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    Intermittent dosing of nitric oxide gas
    1.
    发明授权
    Intermittent dosing of nitric oxide gas 有权
    间歇给药一氧化氮气体

    公开(公告)号：US09095534B2

    公开(公告)日：2015-08-04

    申请号：US13369205

    申请日：2012-02-08

    申请人： Alex Stenzler ,  Chris Miller ,  Bevin B. McMullin

    发明人： Alex Stenzler ,  Chris Miller ,  Bevin B. McMullin

    IPC分类号： A61M16/18 ,  A61K33/00 ,  A61M16/00 ,  A61M16/12 ,  A61M16/20 ,  A61H33/14 ,  A61M16/10

    CPC分类号： A61M16/122 ,  A61H33/14 ,  A61K33/00 ,  A61M16/0003 ,  A61M16/0051 ,  A61M16/024 ,  A61M16/04 ,  A61M16/0666 ,  A61M16/0833 ,  A61M16/12 ,  A61M16/201 ,  A61M16/202 ,  A61M16/204 ,  A61M2016/003 ,  A61M2016/102 ,  A61M2202/0275 ,  A61M2205/3327 ,  A61M2205/3334

    摘要： A method and corresponding device are described for combating microbes and infections by delivering intermittent high doses of nitric oxide to a mammal for a period of time and which cycles between high and low concentration of nitric oxide gas. The high concentration of nitric oxide is preferably delivered intermittently for brief periods of time that are interspersed with periods of time with either no nitric oxide delivery or lower concentrations of nitric oxide. The method is advantageous because at higher concentration, nitric oxide gas overwhelms the defense mechanism of pathogens that use the mammalian body to replenish their thiol defense system. A lower dose or concentration of nitric oxide gas delivered in between the bursts of high concentration nitric oxide maintains nitrosative stress pressure on the pathogens and also reduces the risk of toxicity of nitric oxide gas.

    摘要翻译： 描述了一种方法和相应的装置，用于通过向哺乳动物递送间歇性高剂量的一氧化氮一段时间并在高浓度和低浓度的一氧化氮气体之间循环来对抗微生物和感染。 高浓度的一氧化氮优选间歇地递送短暂的时间段，其间隔着不含一氧化氮递送或较低浓度的一氧化氮的时间段。 该方法是有利的，因为在较高的浓度下，一氧化氮气体压倒了使用哺乳动物身体补充其硫醇防御系统的病原体的防御机制。 在高浓度一氧化氮脉冲之间输送的一氧化氮气体的较低剂量或浓度保持对病原体的亚硝化应激压力，并降低一氧化氮气体毒性的风险。

    Device and method for treatment of wounds with nitric oxide
    3.
    发明申请
    Device and method for treatment of wounds with nitric oxide 有权
    用一氧化氮治疗伤口的装置和方法

    公开(公告)号：US20070088316A1

    公开(公告)日：2007-04-19

    申请号：US11487600

    申请日：2006-07-13

    申请人： Alex Stenzler ,  Chris Miller

    发明人： Alex Stenzler ,  Chris Miller

    IPC分类号： A61M31/00

    CPC分类号： A61M35/00 ,  A61B90/40 ,  A61H33/14 ,  A61K33/00 ,  A61L2/0094 ,  A61L15/18 ,  A61L15/44 ,  A61L2300/114 ,  A61L2300/602 ,  A61M1/0031 ,  A61M1/0088 ,  A61M13/003 ,  A61M13/006 ,  A61M2202/0275 ,  A61M2205/3334 ,  A61K2300/00

    摘要： Topical exposure of nitric oxide gas to wounds such as chronic non-healing wounds may be beneficial in promoting healing of the wound and in preparing the wound bed for further treatment and recovery. Nitric oxide gas may be used, for example, to reduce the microbial infection and burden on these wounds, manage exudate secretion by reducing inflammation, upregulate expression of endogenous collagenase to locally debride the wound, and regulate the formation of collagen. High concentration of nitric oxide ranging from about 160 to 400 ppm may be used without inducing toxicity in the healthy cells around a wound site. Additionally, exposure to the high concentration for a first treatment period reduces the microbial burden and inflammation at the wound site and increase collagenase expression to debride necrotic tissue at the wound site. After a first treatment period with high concentration of nitric oxide, a second treatment period at a lower concentration of nitric oxide preferably ranging from about 5-20 ppm may to provided to restore the balance of nitric oxide and induce collagen expression to aid in the closure of the wound.

    摘要翻译： 一氧化氮气体局部暴露于伤口如慢性非愈合伤口可能有益于促进伤口愈合和制备伤口床进一步治疗和恢复。 例如，可以使用一氧化氮气体来减少这些伤口的微生物感染和负担，通过减少炎症，上调内源性胶原酶的表达来局部清创伤口并调节胶原的形成来控制渗出物分泌。 可以使用约160至400ppm范围内的高浓度一氧化氮，而不会在伤口部位周围的健康细胞中引起毒性。 此外，在第一次治疗期间暴露于高浓度可减少伤口部位的微生物负担和炎症，并增加胶原酶表达以清除伤口部位的坏死组织。 在具有高浓度一氧化氮的第一次治疗期后，可提供较低浓度的一氧化氮优选约5-20ppm的第二治疗期以恢复一氧化氮的平衡并诱导胶原表达以帮助闭合 的伤口。

    Device and method for treatment of wounds with nitric oxide
    4.
    发明申请
    Device and method for treatment of wounds with nitric oxide 有权
    用一氧化氮治疗伤口的装置和方法

    公开(公告)号：US20050191372A1

    公开(公告)日：2005-09-01

    申请号：US11021109

    申请日：2004-12-23

    申请人： Alex Stenzler ,  Chris Miller

    发明人： Alex Stenzler ,  Chris Miller

    IPC分类号： A61B19/00 ,  A61H33/14 ,  A61K33/00 ,  A61M1/00 ,  A61M1/16 ,  A61M1/36 ,  A61M13/00 ,  A61M35/00 ,  C12Q1/68

    CPC分类号： A61M35/00 ,  A61B90/40 ,  A61H33/14 ,  A61K33/00 ,  A61L2/0094 ,  A61L15/18 ,  A61L15/44 ,  A61L2300/114 ,  A61L2300/602 ,  A61M1/0031 ,  A61M1/0088 ,  A61M13/003 ,  A61M13/006 ,  A61M2202/0275 ,  A61M2205/3334 ,  A61K2300/00

    摘要： Topical exposure of nitric oxide gas to wounds such as chronic non-healing wounds may be beneficial in promoting healing of the wound and in preparing the wound bed for further treatment and recovery. Nitric oxide gas may be used, for example, to reduce the microbial infection and burden on these wounds, manage exudate secretion by reducing inflammation, upregulate expression of endogenous collagenase to locally debride the wound, and regulate the formation of collagen. High concentration of nitric oxide ranging from about 160 to 400 ppm may be used without inducing toxicity in the healthy cells around a wound site. Additionally, exposure to the high concentration for a first treatment period reduces the microbial burden and inflammation at the wound site and increase collagenase expression to debride necrotic tissue at the wound site. After a first treatment period with high concentration of nitric oxide, a second treatment period at a lower concentration of nitric oxide preferably ranging from about 5-20 ppm may to provided to restore the balance of nitric oxide and induce collagen expression to aid in the closure of the wound.

    摘要翻译： 一氧化氮气体局部暴露于伤口如慢性非愈合伤口可能有益于促进伤口愈合和制备伤口床进一步治疗和恢复。 例如，可以使用一氧化氮气体来减少这些伤口的微生物感染和负担，通过减少炎症，上调内源性胶原酶的表达来局部清创伤口并调节胶原的形成来控制渗出物分泌。 可以使用约160至400ppm范围内的高浓度一氧化氮，而不会在伤口部位周围的健康细胞中引起毒性。 此外，在第一次治疗期间暴露于高浓度可减少伤口部位的微生物负担和炎症，并增加胶原酶表达以清除伤口部位的坏死组织。 在具有高浓度一氧化氮的第一次治疗期后，可提供较低浓度的一氧化氮优选约5-20ppm的第二治疗期以恢复一氧化氮的平衡并诱导胶原表达以帮助闭合 的伤口。

    Intermittent dosing of nitric oxide gas
    5.
    发明申请
    Intermittent dosing of nitric oxide gas 有权
    间歇给药一氧化氮气体

    公开(公告)号：US20070144515A1

    公开(公告)日：2007-06-28

    申请号：US11598221

    申请日：2006-11-10

    申请人： Alex Stenzler ,  Chris Miller ,  Bevin McMullin

    发明人： Alex Stenzler ,  Chris Miller ,  Bevin McMullin

    IPC分类号： A61M15/00 ,  A61M16/00

    CPC分类号： A61M16/122 ,  A61H33/14 ,  A61K33/00 ,  A61M16/0003 ,  A61M16/0051 ,  A61M16/024 ,  A61M16/04 ,  A61M16/0666 ,  A61M16/0833 ,  A61M16/12 ,  A61M16/201 ,  A61M16/202 ,  A61M16/204 ,  A61M2016/003 ,  A61M2016/102 ,  A61M2202/0275 ,  A61M2205/3327 ,  A61M2205/3334

    摘要： A method and corresponding device are described for combating microbes and infections by delivering intermittent high doses of nitric oxide to a mammal for a period of time and which cycles between high and low concentration of nitric oxide gas. The high concentration of nitric oxide is preferably delivered intermittently for brief periods of time that are interspersed with periods of time with either no nitric oxide delivery or lower concentrations of nitric oxide. The method is advantageous because at higher concentration, nitric oxide gas overwhelms the defense mechanism of pathogens that use the mammalian body to replenish their thiol defense system. A lower dose or concentration of nitric oxide gas delivered in between the bursts of high concentration nitric oxide maintains nitrosative stress pressure on the pathogens and also reduces the risk of toxicity of nitric oxide gas.

    摘要翻译： 描述了一种方法和相应的装置，用于通过向哺乳动物递送间歇性高剂量的一氧化氮一段时间并在高浓度和低浓度的一氧化氮气体之间循环来对抗微生物和感染。 高浓度的一氧化氮优选间歇地递送短暂的时间段，其间隔着不含一氧化氮递送或较低浓度的一氧化氮的时间段。 该方法是有利的，因为在较高的浓度下，一氧化氮气体压倒了使用哺乳动物身体补充其硫醇防御系统的病原体的防御机制。 在高浓度一氧化氮脉冲之间输送的一氧化氮气体的较低剂量或浓度保持对病原体的亚硝化应激压力，并降低一氧化氮气体毒性的风险。

    Topical nitric oxide as a treatment of autoimmune diseases
    6.
    发明申请
    Topical nitric oxide as a treatment of autoimmune diseases 审中-公开
    局部一氧化氮作为自身免疫性疾病的治疗

    公开(公告)号：US20080206364A1

    公开(公告)日：2008-08-28

    申请号：US11974247

    申请日：2007-10-12

    申请人： Frank J. McCaney ,  Alex Stenzler ,  Chris Miller

    发明人： Frank J. McCaney ,  Alex Stenzler ,  Chris Miller

    IPC分类号： A61K33/00 ,  A61P31/00

    CPC分类号： A61K33/00

    摘要： The present invention relates to compositions and methods for treatment of a patient affected with an autoimmune disorder, and in an embodiment, a skin-related autoimmune disorder. The treatment involves the application of gaseous nitric oxide to an affected patient, and in an embodiment, to the skin of an affected patient.

    摘要翻译： 本发明涉及用于治疗患有自身免疫性疾病的患者的组合物和方法，在一个实施方案中涉及皮肤相关的自身免疫性疾病。 治疗涉及将气态一氧化氮施用于受影响的患者，并且在一个实施方案中，应用于受影响患者的皮肤。

    Intermittent Dosing Of Nitric Oxide Gas
    7.
    发明申请
    Intermittent Dosing Of Nitric Oxide Gas 审中-公开
    间歇剂量一氧化氮气体

    公开(公告)号：US20080029093A1

    公开(公告)日：2008-02-07

    申请号：US11596027

    申请日：2005-05-11

    申请人： Alex Stenzler ,  Chris Miller ,  Bevin McMullin

    发明人： Alex Stenzler ,  Chris Miller ,  Bevin McMullin

    IPC分类号： A61K33/08 ,  A61M15/00

    CPC分类号： A61M16/122 ,  A61H33/14 ,  A61K33/00 ,  A61M16/0003 ,  A61M16/024 ,  A61M16/04 ,  A61M16/0666 ,  A61M16/0833 ,  A61M16/12 ,  A61M16/201 ,  A61M16/202 ,  A61M16/204 ,  A61M2016/003 ,  A61M2016/102 ,  A61M2202/0275 ,  A61M2205/3327 ,  A61M2205/3334

    摘要： A method and corresponding device are described for combating microbes and infections by delivering intermittent high doses of nitric oxide to a mammal for a period of time and which cycles between high and low concentration of nitric oxide gas. The high concentration of nitric oxide is preferably delivered intermittently for brief periods of time that are interspersed with periods of time with either no nitric oxide delivery or lower concentrations of nitric oxide. The method is advantageous because at higher concentration, nitric oxide gas overwhelms the defense mechanism of pathogens that use the mammalian body to replenish their thiol defense system. A lower dose or concentration of nitric oxide gas delivered in between the bursts of high concentration nitric oxide maintains nitrosative stress pressure on the pathogens and also reduces the risk of toxicity of nitric oxide gas.

    摘要翻译： 描述了一种方法和相应的装置，用于通过向哺乳动物递送间歇性高剂量的一氧化氮一段时间并在高浓度和低浓度的一氧化氮气体之间循环来对抗微生物和感染。 高浓度的一氧化氮优选间歇地递送短暂的时间段，其间隔着不含一氧化氮递送或较低浓度的一氧化氮的时间段。 该方法是有利的，因为在较高的浓度下，一氧化氮气体压倒了使用哺乳动物身体补充其硫醇防御系统的病原体的防御机制。 在高浓度一氧化氮脉冲之间输送的一氧化氮气体的较低剂量或浓度保持对病原体的亚硝化应激压力，并降低一氧化氮气体毒性的风险。

    Device and method for treatment of surface infections with nitric oxide
    8.
    发明授权
    Device and method for treatment of surface infections with nitric oxide 有权
    用一氧化氮治疗表面感染的装置和方法

    公开(公告)号：US08795222B2

    公开(公告)日：2014-08-05

    申请号：US13006218

    申请日：2011-01-13

    申请人： Alex Stenzler ,  Christopher C. Miller

    发明人： Alex Stenzler ,  Christopher C. Miller

    IPC分类号： A61M37/00 ,  A61M1/00 ,  A01N59/02

    CPC分类号： A61M35/00 ,  A61B90/40 ,  A61H33/14 ,  A61K33/00 ,  A61L2/0094 ,  A61L15/18 ,  A61L15/44 ,  A61L2300/114 ,  A61L2300/602 ,  A61M1/0031 ,  A61M1/0088 ,  A61M13/003 ,  A61M13/006 ,  A61M2202/0275 ,  A61M2205/3334 ,  A61K2300/00

    摘要： Topical exposure of nitric oxide gas to wounds such as chronic non-healing wounds may be beneficial in promoting healing of the wound and in preparing the wound bed for further treatment and recovery. Nitric oxide gas may be used, for example, to reduce the microbial infection and burden on these wounds, manage exudate secretion by reducing inflammation, upregulate expression of endogenous collagenase to locally debride the wound, and regulate the formation of collagen. High concentration of nitric oxide ranging from about 160 to 400 ppm may be used without inducing toxicity in the healthy cells around a wound site. Additionally, exposure to the high concentration for a first treatment period reduces the microbial burden and inflammation at the wound site and increase collagenase expression to debride necrotic tissue at the wound site. After a first treatment period with high concentration of nitric oxide, a second treatment period at a lower concentration of nitric oxide preferably ranging from about 5-20 ppm may to provided to restore the balance of nitric oxide and induce collagen expression to aid in the closure of the wound.

    摘要翻译： 一氧化氮气体局部暴露于伤口如慢性非愈合伤口可能有益于促进伤口愈合和制备伤口床进一步治疗和恢复。 例如，可以使用一氧化氮气体来减少这些伤口的微生物感染和负担，通过减少炎症，上调内源性胶原酶的表达来局部清创伤口并调节胶原的形成来控制渗出物分泌。 可以使用约160至400ppm范围内的高浓度一氧化氮，而不会在伤口部位周围的健康细胞中引起毒性。 此外，在第一次治疗期间暴露于高浓度可减少伤口部位的微生物负担和炎症，并增加胶原酶表达以清除伤口部位的坏死组织。 在具有高浓度一氧化氮的第一次治疗期后，可提供较低浓度的一氧化氮优选约5-20ppm的第二治疗期以恢复一氧化氮的平衡并诱导胶原表达以帮助闭合 的伤口。

    Metered dose inhaler spacer
    9.
    发明授权
    Metered dose inhaler spacer 有权
    计量剂量吸入器垫片

    公开(公告)号：US08770188B2

    公开(公告)日：2014-07-08

    申请号：US13077849

    申请日：2011-03-31

    申请人： Alex Stenzler ,  Steve Han

    发明人： Alex Stenzler ,  Steve Han

    IPC分类号： A61M15/00

    CPC分类号： A61M15/0086 ,  A61M15/0015 ,  A61M15/0018 ,  A61M15/002 ,  A61M15/009 ,  A61M2205/3334

    摘要： A metered dose inhaler (MDI) spacer has a body that defines a dose receiving chamber. A proximal end portion coupled between the body and a mouth port through which a metered dose may be inhaled by a user of the MDI spacer. A distal end portion is coupled with the body. A combined one-way and flow rate control valve coupled with the distal end portion is configured for permitting external airflow into and prohibiting internal airflow out of the dose receiving chamber. A collar coupled with the distal end portion is configured for receiving an actuator shaft of a metered dose inhaler and for forming a seal about an aerosol nozzle of the metered dose inhaler such that a metered dose of medication is admissible into the dose receiving chamber via the collar while airflow into and out of the dose receiving chamber via the collar is prohibited.

    摘要翻译： 定量吸入器（MDI）间隔物具有限定剂量接收室的主体。 连接在主体和口端口之间的近端部分，计量剂量可由MDI间隔物的使用者吸入。 远端部分与身体联接。 与远端部分结合的组合的单向和流量控制阀构造成允许外部气流进入并阻止内部空气流出剂量接收室。 与远端部分联接的套环被构造成用于接收计量剂量吸入器的致动器轴并且用于围绕计量剂量吸入器的气溶胶喷嘴形成密封，使得计量剂量的药物可以经由 在通过衣领进入和离开剂量接收室的气流被禁止的情况下。