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    Hydrogel enhanced medical devices
    3.
    发明授权
    Hydrogel enhanced medical devices 有权
    水凝胶增强医疗器械

    公开(公告)号：US09327058B2

    公开(公告)日：2016-05-03

    申请号：US13382348

    申请日：2010-07-07

    申请人： Andrew P. Isch

    发明人： Andrew P. Isch

    IPC分类号： A61F2/82 ,  A61L31/06 ,  A61L31/10 ,  A61L31/14

    CPC分类号： A61L31/06 ,  A61L31/10 ,  A61L31/145 ,  C08L75/04

    摘要： The present disclosure generally provides a stent-graft for insertion into a body vessel that comprises hydrophilic polyurethane hydrogel cuffs and an elongated cylindrical body. This stent-graft exhibits an enhanced ability to maintain its original position when placed into a patient and resist the potential of migration without causing excessive discomfort to the patient. Upon exposure to bodily fluids, the cuffs of the stent-graft expand to exert a sealing or anchoring force against the wall of the body vessel. Such a stent-graft overcomes many of the problems associated with conventional stent-grafts as currently used in many different applications, for example, endovascular repair and ureteral drainage.

    摘要翻译： 本公开通常提供用于插入身体容器中的支架移植物，其包括亲水性聚氨酯水凝胶箍和细长圆柱体。 当放置在患者体内时，该支架移植物具有增强的维持其原始位置的能力，并抵抗迁移的可能性，而不会对患者造成过度的不适。 暴露于体液时，支架移植物的袖口膨胀以对身体血管的壁施加密封或锚定力。 这种支架移植物克服了许多与传统的支架移植相关的问题，如目前在许多不同的应用中所使用的，例如血管内修复和输尿管引流。

    HYDROGEL ENHANCED MEDICAL DEVICES
    4.
    发明申请
    HYDROGEL ENHANCED MEDICAL DEVICES 有权
    HYDROGEL增强医疗器械

    公开(公告)号：US20120123527A1

    公开(公告)日：2012-05-17

    申请号：US13382348

    申请日：2010-07-07

    申请人： Andrew P. Isch

    发明人： Andrew P. Isch

    IPC分类号： A61F2/82

    CPC分类号： A61L31/06 ,  A61L31/10 ,  A61L31/145 ,  C08L75/04

    摘要： The present disclosure generally provides a stent-graft for insertion into a body vessel that comprises hydrophilic polyurethane hydrogel cuffs and an elongated cylindrical body. This stent-graft exhibits an enhanced ability to maintain its original position when placed into a patient and resist the potential of migration without causing excessive discomfort to the patient. Upon exposure to bodily fluids, the cuffs of the stent-graft expand to exert a sealing or anchoring force against the wall of the body vessel. Such a stent-graft overcomes many of the problems associated with conventional stent-grafts as currently used in many different applications, for example, endovascular repair and ureteral drainage.

    摘要翻译： 本公开通常提供用于插入身体容器中的支架移植物，其包括亲水性聚氨酯水凝胶箍和细长圆柱体。 当放置在患者体内时，该支架移植物具有增强的维持其原始位置的能力，并抵抗迁移的可能性，而不会对患者造成过度的不适。 暴露于体液时，支架移植物的袖口膨胀以对身体血管的壁施加密封或锚定力。 这种支架移植物克服了许多与传统的支架移植相关的问题，如目前在许多不同的应用中所使用的，例如血管内修复和输尿管引流。

    Medical Devices Incorporating a Bioactive and Methods of Preparing Such Devices
    6.
    发明申请
    Medical Devices Incorporating a Bioactive and Methods of Preparing Such Devices 审中-公开
    纳入生物活性的医疗器械及其制备方法

    公开(公告)号：US20120027819A1

    公开(公告)日：2012-02-02

    申请号：US13251821

    申请日：2011-10-03

    申请人： Andrew P. Isch ,  Patrick H. Ruane ,  Waleska Pérez-Segarra

    发明人： Andrew P. Isch ,  Patrick H. Ruane ,  Waleska Pérez-Segarra

    IPC分类号： A61K9/00 ,  A61P23/00 ,  A61F2/82 ,  A61K31/445

    CPC分类号： A61L31/16 ,  A61L2300/402

    摘要： One embodiment provides a medical device comprising a base material and a bioactive in contact with the base material, the bioactive having a proton binding site with a non-ionic form and an ionic form, the bioactive being less soluble in water when the proton binding site is in the non-ionic form than when the proton binding site is in the ionic form, wherein at least 5% w/w of the bioactive is present with the proton binding site in the non-ionic form and wherein the bioactive is not an anesthetic. Another embodiment provides such a medical device where the bioactive is an anesthetic and where the device is not a ureteral stent. Another aspect provides method of manufacturing such devices.

    摘要翻译： 一个实施方案提供了包含基础材料和与基底材料接触的生物活性的医疗装置，所述生物活性物质具有非离子形式和离子形式的质子结合位点，当质子结合位点 与质子结合位点处于离子形式相比是非离子形式，其中至少5％w / w的生物活性存在于非离子形式的质子结合位点，并且其中生物活性物质不是 麻药。 另一个实施方案提供了这样的医疗装置，其中生物活性是麻醉剂，并且其中装置不是输尿管支架。 另一方面提供了制造这种装置的方法。

    Mandrel and method for coating open-cell implantable endovascular structures
    7.
    发明授权
    Mandrel and method for coating open-cell implantable endovascular structures 有权
    用于涂层开放细胞可植入血管内结构的心轴和方法

    公开(公告)号：US08092864B2

    公开(公告)日：2012-01-10

    申请号：US12199189

    申请日：2008-08-27

    申请人： Andrew P. Isch ,  Jeff P. Little ,  Patrick H. Ruane

    发明人： Andrew P. Isch ,  Jeff P. Little ,  Patrick H. Ruane

    IPC分类号： B05D3/00

    CPC分类号： B05D1/02 ,  A61F2/88 ,  A61F2220/0033 ,  A61F2220/0041 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2240/001 ,  A61F2250/0067 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2420/02 ,  B05D1/002 ,  C08L67/04

    摘要： Methods of coating a medical device are provided to improve coating uniformity and reduce coating irregularities while reducing direct coating of the luminal surface of the medical device. Preferably, methods of coating a tubular medical device include the steps of: positioning the tubular medical device around a mandrel coating assembly, mounting the tubular medical device on the mandrel coating assembly and spraying a coating solution including a therapeutic agent and a solvent onto the abluminal surface of the tubular medical device mounted on the mandrel coating assembly. The mandrel coating assembly may include an axial member of a diameter that is less than the diameter of the lumen of the tubular medical device and at least one annular projection extending from the axial member to an outer surface having a diameter greater than or substantially equal to the diameter of the lumen of the medical device. Improved coating uniformity may be achieved by providing an annular space between the luminal surface of the medical device and an axial member. Coating on the luminal surface may be minimized by providing an axial member having an outer diameter that is greater than the maximum width or length of the spray contacting the axial member after passing through the openings in the medical device.

    摘要翻译： 提供涂覆医疗装置的方法以改善涂层的均匀性并减少涂层不规则，同时减少医疗装置的腔表面的直接涂覆。 优选地，涂覆管状医疗装置的方法包括以下步骤：将管状医疗装置定位在心轴涂层组件周围，将管状医疗装置安装在心轴涂层组件上，并将包括治疗剂和溶剂的包衣溶液喷涂在腹腔镜 安装在心轴涂层组件上的管状医疗装置的表面。 心轴涂层组件可以包括直径小于管状医疗装置的内腔的直径的轴向构件，以及从轴向构件延伸到外表面的至少一个环形凸起，该外表面的直径大于或基本上等于 医疗装置的管腔直径。 可以通过在医疗装置的腔表面和轴向构件之间提供环形空间来实现改进的涂层均匀性。 通过提供具有大于在穿过医疗装置中的开口之后接触轴向构件的喷雾器的最大宽度或长度的外径的轴向构件，腔体表面上的涂层可以最小化。

    MANDREL AND METHOD FOR COATING OPEN-CELL IMPLANTABLE ENDOVASCULAR STRUCTURES
    8.
    发明申请
    MANDREL AND METHOD FOR COATING OPEN-CELL IMPLANTABLE ENDOVASCULAR STRUCTURES 有权
    用于涂覆开放细胞可植入性内膜结构的方法和方法

    公开(公告)号：US20090061072A1

    公开(公告)日：2009-03-05

    申请号：US12199189

    申请日：2008-08-27

    申请人： Andrew P. Isch ,  Jeff P. Little ,  Patrick H. Ruane

    发明人： Andrew P. Isch ,  Jeff P. Little ,  Patrick H. Ruane

    IPC分类号： B05D5/00

    CPC分类号： B05D1/02 ,  A61F2/88 ,  A61F2220/0033 ,  A61F2220/0041 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2240/001 ,  A61F2250/0067 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2420/02 ,  B05D1/002 ,  C08L67/04

    摘要： Methods of coating a medical device are provided to improve coating uniformity and reduce coating irregularities while reducing direct coating of the luminal surface of the medical device. Preferably, methods of coating a tubular medical device include the steps of: positioning the tubular medical device around a mandrel coating assembly, mounting the tubular medical device on the mandrel coating assembly and spraying a coating solution including a therapeutic agent and a solvent onto the abluminal surface of the tubular medical device mounted on the mandrel coating assembly. The mandrel coating assembly may include an axial member of a diameter that is less than the diameter of the lumen of the tubular medical device and at least one annular projection extending from the axial member to an outer surface having a diameter greater than or substantially equal to the diameter of the lumen of the medical device. Improved coating uniformity may be achieved by providing an annular space between the luminal surface of the medical device and an axial member. Coating on the luminal surface may be minimized by providing an axial member having an outer diameter that is greater than the maximum width or length of the spray contacting the axial member after passing through the openings in the medical device.

    摘要翻译： 提供涂覆医疗装置的方法以改善涂层的均匀性并减少涂层不规则，同时减少医疗装置的腔表面的直接涂覆。 优选地，涂覆管状医疗装置的方法包括以下步骤：将管状医疗装置定位在心轴涂层组件周围，将管状医疗装置安装在心轴涂层组件上，并将包括治疗剂和溶剂的包衣溶液喷涂在腹腔镜 安装在心轴涂层组件上的管状医疗装置的表面。 心轴涂层组件可以包括直径小于管状医疗装置的内腔的直径的轴向构件，以及从轴向构件延伸到外表面的至少一个环形凸起，该外表面的直径大于或基本上等于 医疗装置的管腔直径。 可以通过在医疗装置的腔表面和轴向构件之间提供环形空间来实现改进的涂层均匀性。 通过提供具有大于在穿过医疗装置中的开口之后接触轴向构件的喷雾器的最大宽度或长度的外径的轴向构件，腔体表面上的涂层可以最小化。

    IMPERMEABLE GRAFT FABRIC COATING AND METHODS
    10.
    发明申请
    IMPERMEABLE GRAFT FABRIC COATING AND METHODS 审中-公开
    不可磨损的织物涂层和方法

    公开(公告)号：US20140135898A1

    公开(公告)日：2014-05-15

    申请号：US13828161

    申请日：2013-03-14

    申请人： Zachary Wagner ,  Andrew P. Isch

    发明人： Zachary Wagner ,  Andrew P. Isch

    IPC分类号： A61F2/07

    CPC分类号： A61F2/07 ,  A61L27/18 ,  A61L27/34 ,  A61L27/50 ,  A61L27/507 ,  A61L2400/10 ,  C08L83/04 ,  C08L67/02

    摘要： Composite grafts and implantable medical devices include a polymeric layer and a non-porous silicone coating that includes a two-part dispersion of silicone material in an organic solvent. The polymeric layer has a first surface and a second surface, where the first surface and the second surface are positioned on opposite sides of the polymeric layer, and where the first surface is the blood-contacting surface and the second surface is the tissue-contacting surface. The non-porous silicone coating includes a two-part dispersion of silicone material in an organic solvent. The silicone coating is disposed on at least the first surface of the polymeric layer such that the at least first surface or a portion thereof has a substantially reduced permeability or is entirely impermeable. The coating does not substantially increase the thickness of the medical device and reduces the surface friction of the medical device while making the graft layer impermeable to fluids. Methods of making the implantable medical device and methods of repairing or treating a defective vessel in an individual, including treating AAA and thoracic aneurysm, are also provided.

    摘要翻译： 复合移植物和可植入医疗装置包括聚合物层和无孔硅树脂涂层，其包括硅酮材料在有机溶剂中的两份分散体。 聚合物层具有第一表面和第二表面，其中第一表面和第二表面位于聚合物层的相对侧上，并且其中第一表面是血液接触表面，而第二表面是组织接触的 表面。 无孔硅涂层包括硅酮材料在有机溶剂中的两部分分散体。 硅氧烷涂层设置在聚合物层的至少第一表面上，使得至少第一表面或其一部分具有显着降低的渗透性或完全不渗透。 涂层基本上不增加医疗装置的厚度，并且在使接枝层不能渗透流体的同时降低医疗装置的表面摩擦。 还提供了制造可植入医疗装置的方法和修复或治疗个体中的有缺陷的血管的方法，包括治疗AAA和胸动脉瘤。