公开(公告)号：US20120136410A1

公开(公告)日：2012-05-31

申请号：US13365549

申请日：2012-02-03

申请人： Ali Rezai ,  Andre Machado ,  Keith Carlton

发明人： Ali Rezai ,  Andre Machado ,  Keith Carlton

IPC分类号： A61N1/36

CPC分类号： A61N1/36103 ,  A61N1/00 ,  A61N1/0529 ,  A61N1/36 ,  A61N1/36067 ,  A61N1/37229

摘要： A method is provided for neuromodulation to treat stroke. One step of the method includes recording an input waveform from a first site in the nervous system in a source subject. The first site is healthy or at least partially functioning. Next, an output waveform is applied to a second site in the nervous system of a target subject suffering from the stoke. The second site is diseased due to the stroke.

摘要翻译： 提供神经调节治疗中风的方法。 该方法的一个步骤包括从源对象中的神经系统中的第一位置记录输入波形。 第一个网站是健康的或至少部分功能。 接下来，输出波形被施加到遭受脚蹬的目标对象的神经系统中的第二位置。 第二个部位由于中风而患病。

公开(公告)号：US08112154B2

公开(公告)日：2012-02-07

申请号：US11943344

申请日：2007-11-20

申请人： Ali Rezai ,  Andre Machado ,  Keith Carlton

发明人： Ali Rezai ,  Andre Machado ,  Keith Carlton

IPC分类号： A61N1/05

CPC分类号： A61N1/36067 ,  A61B5/0476 ,  A61B5/11 ,  A61B5/1106 ,  A61B5/4047 ,  A61B5/4052 ,  A61B5/6814 ,  A61N1/0529 ,  A61N1/36071

摘要： Methods for neuromodulation using waveform signals. In certain embodiments, an input waveform is obtained from a signal source site in a source subject and an output waveform is applied to a target site in a target subject. The source subject is a human or animal and the signal source site is in the nervous system, including the brain. The source subject and target subject are the same subjects or different subjects. The output waveform is identical to the input waveform or derived from the input waveform. In some embodiments, the output waveform is modified in response to physiologic feedback. Also provided are systems for neuromodulation using waveform signals.

摘要翻译： 使用波形信号进行神经调节的方法。 在某些实施例中，从源对象中的信号源站点获得输入波形，并且将输出波形应用于目标对象中的目标位置。 来源主题是人或动物，信号源位置在神经系统中，包括大脑。 来源科目和目标科目是相同的科目或不同科目。 输出波形与输入波形相同或从输入波形导出。 在一些实施例中，响应于生理反馈修改输出波形。 还提供了使用波形信号进行神经调节的系统。

公开(公告)号：US09339650B2

公开(公告)日：2016-05-17

申请号：US13365549

申请日：2012-02-03

申请人： Ali Rezai ,  Andre Machado ,  Keith Carlton

发明人： Ali Rezai ,  Andre Machado ,  Keith Carlton

IPC分类号： A61N1/36 ,  A61N1/00 ,  A61N1/05 ,  A61N1/372

CPC分类号： A61N1/36103 ,  A61N1/00 ,  A61N1/0529 ,  A61N1/36 ,  A61N1/36067 ,  A61N1/37229

摘要： A method is provided for neuromodulation to treat stroke. One step of the method includes recording an input waveform from a first site in the nervous system in a source subject. The first site is healthy or at least partially functioning. Next, an output waveform is applied to a second site in the nervous system of a target subject suffering from the stoke. The second site is diseased due to the stroke.

摘要翻译： 提供神经调节治疗中风的方法。 该方法的一个步骤包括从源对象中的神经系统中的第一位点记录输入波形。 第一个网站是健康的或至少部分功能。 接下来，输出波形被施加到遭受脚蹬的目标对象的神经系统中的第二位置。 第二个部位由于中风而患病。

公开(公告)号：US20080208284A1

公开(公告)日：2008-08-28

申请号：US11943344

申请日：2007-11-20

申请人： Ali Rezai ,  Andre Machado ,  Keith Carlton

发明人： Ali Rezai ,  Andre Machado ,  Keith Carlton

IPC分类号： A61N1/04

CPC分类号： A61N1/36067 ,  A61B5/0476 ,  A61B5/11 ,  A61B5/1106 ,  A61B5/4047 ,  A61B5/4052 ,  A61B5/6814 ,  A61N1/0529 ,  A61N1/36071

摘要： Methods for neuromodulation using waveform signals. In certain embodiments, an input waveform is obtained from a signal source site in a source subject and an output waveform is applied to a target site in a target subject. The source subject is a human or animal and the signal source site is in the nervous system, including the brain. The source subject and target subject are the same subjects or different subjects. The output waveform is identical to the input waveform or derived from the input waveform. In some embodiments, the output waveform is modified in response to physiologic feedback. Also provided are systems for neuromodulation using waveform signals.

摘要翻译： 使用波形信号进行神经调节的方法。 在某些实施例中，从源对象中的信号源站点获得输入波形，并且将输出波形应用于目标对象中的目标位置。 来源主题是人或动物，信号源位置在神经系统中，包括大脑。 来源科目和目标科目是相同的科目或不同科目。 输出波形与输入波形相同或从输入波形导出。 在一些实施例中，响应于生理反馈修改输出波形。 还提供了使用波形信号进行神经调节的系统。

公开(公告)号：US07865237B2

公开(公告)日：2011-01-04

申请号：US11222773

申请日：2005-09-12

申请人： Sandra Machado ,  Ali Rezai ,  Andre Machado

发明人： Sandra Machado ,  Ali Rezai ,  Andre Machado

IPC分类号： A61N1/372

CPC分类号： A61N1/32 ,  A61B5/0215 ,  A61B5/029 ,  A61B5/412 ,  A61N1/05 ,  A61N1/0558

摘要： Method of treating hemodynamic derangement and controlling the mobilization of splanchnic circulation. The method comprises applying a therapy signal to a celiac ganglion, a celiac plexus, a splanchnic nerve, or any combination thereof and adjusting the signal to effectuate treatment. The present invention also provides methods of treating hemodynamic derangement and controlling the mobilization of splanchnic circulation by transluminal modulation of the celiac ganglion, the celiac plexus, the splanchnic nerve.

摘要翻译： 治疗血液动力学紊乱和控制内脏循环动员的方法。 该方法包括将治疗信号应用于腹腔神经节，腹腔神经丛，内脏神经或其任何组合，并调整信号以进行治疗。 本发明还提供了通过腹腔神经节，腹腔神经丛，内脏神经的腔内调节来治疗血液动力紊乱和控制内脏循环动员的方法。

公开(公告)号：US20050283201A1

公开(公告)日：2005-12-22

申请号：US11121056

申请日：2005-05-04

申请人： Andre Machado ,  Ali Rezai

发明人： Andre Machado ,  Ali Rezai

IPC分类号： A61N1/05 ,  A61N1/18 ,  A61N1/36

CPC分类号： A61N1/36103 ,  A61N1/36067 ,  A61N1/36075 ,  A61N1/36082

摘要： Methods of treating various medical conditions by neuromodulation of a target site of interhemispheric fibers. Such medical conditions include unilateral motor deficits, movement disorders, psychiatric disorders, speech or cognitive deficits associated with hemispheric lesions, visual deficits associated with hemispheric lesions, hereditary/genetic disorders, congenital malformations, infection disease, degenerative disorder, autoimmune disorders, and metabolic disorders. A method of providing recovery and rehabilitation from states of reduced consciousness by neuromodulating a target site of interhemispheric fibers is also provided.

摘要翻译： 通过神经调节大脑半球纤维目标部位治疗各种疾病的方法。 这种医疗状况包括单侧运动障碍，运动障碍，精神障碍，与半球病变相关的言语或认知缺陷，与半球病变相关的视力缺陷，遗传性/遗传性疾病，先天性畸形，感染疾病，退行性疾病，自身免疫性疾病和代谢性疾病 。 还提供了一种通过神经调节大脑半球纤维的目标部位来提供恢复和恢复的意识降低的方法。

公开(公告)号：US07532938B2

公开(公告)日：2009-05-12

申请号：US11222774

申请日：2005-09-12

申请人： Sandra Machado ,  Andre Machado ,  Ali Rezai

发明人： Sandra Machado ,  Andre Machado ,  Ali Rezai

IPC分类号： A61N1/05

CPC分类号： A61N1/32 ,  A61B5/0215 ,  A61B5/029 ,  A61B5/412 ,  A61N1/05 ,  A61N1/0558

摘要： A minimally invasive intraluminal electrode assembly that includes a cannulated tube and a plurality of wires disposed within the cannulated tube. Each of the plurality of wires has one of a plurality of electrical contacts on a distal end thereof. The distal portion of the plurality of wires assumes a radially constrained configuration within the cannulated tube in a retracted position and a radially extended position outward of the cannulated tube in a deployed position. The electrode assembly further comprises a spring electrode connecting the plurality of electrical contacts to collectively form a substantially circular configuration in a deployed position.

摘要翻译： 一种微创管腔内电极组件，其包括插管和设置在插管内的多根线。 多个电线中的每一个在其远端具有多个电接触中的一个。 多根丝线的远端部分在缩回位置内的管状管内呈径向约束的构型，并且在展开位置中呈放射状延伸位置。 电极组件还包括连接多个电触头的弹簧电极，以在展开位置中共同形成大致圆形的构造。

公开(公告)号：US09539425B2

公开(公告)日：2017-01-10

申请号：US11871727

申请日：2007-10-12

申请人： Ali Rezai ,  Nicholas Schiff ,  Scott Kokones ,  Andre Machado ,  Sierra Farris

发明人： Ali Rezai ,  Nicholas Schiff ,  Scott Kokones ,  Andre Machado ,  Sierra Farris

IPC分类号： A61N1/36

CPC分类号： A61N1/361 ,  A61N1/36017 ,  A61N1/36025 ,  A61N1/36082

摘要： A system for treating medical conditions by neuromodulation of one or more target sites in the nervous system. In certain embodiments, at least one of the target sites is the medial thalamic region, including the intralaminar nucleus and the adjacent white and grey matter. In certain embodiments, where there is more than one target site, the other target sites is elsewhere in the nervous system, including the globus pallidus interna, subthalamic nucleus, corpus callosum, cerebellum, cerebral cortex (including the premotor cortex, motor cortex, and sensory cortex), ventral striatum, lateral thalamus, substantia nigra, and pedunculopontine nuclei. The medical conditions include movement disorders or improvement of movement function, stroke, neuropsychiatric or neuropsychologic disorders, neurodevelopmental disorders, and pain. Methods for treating medical conditions by neuromodulation of the intralaminar nuclei either alone or in combination with another target site(s) is also provided.

摘要翻译： 用于通过神经调节神经系统中一个或多个靶位点来治疗医疗状况的系统。 在某些实施方案中，目标位点中的至少一个是内侧丘脑区域，包括内层核和相邻的白色和灰色物质。 在某些实施方案中，在存在多于一个靶位点的情况下，其他目标位点在神经系统的其他地方，包括苍白球内丘，丘脑下丘脑核，胼，体，小脑，大脑皮层（包括前运动皮层，运动皮质和 感觉皮质），腹侧纹状体，外侧丘脑，黑质黑质和蝶呤基底核。 医疗条件包括运动障碍或运动功能改善，中风，神经精神障碍或神经心理障碍，神经发育障碍和疼痛。 还提供了通过单独或与另一个靶位点组合的内膜核的神经调节来治疗医学病症的方法。

公开(公告)号：US20060058597A1

公开(公告)日：2006-03-16

申请号：US11222774

申请日：2005-09-12

申请人： Andre Machado ,  Ali Rezai

发明人： Andre Machado ,  Ali Rezai

IPC分类号： A61B5/04 ,  A61B5/02 ,  A61B5/00

CPC分类号： A61N1/32 ,  A61B5/0215 ,  A61B5/029 ,  A61B5/412 ,  A61N1/05 ,  A61N1/0558

摘要： A minimally invasive intraluminal electrode assembly that includes a cannulated tube and a plurality of wires disposed within the cannulated tube. Each of the plurality of wires has one of a plurality of electrical contacts on a distal end thereof. The distal portion of the plurality of wires assumes a radially constrained configuration within the cannulated tube in a retracted position and a radially extended position outward of the cannulated tube in a deployed position. The electrode assembly further comprises a spring electrode connecting the plurality of electrical contacts to collectively form a substantially circular configuration in a deployed position.

公开(公告)号：US08190263B2

公开(公告)日：2012-05-29

申请号：US12617277

申请日：2009-11-12

申请人： Andre Machado ,  Ali Rezai

发明人： Andre Machado ,  Ali Rezai

IPC分类号： A61N1/36

CPC分类号： A61N1/36082 ,  A61N1/36017 ,  A61N1/36025

摘要： Methods of treating various medical conditions by neuromodulation of target sites of a cerebello-thalamo-cortical pathway and/or a cortical-ponto-cerebellar pathway. Such medical conditions include unilateral motor deficits, movement disorders, psychiatric disorders, epilepsy, speech or cognitive deficits associated with hemispheric lesions, visual deficits associated with hemispheric lesions, learning disorders associated with hemispheric lesions, vertigo and/or dizziness, gait disturbances, hereditary/genetic disorders, congenital malformations, infectious disease, degenerative disorders, autoimmune disorders, and metabolic disorders. A method of enhancing memory, learning and/or cognitive capacity in a normal individual by stimulating a target site of a cerebello-thalamo-cortical pathway and/or a cortical-ponto-cerebellar pathway is also provided.

摘要翻译： 通过神经调节大脑 - 皮质 - 皮层途径和/或皮层 - 脑 - 小脑通路的靶位点治疗各种医学病症的方法。 这种医疗状况包括单侧运动障碍，运动障碍，精神障碍，癫痫，与半球病变相关的言语或认知缺陷，与半球病变相关的视力缺陷，与半球病变相关的学习障碍，眩晕和/或头晕，步态障碍，遗传性/ 遗传性疾病，先天性畸形，感染性疾病，退行性疾病，自身免疫性疾病和代谢性疾病。 还提供了通过刺激小脑 - 皮层 - 皮层途径的靶位点和/或皮层 - 小脑 - 小脑途径来增强正常个体的记忆，学习和/或认知能力的方法。