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    Centrifuge vessel with coaxial waste chamber having cap to prevent waste fluid transfer from the chamber into the vessel
    1.
    发明授权
    Centrifuge vessel with coaxial waste chamber having cap to prevent waste fluid transfer from the chamber into the vessel 失效
    具有同轴废物室的离心容器具有盖以防止废液从室转移到容器中

    公开(公告)号：US5244635A

    公开(公告)日：1993-09-14

    申请号：US901430

    申请日：1992-06-19

    申请人： Arthur L. Rabson ,  Thomas Palmieri ,  Douglas R. Olson

    发明人： Arthur L. Rabson ,  Thomas Palmieri ,  Douglas R. Olson

    IPC分类号： G01N21/07 ,  G01N30/74 ,  G01N33/53

    CPC分类号： B01L3/502 ,  B01L3/5021 ,  G01N21/07 ,  G01N33/5302 ,  G01N33/5304 ,  B01L2300/0681 ,  B01L2400/0409

    摘要： A centrifuge vessel for performing immunoassays, affinity chromatography, and like experiments includes a center tube and an outer waste chamber. A biomaterial is held within the center tube and is capable of binding specific analytes in test samples. In operation the centrifuge vessel is rotated at high speed about its longitudinal axis, thereby causing all fluid within the center tube to be transported into the outer waste chamber while the analyte of interest remains bound to the biomaterial positioned within the center tube In the centrifuge vessel, a cap connected to the outer waste chamber and extending over the center tube includes structure for preventing waste fluid expelled to the waste chamber from re-entering the center tube. In a first embodiment, the cap is either constructed from or the inside surface is coated with a hydrophobic material which repels fluids back into the waste chamber. In a second embodiment, the cap includes a dam which allows fluid to pass into the waste chamber but blocks the migration of waste fluid back to the center tube. In a third embodiment, the cap includes a sponge that allows fluids in the center tube influenced by the intense centrifugal forces generated during high speed rotation to pass into the waste chamber, but which prevents fluids in the waste chamber, which are influenced by relatively weaker forces, from returning to the center tube.

    摘要翻译： 用于进行免疫测定，亲和层析和类似实验的离心容器包括中心管和外部废物室。 生物材料保持在中心管内，并且能够结合测试样品中的特异性分析物。 在操作中，离心机容器围绕其纵向轴线以高速旋转，从而使得中心管内的所有流体被输送到外部废物室中，而感兴趣的分析物仍然结合到位于中心管内的生物材料。在离心机容器 连接到外部废物室并且在中心管上延伸的盖包括用于防止排出到废物室的废液再次进入中心管的结构。 在第一实施例中，盖子由或由内表面涂覆疏水材料构成，该疏水材料将流体排斥回废物室。 在第二实施例中，盖包括允许流体进入废物室但阻止废液返回到中心管的迁移的坝。 在第三实施例中，盖包括海绵，其允许受高速旋转期间产生的强烈离心力影响的中心管中的流体进入废物室，但是这防止废物室中的流体受相对较弱的影响 力量，返回中心管。

    Immunological color change test involving two differently colored reagent spots
    2.
    发明授权
    Immunological color change test involving two differently colored reagent spots 失效
    涉及两种不同颜色的试剂点的免疫色变试验

    公开(公告)号：US4639419A

    公开(公告)日：1987-01-27

    申请号：US653384

    申请日：1984-09-21

    申请人： Douglas R. Olson ,  James R. Harness ,  John W. Waterston

    发明人： Douglas R. Olson ,  James R. Harness ,  John W. Waterston

    IPC分类号： G01N33/532 ,  G01N33/543 ,  G01N33/58 ,  G01N33/76 ,  G01N33/546 ,  G01N33/564 ,  G01N33/569

    CPC分类号： G01N33/543 ,  G01N33/532 ,  G01N33/585 ,  G01N33/76 ,  Y10S435/962 ,  Y10S435/975 ,  Y10S436/805 ,  Y10S436/808 ,  Y10S436/81 ,  Y10S436/814 ,  Y10S436/818 ,  Y10S436/828

    摘要： A method and device for detecting an antigenic material in which the device comprises a test utensil having an indentation in which two reagent spots are placed, the first body being a dyed substrate having a coating of an antibody or antibody-like material thereon and the second of the two reagent spots comprising a dyed test-inert material or a dyed substrate with a coating of a normal animal serum, the dye employed in the second reagent spot having a different color than that employed in the first spot. When a liquid test sample is added to the indentation, the dyed substrate particles or components are suspended or solubilized, and the resulting suspension gives the appearance of a third color. A positive agglutination test is indicated by the formation of at least one spot having the color of the first dyed substrate against a background having the color of the second dyed substrate.

    摘要翻译： 一种用于检测抗原材料的方法和装置，其中所述装置包括具有其中放置两个试剂点的凹陷的测试用具，所述第一身体是其上具有抗体或抗体样材料的涂层的染色底物， 的两个试剂点包含染色的测试惰性材料或具有正常动物血清的染色的染色底物，第二试剂斑点中使用的染料具有与第一斑点中使用的颜色不同的颜色。 当将液体测试样品加入到凹陷中时，染色的底物颗粒或组分被悬浮或溶解，并且得到的悬浮液呈现出第三种颜色的外观。 阳性凝集试验通过形成具有第一染色基底的颜色的至少一个点与具有第二染色基底的颜色的背景而形成。

    High temperature box annealing furnace
    5.
    发明授权
    High temperature box annealing furnace 失效
    高温箱退火炉

    公开(公告)号：US4504957A

    公开(公告)日：1985-03-12

    申请号：US435338

    申请日：1982-10-20

    申请人： John R. McClelland ,  Wade S. Wright ,  Edward P. Diamond ,  Leroy C. Pryor ,  Douglas R. Olson

    发明人： John R. McClelland ,  Wade S. Wright ,  Edward P. Diamond ,  Leroy C. Pryor ,  Douglas R. Olson

    IPC分类号： C21D9/54 ,  C21D9/663 ,  F27B9/00

    CPC分类号： C21D9/663

    摘要： A high temperature box annealing furnace for metallic coil annealing practices. The furnace comprises a fixed base and a removable bell capable of achieving a sealed relationship with the base. The interior of the bell side walls, end walls and roof are lined with ceramic fiber insulation and are provided with electrical resistance heating elements. The heating elements are divided into at least two separately controllable zones, a first zone including the heating elements mounted on the bell roof and the upper portions of the bell side and end walls and a second zone including the heating elements mounted on the lower portion of the bell side and end walls. The base comprises a steel framework supporting a cast refractory base member configured to support one or more coils. Each coil is provided with a cover and the cast refractory base member provides a sand seal for the lower edge of the covers. The cast refractory base has an atmosphere inlet for each coil positioned at the center or eye of the coil. Cooling capacity for the furnace is provided by inlets and outlets for an appropriate cooling gas.

    摘要翻译： 用于金属线圈退火的高温箱式退火炉。 该炉包括固定基座和可与基座实现密封关系的可拆卸的钟罩。 铃铛侧壁，端壁和屋顶的内部衬有陶瓷纤维绝缘体，并配有电阻加热元件。 加热元件被分成至少两个可分离的可控区域，第一区域包括安装在钟形屋顶上的加热元件和钟形侧壁和端壁的上部，第二区域包括安装在下侧的加热元件 钟面和墙壁。 底座包括一个支撑铸造耐火基座构件的钢框架，该铸造耐火基座构件支撑一个或多个线圈。 每个线圈设置有盖，并且铸造耐火基座构件为盖的下边缘提供砂密封。 铸造耐火基座具有位于线圈中心或眼睛处的每个线圈的气氛入口。 炉的冷却能力由用于适当冷却气体的入口和出口提供。

    Automated immunoassay analyzer with pictorial display of assay information
    6.
    发明授权
    Automated immunoassay analyzer with pictorial display of assay information 失效
    自动免疫分析仪，具有图形显示测定信息

    公开(公告)号：US5316726A

    公开(公告)日：1994-05-31

    申请号：US986883

    申请日：1992-12-04

    申请人： Arthur L. Babson ,  Arthur F. Ross ,  Douglas R. Olson ,  Gershon Giter ,  Victor R. Huebner

    发明人： Arthur L. Babson ,  Arthur F. Ross ,  Douglas R. Olson ,  Gershon Giter ,  Victor R. Huebner

    IPC分类号： G01N21/76 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  G01N21/13 ,  G01N21/01

    CPC分类号： G01N35/021 ,  G01N35/0092 ,  G01N35/0095 ,  G01N2035/00356 ,  G01N2035/00435 ,  G01N2035/00524 ,  G01N2035/00752 ,  G01N2035/0093 ,  G01N2035/0437 ,  G01N2035/0443 ,  G01N2035/0467 ,  G01N2035/1025 ,  G01N2035/1032 ,  G01N2035/1086 ,  G01N21/763 ,  G01N35/025 ,  Y10T436/111666 ,  Y10T436/113332

    摘要： An automated immunoassay analyzer includes a computer controlled instrument (10) and display (16). The display (16) provides a real-time presentation of all operations being performed within the instrument (10). A large number of samples can be loaded into the instrument (10), and the order of testing the samples can be rearranged according to a priority determined by the operator at any time. A wide variety of immunoassays can be performed on each sample and several different immunoassays can be performed on any one sample. Information related to the type of immunoassays being performed on particular samples is collected by a bar code reader (44) and this information is conveyed to the computer (12) for presentation on the display (16). The computer (12) tracks the progress of each immunoassay through the reaction circuit to the detection station (46). The time to completion for particular immunoassays as well as the concentration information for recently completed immunoassays is provided in a readily usable format. The immunoassay automation process is improved by performing the washing operation with an assay tube (26) which allows water to be expelled by centrifugal forces generated by rotating the tube about its longitudinal axis; rather, than by using more conventional aspirating equipment. Bound label is detected by chemiluminescence using a photomultiplier tube (96).

    摘要翻译： 自动免疫分析仪包括计算机控制仪器（10）和显示器（16）。 显示器（16）提供在仪器（10）内正在执行的所有操作的实时显示。 可以将大量样品加载到仪器（10）中，并且可以根据操作者在任何时间确定的优先级重新排列样品测试顺序。 可以对每个样品进行各种免疫测定，并且可以在任何一个样品上进行几种不同的免疫测定。 通过条形码读取器（44）收集与特定样品进行的免疫测定类型相关的信息，并将该信息传送到计算机（12）以呈现在显示器（16）上。 计算机（12）通过反应电路跟踪检测站（46）的每次免疫测定的进度。 针对特定免疫测定的完成时间以及最近完成的免疫测定的浓度信息以容易使用的形式提供。 通过用分析管（26）执行洗涤操作来改善免疫测定自动化过程，其允许通过围绕其纵向轴线旋转管而产生的离心力排出水; 而不是使用更传统的抽吸设备。 使用光电倍增管（96）通过化学发光检测结合标记。

    Multichambered container and instrument for performing diagnostic tests
    8.
    发明授权
    Multichambered container and instrument for performing diagnostic tests 失效
    多用途容器和仪器进行诊断测试

    公开(公告)号：US5149501A

    公开(公告)日：1992-09-22

    申请号：US471416

    申请日：1990-01-29

    申请人： Arthur L. Babson ,  Thomas Palmieri ,  Douglas R. Olson

    发明人： Arthur L. Babson ,  Thomas Palmieri ,  Douglas R. Olson

    IPC分类号： G01N21/07 ,  G01N33/483 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10

    CPC分类号： G01N35/00594 ,  G01N21/07 ,  G01N35/025 ,  G01N2035/00495 ,  G01N2035/00504 ,  G01N2035/0446 ,  G01N35/00693 ,  G01N35/10 ,  G01N35/1004 ,  Y10S435/975 ,  Y10S436/808 ,  Y10S436/809 ,  Y10T436/111666

    摘要： An instrument (50) automatically determines the concentrations of HDL cholesterol, LDL cholesterol, total cholesterol and triglycerides for a sample (80) of whole, anticoagulated blood placed in a doughnut shaped container (10). The sample (80) is first separated into its blood cell and plasma (84) constituents using high speed centrifugation (54) and a thixotropic gel (82). Part of the plasma (84) is then deposited in an HDL separation chamber (14) where LDL cholesterol and VLDL cholesterol are precipitated by a reagent and the precipitant is sedimented by high speed centrifugation (54) against V-shaped grooves (40) in the outermost wall (38) of the HDL separation chamber (14). Part of the plasma (84) is diluted ten-fold. The supernatant in the HDL separation chamber is then placed in a cuvette reaction chamber (b 18) where it reacts with a cholesterol reagent. The diluted plasma is placed in two other cuvette reaction chambers (18) where it reacts with chloesterol and triglycerides reagents, respectively. Calibration reagents, stored in storage chambers (20), react in two other cuvette reaction chambers (18) to establish a reference absorbance. A pipettor (58) handles all the fluid transfers in the doughnut shaped container (10) and operates in conjunction with a slow speed motor (56) that precisely moves the spindle (52) on which the doughnut shaped container (10) is mounted. A colorimetric measuring system (70, 72, and 74) monitors the absorbance of chemical reactions occurring in the cuvette chambers (18).

    摘要翻译： 仪器（50）自动确定放置在环形容器（10）中的全部抗凝血液样品（80）的HDL胆固醇，低密度脂蛋白胆固醇，总胆固醇和甘油三酯的浓度。 首先使用高速离心（54）和触变凝胶（82）将样品（80）分离成其血细胞和血浆（84）成分。 然后将等离子体（84）的一部分沉积在HDL分离室（14）中，其中LDL胆固醇和VLDL胆固醇被试剂沉淀，并且沉淀剂通过高速离心（54）沉降到V形槽（40）上 HDL分离室（14）的最外壁（38）。 部分血浆（84）稀释十倍。 然后将HDL分离室中的上清液置于比色皿反应室（b18）中，在其中它与胆固醇试剂反应。 将稀释的血浆置于另外两个比色杯反应室（18）中，分别与氯甲醇酯和甘油三酯试剂反应。 存储在储存室（20）中的校准试剂在另外两个反应池反应室（18）中反应以建立参考吸光度。 移液器（58）处理环形容器（10）中的所有流体传送并与低速电动机（56）一起操作，该慢速电动机精确地移动安装有环形容器（10）的心轴（52）。 比色测量系统（70,72和74）监测在比色皿室（18）中发生的化学反应的吸光度。

    Compositions and methods for multiple simultaneous immunoradiometric assay (IRMA) of analytes using radioisotope chelate labels
    9.
    发明授权
    Compositions and methods for multiple simultaneous immunoradiometric assay (IRMA) of analytes using radioisotope chelate labels 失效
    使用放射性同位素螯合标记的分析物的多次同时免疫放射测定（IRMA）的组合物和方法

    公开(公告)号：US5001072A

    公开(公告)日：1991-03-19

    申请号：US59017

    申请日：1987-06-08

    申请人： Douglas R. Olson

    发明人： Douglas R. Olson

    IPC分类号： G01N33/534 ,  G01N33/60 ,  G01N33/74

    CPC分类号： G01N33/74 ,  G01N33/534 ,  G01N33/60 ,  Y10S436/804

    摘要： Compositions and methods are disclosed for multiple simultaneous assays of different analytes using radioactive labeled antibodies to the analytes, at least one portion of the assay being an immunoradiometric assay in which there is employed a metal isotope label, e.g., .sup.57 Co, attached to an antibody to the analyte through a chelator, e.g., ethylenediaminetetraacetic acid. Multiple simultaneous immunoradiometric assays can be performed by this method, as can multiple simultaneous assays in which one portion of the assay is an immunoradiometric assay and another portion or portions involve one or more other radioassay techniques.

    摘要翻译： 公开了使用对分析物的放射性标记抗体对不同分析物的多次同时测定的组合物和方法，所述测定的至少一部分是免疫放射测定法，其中使用附着于抗体的抗体的金属同位素标记（例如57Co） 分析物通过螯合剂，例如乙二胺四乙酸。 多个同时的免疫放射测定可以通过该方法进行，多次同时测定也可以是其中一部分测定是免疫放射测定法，另一部分或部分涉及一种或多种其它放射分析技术。