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1.发明申请公开(公告)号：US20090155874A1
公开(公告)日：2009-06-18
申请号：US12279300
申请日：2007-02-13
申请人： Anthony Clark , Jêrome Maury , Mohammad Ali Asadollahi , Kasper Møller , Jens Nielsen , Michel Schalk
发明人： Anthony Clark , Jêrome Maury , Mohammad Ali Asadollahi , Kasper Møller , Jens Nielsen , Michel Schalk
摘要： The present invention relates to a microorganism capable of producing a terpene of choice. The microorganism expresses a heterologous pathway for the formation of isoprene units and, preferably, a heterologous terpene synthase. In this way, high amounts of terpene can be isolated from the medium of the microorganism.
摘要翻译： 本发明涉及能够产生选择的萜烯的微生物。 微生物表达用于形成异戊二烯单元的异源途径，优选异源萜烯合酶。 以这种方式，可以从微生物的培养基中分离出大量的萜烯。
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2.发明授权公开(公告)号：US08048658B2
公开(公告)日：2011-11-01
申请号：US12279300
申请日：2007-02-13
申请人： Anthony Clark , Jérôme Maury , Mohammad Ali Asadollahi , Kasper Møller , Jens Nielsen , Michel Schalk
发明人： Anthony Clark , Jérôme Maury , Mohammad Ali Asadollahi , Kasper Møller , Jens Nielsen , Michel Schalk
IPC分类号： C12P5/00 , C12N1/19 , C12N1/63 , C07C403/00
摘要： The present invention relates to a microorganism capable of producing a terpene of choice. The microorganism expresses a heterologous pathway for the formation of isoprene units and, preferably, a heterologous terpene synthase. In this way, high amounts of terpene can be isolated from the medium of the microorganism.
摘要翻译： 本发明涉及能够产生选择的萜烯的微生物。 微生物表达用于形成异戊二烯单元的异源途径，优选异源萜烯合酶。 以这种方式，可以从微生物的培养基中分离出大量的萜烯。
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公开(公告)号：US20150079646A1
公开(公告)日：2015-03-19
申请号：US14370959
申请日：2012-12-17
申请人： Jens Nielsen , Verena Siewers , Yun Chen , Laurent Daviet , Michel Schalk
发明人： Jens Nielsen , Verena Siewers , Yun Chen , Laurent Daviet , Michel Schalk
CPC分类号： C12N15/81 , C12N9/0006 , C12N9/0008 , C12N9/1025 , C12N9/1029 , C12N9/93 , C12P5/007 , C12P7/16 , C12P7/625 , C12Y101/01002 , C12Y102/01004 , C12Y203/01009 , C12Y602/01001 , Y02E50/10
摘要： The present invention relates to yeast cells producing high levels of acetoacetyl-CoA. It also relates to a method for making such yeast cells and to the use of such yeast cells in a method for producing acetyl-CoA derived products.
摘要翻译： 本发明涉及产生高含量乙酰乙酰辅酶A的酵母细胞。 本发明还涉及制备这种酵母细胞的方法以及在制备乙酰辅酶A衍生产物的方法中使用这种酵母细胞。
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公开(公告)号：US09745602B2
公开(公告)日：2017-08-29
申请号：US14128074
申请日：2012-06-01
申请人： Laurent Daviet , Michel Schalk , Jens Nielsen , Verena Siewers , Christoph Knuf , Gionata Scalcinati
发明人： Laurent Daviet , Michel Schalk , Jens Nielsen , Verena Siewers , Christoph Knuf , Gionata Scalcinati
IPC分类号： C12P5/00 , C12N15/00 , C12N1/20 , C12N9/10 , C12N1/14 , C12Q1/68 , C07H21/04 , C12P5/02 , C12N9/88 , C12N15/81 , C12N15/63
CPC分类号： C12P5/026 , C12N9/1085 , C12N9/88 , C12N15/635 , C12N15/81 , C12P5/002 , C12P5/007 , C12P5/02
摘要： The present invention relates to the control of gene expression by a heterologous glucose-regulated promoter, to microorganisms in which gene expression is controlled by a heterologous glucose-regulated promoter and to methods using said microorganisms for the production of terpenes during glucose-limited fed-batch fermentation.
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公开(公告)号：US09670494B2
公开(公告)日：2017-06-06
申请号：US14370959
申请日：2012-12-17
申请人： Jens Nielsen , Verena Siewers , Yun Chen , Laurent Daviet , Michel Schalk
发明人： Jens Nielsen , Verena Siewers , Yun Chen , Laurent Daviet , Michel Schalk
IPC分类号： C12P7/16 , C12N9/90 , C12N15/81 , C12N9/04 , C12N9/10 , C12N9/00 , C12P5/00 , C12P7/62 , C12N9/02
CPC分类号： C12N15/81 , C12N9/0006 , C12N9/0008 , C12N9/1025 , C12N9/1029 , C12N9/93 , C12P5/007 , C12P7/16 , C12P7/625 , C12Y101/01002 , C12Y102/01004 , C12Y203/01009 , C12Y602/01001 , Y02E50/10
摘要： The present invention relates to yeast cells producing high levels of acetoacetyl-CoA. It also relates to a method for making such yeast cells and to the use of such yeast cells in a method for producing acetyl-CoA derived products.
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公开(公告)号：US20140113343A1
公开(公告)日：2014-04-24
申请号：US14128074
申请日：2012-06-01
申请人： Lauren Daviet , Michel Schalk , Jens Nielsen , Verena Siewers , Christoph Knuf , Gionata Scalcinati
发明人： Lauren Daviet , Michel Schalk , Jens Nielsen , Verena Siewers , Christoph Knuf , Gionata Scalcinati
CPC分类号： C12P5/026 , C12N9/1085 , C12N9/88 , C12N15/635 , C12N15/81 , C12P5/002 , C12P5/007 , C12P5/02
摘要： The present invention relates to the control of gene expression by a heterologous glucose-regulated promoter, to microorganisms in which gene expression is controlled by a heterologous glucose-regulated promoter and to methods using said microorganisms for the production of terpenes during glucose-limited fed-batch fermentation.
摘要翻译： 本发明涉及通过异源葡萄糖调节启动子对基因表达由异源葡萄糖调节的启动子控制的基因表达的控制以及使用所述微生物用于在葡萄糖限制性加料期间产生萜烯的方法， 分批发酵。
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公开(公告)号：US07790426B2
公开(公告)日：2010-09-07
申请号：US11840535
申请日：2007-08-17
申请人： Michel Schalk , Anthony Clark
发明人： Michel Schalk , Anthony Clark
摘要： The invention relates to sesquiterpene synthases and methods of their production and use. In one embodiment, the invention provides nucleic acids comprising a nucleotide sequence as described herein that encodes for at least one sesquiterpene synthases. In a further embodiment, the invention also provides for sesquiterpene synthases and methods of making and using these enzymes. For example, sesquiterpene synthases of the invention may be used to convert farnesyl-pyrophosphate to various oxygenated and aliphatic sesquiterpenes including valencene, bicyclo-germacrene, cubebol and delta-cadinene.
摘要翻译： 本发明涉及倍半萜合酶及其生产和使用方法。 在一个实施方案中，本发明提供核酸，其包含编码至少一种倍半萜合酶的本文所述的核苷酸序列。 在另一个实施方案中，本发明还提供倍半萜合酶和制备和使用这些酶的方法。 例如，本发明的倍半萜烯合成酶可用于将焦亚磷酸法呢酯转化为各种含氧和脂族倍半萜，包括戊烯，双环锗锗，立方体和δ-卡汀。
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公开(公告)号：US20080213832A1
公开(公告)日：2008-09-04
申请号：US11840535
申请日：2007-08-17
申请人： Michel Schalk , Anthony Clark
发明人： Michel Schalk , Anthony Clark
摘要： The invention relates to sesquiterpene synthases and methods of their production and use. In one embodiment, the invention provides nucleic acids comprising a nucleotide sequence as described herein that encodes for at least one sesquiterpene synthases. In a further embodiment, the invention also provides for sesquiterpene synthases and methods of making and using these enzymes. For example, sesquiterpene synthases of the invention may be used to convert farnesyl-pyrophosphate to various oxygenated and aliphatic sesquiterpenes including valencene, bicyclo-germacrene, cubebol and delta-cadinene.
摘要翻译： 本发明涉及倍半萜合酶及其生产和使用方法。 在一个实施方案中，本发明提供核酸，其包含编码至少一种倍半萜合酶的本文所述的核苷酸序列。 在另一个实施方案中，本发明还提供倍半萜合酶和制备和使用这些酶的方法。 例如，本发明的倍半萜烯合成酶可用于将焦亚磷酸法呢酯转化为各种含氧和脂族倍半萜，包括戊烯，双环锗锗，立方体和δ-卡汀。
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公开(公告)号：US07273735B2
公开(公告)日：2007-09-25
申请号：US11094607
申请日：2005-03-30
申请人： Michel Schalk , Anthony Clark
发明人： Michel Schalk , Anthony Clark
摘要： The invention relates to sesquiterpene synthases and methods of their production and use. In one embodiment, the invention provides nucleic acids comprising a nucleotide sequence as described herein that encodes for at least one sesquiterpene synthases. In a further embodiment, the invention also provides for sesquiterpene synthases and methods of making and using these enzymes. For example, sesquiterpene synthases of the invention may be used to convert farnesyl-pyrophosphate to various oxygenated and aliphatic sesquiterpenes including valencene, bicyclo-germacrene, cubebol and delta-cadinene.
摘要翻译： 本发明涉及倍半萜合酶及其生产和使用方法。 在一个实施方案中，本发明提供核酸，其包含编码至少一种倍半萜合酶的本文所述的核苷酸序列。 在另一个实施方案中，本发明还提供倍半萜合酶和制备和使用这些酶的方法。 例如，本发明的倍半萜烯合成酶可用于将焦亚磷酸法呢酯转化为各种含氧和脂族倍半萜，包括戊烯，双环锗锗，立方体和δ-卡汀。
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公开(公告)号：US20050210549A1
公开(公告)日：2005-09-22
申请号：US11094607
申请日：2005-03-30
申请人： Michel Schalk , Anthony Clark
发明人： Michel Schalk , Anthony Clark
摘要： The invention relates to sesquiterpene synthases and methods of their production and use. In one embodiment, the invention provides nucleic acids comprising a nucleotide sequence as described herein that encodes for at least one sesquiterpene synthases. In a further embodiment, the invention also provides for sesquiterpene synthases and methods of making and using these enzymes. For example, sesquiterpene synthases of the invention may be used to convert farnesyl-pyrophosphate to various oxygenated and aliphatic sesquiterpenes including valencene, bicyclo-germacrene, cubebol and delta-cadinene.
摘要翻译： 本发明涉及倍半萜合酶及其生产和使用方法。 在一个实施方案中，本发明提供核酸，其包含编码至少一种倍半萜合酶的本文所述的核苷酸序列。 在另一个实施方案中，本发明还提供倍半萜合酶和制备和使用这些酶的方法。 例如，本发明的倍半萜烯合成酶可用于将焦亚磷酸法呢酯转化为各种含氧和脂族倍半萜，包括戊烯，双环锗锗，立方体和δ-卡汀。
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