-
公开(公告)号：US07955294B2
公开(公告)日：2011-06-07
申请号：US11598221
申请日：2006-11-10
CPC分类号： A61M16/122 , A61H33/14 , A61K33/00 , A61M16/0003 , A61M16/0051 , A61M16/024 , A61M16/04 , A61M16/0666 , A61M16/0833 , A61M16/12 , A61M16/201 , A61M16/202 , A61M16/204 , A61M2016/003 , A61M2016/102 , A61M2202/0275 , A61M2205/3327 , A61M2205/3334
摘要： A method and corresponding device are described for combating microbes and infections by delivering intermittent high doses of nitric oxide to a mammal for a period of time and which cycles between high and low concentration of nitric oxide gas. The high concentration of nitric oxide is preferably delivered intermittently for brief periods of time that are interspersed with periods of time with either no nitric oxide delivery or lower concentrations of nitric oxide. The method is advantageous because at higher concentration, nitric oxide gas overwhelms the defense mechanism of pathogens that use the mammalian body to replenish their thiol defense system. A lower dose or concentration of nitric oxide gas delivered in between the bursts of high concentration nitric oxide maintains nitrosative stress pressure on the pathogens and also reduces the risk of toxicity of nitric oxide gas.
摘要翻译： 描述了一种方法和相应的装置，用于通过向哺乳动物递送间歇性高剂量的一氧化氮一段时间并在高浓度和低浓度的一氧化氮气体之间循环来对抗微生物和感染。 高浓度的一氧化氮优选间歇地递送短暂的时间段，其间隔着不含一氧化氮递送或较低浓度的一氧化氮的时间段。 该方法是有利的，因为在较高的浓度下，一氧化氮气体压倒了使用哺乳动物身体补充其硫醇防御系统的病原体的防御机制。 在高浓度一氧化氮脉冲之间输送的一氧化氮气体的较低剂量或浓度保持对病原体的亚硝化应激压力，并降低一氧化氮气体毒性的风险。
-
2.发明授权公开(公告)号：US08795222B2
公开(公告)日：2014-08-05
申请号：US13006218
申请日：2011-01-13
CPC分类号： A61M35/00 , A61B90/40 , A61H33/14 , A61K33/00 , A61L2/0094 , A61L15/18 , A61L15/44 , A61L2300/114 , A61L2300/602 , A61M1/0031 , A61M1/0088 , A61M13/003 , A61M13/006 , A61M2202/0275 , A61M2205/3334 , A61K2300/00
摘要： Topical exposure of nitric oxide gas to wounds such as chronic non-healing wounds may be beneficial in promoting healing of the wound and in preparing the wound bed for further treatment and recovery. Nitric oxide gas may be used, for example, to reduce the microbial infection and burden on these wounds, manage exudate secretion by reducing inflammation, upregulate expression of endogenous collagenase to locally debride the wound, and regulate the formation of collagen. High concentration of nitric oxide ranging from about 160 to 400 ppm may be used without inducing toxicity in the healthy cells around a wound site. Additionally, exposure to the high concentration for a first treatment period reduces the microbial burden and inflammation at the wound site and increase collagenase expression to debride necrotic tissue at the wound site. After a first treatment period with high concentration of nitric oxide, a second treatment period at a lower concentration of nitric oxide preferably ranging from about 5-20 ppm may to provided to restore the balance of nitric oxide and induce collagen expression to aid in the closure of the wound.
摘要翻译： 一氧化氮气体局部暴露于伤口如慢性非愈合伤口可能有益于促进伤口愈合和制备伤口床进一步治疗和恢复。 例如，可以使用一氧化氮气体来减少这些伤口的微生物感染和负担，通过减少炎症，上调内源性胶原酶的表达来局部清创伤口并调节胶原的形成来控制渗出物分泌。 可以使用约160至400ppm范围内的高浓度一氧化氮，而不会在伤口部位周围的健康细胞中引起毒性。 此外，在第一次治疗期间暴露于高浓度可减少伤口部位的微生物负担和炎症，并增加胶原酶表达以清除伤口部位的坏死组织。 在具有高浓度一氧化氮的第一次治疗期后，可提供较低浓度的一氧化氮优选约5-20ppm的第二治疗期以恢复一氧化氮的平衡并诱导胶原表达以帮助闭合 的伤口。
-
3.发明授权Method and apparatus for delivery of inhaled nitric oxide to spontaneous-breathing and mechanically-ventilated patients with intermittent dosing 有权将吸入一氧化氮输送到间歇给药的自发呼吸和机械通气患者的方法和装置公开(公告)号：US07516742B2
公开(公告)日：2009-04-14
申请号：US11234849
申请日：2005-09-23
IPC分类号： A61M16/00
CPC分类号： A61M16/12 , A61M16/0833 , A61M16/1015 , A61M16/203 , A61M16/204 , A61M2016/0039 , A61M2016/102 , A61M2016/1025 , A61M2202/0275
摘要： A device and method is disclosed for delivering NO to a patient. The device utilizes a single controller that controls two separate flow controllers to deliver an oxygen-containing gas and a NO-containing gas to the patient to provide NO-containing gas at a flow profile that is proportional or quasi-proportional to a flow profile of the oxygen-containing gas throughout patient inspiration. The controller further comprises logic for setting a nitric oxide delivery profile comprising at least two different concentrations of nitric oxide containing gas and for automatically switching between the at least two different concentrations of nitric oxide containing gas on a timed basis.
摘要翻译： 公开了用于将NO递送给患者的装置和方法。 该装置使用单个控制器，其控制两个单独的流量控制器以向患者输送含氧气体和含NO的气体，以提供含NO气体的流动分布，该流动分布与流动分布成比例或准成比例 含氧气体贯穿患者的灵感。 控制器还包括用于设定包含至少两种不同浓度的一氧化氮的气体的一氧化氮输送曲线的逻辑，并且用于在定时基础上自动切换至少两种不同浓度的一氧化氮气体。
-
4.发明申请公开(公告)号：US20180125882A1
公开(公告)日：2018-05-10
申请号：US15675773
申请日：2017-08-13
CPC分类号： A61K33/00 , A61K9/0043 , A61K9/08 , A61K9/7007 , A61K47/12 , C01B21/24
摘要： The present invention relates to a liquid nitric oxide releasing solution (NORS) comprised of at least one nitric oxide releasing compound and at least one acidifying agent, wherein the NORS provides an extended release of a therapeutically effective amount of nitric oxide gas (gNO). The present invention also relates to a liquid NORS comprised of at least one nitrite compound having a concentration of no greater than about 0.5% w/v and at least one acidifying agent, wherein the NORS releases a therapeutically effective amount of gNO. The present invention also relates to a method for the treatment of a wound in a human, the method comprising administering to the human a liquid NORS comprised of at least one nitric oxide releasing compound and at least one acidifying agent, wherein the NORS provides an extended release of a therapeutically effective amount of gNO. The present invention also relates to a method for the treatment, prevention, or reduction of incidence of a disease or disorder in a human in need thereof, the method comprising administering to the human a liquid NORS comprised of at least one nitrite compound at a concentration of no greater than about 0.5% w/v and at least one acidifying agent, wherein the NORS releases a therapeutically effective amount of gNO.
-
公开(公告)号：US20080287861A1
公开(公告)日：2008-11-20
申请号：US11982430
申请日：2007-10-31
IPC分类号： A61M37/00
CPC分类号： A61M35/00 , A61B90/40 , A61H33/14 , A61K33/00 , A61L2/0094 , A61L15/18 , A61L15/44 , A61L2300/114 , A61L2300/602 , A61M1/0031 , A61M1/0088 , A61M13/003 , A61M13/006 , A61M2202/0275 , A61M2205/3334 , A61K2300/00
摘要： Topical exposure of nitric oxide gas to wounds such as chronic non-healing wounds may be beneficial in promoting healing of the wound and in preparing the wound bed for further treatment and recovery. Nitric oxide gas may be used, for example, to reduce the microbial infection and burden on these wounds, manage exudate secretion by reducing inflammation, upregulate expression of endogenous collagenase to locally debride the wound, and regulate the formation of collagen. High concentration of nitric oxide ranging from about 160 to 400 ppm may be used without inducing toxicity in the healthy cells around a wound site. Additionally, exposure to the high concentration for a first treatment period reduces the microbial burden and inflammation at the wound site and increase collagenase expression to debride necrotic tissue at the wound site. After a first treatment period with high concentration of nitric oxide, a second treatment period at a lower concentration of nitric oxide preferably ranging from about 5-20 ppm may to provided to restore the balance of nitric oxide and induce collagen expression to aid in the closure of the wound.
摘要翻译： 一氧化氮气体局部暴露于伤口如慢性非愈合伤口可能有益于促进伤口愈合和制备伤口床进一步治疗和恢复。 例如，可以使用一氧化氮气体来减少这些伤口的微生物感染和负担，通过减少炎症，上调内源性胶原酶的表达来局部清创伤口并调节胶原的形成来控制渗出物分泌。 可以使用约160至400ppm范围内的高浓度一氧化氮，而不会在伤口部位周围的健康细胞中引起毒性。 此外，在第一次治疗期间暴露于高浓度可减少伤口部位的微生物负担和炎症，并增加胶原酶表达以清除伤口部位的坏死组织。 在具有高浓度一氧化氮的第一次治疗期后，可提供较低浓度的一氧化氮优选约5-20ppm的第二治疗期以恢复一氧化氮的平衡并诱导胶原表达以帮助闭合 的伤口。
-
6.发明申请NITRIC OXIDE TREATMENT OF BOVINE RESPIRATORY DISEASE COMPLEX AND OTHER RESPIRATORY CONDITIONS 审中-公开牛血液呼吸综合征和其他呼吸道疾病的氧化氮治疗公开(公告)号：US20160051579A1
公开(公告)日：2016-02-25
申请号：US14779541
申请日：2014-12-30
CPC分类号： A61K33/00 , A61K9/0043 , A61K9/0078 , A61K47/12
摘要： Methods, devices, and systems for treating a respiratory condition using gNO delivered from a nitric oxide releasing solution (NORS) are disclosed and described. In one embodiment, the respiratory condition may be bovine respiratory disease complex (BRDc).
摘要翻译： 公开和描述了使用从一氧化氮释放溶液（NORS）递送的gNO治疗呼吸状况的方法，装置和系统。 在一个实施方案中，呼吸状况可以是牛呼吸道疾病复合物（BRDc）。
-
公开(公告)号：US09186148B2
公开(公告)日：2015-11-17
申请号：US13344061
申请日：2012-01-05
申请人： Kevin D. Felder , John F. Cummings , Joseph P. Schowalter , Patrick J. Swindon , Johnny H. Alexander, III , Patrick A. Weizman , Cory G. Kimball , Edward G. Chekan , Joseph E. Young , Christopher C. Miller , Barry T. Jamison , John V. Hunt , Kent P. Baker , Cortney E. Henderson , Chester O. Baxter, III , Jerome R. Morgan , Adam R. Dunki-Jacobs , Venkataramanan Mandakolathur Vasudevan , Carl J. Shurtleff , Julia F. Serber
发明人： Kevin D. Felder , John F. Cummings , Joseph P. Schowalter , Patrick J. Swindon , Johnny H. Alexander, III , Patrick A. Weizman , Cory G. Kimball , Edward G. Chekan , Joseph E. Young , Christopher C. Miller , Barry T. Jamison , John V. Hunt , Kent P. Baker , Cortney E. Henderson , Chester O. Baxter, III , Jerome R. Morgan , Adam R. Dunki-Jacobs , Venkataramanan Mandakolathur Vasudevan , Carl J. Shurtleff , Julia F. Serber
IPC分类号： A61B17/068 , A61B17/115 , A61B17/072 , A61B17/00 , A61B17/29 , A61B19/00
CPC分类号： A61B17/064 , A61B17/0686 , A61B17/072 , A61B17/07207 , A61B17/115 , A61B17/1155 , A61B2017/00876 , A61B2017/07214 , A61B2017/0725 , A61B2017/2946 , A61B2090/0811
摘要： A surgical instrument includes a handle assembly having a trigger operable to fire a staple driver to staple tissue. The instrument includes a pointed rod to which an anvil may be coupled. An anvil detection feature is included to determine when the anvil is coupled to the rod. In some versions, the anvil detection feature comprises a translatable rod that inhibits a lockout feature from disengaging. In other versions, an anvil sensing tube is disposed about the pointed rod and interferes with actuation of the trigger in a first position. A recess in the tube permits trigger to actuate when the anvil sensing tube is in the second position. Alternatively, a resilient tab is coupled to the pointed rod and resists actuation of the staple driver. A trigger lockout assembly may include a spring-loaded button that “pops” out when a push rod is actuated, thereby freeing a pivotable lockout feature.
摘要翻译： 一种手术器械包括具有触发器的手柄组件，该触发器可操作以将钉子驱动器射击至钉组织。 该仪器包括可连接砧座的尖杆。 包括砧检测功能以确定砧座何时与杆连接。 在一些形式中，砧座检测特征包括一个能够阻止锁定特征脱离的可平移杆。 在其他形式中，砧感知管围绕尖的杆设置并且在第一位置上干扰触发器的致动。 当砧座感测管处于第二位置时，管中的凹部允许触发器致动。 或者，弹性突舌连接到尖的杆并抵抗钉驱动器的致动。 触发器锁定组件可以包括弹簧加载的按钮，当按压推杆时“弹出”按钮，从而释放可枢转的锁定特征。
-
公开(公告)号：US20150297782A1
公开(公告)日：2015-10-22
申请号：US14585008
申请日：2014-12-29
CPC分类号： A61L15/44 , A41B11/005 , A41B2400/34 , A43B1/0045 , A43B7/00 , A43B7/1455 , A43B17/003 , A43B17/03 , A61F13/00063 , A61F2013/00285 , A61K31/194 , A61K33/00 , A61L15/18 , A61L15/20 , A61L15/46 , A61L2300/114 , A61L2300/404 , A61L2300/602 , A61L2300/608 , A61K2300/00
摘要： A wound dressing comprising nitric oxide gas producing component.
摘要翻译： 包含一氧化氮气体产生组分的伤口敷料。
-
公开(公告)号：US20120108893A1
公开(公告)日：2012-05-03
申请号：US12938719
申请日：2010-11-03
IPC分类号： A61F2/00
CPC分类号： A61M39/0208 , A61F5/0056
摘要： An apparatus comprises a housing and one or more deployable protrusions. The apparatus defines a fluid reservoir and presents an upper surface. The housing is sized and configured to be implanted within a patient. The protrusions are selectively movable from a first position to a second position. The protrusions are at least partially retracted relative to the housing when the protrusions are in the first position. The protrusions are at least partially extended relative to the housing when the protrusions are in the second position. The protrusions may be in the form of substantially cylindraceous posts, semi-circular members, or other shapes. The protrusions may be actuated mechanically, electromechanically, or otherwise. The apparatus may be provided as an injection port, as part of a gastric band system or otherwise. The deployed protrusions may facilitate location of the implanted port through external palpation of the patient's abdomen.
摘要翻译： 一种装置包括壳体和一个或多个可部署突起。 该装置限定流体储存器并呈现上表面。 外壳的尺寸和构造被植入患者体内。 突起可以选择性地从第一位置移动到第二位置。 当突起处于第一位置时，突起至少部分地相对于壳体缩回。 当突起处于第二位置时，突起至少部分地相对于壳体延伸。 突起可以是基本上圆柱形的柱，半圆形构件或其它形状的形式。 突起可以机械地，机电地或其他方式致动。 该装置可以被提供为注射端口，作为胃束带系统的一部分或以其它方式。 部署的突起可以通过患者腹部的外部触诊来促进植入端口的位置。
-
10.发明授权System and elements for managing therapeutic gas administration to a spontaneously breathing non-ventilated patient 有权用于管理治疗气体给自发呼吸的非通气患者的系统和元件公开(公告)号：US06668828B1
公开(公告)日：2003-12-30
申请号：US09688229
申请日：2000-10-16
IPC分类号： A61M1600
CPC分类号： A61M16/0816 , A61M16/0051 , A61M16/024 , A61M16/0677 , A61M16/203 , A61M16/208 , A61M16/209 , A61M2016/0027 , A61M2016/0039 , A61M2016/0042 , A61M2202/0275 , A61M2205/6018 , A61M2205/6027 , A61M2205/8206 , A61M2205/8237 , Y10T137/7808
摘要： A system controls and manages administration of a therapeutic gas, such as NO, O2, or the like, to a spontaneously breathing, non-ventilated patient such that concentrated NO is as low as reasonably possible while delivering the desired amount of NO to the distal portions of the lungs. The system includes an entrainment cell that provides remote, turbulent mixing with low temporal latency and can be used with a nasal cannula or a mask. The entrainment cell uses room air to dilute the therapeutic gas; however, supplementary gases can also be used. A baffle can be included to promote mixing and a flow sensor can also be used if desired. Multiple ports can be included in the entrainment cell. An equalizing valve is also disclosed.
摘要翻译： 系统控制和管理诸如NO，O 2等的治疗气体的给药给自发呼吸的非通气患者，使得浓缩的NO尽可能低，同时将期望量的NO递送到远端 部分肺部。 该系统包括夹带细胞，其提供具有低时间潜伏期的远程湍流混合，并且可以与鼻插管或面罩一起使用。 夹带细胞使用室内空气稀释治疗气体; 然而，也可以使用补充气体。 可以包括挡板以促进混合，并且如果需要也可以使用流量传感器。 夹带单元中可以包含多个端口。 还公开了一种均衡阀。
-
-
-
-
-
-
-
-
-
搜索结果
33 条记录 (耗时 0.048 秒)
