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    EYE TREATMENTS EMPLOYING SERUM FROM WHOLE BLOOD
    5.
    发明申请
    EYE TREATMENTS EMPLOYING SERUM FROM WHOLE BLOOD 有权

    公开(公告)号：US20210046111A1

    公开(公告)日：2021-02-18

    申请号：US17086454

    申请日：2020-11-01

    申请人： David Muller

    发明人： David Muller

    IPC分类号： A61K35/16 ,  A61K9/00 ,  A61K38/13

    摘要： Eye drops for treating dry eye include serum extracted from whole blood. An example method includes collecting whole blood from one or more donors (e.g., allogenic whole blood); separating the whole blood to obtain a serum; applying radiation to the serum for viral inactivation; and adding one or more additives to the serum to produce eye drops.

    SYSTEMS AND METHODS FOR PRODUCING AND APPLYING TISSUE-RELATED STRUCTURES
    6.
    发明申请
    SYSTEMS AND METHODS FOR PRODUCING AND APPLYING TISSUE-RELATED STRUCTURES 审中-公开
    用于生产和应用组织相关结构的系统和方法

    公开(公告)号：US20160325499A1

    公开(公告)日：2016-11-10

    申请号：US15109731

    申请日：2015-01-05

    申请人： David Muller

    发明人： David Muller

    IPC分类号： B29C67/00 ,  A61L27/38 ,  A61F2/14 ,  A61L27/36

    CPC分类号： A61L27/3641 ,  A61F2/142 ,  A61F9/013 ,  A61F2240/002 ,  A61L27/3804 ,  A61L2430/16 ,  B29C64/112 ,  B29C64/20 ,  B29C64/386 ,  B29K2071/02 ,  B29K2105/0058 ,  B29K2105/24 ,  B29K2995/0056 ,  B29L2031/7532

    摘要： Embodiments produce and apply tissue-related structures in connection with various medical treatments. Such structures can be applied, as grafts, implants, scaffolds, etc., to replace, modify, or engineer tissue in the body. For example, such structures can be employed to reshape the cornea in order to correct vision. One example includes a tissue cell source including tissue cells in a fluid and a printer configured to deposit the tissue cells in a three-dimensional arrangement to form a tissue cell-based structure. Another example includes a source including a photoreactive liquid precursor, an application system configured to deposit the photoreactive liquid precursor in one or more applications to form a three-dimensional polymer-based structure, and an illumination system configured to deliver light to the photoreactive liquid precursor deposited by the application system and to solidify the photoreactive liquid precursor into the three-dimensional polymer-based structure.

    摘要翻译： 实施例生产并应用与各种医疗治疗有关的组织相关结构。 这样的结构可以作为移植物，植入物，支架等应用来代替，改变或设计身体中的组织。 例如，可以使用这种结构来重塑角膜以矫正视力。 一个实例包括包括流体中的组织细胞的组织细胞源和被配置为以三维排列沉积组织细胞以形成基于组织细胞的结构的打印机。 另一个实例包括源包括光反应性液体前体，配置成在一个或多个应用中沉积光反应性液体前体以形成基于三维聚合物的结构的施加系统，以及被配置为将光传递到光反应性液体前体的照明系统 通过应用系统沉积并将光反应性液体前体固化成基于三维聚合物的结构。

    Eye therapy system
    7.
    发明授权
    Eye therapy system 失效
    眼科治疗系统

    公开(公告)号：US08712536B2

    公开(公告)日：2014-04-29

    申请号：US12753523

    申请日：2010-04-02

    申请人： David Muller ,  Thomas Ryan ,  Ronald Scharf

    发明人： David Muller ,  Thomas Ryan ,  Ronald Scharf

    IPC分类号： A61N1/00

    CPC分类号： A61B18/18 ,  A61B18/1815 ,  A61F9/007 ,  A61F9/0079 ,  A61F9/013 ,  A61F2009/00872 ,  A61N1/403

    摘要： An electrical energy applicator in one embodiment extends from a proximal end to a distal end. The energy conducting applicator includes, at the proximal end, a connection to one or more electrical energy sources. The energy conducting applicator directs electrical energy from the one or more electrical energy sources to the distal end. The energy conducting applicator includes an outer conductor and an inner conductor extending to the distal end. The outer conductor and the inner conductor are separated by a gap. The outer conductor includes a plurality of moveable outer segments and the inner conductor includes a plurality of moveable inner segments. The plurality of outer segments and the plurality of inner segments form a total contact surface at the distal end. The total contact surface is positionable at a surface of an eye. The electrical energy is applied to the eye according to the total contact surface.

    摘要翻译： 一个实施例中的电能施加器从近端延伸到远端。 能量传导施加器在近端处包括与一个或多个电能源的连接。 能量传导施加器将电能从一个或多个电能源引导到远端。 能量传导施加器包括外导体和延伸到远端的内导体。 外导体和内导体间隔开。 外导体包括多个可移动外部段，并且内部导体包括多个可移动的内部段。 多个外部段和多个内部段在远端处形成总接触表面。 总接触表面可定位在眼睛的表面。 电能根据总接触面施加到眼睛。

    Eye therapy system
    9.
    发明授权
    Eye therapy system 失效
    眼科治疗系统

    公开(公告)号：US08460278B2

    公开(公告)日：2013-06-11

    申请号：US12572019

    申请日：2009-10-01

    申请人： David Muller

    发明人： David Muller

    IPC分类号： A61B18/18

    CPC分类号： A61B18/14 ,  A61B2018/00005 ,  A61B2018/00755 ,  A61B2018/00875 ,  A61F9/0079 ,  A61F9/013

    摘要： A system includes a conducting element that conducts energy from an energy source to apply therapy to an eye. The system includes a covering configured to be removably attached to the conducting element. The covering has an interface surface that is positionable at an eye. At least a portion of the interface surface includes one or more dielectric materials. Energy is deliverable to the eye through the interface surface. In one aspect, the covering provides an electrical insulator to minimize the concentration of electrical current in the area of contact with the eye. In another aspect, the covering allows the eye to be cooled during the application of energy without directly applying coolant to the eye. In another aspect, the covering includes a dielectric layer that may provide varying impedances that allow different patterns for energy delivery. In another aspect, the sheath promotes hygienic use of the conducting element.

    摘要翻译： 一种系统包括从能量源传导能量以将治疗应用于眼睛的导电元件。 该系统包括构造成可移除地附接到导电元件的覆盖物。 覆盖物具有可在眼睛处定位的界面。 界面表面的至少一部分包括一种或多种介电材料。 能量通过界面可传递给眼睛。 在一个方面，覆盖物提供电绝缘体以最小化与眼睛接触的区域中的电流的浓度。 另一方面，覆盖物允许眼睛在施加能量期间被冷却，而不直接将冷却剂施加到眼睛。 在另一方面，覆盖物包括可提供允许不同图案用于能量输送的变化阻抗的介电层。 另一方面，护套促进卫生使用导电元件。

    SYSTEMS AND METHODS FOR ACTIVATING CROSS-LINKING IN AN EYE
    10.
    发明申请
    SYSTEMS AND METHODS FOR ACTIVATING CROSS-LINKING IN AN EYE 审中-公开
    用于在眼睛中进行交叉连接的系统和方法

    公开(公告)号：US20110288466A1

    公开(公告)日：2011-11-24

    申请号：US13086019

    申请日：2011-04-13

    申请人： David Muller ,  John Marshall ,  Stephen L. Trokel ,  Peter Hersh ,  Pavel Kamaev

    发明人： David Muller ,  John Marshall ,  Stephen L. Trokel ,  Peter Hersh ,  Pavel Kamaev

    IPC分类号： A61M37/00

    CPC分类号： A61K31/525 ,  A61F9/008 ,  A61F2009/00844 ,  A61F2009/00857 ,  A61F2009/00872 ,  A61N5/062

    摘要： Devices and approaches for activating cross-linking within at least one eye component of an eye to stabilize and strengthen corneal tissue or other tissues of the eye. Cross-linking is activated within the at least one eye component by conveying a cross-linking agent to regions of the at least one eye component and then activating the cross-linking agent by delivering an initiating element to the at least one eye component. Approaches disclosed herein allow for precisely controlling the three dimensional region of strengthened tissue by conveying the cross-linking agent to regions of the at least one eye component. Approaches allow for conveying the cross-linking agent to a depth below the corneal surface such that cross-linking is activated below the corneal surface.

    摘要翻译： 激活眼睛的至少一个眼睛部件内的交联的装置和方法，以稳定和加强眼睛的角膜组织或其他组织。 通过将交联剂输送到至少一种眼睛部件的区域，然后通过将起始元件递送至至少一种眼睛部件来激活交联剂，在至少一种眼睛部件内激活交联。 本文公开的方法允许通过将交联剂输送到至少一种眼睛部件的区域来精确地控制强化组织的三维区域。 方法允许将交联剂输送到角膜表面下方的深度，使得交联在角膜表面下被激活。