公开(公告)号：US08940960B2

公开(公告)日：2015-01-27

申请号：US13122339

申请日：2009-10-01

申请人： Alexander Ploss ,  Matthew Evans ,  Charles Rice

发明人： Alexander Ploss ,  Matthew Evans ,  Charles Rice

IPC分类号： C12N15/90 ,  C12N15/63

CPC分类号： G01N33/5008 ,  C07K14/705 ,  C12N2740/16043 ,  C12N2770/24211 ,  G01N33/502 ,  G01N2333/186 ,  G01N2500/00

摘要： The human Occludin protein is identified as an essential Hepatitis C Virus (HCV) cell entry factor. Occludin is shown to render murine and other non-human cells infectable with HCV and to be required for HCV-susceptibility of human cells. Associated methods for inhibiting HCV infection, transgenic animal models for HCV pathogenesis, methods of identifying compounds or agents that prevent or mitigate interaction of HCV with Occludin, and HCV inhibitory agents are also disclosed. Kits and cell culture compositions useful for identifying compounds or agents that prevent or mitigate interaction of HCV with Occludin are also provided.

摘要翻译： 人类Occludin蛋白被鉴定为必需的丙型肝炎病毒（HCV）细胞进入因子。 闭合素显示使鼠和其他非人类细胞能够感染HCV，并且需要人类细胞的HCV敏感性。 还公开了用于抑制HCV感染的相关方法，用于HCV发病机理的转基因动物模型，鉴定预防或减轻HCV与Occludin的相互作用的化合物或药剂的方法以及HCV抑制剂。 还提供了可用于鉴定预防或减轻HCV与Occludin相互作用的化合物或试剂的试剂盒和细胞培养组合物。

公开(公告)号：US20110271356A1

公开(公告)日：2011-11-03

申请号：US13122339

申请日：2009-10-01

申请人： Alexander Ploss ,  Matthew Evans ,  Charles Rice

发明人： Alexander Ploss ,  Matthew Evans ,  Charles Rice

IPC分类号： A01K67/00 ,  A61K31/7088 ,  A61P31/14 ,  C40B30/00 ,  G01N33/566 ,  C12Q1/68 ,  A61K39/395 ,  A61K38/02

CPC分类号： G01N33/5008 ,  C07K14/705 ,  C12N2740/16043 ,  C12N2770/24211 ,  G01N33/502 ,  G01N2333/186 ,  G01N2500/00

摘要： The human Occludin protein is identified as an essential Hepatitis C Virus (HCV) cell entry factor. Occludin is shown to render murine and other non-human cells infectable with HCV and to be required for HCV—susceptibility of human cells. Associated methods for inhibiting HCV infection, transgenic animal models for HCV pathogenesis, methods of identifying compounds or agents that prevent or mitigate interaction of HCV with Occludin, and HCV inhibitory agents are also disclosed. Kits and cell culture compositions useful for identifying compounds or agents that prevent or mitigate interaction of HCV with Occludin are also provided.

摘要翻译： 人类Occludin蛋白被鉴定为必需的丙型肝炎病毒（HCV）细胞进入因子。 闭合素显示使鼠和其他非人类细胞能够感染HCV，并且需要人类细胞的HCV敏感性。 还公开了用于抑制HCV感染的相关方法，用于HCV发病机理的转基因动物模型，鉴定预防或减轻HCV与Occludin的相互作用的化合物或药剂的方法以及HCV抑制剂。 还提供了可用于鉴定预防或减轻HCV与Occludin相互作用的化合物或试剂的试剂盒和细胞培养组合物。

公开(公告)号：US20060210969A1

公开(公告)日：2006-09-21

申请号：US11366839

申请日：2006-03-03

申请人： Charles Rice ,  Brett Lindenbach ,  Matthew Evans ,  Christopher Jones

发明人： Charles Rice ,  Brett Lindenbach ,  Matthew Evans ,  Christopher Jones

IPC分类号： C12Q1/70 ,  C07H21/04 ,  C12N7/00 ,  C12N15/86 ,  C12N5/06

CPC分类号： C12N7/00 ,  A61K2039/525 ,  C07K2319/61 ,  C12N15/86 ,  C12N2770/24243 ,  C12N2770/24251 ,  C12N2840/203 ,  C12Q1/18 ,  G01N33/5767 ,  G01N2333/18 ,  G01N2500/00

摘要： The present invention provides infectious recombinant Hepatitis C Viruses (HCV), and vectors, cells and animals comprising the same. The present invention provides methods of producing infectious recombinant HCV, and their use in identifying anti-HCV therapeutic agents, as well as sequences of HCV associated with HCV pathogenesis.

摘要翻译： 本发明提供感染性重组丙型肝炎病毒（HCV），以及包含其的载体，细胞和动物。 本发明提供生产感染性重组HCV的方法及其在鉴定抗HCV治疗剂中的用途以及与HCV发病机制相关的HCV序列。

公开(公告)号：US07246587B2

公开(公告)日：2007-07-24

申请号：US11480157

申请日：2006-06-30

申请人： Matthew Evans ,  Peter Sailer

发明人： Matthew Evans ,  Peter Sailer

IPC分类号： F01L1/14

CPC分类号： F01L13/0005 ,  F01L1/146 ,  F01L13/0031 ,  F01L2105/00

摘要： The invention proposes a deactivating element (1) for a valve train of an internal combustion engine. The deactivating element (1) comprises a housing (2) and an inner element (4) that is axially displaceable in the bore (3) of the housing (2). According to the invention, the pistons (7) arranged in the inner element (4) for coupling into an annular groove (12) in the housing (2) possess two flattened regions (10, 15) arranged diametrically opposite each other in axial direction of the deactivating element (1). The height of the annular groove (12) is reduced by a measure of a height of the second, additional flattened region (15). Due to the reduction of height of the annular groove (12), its volume is also reduced. This results in advantages activation and deactivation times.

公开(公告)号：US20070000459A1

公开(公告)日：2007-01-04

申请号：US11480157

申请日：2006-06-30

申请人： Matthew Evans ,  Peter Sailer

发明人： Matthew Evans ,  Peter Sailer

IPC分类号： F01L1/14

CPC分类号： F01L13/0005 ,  F01L1/146 ,  F01L13/0031 ,  F01L2105/00

摘要： The invention proposes a deactivating element (1) for a valve train of an internal combustion engine. The deactivating element (1) comprises a housing (2) and an inner element (4) that is axially displaceable in the bore (3) of the housing (2). According to the invention, the pistons (7) arranged in the inner element (4) for coupling into an annular groove (12) in the housing (2) possess two flattened regions (10, 15) arranged diametrically opposite each other in axial direction of the deactivating element (1). The height of the annular groove (12) is reduced by a measure of a height of the second, additional flattened region (15). Due to the reduction of height of the annular groove (12), its volume is also reduced. This results in advantages activation and deactivation times.

摘要翻译： 本发明提出了一种用于内燃机的气门机构的停用元件（1）。 所述失活元件（1）包括壳体（2）和可在所述壳体（2）的所述孔（3）中轴向移动的内部元件）。 根据本发明，布置在内部元件（4）中用于联接到壳体（2）中的环形槽（12）中的活塞（7）具有两个在轴向方向上彼此径向相对布置的扁平区域（10,15） 的去激活元件（1）。 通过测量第二附加平坦化区域（15）的高度来减小环形槽（12）的高度。 由于环形槽（12）的高度减小，其体积也减小。 这导致了激活和停用时间的优势。

公开(公告)号：USD532379S1

公开(公告)日：2006-11-21

申请号：US29195495

申请日：2003-12-11

申请人： Gregory Sorrentino ,  Matthew Evans

设计人： Gregory Sorrentino ,  Matthew Evans

公开(公告)号：US20060225682A1

公开(公告)日：2006-10-12

申请号：US11375348

申请日：2006-03-14

申请人： Matthew Evans ,  Jermel Jones ,  Peter Sailer ,  Oliver Schnell ,  Tim Hosenfeldt

发明人： Matthew Evans ,  Jermel Jones ,  Peter Sailer ,  Oliver Schnell ,  Tim Hosenfeldt

IPC分类号： F01L1/14

CPC分类号： C23C14/025 ,  C23C14/0605 ,  F01L1/14 ,  F01L1/146 ,  F01L1/16 ,  F01L13/0005 ,  F01L13/0036 ,  F01L2001/256 ,  F01L2101/00 ,  F01L2103/00 ,  F01L2105/00 ,  F01L2107/00 ,  F01L2800/02 ,  F01L2820/01 ,  Y10T74/2107

摘要： A switchable valve-drive component (1) for variable transmission of a stroke generated by one or more cam projections to a gas-exchange valve of an internal combustion engine is provided. The valve-drive component (1) has transmission elements (3, 4), which can be connected with a positive fit by coupling elements (8) in the transmission direction, in which force transmission surface sections (16) of the coupling elements (8) can be clamped between force transmission surface sections (20) of the transmission elements (3, 4). Here, at least one of the force transmission surface sections (16, 20) should be provided with a wear protection layer (23). This layer comprises at least one metal-free amorphous hydrocarbon layer with sp2-hybridized and sp3-hybridized carbon.

摘要翻译： 提供了一种用于将由一个或多个凸轮突起产生的冲程可变地传递到内燃机的气体交换阀的可切换阀驱动部件（1）。 所述阀驱动部件（1）具有传动元件（3,4），所述传动元件（3,4）可以通过所述传动方向上的联接元件（8）与所述连接元件（8）的力传递表面部分（16） 8）可以夹持在传动元件（3,4）的力传递表面部分（20）之间。 这里，力传递表面部分（16,20）中的至少一个应设置有磨损保护层（23）。 该层包含至少一个具有sp2-2杂化和sp3-3杂化碳的无金属无定形烃层。

公开(公告)号：US08698372B2

公开(公告)日：2014-04-15

申请号：US13151213

申请日：2011-06-01

申请人： Charles Chase ,  Matthew Evans

发明人： Charles Chase ,  Matthew Evans

IPC分类号： H01L37/02

CPC分类号： H01L37/02 ,  Y02B10/30

摘要： A power-generating device is disclosed that includes a pyroelectric material having first and second surfaces on opposite sides of the pyroelectric material. The device also includes a first conductive electrode coupled to a first support element that is configured to intermittently bring the first electrode into proximity with the first surface and a second conductive electrode proximate to the second surface at least while the first electrode is proximate to the first surface. The device also includes a power module that is electrically coupled between the first and second electrodes. The power module is configured to capture power from an electrical current flowing between the first and second electrodes.

摘要翻译： 公开了一种发电装置，其包括在热电材料的相对侧上具有第一和第二表面的热电材料。 该装置还包括耦合到第一支撑元件的第一导电电极，其被配置为间断地使第一电极接近第一表面，而第二导电电极至少在第一电极接近第一电极 表面。 该装置还包括电耦合在第一和第二电极之间的功率模块。 功率模块被配置为从在第一和第二电极之间流动的电流捕获功率。

公开(公告)号：US07934203B2

公开(公告)日：2011-04-26

申请号：US11139232

申请日：2005-05-27

申请人： William O. Lovett ,  David Haikney ,  Matthew Evans

发明人： William O. Lovett ,  David Haikney ,  Matthew Evans

IPC分类号： G06F9/45 ,  G06F9/30

CPC分类号： G06F9/45516 ,  G06F9/3885

摘要： During program code conversion, such as in a dynamic binary translator, automatic code generation provides target code 21 executable by a target processor 13. Multiple instruction ports 610 disperse a group of instructions to functional units 620 of the processor 13. Disclosed is a mechanism of preparing an instruction group 606 using a plurality of pools 700 having a hierarchical structure 711-715. Each pool represents a different overlapping subset of the issue ports 610. Placing an instruction 600 into a particular pool 700 also reduces vacancies in any one or more subsidiary pools in the hierarchy. In a preferred embodiment, a counter value 702 is associated with each pool 700 to track vacancies. A valid instruction group 606 is formed by picking the placed instructions 600 from the pools 700. The instruction groups are generated accurately and automatically. Decoding errors and stalls are minimized or completely avoided.

摘要翻译： 在程序代码转换期间，例如在动态二进制转换器中，自动代码生成提供可由目标处理器13执行的目标代码21.多个指令端口610将一组指令分散到处理器13的功能单元620中。公开了一种机制 使用具有分层结构711-715的多个池700准备指令组606。 每个池代表问题端口610的不同重叠子集。将指令600放置到特定池700中还可以降低层级中任何一个或多个子池中的空位。 在优选实施例中，计数器值702与每个池700相关联以跟踪空位。 通过从池700拾取所放置的指令600来形成有效指令组606.准确且自动地生成指令组。 解码错误和失速被最小化或完全避免。

公开(公告)号：US20080057034A1

公开(公告)日：2008-03-06

申请号：US11780358

申请日：2007-07-19

申请人： Hosni Hassan ,  Ryan Fink ,  Matthew Evans

发明人： Hosni Hassan ,  Ryan Fink ,  Matthew Evans

IPC分类号： A61K45/00 ,  A61P37/00 ,  C12N1/36

CPC分类号： A61K39/0258 ,  A61K39/0275 ,  A61K2039/522 ,  Y02A50/474 ,  Y02A50/482

摘要： The invention provides an attenuated enterobacterium comprising an attenuating mutation in the fnr gene, and optionally further comprising a heterologous nucleic acid encoding a foreign antigen. Also provided are pharmaceutical formulations comprising the attenuated enterobacteria of the invention. Further disclosed are methods of inducing an immune response in a subject by administration of an immunogenically effective amount of an attenuated enterobacterium or pharmaceutical formulation of the invention.

摘要翻译： 本发明提供了一种减毒的肠杆菌，其包含fn基因中的减毒突变，并任选地还包含编码外源抗原的异源核酸。 还提供了包含本发明的减毒肠杆菌的药物制剂。 进一步公开的是通过施用免疫原性有效量的本发明的减毒的肠杆菌或药物制剂在受试者中诱导免疫应答的方法。