公开(公告)号：US20070231858A1

公开(公告)日：2007-10-04

申请号：US11690159

申请日：2007-03-23

Applicant: Ramesh Patel ,  Yijun Chen ,  Steven Goldberg ,  Iqbal Gill ,  Animesh Goswami ,  Thomas Tully ,  William Parker ,  Ronald Hanson

Inventor： Ramesh Patel ,  Yijun Chen ,  Steven Goldberg ,  Iqbal Gill ,  Animesh Goswami ,  Thomas Tully ,  William Parker ,  Ronald Hanson

IPC: C12P21/06 ,  C12P13/04 ,  C12N9/90 ,  C07D213/55

CPC classification number: C12N9/1096 ,  C07D213/55 ,  C12N9/0016 ,  C12P13/04 ,  C12P17/12 ,  C12P41/002

Abstract: Disclosed and claimed herein are novel biocatalysts for converting racemic mixtures of amino acids to an enantiomerically pure (S) form of the amino acid, methods for their use, and the enantiomerically enriched products of such biocatalytic processes.

Abstract translation: 本文公开和要求保护的是用于将氨基酸的外消旋混合物转化为对映体纯的（S）形式的氨基酸的新型生物催化剂，其使用方法以及这些生物催化方法的对映异构体富集的产物。

公开(公告)号：US20060286646A1

公开(公告)日：2006-12-21

申请号：US11421112

申请日：2006-05-31

Applicant: Ramesh Patel ,  Linda Chu ,  Robert Johnson ,  Zhiwei Guo ,  Yijun Chen ,  Steven Goldberg ,  Ronald Hanson ,  Animesh Goswami ,  Kishta Katipally

Inventor： Ramesh Patel ,  Linda Chu ,  Robert Johnson ,  Zhiwei Guo ,  Yijun Chen ,  Steven Goldberg ,  Ronald Hanson ,  Animesh Goswami ,  Kishta Katipally

IPC: C12P17/16 ,  C07D487/04

CPC classification number: C12N9/0006 ,  C07D487/04 ,  C12P17/165

Abstract: The invention relates to a process for the enzymatic, stereoselective reduction of ketone compounds to provide chiral alcohols, for example the compound of formula Ib:

Abstract translation: 本发明涉及一种用于酶促立构选择性还原酮化合物以提供手性醇的方法，例如式Ib化合物：

公开(公告)号：US5997907A

公开(公告)日：1999-12-07

申请号：US994410

申请日：1997-12-19

Applicant: Animesh Goswami ,  Paul-Joel Derian

Inventor： Animesh Goswami ,  Paul-Joel Derian

IPC: A61L2/10 ,  C08B37/00 ,  C08L5/14 ,  A61K9/50 ,  A61K7/00 ,  A61K9/14 ,  A61K47/00

CPC classification number: A61L2/10 ,  C08B37/0096 ,  C08L5/14

Abstract: Methods for enhancing the stability of thickening agent solutions, especially guar solutions, by sterilizing the solution with UV light and/or adding a surfactant to the solution are disclosed. Thickening agent solutions and powders, including guar solutions and powders, as well as products made from these solutions and powders, are also disclosed.

Abstract translation: 公开了通过用UV光灭菌溶液和/或向溶液中加入表面活性剂来增强增稠剂溶液，尤其是瓜尔胶溶液的稳定性的方法。 还公开了增稠剂溶液和粉末，包括瓜尔胶溶液和粉末，以及由这些溶液和粉末制成的产品。

公开(公告)号：US5108916A

公开(公告)日：1992-04-28

申请号：US361049

申请日：1989-06-05

Applicant: Carrington S. Cobbs ,  Michael J. Barton ,  Lin Peng ,  Animesh Goswami ,  Adrien P. Malick ,  John P. Hamman ,  Gary J. Calton

Inventor： Carrington S. Cobbs ,  Michael J. Barton ,  Lin Peng ,  Animesh Goswami ,  Adrien P. Malick ,  John P. Hamman ,  Gary J. Calton

IPC: C12N9/20 ,  C12N9/18 ,  C12N11/08 ,  C12P7/40 ,  C12P7/62 ,  C12P7/64 ,  C12P41/00 ,  C12R1/72

CPC classification number: C12P7/6418 ,  C12N9/18 ,  C12P41/003 ,  C12P41/005 ,  C12P7/40 ,  C12P7/6436 ,  C12P7/6445 ,  C12P7/6454 ,  C12P7/6472

Abstract: An immobilized isozyme of Lipase MY or AY from Candida rugosa is used for stereoselectively hydrolyzing racemic mixtures of esters of 2-substituted acids, other than 2-halo propionic acids, transesterifying esters or acids or esterify acids or alcohols, at high enantiomeric excess, in an organic solvent. Immobilization of the isozyme may be carried out in the presence of an organic acid such as stearic acid. The immobilized isozyme may be used with a fatty acid or fatty acid ester that increases stereoselectivity or rate of hydrolysis of a mixture of racemic esters.

公开(公告)号：US07393667B2

公开(公告)日：2008-07-01

申请号：US11421112

申请日：2006-05-31

Applicant: Ramesh N. Patel ,  Linda Nga Hoong Chu ,  Robert M. Johnson ,  Zhiwei Guo ,  Yijun Chen ,  Steven L. Goldberg ,  Ronald L. Hanson ,  Animesh Goswami ,  Kishta Katipally

Inventor： Ramesh N. Patel ,  Linda Nga Hoong Chu ,  Robert M. Johnson ,  Zhiwei Guo ,  Yijun Chen ,  Steven L. Goldberg ,  Ronald L. Hanson ,  Animesh Goswami ,  Kishta Katipally

IPC: C12P17/16 ,  C07D253/08 ,  C12N1/00

CPC classification number: C12N9/0006 ,  C07D487/04 ,  C12P17/165

Abstract: The invention relates to a process for the enzymatic, stereoselective reduction of ketone compounds to provide chiral alcohols, for example the compound of formula Ib:

Abstract translation: 本发明涉及一种用于酶促立构选择性还原酮化合物以提供手性醇的方法，例如式Ib化合物：

公开(公告)号：US5532350A

公开(公告)日：1996-07-02

申请号：US196357

申请日：1994-02-15

Applicant: Ian W. Cottrell ,  Animesh Goswami ,  Manjit S. Chowdhary

Inventor： Ian W. Cottrell ,  Animesh Goswami ,  Manjit S. Chowdhary

IPC: A61L15/28 ,  C08B3/06 ,  C08B3/22

CPC classification number: A61L15/28 ,  Y10S106/90 ,  Y10S604/904

Abstract: A solid composition of matter comprising one or more polysaccharides which has been cross-linked with either titanium or zirconium cross-linking agents is provided. The composition demonstrates absorbent properties and is useful in absorbent articles of manufacture. Also provided is a method for preparing the compositions.

Abstract translation: 提供了包含一种或多种已经与钛或锆交联剂交联的多糖的物质的固体组合物。 该组合物显示出吸收性能并且可用于吸收制品。 还提供了制备组合物的方法。

公开(公告)号：US5175100A

公开(公告)日：1992-12-29

申请号：US724554

申请日：1991-06-24

Applicant: Animesh Goswami

Inventor： Animesh Goswami

IPC: C12P7/40 ,  C12P41/00

CPC classification number: C12P41/005 ,  C12P7/40

Abstract: 2-Arylpropionic acids such as ketoprofen, ibuprofen and naproxen can be stereospecifically resolved from their esters by hydrolysis using liver enzymes and particularly liver acetone powders derived from specific animals such as dog, pigeon, horse and goat.

Abstract translation: 2-芳基丙酸如酮洛芬，布洛芬和萘普生可以通过水解使用肝酶，特别是衍生自特定动物如狗，鸽，马和山羊的肝丙酮粉末从其酯中立即专一地分解。

公开(公告)号：US20090298794A1

公开(公告)日：2009-12-03

申请号：US12473346

申请日：2009-05-28

Applicant: William N. Washburn ,  Saleem Ahmad ,  Pratik Devasthale ,  Jeffrey A. Robl ,  Animesh Goswami ,  Zhiwei Guo ,  Ramesh N. Patel

Inventor： William N. Washburn ,  Saleem Ahmad ,  Pratik Devasthale ,  Jeffrey A. Robl ,  Animesh Goswami ,  Zhiwei Guo ,  Ramesh N. Patel

IPC: A61K31/519 ,  C07D495/04 ,  C07F9/6512 ,  A61K31/675 ,  C12P17/16 ,  A61P3/00 ,  A61P25/00 ,  A61P29/00

CPC classification number: C07D495/04

Abstract: The present invention provides compounds having the following Formula IA and IB, which are useful as MCHR1 antagonists, and includes prodrugs and pharmaceutically acceptable salts thereof:

Abstract translation: 本发明提供具有以下式IA和IB的化合物，其可用作MCHR1拮抗剂，并且包括其前药和药学上可接受的盐：

公开(公告)号：US06800477B2

公开(公告)日：2004-10-05

申请号：US10092263

申请日：2002-03-06

Applicant: Ramesh Patel ,  Animesh Goswami ,  Linda N. Chu ,  Venkata B. Nanduri ,  Steven L. Goldberg ,  Robert M. Johnston ,  Mary Jo Donovan ,  K. David Mirfakhrae

Inventor： Ramesh Patel ,  Animesh Goswami ,  Linda N. Chu ,  Venkata B. Nanduri ,  Steven L. Goldberg ,  Robert M. Johnston ,  Mary Jo Donovan ,  K. David Mirfakhrae

IPC: C12P4100

CPC classification number: C12P7/22 ,  Y10S435/911 ,  Y10S435/938

Abstract: The present invention is directed to novel stereoselective processes for the preparation of (S)-1-arylethanols by the reduction of the corresponding keto group containing compounds by microorganisms. (S)-1-arylethanols are useful as intermediates in the synthesis of compounds that are inhibitors of &ggr;-secretase useful in the treatment of Alzheimer's disease.

Abstract translation: 本发明涉及通过微生物还原相应的含有酮基的化合物来制备（S）-1-芳基乙醇的新的立体选择性方法。 （S）-1-芳基乙醇可用作合成作为可用于治疗阿尔茨海默病的γ-分泌酶的抑制剂的化合物的中间体。

公开(公告)号：US5281534A

公开(公告)日：1994-01-25

申请号：US885923

申请日：1992-05-18

Applicant: Animesh Goswami

Inventor： Animesh Goswami

IPC: C12P7/40 ,  C12P41/00

CPC classification number: C12P41/004 ,  C12P7/40

Abstract: Chrysanthemic acid esters can be geometrically separated into its cis- and trans- isomers as well as resolved into enantiomers by hydrolysis using liver enzymes, particularly from sheep, goat, bovine, dog, chicken, mouse, calf, horse, pigeon, rabbit, cat, whale and rat and particularly horse.

Abstract translation: 菊酸酯可以几何分离成其顺式和反式异构体，并通过使用肝酶，特别是羊，山羊，牛，狗，鸡，小鼠，小牛，马，鸽，兔，猫的肝酶水解而分解为对映异构体 ，鲸鱼和老鼠，特别是马。