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1.发明申请PROCESS FOR THE BIOLOGICAL PRODUCTION OF 3-HYDROXYPROPIONIC ACID WITH HIGH YIELD 审中-公开具有高生产力的3-羟基丙酸生物工艺公开(公告)号：US20110144377A1
公开(公告)日：2011-06-16
申请号：US12815461
申请日：2010-06-15
申请人： Andrew C. Eliot , Tina K. Van Dyk
发明人： Andrew C. Eliot , Tina K. Van Dyk
CPC分类号： C12P7/42 , C12N9/0006 , C12N9/0008 , C12N9/16 , C12N9/88
摘要： The present invention provides a microorganism useful for biologically producing 3-hydroxypropionic acid from a fermentable carbon source. Further, the microorganism comprises disruptions in specified genes and alterations in the expression levels of specified genes that are useful in a higher yielding process to produce 3-hydroxypropionic acid, compositions comprising renewably sourced 3-hydroxypropionic acid provided by said microorganism, and industrial relevant products made using such renewably sourced 3-hydroxypropionic acid.
摘要翻译： 本发明提供可用于从可发酵碳源生物学生产3-羟基丙酸的微生物。 此外，微生物包含特定基因的破坏以及可用于产生3-羟基丙酸的较高产率过程的特定基因的表达水平的改变，包含由所述微生物提供的可再生来源的3-羟基丙酸的组合物和工业相关产品 使用这种可再生来源的3-羟基丙酸制备。
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2.发明授权Butanol dehydrogenase enzyme from the bacterium Achromobacter xylosoxidans 有权丁醇脱氢酶从细菌无色杆菌xylosoxidans公开(公告)号：US08691540B2
公开(公告)日：2014-04-08
申请号：US13479643
申请日：2012-05-24
IPC分类号： C12P7/16 , C12N9/04 , C12N1/12 , C12N1/13 , C12N1/14 , C12N1/21 , C12N15/56 , C12N1/18 , C12N1/20
摘要： From a bacterial strain isolated from an environmental sample, after enrichment in medium containing 1-butanol as the carbon source, a new enzyme with butanol dehydrogenase activity was identified. The enzyme can convert butyraldehyde to 1-butanol, isobutyraldehyde to isobutanol, as well as 2-butanone to 2-butanol and thus is useful for biosynthesis of butanol in recombinant microbial hosts producing these substrates. The encoding gene, named sadB, was isolated from the strain identified as an isolate of Achromobacter xylosoxidans.
摘要翻译： 从分离自环境样品的细菌菌株中，在含有1-丁醇作为碳源的培养基中富集后，鉴定出具有丁醇脱氢酶活性的新酶。 该酶可将丁醛转化为1-丁醇，异丁醛至异丁醇，以及2-丁酮转化为2-丁醇，因此可用于生产这些底物的重组微生物宿主中丁醇的生物合成。 将编码基因命名为sadB，从鉴定为无色杆菌木糖苷的分离株的菌株中分离出来。
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公开(公告)号：US08273558B2
公开(公告)日：2012-09-25
申请号：US12966333
申请日：2010-12-13
摘要： Methods for the fermentative production of four carbon alcohols is provided. Specifically, butanol, preferably isobutanol is produced by the fermentative growth of a recombinant bacterium expressing an isobutanol biosynthetic pathway.
摘要翻译： 提供了发酵生产四种碳醇的方法。 具体地，通过表达异丁醇生物合成途径的重组细菌的发酵生长来生产丁醇，优选异丁醇。
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公开(公告)号：US20110300594A1
公开(公告)日：2011-12-08
申请号：US13131138
申请日：2009-12-11
申请人： Joachim C. Ritter , Sourav Kumar Sengupta , Hasan Dindi , Robert D. Fallon , Ekaterini Korovessi , Andrew C. Eliot , John Joseph Hagedorn
发明人： Joachim C. Ritter , Sourav Kumar Sengupta , Hasan Dindi , Robert D. Fallon , Ekaterini Korovessi , Andrew C. Eliot , John Joseph Hagedorn
IPC分类号： C12P7/44
CPC分类号： C10G3/50 , C10G3/46 , C10G3/54 , C10G2300/1014 , C10G2300/1018 , C10L1/02 , C11C1/002 , C12P7/6409 , Y02E50/13 , Y02P30/20
摘要： This invention provides a process of making a linear dicarboxylic acid of C10, C12, C14, C16 or C18 chain length, the process comprising providing a feed which is a renewable resource, contacting the feed with a catalyst in the presence of hydrogen and at a temperature of about 250° C. to about 425° C. and at a pressure of about 500 psig to about 2500 psig (3450 kPa to about 17,250 kPa) to produce a hydrocarbon product having at least a 5:1 ratio of even-numbered alkanes to odd-numbered alkanes and comprising a linear alkane of Cn chain length; and fermenting at least a portion of the linear alkane of Cn chain length to a linear dicarboxylic acid of Cn chain length, wherein n=10, 12, 14, 16 or 18. The catalyst comprises an oxide, molybdenum, and one or more active metals selected from the group consisting of nickel, cobalt, and mixtures thereof and the catalyst is in sulfided form.
摘要翻译： 本发明提供了制备C 10，C 12，C 14，C 16或C 18链长度的线性二羧酸的方法，该方法包括提供作为可再生资源的进料，在氢气存在下使进料与催化剂接触 温度为约250℃至约425℃，压力为约500psig至约2500psig（3450kPa至约17,250kPa），以产生具有至少5:1比例偶数编号的烃产物 烷烃至奇数烷烃并且包含Cn链长度的直链烷烃; 并将Cn链长度的直链烷烃的至少一部分发酵成C n链长度的线性二羧酸，其中n = 10,12,14,16或18.所述催化剂包含氧化物，钼和一种或多种活性物质 选自镍，钴及其混合物的金属，催化剂为硫化形式。
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公开(公告)号：US09068190B2
公开(公告)日：2015-06-30
申请号：US13539125
申请日：2012-06-29
IPC分类号： C12P21/06 , C12P7/16 , C12N9/00 , C12N1/20 , C07H21/04 , C12N15/81 , C12N9/04 , C12N9/02 , C12N9/06 , C12N9/10 , C12N9/88 , C12N15/52 , C12N15/70 , C12N15/75 , C12N15/74
CPC分类号： C12P7/16 , C12N9/0006 , C12N9/0008 , C12N9/0016 , C12N9/1022 , C12N9/1096 , C12N9/88 , C12N15/52 , C12N15/70 , C12N15/74 , C12N15/746 , C12N15/75 , C12N15/81 , C12Y101/01001 , C12Y101/01002 , C12Y101/01086 , C12Y102/00 , C12Y102/01003 , C12Y102/04004 , C12Y202/01006 , C12Y401/01072 , C12Y402/01009 , Y02E50/10 , Y02E50/343 , Y02P20/52
摘要： Methods for the fermentative production of four carbon alcohols is provided. Specifically, butanol, preferably isobutanol is produced by the fermentative growth of a recombinant bacterium expressing an isobutanol biosynthetic pathway.
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公开(公告)号：US20120196341A1
公开(公告)日：2012-08-02
申请号：US13281872
申请日：2011-10-26
申请人： Gail K. Donaldson , Andrew C. Eliot , Vasantha Nagarajan , Charles E. Nakamura , Lixuan Lisa Huang
发明人： Gail K. Donaldson , Andrew C. Eliot , Vasantha Nagarajan , Charles E. Nakamura , Lixuan Lisa Huang
IPC分类号： C12P7/16
CPC分类号： C12N9/88 , C12N9/0006 , C12N9/1205 , C12N9/78 , C12P7/16 , C12P7/26 , Y02E50/10
摘要： Methods for the fermentive production of four carbon alcohols are provided. Specifically, butanol, preferably 2-butanol is produced by the fermentive growth of a recombinant bacteria expressing a 2-butanol biosynthetic pathway. The recombinant microorganisms and methods of the invention can also be adapted to produce 2-butanone, an intermediate in the 2-butanol biosynthetic pathways disclosed herein.
摘要翻译： 提供了发酵生产四种碳醇的方法。 具体地，通过表达2-丁醇生物合成途径的重组细菌的发酵生长来制备丁醇，优选2-丁醇。 本发明的重组微生物和方法也可适用于生产2-丁酮，本文公开的2-丁醇生物合成途径中的中间体。
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7.发明授权Butanol dehydrogenase enzyme from the bacterium Achromobacter xylosoxidans 有权丁醇脱氢酶从细菌无色杆菌xylosoxidans公开(公告)号：US08188250B2
公开(公告)日：2012-05-29
申请号：US12430356
申请日：2009-04-27
摘要： From a bacterial strain isolated from an environmental sample, after enrichment in medium containing 1-butanol as the carbon source, a new enzyme with butanol dehydrogenase activity was identified. The enzyme can convert butyraldehyde to 1-butanol, isobutyraldehyde to isobutanol, as well as 2-butanone to 2-butanol and thus is useful for biosynthesis of butanol in recombinant microbial hosts producing these substrates. The encoding gene, named sadB, was isolated from the strain identified as an isolate of Achromobacter xylosoxidans.
摘要翻译： 从分离自环境样品的细菌菌株中，在含有1-丁醇作为碳源的培养基中富集后，鉴定出具有丁醇脱氢酶活性的新酶。 该酶可将丁醛转化为1-丁醇，异丁醛至异丁醇，以及2-丁酮转化为2-丁醇，因此可用于生产这些底物的重组微生物宿主中丁醇的生物合成。 将编码基因命名为sadB，从鉴定为无色杆菌木糖苷的分离株的菌株中分离出来。
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公开(公告)号：US20110112334A1
公开(公告)日：2011-05-12
申请号：US12939315
申请日：2010-11-04
CPC分类号： C12P7/16 , C12N9/0006 , C12N9/0008 , C12N9/0016 , C12N9/1022 , C12N9/1096 , C12N9/88 , C12N15/52 , C12N15/70 , C12N15/74 , C12N15/746 , C12N15/75 , C12N15/81 , C12Y101/01001 , C12Y101/01002 , C12Y101/01086 , C12Y102/00 , C12Y102/01003 , C12Y102/04004 , C12Y202/01006 , C12Y401/01072 , C12Y402/01009 , Y02E50/10 , Y02E50/343 , Y02P20/52
摘要： Methods for the fermentative production of four carbon alcohols is provided. Specifically, butanol, preferably isobutanol is produced by the fermentative growth of a recombinant bacterium expressing an isobutanol biosynthetic pathway.
摘要翻译： 提供了发酵生产四种碳醇的方法。 具体地，通过表达异丁醇生物合成途径的重组细菌的发酵生长来生产丁醇，优选异丁醇。
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公开(公告)号：US20090155870A1
公开(公告)日：2009-06-18
申请号：US12111359
申请日：2008-04-29
申请人： GAIL K. DONALDSON , Andrew C. Eliot , Lori Ann Maggio-Hall , Vasantha Nagarajan , Charles E. Nakamura , Jean-Francois Tomb
发明人： GAIL K. DONALDSON , Andrew C. Eliot , Lori Ann Maggio-Hall , Vasantha Nagarajan , Charles E. Nakamura , Jean-Francois Tomb
CPC分类号： C12N15/63 , C12N9/0006 , C12N9/1205 , C12N9/78 , C12N9/88 , C12P7/16 , C12P7/26 , Y02E50/10
摘要： Methods for the fermentive production of four carbon alcohols are provided. Specifically, butanol, preferably 2-butanol is produced by the fermentive growth of a recombinant bacteria expressing a 2-butanol biosynthetic pathway. The recombinant microorganisms and methods of the invention can also be adapted to produce 2-butanone, an intermediate in the 2-butanol biosynthetic pathways disclosed herein. Specifically disclosed herein are the use of coenzyme B12-independent butanediol dehydratases that catalyzes the substrate to product conversion of 2,3-butanediol to 2-butanone in the process of producing 2-butanol and 2-butanone.
摘要翻译： 提供了发酵生产四种碳醇的方法。 具体地，通过表达2-丁醇生物合成途径的重组细菌的发酵生长来制备丁醇，优选2-丁醇。 本发明的重组微生物和方法也可适用于生产2-丁酮，本文公开的2-丁醇生物合成途径中的中间体。 本文具体公开的是在生产2-丁醇和2-丁酮的过程中催化基质以产生2,3-丁二醇转化为2-丁酮的辅酶B12非依赖性丁二醇脱水酶的用途。
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公开(公告)号：US20130171706A1
公开(公告)日：2013-07-04
申请号：US13539125
申请日：2012-06-29
CPC分类号： C12P7/16 , C12N9/0006 , C12N9/0008 , C12N9/0016 , C12N9/1022 , C12N9/1096 , C12N9/88 , C12N15/52 , C12N15/70 , C12N15/74 , C12N15/746 , C12N15/75 , C12N15/81 , C12Y101/01001 , C12Y101/01002 , C12Y101/01086 , C12Y102/00 , C12Y102/01003 , C12Y102/04004 , C12Y202/01006 , C12Y401/01072 , C12Y402/01009 , Y02E50/10 , Y02E50/343 , Y02P20/52
摘要： Methods for the fermentative production of four carbon alcohols is provided. Specifically, butanol, preferably isobutanol is produced by the fermentative growth of a recombinant bacterium expressing an isobutanol biosynthetic pathway.
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