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1.发明授权Centrifuge vessel with coaxial waste chamber having cap to prevent waste fluid transfer from the chamber into the vessel 失效具有同轴废物室的离心容器具有盖以防止废液从室转移到容器中
公开(公告)号：US5244635A
公开(公告)日：1993-09-14
申请号：US901430
申请日：1992-06-19
CPC分类号： B01L3/502 , B01L3/5021 , G01N21/07 , G01N33/5302 , G01N33/5304 , B01L2300/0681 , B01L2400/0409
摘要： A centrifuge vessel for performing immunoassays, affinity chromatography, and like experiments includes a center tube and an outer waste chamber. A biomaterial is held within the center tube and is capable of binding specific analytes in test samples. In operation the centrifuge vessel is rotated at high speed about its longitudinal axis, thereby causing all fluid within the center tube to be transported into the outer waste chamber while the analyte of interest remains bound to the biomaterial positioned within the center tube In the centrifuge vessel, a cap connected to the outer waste chamber and extending over the center tube includes structure for preventing waste fluid expelled to the waste chamber from re-entering the center tube. In a first embodiment, the cap is either constructed from or the inside surface is coated with a hydrophobic material which repels fluids back into the waste chamber. In a second embodiment, the cap includes a dam which allows fluid to pass into the waste chamber but blocks the migration of waste fluid back to the center tube. In a third embodiment, the cap includes a sponge that allows fluids in the center tube influenced by the intense centrifugal forces generated during high speed rotation to pass into the waste chamber, but which prevents fluids in the waste chamber, which are influenced by relatively weaker forces, from returning to the center tube.
摘要翻译： 用于进行免疫测定，亲和层析和类似实验的离心容器包括中心管和外部废物室。 生物材料保持在中心管内，并且能够结合测试样品中的特异性分析物。 在操作中，离心机容器围绕其纵向轴线以高速旋转，从而使得中心管内的所有流体被输送到外部废物室中，而感兴趣的分析物仍然结合到位于中心管内的生物材料。在离心机容器 连接到外部废物室并且在中心管上延伸的盖包括用于防止排出到废物室的废液再次进入中心管的结构。 在第一实施例中，盖子由或由内表面涂覆疏水材料构成，该疏水材料将流体排斥回废物室。 在第二实施例中，盖包括允许流体进入废物室但阻止废液返回到中心管的迁移的坝。 在第三实施例中，盖包括海绵，其允许受高速旋转期间产生的强烈离心力影响的中心管中的流体进入废物室，但是这防止废物室中的流体受相对较弱的影响 力量，返回中心管。
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公开(公告)号：US5149501A
公开(公告)日：1992-09-22
申请号：US471416
申请日：1990-01-29
CPC分类号： G01N35/00594 , G01N21/07 , G01N35/025 , G01N2035/00495 , G01N2035/00504 , G01N2035/0446 , G01N35/00693 , G01N35/10 , G01N35/1004 , Y10S435/975 , Y10S436/808 , Y10S436/809 , Y10T436/111666
摘要： An instrument (50) automatically determines the concentrations of HDL cholesterol, LDL cholesterol, total cholesterol and triglycerides for a sample (80) of whole, anticoagulated blood placed in a doughnut shaped container (10). The sample (80) is first separated into its blood cell and plasma (84) constituents using high speed centrifugation (54) and a thixotropic gel (82). Part of the plasma (84) is then deposited in an HDL separation chamber (14) where LDL cholesterol and VLDL cholesterol are precipitated by a reagent and the precipitant is sedimented by high speed centrifugation (54) against V-shaped grooves (40) in the outermost wall (38) of the HDL separation chamber (14). Part of the plasma (84) is diluted ten-fold. The supernatant in the HDL separation chamber is then placed in a cuvette reaction chamber (b 18) where it reacts with a cholesterol reagent. The diluted plasma is placed in two other cuvette reaction chambers (18) where it reacts with chloesterol and triglycerides reagents, respectively. Calibration reagents, stored in storage chambers (20), react in two other cuvette reaction chambers (18) to establish a reference absorbance. A pipettor (58) handles all the fluid transfers in the doughnut shaped container (10) and operates in conjunction with a slow speed motor (56) that precisely moves the spindle (52) on which the doughnut shaped container (10) is mounted. A colorimetric measuring system (70, 72, and 74) monitors the absorbance of chemical reactions occurring in the cuvette chambers (18).
摘要翻译： 仪器（50）自动确定放置在环形容器（10）中的全部抗凝血液样品（80）的HDL胆固醇，低密度脂蛋白胆固醇，总胆固醇和甘油三酯的浓度。 首先使用高速离心（54）和触变凝胶（82）将样品（80）分离成其血细胞和血浆（84）成分。 然后将等离子体（84）的一部分沉积在HDL分离室（14）中，其中LDL胆固醇和VLDL胆固醇被试剂沉淀，并且沉淀剂通过高速离心（54）沉降到V形槽（40）上 HDL分离室（14）的最外壁（38）。 部分血浆（84）稀释十倍。 然后将HDL分离室中的上清液置于比色皿反应室（b18）中，在其中它与胆固醇试剂反应。 将稀释的血浆置于另外两个比色杯反应室（18）中，分别与氯甲醇酯和甘油三酯试剂反应。 存储在储存室（20）中的校准试剂在另外两个反应池反应室（18）中反应以建立参考吸光度。 移液器（58）处理环形容器（10）中的所有流体传送并与低速电动机（56）一起操作，该慢速电动机精确地移动安装有环形容器（10）的心轴（52）。 比色测量系统（70,72和74）监测在比色皿室（18）中发生的化学反应的吸光度。
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公开(公告)号：US20050220669A1
公开(公告)日：2005-10-06
申请号：US10813575
申请日：2004-03-31
申请人： Ilya Malyarov , Thomas Palmieri
发明人： Ilya Malyarov , Thomas Palmieri
CPC分类号： G01N21/76 , G01N21/645 , G01N35/0092 , G01N35/0095 , G01N35/021 , G01N2035/00524 , G01N2035/00564 , G01N2035/0093 , G01N2035/0408 , Y10T436/113332
摘要： A rotary luminometer subsystem presents test vessels to a detection mechanism to be read as part of the automated immunoassay analyzer system. The rotary luminometer provides a read station separate from that of the transportation element of the luminometer. Within the read station, a housing and shield eliminates light leakage from the sample under test. In addition, the read station regulates the intensity of the light by providing an attenuation capability.
摘要翻译： 旋转光度计子系统将测试容器呈现为检测机构，作为自动化免疫分析仪系统的一部分进行读取。 旋转发光计提供与发光计的传输元件分离的读站。 在读站内，外壳和屏蔽层可以消除被测样品的漏光。 此外，读站通过提供衰减能力来调节光的强度。
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公开(公告)号：US5885530A
公开(公告)日：1999-03-23
申请号：US113513
申请日：1998-07-10
申请人： Arthur L. Babson , Thomas Palmieri , Anthony P. Montalbano , Chris P. Montalbano , Greg A. Montalbano , Eric C. Fleischer
发明人： Arthur L. Babson , Thomas Palmieri , Anthony P. Montalbano , Chris P. Montalbano , Greg A. Montalbano , Eric C. Fleischer
CPC分类号： B01L3/50853 , G01N35/02 , G01N35/1002 , G01N2035/00435 , G01N2035/0405 , G01N2035/0451 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/115831 , Y10T436/25375 , Y10T436/25625 , Y10T436/2575
摘要： An improved automated immunoassay analyzer including a high throughput automated immunoassay system which can perform high volume testing on a broad range of analytes while selecting from among a diverse set of immunoassays for any given sample. The immunoanalyzer has the capacity to perform a wide range of different types of immunoassays by facile storage and automated combination aboard the instrument among a wide variety of different types of reagents and heterogenous immunoassay beads stored on-board the instrument. The automated design allows reduced user interface (e.g., tests are performed automatically from computer input) including the ability to order, perform and reassay tests reflexively based on test results without operator intervention. Further, the inventive analyzer is not sample tube specific; that is, an instrument that can accept sample tube sizes within a broad size range. The inventive automated immunoassay analyzer also provides a re-useable sample dilution well, and a high speed bead washing station that eliminates the need for assay tubes having integral, waste fluid collection chambers.
摘要翻译： 一种改进的自动免疫测定分析仪，其包括高通量自动化免疫测定系统，其可以在宽范围的分析物上进行高体积测试，同时从任何给定样品的多种免疫测定中进行选择。 免疫分析仪具有通过在仪器上存储的各种不同类型的试剂和异源免疫测定珠子中的便利储存和自动化组合来执行各种不同类型的免疫测定的能力。 自动设计允许减少用户界面（例如，从计算机输入自动执行测试），包括基于没有操作员干预的测试结果反复地排序，执行和重新测试测试的能力。 此外，本发明的分析仪不是样品管特异性的; 也就是说，可以在宽范围内接受样品管尺寸的仪器。 本发明的自动免疫测定分析仪还提供可重复使用的样品稀释孔和高速珠洗涤台，其不需要具有整体的废液收集室的测定管。
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公开(公告)号：US5029583A
公开(公告)日：1991-07-09
申请号：US431914
申请日：1989-11-06
申请人： Peter M. Meserol , Thomas Palmieri
发明人： Peter M. Meserol , Thomas Palmieri
CPC分类号： A61B5/157 , A61B5/14532 , A61B5/1455 , A61B5/150022 , A61B5/150412 , A61B5/150633 , A61B5/150702 , A61B5/15113 , A61B5/15117 , A61B5/15128 , A61B5/15194 , G01N21/251 , G01N2021/0371 , G01N21/78 , G01N2201/122 , G01N2201/126
摘要： An optical analyzer for determining an analyte in a fluid of interest such as a body fluid of interest satisfying the foregoing need and embodying the present invention may include a housing; combination optically transparent cuvette and lancet mounted removably in the housing, the cuvette may receive an optically transparent reagent test system for reacting with the body fluid to produce a change in at least one optical transmissive characteristic of the system indicative of the analyte; a cuvette carrier mounted slidably in the housing and for removably receiving the cuvette; a spring actuator mounted in the housing and connected to the cuvette carrier, the spring actuator may be compressed and released to advance the carrier and thereby advance the lancet into engagement with a portion of a body to produce the body fluid; depth control apparatus for controlling the depth of penetration of the lancet into the body portion; an electrooptical system mounted in the housing in optical engagement with the cuvette and for passing a light beam through the cuvette and the reagent system and for receiving the light beam modified by the change in optical transmissive characteristic of the system and for transmitting computation signals indicative of the analyte to a computer; a computer mounted in the housing for receiving the computation signals and for comparing the computation signals against predetermined data to produce display signals indicative of the analyte; a display mounted in the housing and for receiving the display signals and for providing a vehicle display indicative of the analyte; and control switches mounted in the housing and connected to the computer for controlling the operation of the computer.
摘要翻译： 用于确定感兴趣的流体（例如满足上述需要的体液的分析物）并体现本发明的光学分析仪可以包括壳体; 组合的光学透明比色杯和可拆卸地安装在壳体中的刺血针，反应杯可以接收光学透明的试剂测试系统，用于与体液反应以产生指示分析物的系统的至少一个光学透射特性的变化; 比色杯托架，其可滑动地安装在所述壳体中并用于可移除地接收所述比色皿; 安装在壳体中并连接到比色杯托架的弹簧致动器可以压缩和释放弹簧致动器以使托架前进，从而使刺血针与身体的一部分接合以产生体液; 深度控制装置，用于控制刺血针穿入体部的深度; 安装在壳体中的电光学系统与比色皿光学接合并使光束通过比色杯和试剂系统，并用于接收由系统的光学透射特性的改变而修改的光束，并且用于发射指示 分析物到计算机; 安装在壳体中用于接收计算信号并用于将计算信号与预定数据进行比较以产生指示分析物的显示信号的计算机; 安装在壳体中并用于接收显示信号并提供指示分析物的车辆显示器的显示器; 以及安装在壳体中并连接到计算机以控制计算机的操作的控制开关。
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6.发明申请公开(公告)号：US20050220670A1
公开(公告)日：2005-10-06
申请号：US10813604
申请日：2004-03-31
申请人： Thomas Palmieri , Arthur Babson , Ilya Malyarov , David Stein
发明人： Thomas Palmieri , Arthur Babson , Ilya Malyarov , David Stein
CPC分类号： G01N35/021 , G01N35/0092 , G01N2035/00356 , G01N2035/00524 , G01N2035/00564 , G01N2035/0093 , G01N2035/0472
摘要： A multipath incubator that enables an immunoassay analyzer to perform tests that are not conducted serially relative to when the test samples entered the analyzer is provided.
摘要翻译： 一种多途径培养箱，使得免疫测定分析仪能够进行相对于测试样品进入分析仪时不连续进行的测试。
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公开(公告)号：US5885529A
公开(公告)日：1999-03-23
申请号：US672654
申请日：1996-06-28
申请人： Arthur L. Babson , Thomas Palmieri , Anthony P. Montalbano , Chris P. Montalbano , Greg A. Montalbano , Eric C. Fleischer
发明人： Arthur L. Babson , Thomas Palmieri , Anthony P. Montalbano , Chris P. Montalbano , Greg A. Montalbano , Eric C. Fleischer
CPC分类号： B01L3/50853 , G01N35/02 , G01N35/1002 , G01N2035/00435 , G01N2035/0405 , G01N2035/0451 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/115831 , Y10T436/25375 , Y10T436/25625 , Y10T436/2575
摘要： An improved automated immunoassay analyzer including a high throughput automated immunoassay system which can perform high volume testing on a broad range of analytes while selecting from among a diverse set of immunoassays for any given sample. The immunoanalyzer has the capacity to perform a wide range of different types of immunoassays by facile storage and automated combination aboard the instrument among a wide variety of different types of reagents and heterogenous immunoassay beads stored on-board the instrument. The automated design allows reduced user interface (e.g., tests are performed automatically from computer input) including the ability to order, perform and reassay tests reflexively based on test results without operator intervention. Further, the inventive analyzer is not sample tube specific; that is, an instrument that can accept sample tube sizes within a broad size range. The inventive automated immunoassay analyzer also provides a re-useable sample dilution well, and a high speed bead washing station that eliminates the need for assay tubes having integral, waste fluid collection chambers.
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公开(公告)号：US5468453A
公开(公告)日：1995-11-21
申请号：US76450
申请日：1993-06-14
申请人： Robert W. Holt , Thomas Palmieri
发明人： Robert W. Holt , Thomas Palmieri
CPC分类号： B01L3/0275 , G01N35/1004 , G01N2035/00752 , G01N2035/0408 , G01N2035/0443 , G01N2035/1025 , G01N21/76 , G01N35/025 , Y10T436/11 , Y10T436/2575
摘要： An improved pipette probe in an automated chemical analysis system is provided, along with a pipette tip wash protocol to reduce carryover. The pipette tip comprises an elongated stainless-steel barrel which houses a polytetrafluoroethylene tube. The non-wettable properties of polytetrafluoroethylene inhibit fluid adhesion and thereby reduce carryover. The pipette tip is swaged at a fluid dispensing end to a restrictive diameter for good pipetting precision and accuracy. A novel wash protocol is also provided which includes a novel wash solution comprising quantities of Triton X-100 nonionic detergent, Diethanolamine, and NaCl.
摘要翻译： 提供了一种自动化学分析系统中的改进的移液管探针，以及移液器吸头清洗方案，以减少携带。 移液管尖端包括容纳聚四氟乙烯管的细长不锈钢桶。 聚四氟乙烯的不可润湿性能抑制流体粘附，从而减少残留。 移液管尖端在流体分配端被模压到限制直径，以获得良好的移液精度和精度。 还提供了一种新的洗涤方案，其包括含有量的Triton X-100非离子洗涤剂，二乙醇胺和NaCl的新型洗涤溶液。
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公开(公告)号：US08215821B2
公开(公告)日：2012-07-10
申请号：US11611163
申请日：2006-12-15
申请人： Arthur L. Babson , Thomas Palmieri
发明人： Arthur L. Babson , Thomas Palmieri
IPC分类号： B01F11/00
CPC分类号： B01F11/0008 , B01F11/0266 , B01F11/0275 , B01F2215/0037
摘要： A test vessel agitator assembly that agitates test vessels and the contents therein within an immunoassay automated analyzer system. The test vessels are transported along an element that is comprised of ridges and troughs such that the test vessel is moved in a directions that is approximately perpendicular to the direction of transportation.
摘要翻译： 一种测试容器搅拌器组件，其在免疫测定自动分析仪系统内搅动测试容器及其中的内容物。 试验容器沿着由脊和槽组成的元件输送，使得试验容器沿大致垂直于运输方向的方向移动。
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公开(公告)号：US07951329B2
公开(公告)日：2011-05-31
申请号：US10813575
申请日：2004-03-31
申请人： Ilya Malyarov , Thomas Palmieri
发明人： Ilya Malyarov , Thomas Palmieri
IPC分类号： G01N35/02
CPC分类号： G01N21/76 , G01N21/645 , G01N35/0092 , G01N35/0095 , G01N35/021 , G01N2035/00524 , G01N2035/00564 , G01N2035/0093 , G01N2035/0408 , Y10T436/113332
摘要： A rotary luminometer subsystem presents test vessels to a detection mechanism to be read as part of the automated immunoassay analyzer system. The rotary luminometer provides a read station separate from that of the transportation element of the luminometer. Within the read station, a housing and shield eliminates light leakage from the sample under test. In addition, the read station regulates the intensity of the light by providing an attenuation capability.
摘要翻译： 旋转光度计子系统将测试容器呈现为检测机构，作为自动化免疫分析仪系统的一部分进行读取。 旋转发光计提供与发光计的传输元件分离的读站。 在读站内，外壳和屏蔽层可以消除被测样品的漏光。 此外，读站通过提供衰减能力来调节光的强度。
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