利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

61 条记录 (耗时 0.024 秒)

    Device and method for treatment of surface infections with nitric oxide
    1.
    发明授权
    Device and method for treatment of surface infections with nitric oxide 有权
    用一氧化氮治疗表面感染的装置和方法

    公开(公告)号：US08795222B2

    公开(公告)日：2014-08-05

    申请号：US13006218

    申请日：2011-01-13

    申请人： Alex Stenzler ,  Christopher C. Miller

    发明人： Alex Stenzler ,  Christopher C. Miller

    IPC分类号： A61M37/00 ,  A61M1/00 ,  A01N59/02

    CPC分类号： A61M35/00 ,  A61B90/40 ,  A61H33/14 ,  A61K33/00 ,  A61L2/0094 ,  A61L15/18 ,  A61L15/44 ,  A61L2300/114 ,  A61L2300/602 ,  A61M1/0031 ,  A61M1/0088 ,  A61M13/003 ,  A61M13/006 ,  A61M2202/0275 ,  A61M2205/3334 ,  A61K2300/00

    摘要： Topical exposure of nitric oxide gas to wounds such as chronic non-healing wounds may be beneficial in promoting healing of the wound and in preparing the wound bed for further treatment and recovery. Nitric oxide gas may be used, for example, to reduce the microbial infection and burden on these wounds, manage exudate secretion by reducing inflammation, upregulate expression of endogenous collagenase to locally debride the wound, and regulate the formation of collagen. High concentration of nitric oxide ranging from about 160 to 400 ppm may be used without inducing toxicity in the healthy cells around a wound site. Additionally, exposure to the high concentration for a first treatment period reduces the microbial burden and inflammation at the wound site and increase collagenase expression to debride necrotic tissue at the wound site. After a first treatment period with high concentration of nitric oxide, a second treatment period at a lower concentration of nitric oxide preferably ranging from about 5-20 ppm may to provided to restore the balance of nitric oxide and induce collagen expression to aid in the closure of the wound.

    摘要翻译： 一氧化氮气体局部暴露于伤口如慢性非愈合伤口可能有益于促进伤口愈合和制备伤口床进一步治疗和恢复。 例如，可以使用一氧化氮气体来减少这些伤口的微生物感染和负担，通过减少炎症，上调内源性胶原酶的表达来局部清创伤口并调节胶原的形成来控制渗出物分泌。 可以使用约160至400ppm范围内的高浓度一氧化氮，而不会在伤口部位周围的健康细胞中引起毒性。 此外，在第一次治疗期间暴露于高浓度可减少伤口部位的微生物负担和炎症，并增加胶原酶表达以清除伤口部位的坏死组织。 在具有高浓度一氧化氮的第一次治疗期后，可提供较低浓度的一氧化氮优选约5-20ppm的第二治疗期以恢复一氧化氮的平衡并诱导胶原表达以帮助闭合 的伤口。

    Method and apparatus for delivery of inhaled nitric oxide to spontaneous-breathing and mechanically-ventilated patients with intermittent dosing
    2.
    发明授权
    Method and apparatus for delivery of inhaled nitric oxide to spontaneous-breathing and mechanically-ventilated patients with intermittent dosing 有权
    将吸入一氧化氮输送到间歇给药的自发呼吸和机械通气患者的方法和装置

    公开(公告)号：US07516742B2

    公开(公告)日：2009-04-14

    申请号：US11234849

    申请日：2005-09-23

    申请人： Alex Stenzler ,  Christopher C. Miller ,  Bevin McMullin

    发明人： Alex Stenzler ,  Christopher C. Miller ,  Bevin McMullin

    IPC分类号： A61M16/00

    CPC分类号： A61M16/12 ,  A61M16/0833 ,  A61M16/1015 ,  A61M16/203 ,  A61M16/204 ,  A61M2016/0039 ,  A61M2016/102 ,  A61M2016/1025 ,  A61M2202/0275

    摘要： A device and method is disclosed for delivering NO to a patient. The device utilizes a single controller that controls two separate flow controllers to deliver an oxygen-containing gas and a NO-containing gas to the patient to provide NO-containing gas at a flow profile that is proportional or quasi-proportional to a flow profile of the oxygen-containing gas throughout patient inspiration. The controller further comprises logic for setting a nitric oxide delivery profile comprising at least two different concentrations of nitric oxide containing gas and for automatically switching between the at least two different concentrations of nitric oxide containing gas on a timed basis.

    摘要翻译： 公开了用于将NO递送给患者的装置和方法。 该装置使用单个控制器，其控制两个单独的流量控制器以向患者输送含氧气体和含NO的气体，以提供含NO气体的流动分布，该流动分布与流动分布成比例或准成比例 含氧气体贯穿患者的灵感。 控制器还包括用于设定包含至少两种不同浓度的一氧化氮的气体的一氧化氮输送曲线的逻辑，并且用于在定时基础上自动切换至少两种不同浓度的一氧化氮气体。

    Compositions And Methods For Treating Diseases Or Disorders Using Extended Release Nitric Oxide Releasing Solutions
    3.
    发明申请
    Compositions And Methods For Treating Diseases Or Disorders Using Extended Release Nitric Oxide Releasing Solutions 审中-公开

    公开(公告)号：US20180125882A1

    公开(公告)日：2018-05-10

    申请号：US15675773

    申请日：2017-08-13

    申请人： Alex Stenzler ,  Christopher C. Miller ,  Gilly Regev-Shoshani

    发明人： Alex Stenzler ,  Christopher C. Miller ,  Gilly Regev-Shoshani

    IPC分类号： A61K33/00 ,  A61K9/00 ,  A61K9/08 ,  A61K9/70 ,  A61K47/12 ,  C01B21/24

    CPC分类号： A61K33/00 ,  A61K9/0043 ,  A61K9/08 ,  A61K9/7007 ,  A61K47/12 ,  C01B21/24

    摘要： The present invention relates to a liquid nitric oxide releasing solution (NORS) comprised of at least one nitric oxide releasing compound and at least one acidifying agent, wherein the NORS provides an extended release of a therapeutically effective amount of nitric oxide gas (gNO). The present invention also relates to a liquid NORS comprised of at least one nitrite compound having a concentration of no greater than about 0.5% w/v and at least one acidifying agent, wherein the NORS releases a therapeutically effective amount of gNO. The present invention also relates to a method for the treatment of a wound in a human, the method comprising administering to the human a liquid NORS comprised of at least one nitric oxide releasing compound and at least one acidifying agent, wherein the NORS provides an extended release of a therapeutically effective amount of gNO. The present invention also relates to a method for the treatment, prevention, or reduction of incidence of a disease or disorder in a human in need thereof, the method comprising administering to the human a liquid NORS comprised of at least one nitrite compound at a concentration of no greater than about 0.5% w/v and at least one acidifying agent, wherein the NORS releases a therapeutically effective amount of gNO.

    Intermittent dosing of nitric oxide gas
    4.
    发明授权
    Intermittent dosing of nitric oxide gas 有权
    间歇给药一氧化氮气体

    公开(公告)号：US07955294B2

    公开(公告)日：2011-06-07

    申请号：US11598221

    申请日：2006-11-10

    申请人： Alex Stenzler ,  Christopher C. Miller ,  Bevin B. McMullin

    发明人： Alex Stenzler ,  Christopher C. Miller ,  Bevin B. McMullin

    IPC分类号： A61M35/00 ,  A61M16/10

    CPC分类号： A61M16/122 ,  A61H33/14 ,  A61K33/00 ,  A61M16/0003 ,  A61M16/0051 ,  A61M16/024 ,  A61M16/04 ,  A61M16/0666 ,  A61M16/0833 ,  A61M16/12 ,  A61M16/201 ,  A61M16/202 ,  A61M16/204 ,  A61M2016/003 ,  A61M2016/102 ,  A61M2202/0275 ,  A61M2205/3327 ,  A61M2205/3334

    摘要： A method and corresponding device are described for combating microbes and infections by delivering intermittent high doses of nitric oxide to a mammal for a period of time and which cycles between high and low concentration of nitric oxide gas. The high concentration of nitric oxide is preferably delivered intermittently for brief periods of time that are interspersed with periods of time with either no nitric oxide delivery or lower concentrations of nitric oxide. The method is advantageous because at higher concentration, nitric oxide gas overwhelms the defense mechanism of pathogens that use the mammalian body to replenish their thiol defense system. A lower dose or concentration of nitric oxide gas delivered in between the bursts of high concentration nitric oxide maintains nitrosative stress pressure on the pathogens and also reduces the risk of toxicity of nitric oxide gas.

    摘要翻译： 描述了一种方法和相应的装置，用于通过向哺乳动物递送间歇性高剂量的一氧化氮一段时间并在高浓度和低浓度的一氧化氮气体之间循环来对抗微生物和感染。 高浓度的一氧化氮优选间歇地递送短暂的时间段，其间隔着不含一氧化氮递送或较低浓度的一氧化氮的时间段。 该方法是有利的，因为在较高的浓度下，一氧化氮气体压倒了使用哺乳动物身体补充其硫醇防御系统的病原体的防御机制。 在高浓度一氧化氮脉冲之间输送的一氧化氮气体的较低剂量或浓度保持对病原体的亚硝化应激压力，并降低一氧化氮气体毒性的风险。

    Device and method for treatment of wounds with nitric oxide
    5.
    发明申请
    Device and method for treatment of wounds with nitric oxide 审中-公开
    用一氧化氮治疗伤口的装置和方法

    公开(公告)号：US20080287861A1

    公开(公告)日：2008-11-20

    申请号：US11982430

    申请日：2007-10-31

    申请人： Alex Stenzler ,  Christopher C. Miller

    发明人： Alex Stenzler ,  Christopher C. Miller

    IPC分类号： A61M37/00

    CPC分类号： A61M35/00 ,  A61B90/40 ,  A61H33/14 ,  A61K33/00 ,  A61L2/0094 ,  A61L15/18 ,  A61L15/44 ,  A61L2300/114 ,  A61L2300/602 ,  A61M1/0031 ,  A61M1/0088 ,  A61M13/003 ,  A61M13/006 ,  A61M2202/0275 ,  A61M2205/3334 ,  A61K2300/00

    摘要： Topical exposure of nitric oxide gas to wounds such as chronic non-healing wounds may be beneficial in promoting healing of the wound and in preparing the wound bed for further treatment and recovery. Nitric oxide gas may be used, for example, to reduce the microbial infection and burden on these wounds, manage exudate secretion by reducing inflammation, upregulate expression of endogenous collagenase to locally debride the wound, and regulate the formation of collagen. High concentration of nitric oxide ranging from about 160 to 400 ppm may be used without inducing toxicity in the healthy cells around a wound site. Additionally, exposure to the high concentration for a first treatment period reduces the microbial burden and inflammation at the wound site and increase collagenase expression to debride necrotic tissue at the wound site. After a first treatment period with high concentration of nitric oxide, a second treatment period at a lower concentration of nitric oxide preferably ranging from about 5-20 ppm may to provided to restore the balance of nitric oxide and induce collagen expression to aid in the closure of the wound.

    摘要翻译： 一氧化氮气体局部暴露于伤口如慢性非愈合伤口可能有益于促进伤口愈合和制备伤口床进一步治疗和恢复。 例如，可以使用一氧化氮气体来减少这些伤口的微生物感染和负担，通过减少炎症，上调内源性胶原酶的表达来局部清创伤口并调节胶原的形成来控制渗出物分泌。 可以使用约160至400ppm范围内的高浓度一氧化氮，而不会在伤口部位周围的健康细胞中引起毒性。 此外，在第一次治疗期间暴露于高浓度可减少伤口部位的微生物负担和炎症，并增加胶原酶表达以清除伤口部位的坏死组织。 在具有高浓度一氧化氮的第一次治疗期后，可提供较低浓度的一氧化氮优选约5-20ppm的第二治疗期以恢复一氧化氮的平衡并诱导胶原表达以帮助闭合 的伤口。

    Metered dose inhaler spacer
    6.
    发明授权
    Metered dose inhaler spacer 有权
    计量剂量吸入器垫片

    公开(公告)号：US08770188B2

    公开(公告)日：2014-07-08

    申请号：US13077849

    申请日：2011-03-31

    申请人： Alex Stenzler ,  Steve Han

    发明人： Alex Stenzler ,  Steve Han

    IPC分类号： A61M15/00

    CPC分类号： A61M15/0086 ,  A61M15/0015 ,  A61M15/0018 ,  A61M15/002 ,  A61M15/009 ,  A61M2205/3334

    摘要： A metered dose inhaler (MDI) spacer has a body that defines a dose receiving chamber. A proximal end portion coupled between the body and a mouth port through which a metered dose may be inhaled by a user of the MDI spacer. A distal end portion is coupled with the body. A combined one-way and flow rate control valve coupled with the distal end portion is configured for permitting external airflow into and prohibiting internal airflow out of the dose receiving chamber. A collar coupled with the distal end portion is configured for receiving an actuator shaft of a metered dose inhaler and for forming a seal about an aerosol nozzle of the metered dose inhaler such that a metered dose of medication is admissible into the dose receiving chamber via the collar while airflow into and out of the dose receiving chamber via the collar is prohibited.

    摘要翻译： 定量吸入器（MDI）间隔物具有限定剂量接收室的主体。 连接在主体和口端口之间的近端部分，计量剂量可由MDI间隔物的使用者吸入。 远端部分与身体联接。 与远端部分结合的组合的单向和流量控制阀构造成允许外部气流进入并阻止内部空气流出剂量接收室。 与远端部分联接的套环被构造成用于接收计量剂量吸入器的致动器轴并且用于围绕计量剂量吸入器的气溶胶喷嘴形成密封，使得计量剂量的药物可以经由 在通过衣领进入和离开剂量接收室的气流被禁止的情况下。

    Venturi geometry design for flow-generator patient circuit
    8.
    发明授权
    Venturi geometry design for flow-generator patient circuit 有权
    文丘里几何设计用于流量发生器患者回路

    公开(公告)号：US08100125B2

    公开(公告)日：2012-01-24

    申请号：US11241303

    申请日：2005-09-30

    申请人： Steven Duquette ,  Alex Stenzler ,  Steve Han

    发明人： Steven Duquette ,  Alex Stenzler ,  Steve Han

    IPC分类号： A61M11/00

    CPC分类号： A61M16/0666 ,  A61M16/0012 ,  A61M16/0858

    摘要： Provided is a universal interface adapted for providing continuous positive airway pressure to a patient when the interface is used with a standard ventilator. The interface is configured to operate at a supply pressure no greater than about 120 centimeters of H2O in order to deliver pressure to the patient of up to about 15 cm of H2O at a flow rate of up to about 12 liters/minute. The universal interface may comprise an interface body having a space pair of breathing passageways intersecting a corresponding of supply passageways. Each one of the breathing passageways is comprised of a patient passageway and an exhalation passageway. Each one of the supply passageways includes a jet venturi having a taper portion. Each one of the exhalation passageways includes a taper portion which tapers outwardly along a direction from the patient passageway toward the exhalation passageway.

    摘要翻译： 提供了一种通用接口，其适于在接口与标准通气机一起使用时向患者提供持续的正气道压力。 该界面构造成在不超过约120厘米H 2 O的供应压力下操作，以便以高达约12升/分钟的流速向患者输送高达约15cm H 2 O的压力。 通用接口可以包括具有与供应通道相对应的空间对的呼吸通道的接口体。 每个呼吸通道由患者通道和呼气通道组成。 每个供应通道包括具有锥形部分的喷射文丘里管。 每个呼气通道包括锥形部分，其沿着从患者通道朝向呼气通道的方向向外变细。