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公开(公告)号：US20120028333A1
公开(公告)日：2012-02-02
申请号：US13262662
申请日：2010-03-31
申请人： Andrea Piatesi , Tilo Habicher , Michael Büschel , Li-Wen Wang , Jürgen Reichert , Rainer Packe-Wirth , Kai-Uwe Baldenius , Erich Kromm , Stefan Häfner , Carsten Schwalb , Hans Wolfgang Höffken
发明人： Andrea Piatesi , Tilo Habicher , Michael Büschel , Li-Wen Wang , Jürgen Reichert , Rainer Packe-Wirth , Kai-Uwe Baldenius , Erich Kromm , Stefan Häfner , Carsten Schwalb , Hans Wolfgang Höffken
CPC分类号： C12N9/0008 , C11D3/38654 , C12N15/63 , C12P7/00 , D06M15/423 , D06M16/003 , D06P1/0004 , D06P1/56
摘要： The invention relates to the use of an enzyme preparation which catalyzes the degradation of formaldehyde for reducing the formaldehyde content in a formaldehyde-containing formulation. In a preferred embodiment, the enzyme preparation contains a formaldehyde dismutase from a Pseudomonas putida strain. Further, the invention refers to a process for reducing the formaldehyde content in cross-linking agents for textile finishing or in polymer dispersions used, e.g. in construction chemistry. Further the invention relates to the use of an enzyme preparation which catalyzes the degradation of aldehydes for reducing the formaldehyde content in an aldehyde-containing formulation. Furthermore, the invention relates to a novel variant of the formaldehyde dismutase from Pseudomonas putida.
摘要翻译： 本发明涉及催化甲醛降解以降低含甲醛制剂中的甲醛含量的酶制剂的用途。 在优选的实施方案中，酶制剂含有恶臭假单胞菌菌株的甲醛歧化酶。 此外，本发明涉及用于降低用于织物整理的交联剂或所用聚合物分散体中的甲醛含量的方法。 在建筑化学。 此外，本发明涉及催化醛降解以降低含醛制剂中的甲醛含量的酶制剂的用途。 此外，本发明涉及恶臭假单胞菌的甲醛歧化酶的新型变体。
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公开(公告)号：US09109200B2
公开(公告)日：2015-08-18
申请号：US13262662
申请日：2010-03-31
申请人： Andrea Piatesi , Tilo Habicher , Michael Büschel , Li-Wen Wang , Jürgen Reichert , Rainer Packe-Wirth , Kai-Uwe Baldenius , Erich Kromm , Stefan Häfner , Carsten Schwalb , Hans Wolfgang Höffken
发明人： Andrea Piatesi , Tilo Habicher , Michael Büschel , Li-Wen Wang , Jürgen Reichert , Rainer Packe-Wirth , Kai-Uwe Baldenius , Erich Kromm , Stefan Häfner , Carsten Schwalb , Hans Wolfgang Höffken
IPC分类号： C12N9/06 , C11D3/386 , C12N15/00 , C12N1/20 , C12P7/00 , C07H21/04 , C12N9/02 , C12N15/63 , D06M16/00 , D06M15/423 , D06P1/00 , D06P1/56
CPC分类号： C12N9/0008 , C11D3/38654 , C12N15/63 , C12P7/00 , D06M15/423 , D06M16/003 , D06P1/0004 , D06P1/56
摘要： The invention relates to the use of an enzyme preparation which catalyzes the degradation of formaldehyde for reducing the formaldehyde content in a formaldehyde-containing formulation. In a preferred embodiment, the enzyme preparation contains a formaldehyde dismutase from a Pseudomonas putida strain. Further, the invention refers to a process for reducing the formaldehyde content in cross-linking agents for textile finishing or in polymer dispersions used, e.g. in construction chemistry. Further the invention relates to the use of an enzyme preparation which catalyzes the degradation of aldehydes for reducing the formaldehyde content in an aldehyde-containing formulation. Furthermore, the invention relates to a novel variant of the formaldehyde dismutase from Pseudomonas putida.
摘要翻译： 本发明涉及催化甲醛降解以降低含甲醛制剂中的甲醛含量的酶制剂的用途。 在优选的实施方案中，酶制剂含有恶臭假单胞菌菌株的甲醛歧化酶。 此外，本发明涉及用于降低用于织物整理的交联剂或所用聚合物分散体中的甲醛含量的方法。 在建筑化学。 此外，本发明涉及催化醛降解以降低含醛制剂中的甲醛含量的酶制剂的用途。 此外，本发明涉及恶臭假单胞菌的甲醛歧化酶的新型变体。
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公开(公告)号：US10316304B2
公开(公告)日：2019-06-11
申请号：US13512202
申请日：2010-11-26
摘要： The invention relates to chimeric endonucleases, comprising a endonuclease and a heterologous DNA binding domain comprising one or more Zn2C6 zinc fingers, as well as methods of targeted integration, targeted deletion or targeted mutation of polynucleotides using chimeric endonucleases.
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4.发明授权Method for the enzyme-catalysed hydrolysis of polyacrylic acid esters, and esterases used therefor 失效聚丙烯酸酯的酶催化水解方法和用于其的酯酶的方法公开(公告)号：US08617858B2
公开(公告)日：2013-12-31
申请号：US13003597
申请日：2009-07-17
申请人： Bernhard Hauer , Hans Wolfgang Höffken , Cecilia Kvarnström Branneby , Helmut Schwab , Sabine Feichtenhofer , Marlene Buchebner , Brigitte Pohn
发明人： Bernhard Hauer , Hans Wolfgang Höffken , Cecilia Kvarnström Branneby , Helmut Schwab , Sabine Feichtenhofer , Marlene Buchebner , Brigitte Pohn
IPC分类号： C12P7/52
CPC分类号： C12P7/62 , C08F8/12 , C12N9/16 , C12N9/18 , C12Y301/01001 , C08F120/18
摘要： The invention relates to a method for the enzyme-catalysed hydrolysis of polyacrylic acid esters. According to the method, at least one polyacrylic acid ester is provided and incubated with at least one enzyme selected from enzymes (EC 3.1) acting on ester bindings, until the ester groups contained in the polyacrylic acid ester are partially or fully hydrolytically split, and optionally the modified polymer obtained thereby is isolated. The invention also relates to the enzymes used and mutants thereof, nucleic acids coding for the enzymes, vectors comprising the nucleic acids, micro-organisms comprising the vectors, and the use of the enzymes, the vectors or the micro-organisms for carrying out a method for the enzyme-catalysed hydrolysis of polyacrylic acid esters. The present application also relates to polymer reaction products that can be obtained by the method, and methods for producing esterases.
摘要翻译： 本发明涉及聚丙烯酸酯的酶催化水解方法。 根据该方法，提供至少一种聚丙烯酸酯，并与至少一种选自作用于酯结合的酶（EC 3.1）的酶进行温育，直到聚丙烯酸酯中所含的酯基部分或完全水解分裂为止，以及 由此分离获得的改性聚合物。 本发明还涉及使用的酶及其突变体，编码酶的核酸，包含核酸的载体，包含载体的微生物，以及使用酶，载体或微生物进行酶 聚丙烯酸酯酶催化水解的方法。 本申请还涉及可以通过该方法获得的聚合物反应产物和生产酯酶的方法。
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公开(公告)号：US06900319B2
公开(公告)日：2005-05-31
申请号：US10100099
申请日：2002-03-19
申请人： Hans-Joachim Boehm , Hans Wolfgang Höffken , Wilfried Hornberger , Stefan Koser , Helmut Mack , Thomas Pfeiffer , Werner Seitz , Thomas Zierke
发明人： Hans-Joachim Boehm , Hans Wolfgang Höffken , Wilfried Hornberger , Stefan Koser , Helmut Mack , Thomas Pfeiffer , Werner Seitz , Thomas Zierke
IPC分类号： A61K31/00 , A61K38/55 , A61P7/02 , C07D205/04 , C07D207/16 , C07D213/53 , C07D213/63 , C07D213/72 , C07D213/78 , C07D213/79 , C07D239/28 , C07D241/14 , C07D241/24 , C07D401/12 , C07K5/06 , C07K5/062 , C07K5/078 , C07D403/12
CPC分类号： C07D213/78 , C07D205/04 , C07D207/16 , C07D239/28 , C07D241/24 , C07D401/12 , C07K5/06165
摘要： The invention relates to a compound of the formula I: or a salt thereof with a physiologically tolerated acid, or stereoisomers thereof, wherein R1, R2, A, B, C and D have the meanings described in the specification.
摘要翻译： 本发明涉及式I化合物或其盐与生理上耐受的酸或其立体异构体，其中R 1，R 2，A，B， C和D具有说明书中描述的含义。
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公开(公告)号：US06444817B1
公开(公告)日：2002-09-03
申请号：US09414681
申请日：1999-10-08
申请人： Hans-Joachim Böhm , Hans Wolfgang Höffken , Wilfried Hornberger , Stefan Koser , Helmut Mack , Thomas Pfeiffer , Werner Seitz , Thomas Zierke
发明人： Hans-Joachim Böhm , Hans Wolfgang Höffken , Wilfried Hornberger , Stefan Koser , Helmut Mack , Thomas Pfeiffer , Werner Seitz , Thomas Zierke
IPC分类号： C07D23942
CPC分类号： C07D213/78 , C07D205/04 , C07D207/16 , C07D239/28 , C07D241/24 , C07D401/12 , C07K5/06165
摘要： Compounds of the formula where A, B, D, R1 and R2 have the meanings stated in the description, are described. The compounds are suitable for controlling diseases. The novel compounds are prepared via compounds of the formula H2N—CH2—G—M.
摘要翻译： A，B，D，R1和R2的化合物具有描述中所述的含义。 该化合物适用于控制疾病。新化合物通过式H2N-CH2-G-M的化合物制备。
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公开(公告)号：US08658400B2
公开(公告)日：2014-02-25
申请号：US13140255
申请日：2009-12-16
IPC分类号： C12P17/00 , C12P7/02 , C12N9/04 , C12N1/20 , C12P21/06 , C12N15/00 , C07D333/12 , C07H21/04 , C07K1/00
CPC分类号： C12P17/00 , C12N9/0006 , C12P7/02 , C12P7/22
摘要： The present invention relates to novel phenylethanol dehydrogenase mutants, to a method for the manufacture thereof; to coded nucleic acid sequences therefor, to expression cassettes, to vectors and recombinant microorganisms that contain said sequences; to a method for the biocatalytic synthesis of substituted, optically active alcohols and to the use of said mutants; and particularly to a method for manufacturing duloxetine alcohol or duloxetine, comprising a synthesis step catalyzed biocatalytic by said mutants.
摘要翻译： 本发明涉及新型苯乙醇脱氢酶突变体，涉及其制备方法; 将其编码的核酸序列，表达盒，载体和包含所述序列的重组微生物; 涉及用于生物催化合成取代的光学活性醇和使用所述突变体的方法; 特别涉及一种制造度洛西汀醇或度洛西汀的方法，其包括由所述突变体催化生物催化的合成步骤。
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公开(公告)号：US20120324603A1
公开(公告)日：2012-12-20
申请号：US13511727
申请日：2010-11-26
IPC分类号： C12N9/22 , C12N15/62 , C12N15/63 , C07H21/04 , A01H5/00 , C12N1/19 , C12N5/10 , C12N1/13 , C12Q1/68 , C12N15/87 , C12N15/55 , C12N1/15
CPC分类号： C12N15/8213 , C07K2319/80 , C07K2319/81 , C12N9/22 , C12N15/1082
摘要： The invention relates to chimeric endonucleases, comprising an endonuclease and a heterologous DNA binding domain, as well as methods of targeted integration, targeted deletion or targeted mutation of polynucleotides using chimeric endonucleases.
摘要翻译： 本发明涉及包含核酸内切酶和异源DNA结合结构域的嵌合核酸内切酶，以及使用嵌合内切核酸酶的多核苷酸的靶向整合，靶向缺失或靶向突变的方法。
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公开(公告)号：US20110250655A1
公开(公告)日：2011-10-13
申请号：US13140255
申请日：2009-12-16
CPC分类号： C12P17/00 , C12N9/0006 , C12P7/02 , C12P7/22
摘要： The present invention relates to novel phenylethanol dehydrogenase mutants, to a method for the manufacture thereof; to coded nucleic acid sequences therefor, to expression cassettes, to vectors and recombinant microorganisms that contain said sequences; to a method for the biocatalytic synthesis of substituted, optically active alcohols and to the use of said mutants; and particularly to a method for manufacturing duloxetine alcohol or duloxetine, comprising a synthesis step catalyzed biocatalytic by said mutants.
摘要翻译： 本发明涉及新型苯乙醇脱氢酶突变体，涉及其制备方法; 将其编码的核酸序列，表达盒，载体和包含所述序列的重组微生物; 涉及用于生物催化合成取代的光学活性醇和使用所述突变体的方法; 特别涉及一种制造度洛西汀醇或度洛西汀的方法，其包括由所述突变体催化生物催化的合成步骤。
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公开(公告)号：US06878536B2
公开(公告)日：2005-04-12
申请号：US10076157
申请日：2002-02-15
申请人： Markus Pompejus , Harald Seulberger , Hans Wolfgang Höffken , Jose Luis Revuelta Doval , Alberto Jimenez , Maria Angeles Santos Garcia
发明人： Markus Pompejus , Harald Seulberger , Hans Wolfgang Höffken , Jose Luis Revuelta Doval , Alberto Jimenez , Maria Angeles Santos Garcia
IPC分类号： C12N15/09 , C07K14/39 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N9/02 , C12N9/04 , C12N9/10 , C12N9/12 , C12N15/00 , C12N15/52 , C12N15/53 , C12N15/80 , C12P19/28 , C12P25/00 , C12R1/645
CPC分类号： C12N9/93 , C12N9/0006 , C12N9/1077 , C12N9/1235 , C12P25/00
摘要： Genes of purine biosynthesis from Ashbya gossypii are used in microbial riboflavin synthesis.
摘要翻译： 用于生物合成核黄素的嘌呤生物合成基因。
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