公开(公告)号：US20140378873A1

公开(公告)日：2014-12-25

申请号：US14312967

申请日：2014-06-24

申请人： Ary S. Chernomorsky ,  Michael Rontal ,  Prasad Nalluri

发明人： Ary S. Chernomorsky ,  Michael Rontal ,  Prasad Nalluri

IPC分类号： A61N7/00 ,  A61M37/00

CPC分类号： A61N7/00 ,  A61B2018/00285 ,  A61M37/0092 ,  A61M2205/0216 ,  A61N2007/0043 ,  A61N2007/0056

摘要： Embodiments isolate exposed surfaces to increase the effectiveness of different treatment modalities. Embodiments isolate hollow spaces within the body to increase the effectiveness of ultrasound energy and/or other treatments. Such hollow spaces within the body may include nasal surfaces, and recessed or sequestered surfaces, e.g. sinus cavity surfaces or other anatomical structures, such as upper and lower gastrointestinal tract, airways, uterine and vaginal cavities and the anorectal canal, for example. Isolating the area to be treated reduces the volume of the enclosed and delimited space and reduces the tissue surface against which the ultrasound and/or biologically active substances act. For example, isolating a hollow passageway within the body enhances the effectiveness of ultrasound within the isolated space, and constrains the biologically active fluid and/or the gel or fluid configured to conducts the ultrasonic energy from the emitter thereof (e.g., an ultrasound waveguide) to the surfaces to be treated.

摘要翻译： 实施例分离暴露的表面以增加不同治疗方式的有效性。 实施例隔离体内的中空空间以增加超声能量和/或其他治疗的有效性。 体内的这样的中空空间可以包括鼻表面，凹陷或隔离表面，例如， 窦腔表面或其他解剖结构，例如上，下胃肠道，气道，子宫和阴道腔以及肛肠直肠。 隔离待治疗的区域减少封闭和限定空间的体积，并减少超声波和/或生物活性物质发生作用的组织表面。 例如，隔离体内的中空通道增强隔离空间内的超声波的有效性，并限制生物活性流体和/或配置成从其发射器（例如，超声波导管）传导超声能量的凝胶或流体， 到待处理的表面。

公开(公告)号：US20180014746A1

公开(公告)日：2018-01-18

申请号：US15650780

申请日：2017-07-14

申请人： Rick Harrington ,  Charles W. Krapf ,  Michael Rontal

发明人： Rick Harrington ,  Charles W. Krapf ,  Michael Rontal

IPC分类号： A61B5/055 ,  G01R33/28 ,  A61B17/3207

CPC分类号： A61B5/055 ,  A61B17/3207 ,  A61B17/320758 ,  A61B2017/00411 ,  A61B2090/374 ,  G01R33/28 ,  G01R33/287

摘要： A tissue-modifying catheter adapted for use with an MRI machine includes an elongated hollow sheath configured for intraluminal introduction with proximal and distal open ends. A coil of electrically conductive, non-magnetic wire, disposed at the proximal open end of the sheath is in electrical communication with an electrical waveform generator through a set of electrical conductors entering into the open proximal end of the sheath. A non-magnetic end effector is physically or mechanically coupled to the coil of wire, such that when a voltage is imposed upon the coil of wire through the waveform generator, the coil experiences a directional torque due to the presence of the MRI-oriented magnetic field, causing the end effector to interact with surrounding tissue. The waveform generator preferably delivers a time-varying waveform such as sinusoid that may be synchronized with the MRI-oriented magnetic field. The catheter may include a plurality of different end effectors for different application.

公开(公告)号：US20150038790A1

公开(公告)日：2015-02-05

申请号：US14518539

申请日：2014-10-20

申请人： Michael Rontal ,  Robert Stubbers ,  David Ruzic ,  Brian Jurczyk

发明人： Michael Rontal ,  Robert Stubbers ,  David Ruzic ,  Brian Jurczyk

IPC分类号： A61B18/04 ,  A61B1/06 ,  A61B1/267 ,  A61B1/07 ,  A61B1/015 ,  A61B1/005

CPC分类号： A61B18/042 ,  A61B1/0051 ,  A61B1/0057 ,  A61B1/015 ,  A61B1/0669 ,  A61B1/07 ,  A61B1/233 ,  A61B1/267 ,  A61B2017/00323 ,  A61B2018/00327 ,  A61B2018/00583 ,  A61B2090/306 ,  A61B2090/3614

摘要： Chronic sinusitis is treated by the application of cold plasma or plasma-activated species to the infected mucosal surfaces through use of an endoscope having a steerable end which may be projected into the sinus cavities through the nasal cavity. The cold plasma is generated at either the distal end of the endoscope with a power source by application of a power, or at the distal end by gas and electrical connections extending through the endoscope. The cold plasma or plasma-activated species act to destroy bacterial cells but not eukaryotic cells.

摘要翻译： 通过使用具有可转向端的内窥镜，通过将冷血浆或血浆活化物质施用于感染的粘膜表面来治疗慢性鼻窦炎，所述内窥镜具有通过鼻腔投射到窦腔中的可转向端。 冷等离子体通过施加电力而在内窥镜的远端处产生电源，或者通过延伸穿过内窥镜的气体和电连接在远端产生。 冷血浆或血浆活化物质可以破坏细菌细胞而不是真核细胞。

公开(公告)号：US20050080396A1

公开(公告)日：2005-04-14

申请号：US11004392

申请日：2004-12-03

申请人： Michael Rontal

发明人： Michael Rontal

IPC分类号： A61B17/22 ,  A61B19/00 ,  A61L2/00 ,  A61L2/26 ,  A61M31/00 ,  B08B3/02 ,  B08B3/10 ,  B08B3/12

CPC分类号： A61B17/22004 ,  A61B90/40 ,  A61L2/0011 ,  A61L2/0082 ,  A61L2/26 ,  B08B3/02 ,  B08B3/10 ,  B08B3/12 ,  B08B2203/0229 ,  B08B2203/0288

摘要： To treat body surfaces, such as the sinuses, which are coated with biofilms, the surface is irrigated and suctioned with a fluid which may contain a biocide or other chemical agent for disrupting the biofilm while ultrasonic energy is applied to the fluid barrier formed over the biofilm. Action of the fluid enhanced by the ultrasonic energy tends to remove sections of biofilm which are suctioned out of the site. An electrical field may also be applied to the biofilm to enhance the disruptive action. Apparatus for practicing this method to treat chronic rhinosinusitis comprises an elongated tube adapted to be inserted into sinus cavities through the nose or mouth. The tube includes a first lumen which feeds an irrigating fluid containing biocides and/or biofilm-disruptive chemicals to the treatment site and a second lumen which suctions fluid from the site. An ultrasound horn extends through the tube and its distal end introduces ultrasonic energy into the fluid layer overlying the biofilm. In an alternative embodiment, the tube includes a pair of electrodes which establish an electric field across the biofilm, accelerating degradation.

公开(公告)号：US10758667B2

公开(公告)日：2020-09-01

申请号：US14172393

申请日：2014-02-04

申请人： Michael Rontal

发明人： Michael Rontal

IPC分类号： A61M3/02

摘要： A method and apparatus for cleansing the interior surfaces of body cavities employs a balloon catheter adopted to be inserted into a cavity through its ostium with the balloon in collapsed condition. An input flow tube for a cleansing and/or medicating fluid passes through a central passage in the balloon. When the balloon is inflated to establish a narrow passage between the balloon and the cavity walls, a pressurized flow of the fluid is pumped out the distal end of the input flow tube through the passage, parallel to the cavity walls, where it scours the inner wall of the cavity, removing debris as it flows out of the ostium. The fluid flow is urged toward a turbulent condition by attachments to the outer wall of the balloon.

公开(公告)号：US20140005481A1

公开(公告)日：2014-01-02

申请号：US13963364

申请日：2013-08-09

申请人： Michael Rontal ,  David Ruzic ,  Brian Jurczyk ,  Robert Stubbers

发明人： Michael Rontal ,  David Ruzic ,  Brian Jurczyk ,  Robert Stubbers

IPC分类号： A61B18/04

CPC分类号： A61B18/042 ,  A61B1/0051 ,  A61B1/015 ,  A61B1/267 ,  A61B2017/00323 ,  A61B2018/00327 ,  A61B2090/306 ,  A61B2090/3614

摘要： Chronic sinusitis is treated by the application of cold plasma or plasma-activated species to the infected mucosal surfaces through use of an endoscope having a steerable end which may be projected into the sinus cavities through the nasal cavity. The cold plasma is generated at either the distal end of the endoscope with a power source by application of a power, or at the distal end by gas and electrical connections extending through the endoscope. The cold plasma or plasma-activated species act to destroy bacterial cells but not eukaryotic cells.

摘要翻译： 通过使用具有可转向端的内窥镜，通过将冷血浆或血浆活化物质施用于感染的粘膜表面来治疗慢性鼻窦炎，所述内窥镜具有通过鼻腔投射到窦腔中的可转向端。 冷等离子体通过施加电力而在内窥镜的远端处产生电源，或者通过延伸穿过内窥镜的气体和电连接在远端产生。 冷血浆或血浆活化物质可以破坏细菌细胞而不是真核细胞。

公开(公告)号：US20100174226A1

公开(公告)日：2010-07-08

申请号：US12724306

申请日：2010-03-15

申请人： Michael Rontal

发明人： Michael Rontal

IPC分类号： A61B17/24 ,  A61N1/30

CPC分类号： A61B17/22004 ,  A61B90/40 ,  A61L2/0011 ,  A61L2/0082 ,  A61L2/26 ,  B08B3/02 ,  B08B3/10 ,  B08B3/12 ,  B08B2203/0229 ,  B08B2203/0288

摘要： To treat body surfaces, such as the sinuses, which are coated with biofilms, the surface is irrigated and suctioned with a fluid which may contain a biocide or other chemical agent for disrupting the biofilm while ultrasonic energy is applied to the fluid barrier formed over the biofilm. Action of the fluid enhanced by the ultrasonic energy tends to remove sections of biofilm which are suctioned out of the site. An electrical field may also be applied to the biofilm to enhance the disruptive action. Apparatus for practicing this method to treat chronic rhinosinusitis comprises an elongated tube adapted to be inserted into sinus cavities through the nose or mouth. The tube includes a first lumen which feeds an irrigating fluid containing biocides and/or biofilm-disruptive chemicals to the treatment site and a second lumen which suctions fluid from the site. An ultrasound horn extends through the tube and its distal end introduces ultrasonic energy into the fluid layer overlying the biofilm. In an alternative embodiment, the tube includes a pair of electrodes which establish an electric field across the biofilm, accelerating degradation.

摘要翻译： 为了治疗身体表面，例如涂覆有生物膜的鼻窦，表面被灌注并用可能含有杀生物剂或其它化学试剂的流体吸入，以破坏生物膜，同时将超声波能量施加到形成在 生物膜 通过超声波能量增强的流体的作用倾向于去除从现场抽出的生物膜的部分。 电场也可以应用于生物膜以增强破坏性作用。 用于实施该方法治疗慢性鼻鼻窦炎的装置包括适于通过鼻子或嘴部插入窦腔的细长管。 该管包括第一内腔，其将含有杀生物剂和/或生物膜破坏性化学品的冲洗流体供给到处理部位，以及从该部位吸取流体的第二内腔。 超声波喇叭延伸穿过管，其远端将超声波能量引入覆盖生物膜的流体层。 在替代实施例中，管包括一对电极，其在整个生物膜上建立电场，加速退化。

公开(公告)号：US07522955B2

公开(公告)日：2009-04-21

申请号：US11257198

申请日：2005-10-24

申请人： Michael Rontal

发明人： Michael Rontal

IPC分类号： A61N1/30

CPC分类号： A61B17/24 ,  A61B17/22 ,  A61B17/22004 ,  A61B90/40 ,  A61B2017/22082 ,  A61B2217/005 ,  A61B2217/007 ,  A61L2/0005

摘要： To treat body surfaces, such as the sinuses, which are coated with biofilms, the surface is irrigated and suctioned with a fluid which may contain a biocide or other chemical agent for disrupting the biofilm while ultrasonic energy is applied to either the fluid barrier formed over the biofilm or a body surface proximal to the biofilm. Action of the fluid enhanced by the ultrasonic energy tends to remove sections of biofilm which are suctioned out of the site. An electrical field may also be applied to the biofilm to enhance the disruptive action. Apparatus for practicing this method to treat chronic rhinosinusitis comprises an elongated tube adapted to be inserted into sinus cavities through the nose or mouth. The tube includes a first lumen which feeds an irrigating fluid containing biocides and/or biofilm-disruptive chemicals to the treatment site and a second lumen which suctions fluid from the site. An ultrasound horn extends through the tube and its distal end introduces ultrasonic energy into the fluid layer overlying the biofilm. Alternatively, an ultrasound probe may be applied to an adjacent body surface, such as the face over a sinus cavity. In an alternative embodiment, the tube includes a pair of electrodes which establish an electric field across the biofilm, accelerating degradation.

摘要翻译： 为了治疗身体表面，例如用生物膜涂覆的鼻窦，表面被灌注并用可能含有杀生物剂或其它化学试剂的流体吸入，以破坏生物膜，同时将超声波能量施加到形成的流体屏障上 生物膜或靠近生物膜的体表。 通过超声波能量增强的流体的作用倾向于去除从现场抽出的生物膜的部分。 电场也可以应用于生物膜以增强破坏性作用。 用于实施该方法治疗慢性鼻鼻窦炎的装置包括适于通过鼻子或嘴部插入窦腔的细长管。 该管包括第一内腔，其将含有杀生物剂和/或生物膜破坏性化学品的冲洗流体供给到处理部位，以及从该部位吸取流体的第二内腔。 超声波喇叭延伸穿过管，其远端将超声波能量引入覆盖生物膜的流体层。 或者，可以将超声波探头施加到相邻的身体表面，例如在窦腔上的面。 在替代实施例中，管包括一对电极，其在整个生物膜上建立电场，加速退化。

公开(公告)号：US20060224103A1

公开(公告)日：2006-10-05

申请号：US11429044

申请日：2006-05-05

申请人： Michael Rontal

发明人： Michael Rontal

IPC分类号： A61B17/20

CPC分类号： A61B17/22 ,  A61B17/22004 ,  A61B17/24 ,  A61B90/40 ,  A61B2017/22082 ,  A61B2217/005 ,  A61B2217/007 ,  A61L2/0005

摘要： To treat body surfaces, such as the sinuses or lungs, which are coated with biofilms, the surface is irrigated and suctioned with a fluid which may contain a biocide or other chemical agent for disrupting the biofilm while ultrasonic energy is applied to either the fluid barrier formed over the biofilm or a body surface proximal to the biofilm. Action of the fluid enhanced by the ultrasonic energy tends to remove sections of biofilm which are suctioned out of the site. An electrical field may also be applied to the biofilm to enhance the disruptive action. Apparatus for practicing this method to treat chronic rhinosinusitis comprises an elongated tube adapted to be inserted into sinus cavities through the nose or mouth. The tube includes a first lumen which feeds an irrigating fluid containing biocides and/or biofilm-disruptive chemicals to the treatment site and a second lumen which suctions fluid from the site. An ultrasound horn extends through the tube and its distal end introduces ultrasonic energy into the fluid layer overlying the biofilm. Alternatively, an ultrasound probe may be applied to an adjacent body surface, such as the face over a sinus cavity. In an alternative embodiment, the tube includes a pair of electrodes which establish an electric field across the biofilm, accelerating degradation. To apply ultrasonic energy to lung areas irrigated through a bronchoscope, a chest encircling, fluid filled belt has ultrasonic energy introduced through spaced transducers. The phases of the signals may be adjusted under control of bronchial imaging apparatus to focus the energy an affected areas.

摘要翻译： 为了治疗涂覆有生物膜的身体表面，例如窦或肺，表面被灌注并用可能含有杀生物剂或其它化学试剂的流体吸入，以破坏生物膜，同时超声能量施加到流体屏障 形成在生物膜上或接近生物膜的身体表面。 通过超声波能量增强的流体的作用倾向于去除从现场抽出的生物膜的部分。 电场也可以应用于生物膜以增强破坏性作用。 用于实施该方法治疗慢性鼻鼻窦炎的装置包括适于通过鼻子或嘴部插入窦腔的细长管。 该管包括第一内腔，其将含有杀生物剂和/或生物膜破坏性化学品的冲洗流体供给到处理部位，以及从该部位吸取流体的第二内腔。 超声波喇叭延伸穿过管，其远端将超声波能量引入覆盖生物膜的流体层。 或者，可以将超声波探头施加到相邻的身体表面，例如在窦腔上的面。 在替代实施例中，管包括一对电极，其在整个生物膜上建立电场，加速退化。 将超声波能量通过支气管镜灌注的肺部区域，胸部环绕，充满流体的皮带通过间隔的换能器引入超声波能量。 可以在支气管成像设备的控制下调整信号的相位，以将能量聚焦在受影响的区域。

公开(公告)号：US10806482B2

公开(公告)日：2020-10-20

申请号：US15360932

申请日：2016-11-23

申请人： Michael Rontal

发明人： Michael Rontal

IPC分类号： H01L41/08 ,  A61B17/32 ,  H01L41/23 ,  A61B17/00

摘要： A piezo-driven, vibrating beam is applicable to surgical procedures. A rod of piezoelectric material defines a length with proximal and distal ends. A pattern of electrodes, disposed adjacent to and along the length of the rod of piezoelectric material, is adapted for connection to a generator operative to stimulate the piezoelectric material, causing the rod to assume one or more vibratory states. In preferred embodiments, the proximal end of the rod of piezoelectric material is adapted for coupling to a blocking mass causing the vibratory states to be concentrated at the distal end of the rod of piezoelectric material. The pattern of electrodes may comprise interdigitated fingers, and the system may further include a material encapsulating the rod and the pattern of electrodes. Preferred embodiments may further include a plurality of coextensive, parallel rods forming a basic unit, each rod having a separate pattern of electrodes adjacent thereto.