苯氧基醇的浓度低于选择的苯氧基 对于绿脓假单胞菌（ATCC 15442）的酒精，并且其中所述组合仍然有效地在4小时内降低至少1对数浓度的绿脓假单胞菌（ATCC 15442）的6对数浓度。 组合物或浓缩物可以进一步包括或多个水解酶和/或硼化合物。 该组合物可用于清洁被污染的医疗或牙科器械的方法中，例如在超声波浴中。

公开(公告)号：US06939836B2

公开(公告)日：2005-09-06

申请号：US10377294

申请日：2003-02-27

申请人： Steven Kritzler ,  Alex Sava

发明人： Steven Kritzler ,  Alex Sava

IPC分类号： A61L2/16 ,  A61L2/18 ,  C11D1/66 ,  C11D1/68 ,  C11D3/28 ,  C11D3/386 ,  C11D3/43 ,  C11D17/08 ,  C11D3/22

CPC分类号： A61L2/16 ,  A61L2/18 ,  C11D1/662 ,  C11D3/28 ,  C11D3/386

摘要： The invention relates to an aqueous composition comprising in combination an alkyl pyrrolidone, such as a C8-C18 linear alkyl pyrrolidone, and an alkyl polysaccharide such as an alkyl polyglucoside, and a method of .enhancing the efficacy of an enzyme containing composition for use in cleaning medical instruments comprising the step of including in said composition an alkyl pyrrolidone and an alkyl polysaccharide. The methods and compositions of the present invention may further include at least one enzyme such as proteases, lipases, amylases, and cellulases.

摘要翻译： 本发明涉及包含组合烷基吡咯烷酮（例如C 8 -C 18直链烷基吡咯烷酮）和烷基多糖例如烷基聚葡萄糖苷的水性组合物，以及增强含酶组合物的功效的方法 清洁医疗器械包括在所述组合物中包含烷基吡咯烷酮和烷基多糖的步骤。 本发明的方法和组合物还可以包括至少一种酶，例如蛋白酶，脂肪酶，淀粉酶和纤维素酶。

公开(公告)号：US06762161B2

公开(公告)日：2004-07-13

申请号：US10257088

申请日：2003-04-10

申请人： Alex Sava ,  Steven Kritzler

发明人： Alex Sava ,  Steven Kritzler

IPC分类号： C11D348

CPC分类号： C11D11/0041 ,  A01N33/12 ,  A61L2/18 ,  A61L2202/24 ,  C11D1/62 ,  C11D3/38618 ,  C11D3/38627 ,  C11D3/38636 ,  C11D3/38645 ,  C11D3/48 ,  A01N63/00 ,  A01N37/46 ,  A01N25/30 ,  A01N25/22 ,  A01N2300/00

摘要： The invention relates to a method for cleaning a contaminated medical instrument including the step of immersing the instrument in a solution containing an enzyme based cleaning composition including a “hospital grade disinfectant”. Compositions useful for cleaning contaminated medical instruments in accordance with the method include an enzyme, a quat biocide and an “activity protector”, which may be for example, enzyme stabilizers, enzyme stabilizing systems, micelle formation modifiers and inhibitors, and combinations thereof.

摘要翻译： 本发明涉及一种清洗受污染医疗器械的方法，包括将仪器浸入含有“医院级消毒剂”的酶系清洗组合物的溶液中的步骤。 用于根据该方法清洁受污染的医疗器械的组合物包括酶，季铵杀生物剂和“活性保护剂”，其可以是例如酶稳定剂，酶稳定体系，胶束形成改性剂和抑制剂及其组合。

公开(公告)号：US09480761B2

公开(公告)日：2016-11-01

申请号：US10467591

申请日：2002-01-31

申请人： Steven Kritzler ,  Alex Sava ,  Michael Zalunardo

发明人： Steven Kritzler ,  Alex Sava ,  Michael Zalunardo

IPC分类号： C12N1/22 ,  C12N1/20 ,  A61L2/12 ,  A01N63/00 ,  A61L2/00 ,  A61L2/025 ,  A61L2/08 ,  A61L2/16

CPC分类号： A61L2/12 ,  A01N63/00 ,  A61L2/0082 ,  A61L2/025 ,  A61L2/085 ,  A61L2/16 ,  A61L2202/24

摘要： The invention relates to a methods and compositions for treating a surface, suspension or solution contaminated with a PrPSc prion protein or a surrogate thereof. The methods and compositions employ a combination of one or more enzymes effective to cleave a prion protein to fragments having a non-infective molecular weight, and one or more agents selected to favor conformational unfolding of the PrPSc prion protein while not denaturing the one or more enzymes.

摘要翻译： 本发明涉及用于处理被PrPSc朊蛋白或其替代物污染的表面，悬浮液或溶液的方法和组合物。 所述方法和组合物采用有效将朊病毒蛋白切割成具有非感染性分子量的片段的一种或多种酶的组合，以及一种或多种选择用于促进PrPSc朊病毒蛋白构象展开的试剂，而不使所述一种或多种 酶。

公开(公告)号：US09023778B2

公开(公告)日：2015-05-05

申请号：US12374157

申请日：2007-07-18

申请人： Steven Kritzler ,  Alex Sava

发明人： Steven Kritzler ,  Alex Sava

IPC分类号： C11D3/20 ,  C11D3/00 ,  C11D17/00 ,  C11D17/08 ,  C11D7/42 ,  C11D3/386 ,  C11D3/48 ,  C11D7/34 ,  C11D7/50 ,  C11D11/00 ,  C11D7/26

CPC分类号： C11D3/38618 ,  C11D3/0026 ,  C11D3/48 ,  C11D7/263 ,  C11D7/34 ,  C11D7/5022 ,  C11D11/0041

摘要： Liquid compositions for cleaning, in particular medical instruments and air conditioning surfaces, said composition excluding surfactants and comprising one or more enzymes including a protease and optionally a hydrolase, a solvent system including a water soluble glycol ether solvent, at least one anionic hydrotrope, and wherein the molar ratio of said at least one hydrotrope to said glycol ether in the composition is selected to preserve the activity of said one or more enzymes. The hydrotrope is advantageously an anionic hydrotrope selected from the group consisting of water soluble anionic hydrotropes of the formula (I) and having no alkyl side chain greater than six carbons in length, for example a xylene sulfonate or cumene sulfonate salt.

摘要翻译： 用于清洁的液体组合物，特别是医疗仪器和空调表面，所述组合物不包括表面活性剂，并且包含一种或多种酶，包括蛋白酶和任选的水解酶，溶剂体系，包括水溶性二醇醚溶剂，至少一种阴离子水溶助长剂和 其中选择所述组合物中所述至少一种水溶助长剂与所述二醇醚的摩尔比以保持所述一种或多种酶的活性。 水溶助长剂有利地是选自由式（I）的水溶性阴离子水溶助长剂组成的组的阴离子水溶助长剂，并且不具有大于六个碳原子的烷基侧链，例如二甲苯磺酸盐或枯烯磺酸盐。

公开(公告)号：US20110086414A1

公开(公告)日：2011-04-14

申请号：US12965697

申请日：2010-12-10

申请人： Steven Kritzler ,  Alex Sava ,  Michael Zalunardo

发明人： Steven Kritzler ,  Alex Sava ,  Michael Zalunardo

IPC分类号： C12S9/00 ,  C12S99/00 ,  C12N9/50

CPC分类号： A61L2/12 ,  A01N63/00 ,  A61L2/0082 ,  A61L2/025 ,  A61L2/085 ,  A61L2/16 ,  A61L2202/24

摘要： The invention relates to a methods and compositions for treating a surface, suspension or solution contaminated with a PrPSc prion protein or a surrogate thereof. The methods and compositions employ a combination of one or more enzymes effective to cleave a prion protein to fragments having a non-infective molecular weight, and one or more agents selected to favour conformational unfolding of the PrPSc prion protein while not denaturing the one or more enzymes.

摘要翻译： 本发明涉及用于处理被PrPSc朊蛋白或其替代物污染的表面，悬浮液或溶液的方法和组合物。 所述方法和组合物采用有效将朊病毒蛋白切割成具有非感染性分子量的片段的一种或多种酶的组合，以及一种或多种选择用于促进PrPSc朊病毒蛋白构象展开的试剂，而不使所述一种或多种 酶。