利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

20 条记录 (耗时 0.034 秒)

    HCV entry factor, Occludin
    2.
    发明授权
    HCV entry factor, Occludin 有权
    HCV进入因子，Occludin

    公开(公告)号：US08940960B2

    公开(公告)日：2015-01-27

    申请号：US13122339

    申请日：2009-10-01

    申请人： Alexander Ploss ,  Matthew Evans ,  Charles Rice

    发明人： Alexander Ploss ,  Matthew Evans ,  Charles Rice

    IPC分类号： C12N15/90 ,  C12N15/63

    CPC分类号： G01N33/5008 ,  C07K14/705 ,  C12N2740/16043 ,  C12N2770/24211 ,  G01N33/502 ,  G01N2333/186 ,  G01N2500/00

    摘要： The human Occludin protein is identified as an essential Hepatitis C Virus (HCV) cell entry factor. Occludin is shown to render murine and other non-human cells infectable with HCV and to be required for HCV-susceptibility of human cells. Associated methods for inhibiting HCV infection, transgenic animal models for HCV pathogenesis, methods of identifying compounds or agents that prevent or mitigate interaction of HCV with Occludin, and HCV inhibitory agents are also disclosed. Kits and cell culture compositions useful for identifying compounds or agents that prevent or mitigate interaction of HCV with Occludin are also provided.

    摘要翻译： 人类Occludin蛋白被鉴定为必需的丙型肝炎病毒（HCV）细胞进入因子。 闭合素显示使鼠和其他非人类细胞能够感染HCV，并且需要人类细胞的HCV敏感性。 还公开了用于抑制HCV感染的相关方法，用于HCV发病机理的转基因动物模型，鉴定预防或减轻HCV与Occludin的相互作用的化合物或药剂的方法以及HCV抑制剂。 还提供了可用于鉴定预防或减轻HCV与Occludin相互作用的化合物或试剂的试剂盒和细胞培养组合物。

    HCV ENTRY FACTOR, OCCLUDIN
    3.
    发明申请
    HCV ENTRY FACTOR, OCCLUDIN 有权
    HCV进入因子，OCCLUDIN

    公开(公告)号：US20110271356A1

    公开(公告)日：2011-11-03

    申请号：US13122339

    申请日：2009-10-01

    申请人： Alexander Ploss ,  Matthew Evans ,  Charles Rice

    发明人： Alexander Ploss ,  Matthew Evans ,  Charles Rice

    IPC分类号： A01K67/00 ,  A61K31/7088 ,  A61P31/14 ,  C40B30/00 ,  G01N33/566 ,  C12Q1/68 ,  A61K39/395 ,  A61K38/02

    CPC分类号： G01N33/5008 ,  C07K14/705 ,  C12N2740/16043 ,  C12N2770/24211 ,  G01N33/502 ,  G01N2333/186 ,  G01N2500/00

    摘要： The human Occludin protein is identified as an essential Hepatitis C Virus (HCV) cell entry factor. Occludin is shown to render murine and other non-human cells infectable with HCV and to be required for HCV—susceptibility of human cells. Associated methods for inhibiting HCV infection, transgenic animal models for HCV pathogenesis, methods of identifying compounds or agents that prevent or mitigate interaction of HCV with Occludin, and HCV inhibitory agents are also disclosed. Kits and cell culture compositions useful for identifying compounds or agents that prevent or mitigate interaction of HCV with Occludin are also provided.

    摘要翻译： 人类Occludin蛋白被鉴定为必需的丙型肝炎病毒（HCV）细胞进入因子。 闭合素显示使鼠和其他非人类细胞能够感染HCV，并且需要人类细胞的HCV敏感性。 还公开了用于抑制HCV感染的相关方法，用于HCV发病机理的转基因动物模型，鉴定预防或减轻HCV与Occludin的相互作用的化合物或药剂的方法以及HCV抑制剂。 还提供了可用于鉴定预防或减轻HCV与Occludin相互作用的化合物或试剂的试剂盒和细胞培养组合物。

    Quick loader assembly
    6.
    发明授权
    Quick loader assembly 有权

    公开(公告)号：US10429142B1

    公开(公告)日：2019-10-01

    申请号：US16026838

    申请日：2018-07-03

    申请人： Charles Rice

    发明人： Charles Rice

    IPC分类号： F41A9/83 ,  F41A9/72

    摘要： A quick loader assembly for loading a breech loading or muzzle loading rifle includes a rifle that has a breech loader and the breech loader has an open end. A tube is include and a plurality of bullets is slidably positionable in the tube for loading the rifle. The tube is insertable into the open end of the breech loader thereby facilitating the bullets to be slid into the breech loader. A first cap is slidably positionable on the tube to close the tube thereby retaining the bullets within the tube.

    Heterologous biomass degrading enzyme expression in thermoanaerobacterium saccharolyticum
    7.
    发明授权
    Heterologous biomass degrading enzyme expression in thermoanaerobacterium saccharolyticum 有权
    异烟生物降解酶在酵母菌中的表达

    公开(公告)号：US09206434B2

    公开(公告)日：2015-12-08

    申请号：US13141952

    申请日：2009-12-23

    申请人： Heidi Hau ,  Charles Rice ,  Chris Herring ,  John McBride ,  Arthur J. Shaw, IV ,  Erin Wiswall

    发明人： Heidi Hau ,  Charles Rice ,  Chris Herring ,  John McBride ,  Arthur J. Shaw, IV ,  Erin Wiswall

    IPC分类号： C12P7/10 ,  C12P19/14 ,  C12N9/42 ,  C12N15/74 ,  C12P7/06

    CPC分类号： C12N15/74 ,  C12N9/2437 ,  C12P7/065 ,  C12P7/10 ,  Y02E50/16 ,  Y02E50/17

    摘要： Thermophilic gram-positive anaerobic host cells, for example Thermoanaerobacterium saccharolyticum (“T sacch”), express heterologous biomass degrading enzymes, such as cellulases, and are able to produce useful fermentation products from cellulose. Useful fermentation products include, for example, ethanol, acetic acid, lactic acid or CO2. In order to provide maximum expression and activity levels, biomass degrading enzymes can be expressed from codon-optimized nucleotide sequences, can be expressed under the control of a high-efficiency promoter, and/or can be fused to a signal peptide. In addition, the host cell, for example, a T sacch host cell, can be genetically altered to further improve ethanol production, for example by disrupting the production of organic products other than ethanol.

    摘要翻译： 嗜热革兰氏阳性厌氧宿主细胞，例如解糖热酵母杆菌（“T sacch”）表达异源生物降解酶，如纤维素酶，并且能够从纤维素产生有用的发酵产物。 有用的发酵产物包括例如乙醇，乙酸，乳酸或二氧化碳。 为了提供最大的表达和活性水平，生物降解酶可以由密码子优化的核苷酸序列表达，可以在高效启动子的控制下表达，和/或可以与信号肽融合。 此外，宿主细胞，例如T细胞宿主细胞，可进行遗传改变以进一步改善乙醇生产，例如通过破坏除乙醇以外的有机产物的生产。

    HCV coreceptor and methods of use thereof
    8.
    发明授权
    HCV coreceptor and methods of use thereof 失效
    HCV共受体及其使用方法

    公开(公告)号：US08703149B2

    公开(公告)日：2014-04-22

    申请号：US13215820

    申请日：2011-08-23

    申请人： Charles Rice ,  Matthew J. Evans ,  Thomas Von Hahn

    发明人： Charles Rice ,  Matthew J. Evans ,  Thomas Von Hahn

    IPC分类号： A61K39/29 ,  A61K39/395 ,  C07K16/00

    CPC分类号： C07K16/28 ,  C07K16/2896 ,  C07K2317/76

    摘要： The invention relates to the discovery that the Claudin-1 protein functions as a co-receptor for entry of HCV into cells. Methods of inhibiting, preventing or mitigating HCV infections by inhibiting HCV interactions with Claudin-1 are provided. Methods of identifying agents or compounds that interfere with HCV interactions with Claudin-1 are also provided. Finally, useful kits, cell culture compositions, agents, and compounds related to the inhibition of HCV interactions with Claudin-1 are also disclosed.

    摘要翻译： 本发明涉及发现紧密连接蛋白-1蛋白质作为HCV进入细胞的共同受体。 提供了通过抑制与Claudin-1的HCV相互作用来抑制，预防或减轻HCV感染的方法。 还提供了鉴定干扰HCV与Claudin-1相互作用的试剂或化合物的方法。 最后，还公开了与抑制与Claudin-1的HCV相互作用相关的有用的试剂盒，细胞培养组合物，试剂和化合物。

    Method of Increasing the Milk and/or Meat Quantity of Silage-Fed Animals
    9.
    发明申请
    Method of Increasing the Milk and/or Meat Quantity of Silage-Fed Animals 审中-公开
    增加饲喂动物饲料的牛奶和/或肉量的方法

    公开(公告)号：US20100272853A1

    公开(公告)日：2010-10-28

    申请号：US12808258

    申请日：2008-12-16

    申请人： Annette Freund ,  Egon Haden ,  Jerry Minore ,  Paul M. Vassalotti ,  Thomas Garfield ,  Jim Vandecoevering ,  Charles Rice ,  Gary Fellows

    发明人： Annette Freund ,  Egon Haden ,  Jerry Minore ,  Paul M. Vassalotti ,  Thomas Garfield ,  Jim Vandecoevering ,  Charles Rice ,  Gary Fellows

    IPC分类号： A23K1/18 ,  A23K1/00

    CPC分类号： A23K20/195 ,  A01N37/50 ,  A01N47/24 ,  A23K20/111 ,  A23K30/15 ,  A23K50/10 ,  A23K50/20 ,  A23K50/30

    摘要： The present invention relates to a method of increasing the milk and/or meat quantity of silage-fed animals comprising the steps: a) treating plants and/or propagules and/or sites where the plants are growing or are to grow with at least one strobilurin compound b) producing silage from the plants treated according to step a) c) feeding the milk and/or meat producing animals with the silage produced according to step b) made from the plants treated according to step a). Furthermore, the present invention relates to silage for feeding animals, produced from plants treated with at least one strobilurin compound prior to producing said silage. In addition, the present invention relates to the use of at least one strobilurin compound to increase the milk quantity of silage-fed milk-producing animals. Moreover, the present invention relates to the use of at least one strobilurin compound to increase the meat quantity of silage-fed meat-producing animals.

    摘要翻译： 本发明涉及一种增加青饲料动物的乳和/或肉量的方法，包括以下步骤：a）处理植物和/或繁殖体和/或植物正在生长或将与至少一种 嗜球果伞菌素化合物b）从根据步骤a）处理的植物产生青贮饲料，c）用由根据步骤a）处理的植物制备的根据步骤b）生产的青贮饲料给奶和/或肉生产动物。 此外，本发明涉及在生产所述青贮饲料之前，用至少一种嗜球果伞素化合物处理的植物产生的用于饲养动物的青贮饲料。 此外，本发明涉及使用至少一种嗜球果伞素化合物来增加饲喂青贮饲料的产奶动物的奶量。 此外，本发明涉及使用至少一种嗜球果伞素化合物来增加饲喂青饲料的产肉动物的肉量。