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39 条记录 (耗时 0.031 秒)

    Phenylethylamine derivatives
    5.
    发明授权
    Phenylethylamine derivatives 失效
    苯乙胺衍生物

    公开(公告)号：US06251938B1

    公开(公告)日：2001-06-26

    申请号：US09335555

    申请日：1999-06-18

    申请人： Michael Chorev ,  Tamar Goren ,  Yacov Herzig ,  Jeffrey Sterling ,  Marta Weinstock-Rosin ,  Moussa B. H. Youdim

    发明人： Michael Chorev ,  Tamar Goren ,  Yacov Herzig ,  Jeffrey Sterling ,  Marta Weinstock-Rosin ,  Moussa B. H. Youdim

    IPC分类号： A61K3127

    CPC分类号： C07C271/42 ,  C07C271/56

    摘要： This invention is directed to compounds of the following formula: wherein m is from 0-4; X is O or S; Y is halogeno; R1 is hydrogen or C1-4 alkyl; R2 is hydrogen, C1-4 alkyl or optionally substituted propargyl; and R3 and R4 are each independently hydrogen, C1-8 alkyl, C6-12 aryl, C6-12 cycloalkyl or C6-12 aralkyl, R5 is hydrogen or C1-4 alkyl; and pharmaceutically acceptable salts thereof, provided that when X is O, R2 is optionally substituted propargyl. This invention is also directed to the use of these compounds for treating depression, Attention Deficit Disorder (ADD), Attention Deficit and Hyperactivity Disorder (ADHD), Tourette's Syndrome, Alzheimer's Disease and other dementia's such as senile dementia, dementia of the Parkinson's type, vascular dementia and Lewy body dementia. This invention is further directed to a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier.

    摘要翻译： 本发明涉及下式的化合物：其中m为0-4; X是O或S; Y为卤素; R1是氢或C1-4烷基; R2是氢，C1-4烷基或任选取代的炔丙基; 并且R 3和R 4各自独立地为氢，C 1-8烷基，C 6-12芳基，C 6-12环烷基或C 6-12芳烷基，R 5为氢或C 1-4烷基; 其中X为O时，R2为任选取代的炔丙基。本发明还涉及这些化合物用于治疗抑郁症，注意力缺陷症（ADD），注意力缺陷和多动症（ADHD）的用途， Tourette综合征，阿尔茨海默病和其他痴呆症如老年性痴呆，帕金森氏型痴呆，血管性痴呆和路易体痴呆。本发明还涉及一种药物组合物，其包含治疗有效量的上述化合物和药学上可接受的 载体

    Synthetic peptides and pseudopeptides having osteogenic activity and pharmaceutical compositions containing the same
    10.
    发明授权
    Synthetic peptides and pseudopeptides having osteogenic activity and pharmaceutical compositions containing the same 失效
    具有成骨活性的合成肽和假肽以及含有它们的药物组合物

    公开(公告)号：US07189692B2

    公开(公告)日：2007-03-13

    申请号：US10255679

    申请日：2002-09-27

    申请人： Itai Bab ,  Dan Gazit ,  Chen Yu-Chen ,  Andras Muhlrad ,  Arie Shteyer ,  Michael Chorev

    发明人： Itai Bab ,  Dan Gazit ,  Chen Yu-Chen ,  Andras Muhlrad ,  Arie Shteyer ,  Michael Chorev

    IPC分类号： A61K38/12

    CPC分类号： C07K5/1008 ,  A61K38/00 ,  C07K5/0806 ,  C07K5/126 ,  C07K14/51

    摘要： Cyclic to Synthetic pseudopeptide derivatives of osteogenic growth polypeptide (OGP) and OGP(10-14) which are capable of enhancing bone cell proliferation and bone formation. Pharmaceutical composition comprising as active ingredient at least one pseudopeptide derivative of the invention and to the use of these pseudopeptide derivatives in the preparation of a pharmaceutical composition for stimulating the formation of osteoblastic or fibroblastic cells, enhancing bone formation in osteopenic pathological conditions, repairing fractures, healing wounds, grafting of intraosseous implants, reversing bone loss in osteoporosis and other conditions requiring enhanced bone cells formation.

    摘要翻译： 循环到成骨生长多肽（OGP）和OGP（10-14）的合成假肽衍生物，其能够增强骨细胞增殖和骨形成。 药物组合物，其包含本发明的至少一种假肽衍生物作为活性成分，以及这些假肽衍生物在制备用于刺激成骨细胞或成纤维细胞形成的药物组合物中的用途，增强骨质疏松病理状况中的骨形成，修复骨折， 愈合伤口，骨内植入物移植，逆转骨质疏松症中的骨质流失以及需要增强骨细胞形成的其他病症。