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公开(公告)号:US09309237B2
公开(公告)日:2016-04-12
申请号:US14241329
申请日:2012-09-06
IPC分类号: A61K31/425 , A61K31/41 , A61K31/445 , A61K31/50 , A61K31/535 , C07D417/14 , A61K45/06 , A61K31/167 , A61K31/341 , A61K31/40 , A61K31/427 , A61K31/4402 , A61K31/454 , A61K31/4545 , A61K31/495 , A61K31/5375 , A61K31/538 , A61K31/55 , C07D211/14 , C07D223/04 , C07D307/54 , C07D417/06 , A61K31/4439 , A61K31/47 , C07D213/81 , C07D215/12 , C07D231/40 , C07D233/58 , C07D401/06 , C07D487/04 , C07D207/16 , C07D211/42 , C07D211/46 , C07D211/58 , C07D295/192 , C07D295/26 , C07D307/52
CPC分类号: C07D417/14 , A61K31/167 , A61K31/341 , A61K31/40 , A61K31/427 , A61K31/4402 , A61K31/4439 , A61K31/445 , A61K31/454 , A61K31/4545 , A61K31/47 , A61K31/495 , A61K31/5375 , A61K31/538 , A61K31/55 , A61K45/06 , C07D207/16 , C07D211/14 , C07D211/42 , C07D211/46 , C07D211/58 , C07D213/81 , C07D215/12 , C07D223/04 , C07D231/40 , C07D233/58 , C07D295/192 , C07D295/26 , C07D307/52 , C07D307/54 , C07D401/06 , C07D417/06 , C07D487/04 , A61K2300/00
摘要: Chemical compounds that inhibit retroviruses are presented herein. More particularly, this disclosure provides small molecule compounds that inhibit infection with, or treat infection caused by, human immunodeficiency viruses.
摘要翻译: 本文给出抑制逆转录病毒的化合物。 更具体地,本公开提供抑制人免疫缺陷病毒感染或治疗由人免疫缺陷病毒引起的感染的小分子化合物。
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公开(公告)号:US20120034254A1
公开(公告)日:2012-02-09
申请号:US12866723
申请日:2009-02-06
申请人: Peter D. Kwong , Gary J. Nabel , George Shaw , William Schief , Zhi-yong Yang , Tongqing Zhou , Lei Chen , Young Do Kwon
发明人: Peter D. Kwong , Gary J. Nabel , George Shaw , William Schief , Zhi-yong Yang , Tongqing Zhou , Lei Chen , Young Do Kwon
IPC分类号: A61K39/21 , C07K14/195 , C07K14/37 , C07K14/005 , A61P31/18 , A61K39/00 , C07H21/00 , G01N33/566 , A61P37/04 , C07K14/16 , C07H21/04
CPC分类号: C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/545 , A61K2039/55566 , C12N2740/15022 , C12N2740/16122 , C12N2740/16134 , G16B15/00 , G16B20/00
摘要: Disclosed are antigens that include a target epitope that is defined by atomic coordinates of those amino acids of the antigen that contact an antibody of interest that specifically binds the antigen. The disclosed antigens have between about 10% and about 90% of surface exposed amino acid residues located exterior of the target epitope substituted as compared to a wild-type antigen and less than about 10% of the non-surface exposed amino acid residues substituted as compared to a wild-type antigen. Also disclosed are nucleic acids encoding these antigens and methods of producing these antigens. Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating or preventing a human immunodeficiency type 1 (HIV-1) infection in a subject.
摘要翻译: 公开的是包含由与抗原特异性结合的目的抗体接触的抗原的那些氨基酸的原子坐标定义的靶表位的抗原。 与野生型抗原相比,所公开的抗原具有位于目标表位外部取代的表面暴露的氨基酸残基的约10%至约90%,并且小于约10%的非表面暴露的氨基酸残基被取代为 与野生型抗原相比。 还公开了编码这些抗原的核酸和产生这些抗原的方法。 还公开了在受试者中产生免疫应答的方法。 在一些实施方案中,该方法是用于治疗或预防受试者中的人类免疫缺陷1型(HIV-1)感染的方法。
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公开(公告)号:US08801057B2
公开(公告)日:2014-08-12
申请号:US13317412
申请日:2011-10-18
申请人: Jeong Hun Kim , Yong Jae Kim , Youn Baek Lee , Heum Yong Park , Kyung Shik Roh , Young Do Kwon
发明人: Jeong Hun Kim , Yong Jae Kim , Youn Baek Lee , Heum Yong Park , Kyung Shik Roh , Young Do Kwon
IPC分类号: B60R19/00 , B60R21/0136
CPC分类号: B60R21/0136 , A47L9/009 , A47L9/2805 , A47L2201/04 , G01D5/165
摘要: A bumper structure of a cleaning robot which detects whether or not an obstacle contacts a bumper and a position of the obstacle, allows the bumper to be simply process and reduces the number of components of the cleaning robot to lower the production costs of the cleaning robot. The bumper structure includes a main body, a bumper installed on the front surface of the main body, a resistance film provided between the main body and the bumper and fixed to the main body, and a metal film provided between the main body and the bumper and fixed to the bumper such that the shape of the metal film is deformed together with the bumper and the metal film comes into contact with the resistance film when at least one obstacle contacts the bumper, so as to measure resistance values.
摘要翻译: 清洁机器人的保险杠结构,其检测障碍物是否碰到保险杠和障碍物的位置,允许缓冲器简单地处理并减少清洁机器人的部件数量,以降低清洁机器人的生产成本 。 保险杠结构包括主体,安装在主体前表面上的保险杠,设置在主体和保险杠之间并固定在主体上的电阻膜,以及设置在主体和保险杠之间的金属膜 并且当至少一个障碍物接触保险杠时,金属膜的形状与保险杠一起变形并且金属膜与电阻膜接触,以便测量电阻值,并且固定到保险杠。
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公开(公告)号:US20100057253A1
公开(公告)日:2010-03-04
申请号:US12385888
申请日:2009-04-22
申请人: Sung Gu Kwon , Young Do Kwon , Dong Hun Lee , Won Kuk Kim
发明人: Sung Gu Kwon , Young Do Kwon , Dong Hun Lee , Won Kuk Kim
IPC分类号: G06F19/00
CPC分类号: B25J19/0091
摘要: Disclosed are a robot, which performs biped walking similar to a human being, and a method of controlling safety of the robot. When the robot falls down, an air bag located in the falling direction is operated and the posture of the robot is changed into an attention posture. When the robot secondarily falls down after the falling of the robot, an air bag located in the secondary falling direction is operated to minimize damage to the elements of the robot due to the secondary falling of the robot.
摘要翻译: 公开了一种机器人,其执行类似于人的两足动作,以及控制机器人的安全性的方法。 当机器人落下时,位于下降方向的气囊被操作并且机器人的姿势变成注意姿势。 当机器人坠落后机器人二次跌落时,操作位于次级下落方向的气囊,以使机器人的二次跌落对机器人的元件造成的损害最小化。
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公开(公告)号:US09101324B2
公开(公告)日:2015-08-11
申请号:US13296355
申请日:2011-11-15
申请人: Heum Yong Park , Yong Jae Kim , Youn Baek Lee , Jeong Hun Kim , Kyung Shik Roh , Young Do Kwon
发明人: Heum Yong Park , Yong Jae Kim , Youn Baek Lee , Jeong Hun Kim , Kyung Shik Roh , Young Do Kwon
CPC分类号: A61B5/4887 , A61B5/04 , A61B5/6835 , A61B5/6843 , A61B5/6844 , A61B5/6887
摘要: A vital sign measurement robot which automatically measures vital signs, and a control method thereof. The vital sign measurement robot includes an input unit to receive vital sign measurement instructions, an image recognition unit to detect a distance between the robot and a person, vital signs of whom are to be measured, and a measurement portion of the body of the person, when the vital sign measurement instructions are received, a control unit to move electrodes provided on hands so as to locate the electrodes at the measurement portion of the body of the person, when the distance between the robot and the person and the measurement portion of the body of the person are detected, and a vital sign measurement unit to measure a vital sign, when the electrodes are located at the measurement portion of the body of the person.
摘要翻译: 一种自动测量生命体征的生命体征测量机器人及其控制方法。 生物体征测量机器人包括用于接收生命体征测量指令的输入单元,用于检测机器人与人之间的距离的图像识别单元,要测量的人的生命体征以及人体的测量部分 当接收到生物体征测量指令时,控制单元移动设置在手上的电极,以便当机器人与人的距离与测量部分之间的位置时,将电极定位在人体的测量部分 检测人的身体,以及当电极位于人的身体的测量部分时,测量生命体征的生命体征测量单元。
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公开(公告)号:US20100185325A1
公开(公告)日:2010-07-22
申请号:US12656192
申请日:2010-01-20
申请人: Young Do Kwon
发明人: Young Do Kwon
IPC分类号: G06F19/00
CPC分类号: G05B19/4141
摘要: An apparatus and method for controlling a multi-axis robot are disclosed. An upper controller generates control commands corresponding to a plurality of actuators mounted to axes of a multi-axis robot, and transmits the control commands to servo-controllers over a network. The servo-controllers transmit control commands to the plurality of actuators, and transmit sensor information acting as measurement data indicating status information of the actuators to the upper controller.
摘要翻译: 公开了一种用于控制多轴机器人的装置和方法。 上控制器产生对应于安装在多轴机器人的轴上的多个致动器的控制命令,并通过网络将控制命令发送到伺服控制器。 伺服控制器向多个致动器发送控制命令,并将作为指示致动器的状态信息的测量数据的传感器信息发送到上控制器。
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公开(公告)号:US20120126837A1
公开(公告)日:2012-05-24
申请号:US13317412
申请日:2011-10-18
申请人: Jeong Hun Kim , Yong Jae Kim , Youn Baek Lee , Heum yong Park , Kyung Shik Roh , Young Do Kwon
发明人: Jeong Hun Kim , Yong Jae Kim , Youn Baek Lee , Heum yong Park , Kyung Shik Roh , Young Do Kwon
IPC分类号: G01R27/08
CPC分类号: B60R21/0136 , A47L9/009 , A47L9/2805 , A47L2201/04 , G01D5/165
摘要: A bumper structure of a cleaning robot which detects whether or not an obstacle contacts a bumper and a position of the obstacle, allows the bumper to be simply process and reduces the number of components of the cleaning robot to lower the production costs of the cleaning robot. The bumper structure includes a main body, a bumper installed on the front surface of the main body, a resistance film provided between the main body and the bumper and fixed to the main body, and a metal film provided between the main body and the bumper and fixed to the bumper such that the shape of the metal film is deformed together with the bumper and the metal film comes into contact with the resistance film when at least one obstacle contacts the bumper, so as to measure resistance values.
摘要翻译: 清洁机器人的保险杠结构,其检测障碍物是否碰到保险杠和障碍物的位置,允许缓冲器简单地处理并减少清洁机器人的部件数量,以降低清洁机器人的生产成本 。 保险杠结构包括主体,安装在主体前表面上的保险杠,设置在主体和保险杠之间并固定在主体上的电阻膜,以及设置在主体和保险杠之间的金属膜 并且当至少一个障碍物接触保险杠时,金属膜的形状与保险杠一起变形并且金属膜与电阻膜接触,以便测量电阻值,并且固定到保险杠。
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公开(公告)号:US20090176653A1
公开(公告)日:2009-07-09
申请号:US12171987
申请日:2008-07-11
申请人: Jin-Soo Kim , Kwang-Hee Bae , Kyung-Soon Park , Young Do Kwon , Eun-Hyun Ryu , Moon-Sun Hwang
发明人: Jin-Soo Kim , Kwang-Hee Bae , Kyung-Soon Park , Young Do Kwon , Eun-Hyun Ryu , Moon-Sun Hwang
CPC分类号: C07K14/4702 , C12N15/1034
摘要: Disclosed are libraries of chimeric zinc finger domains. The libraries can include two or more zinc finger domains from naturally occurring proteins, e.g., mammalian proteins and particularly human proteins. Useful chimeric zinc finger domains can be identified from the library. Also disclosed are the amino acid sequences of zinc finger domains that recognize particular sites.
摘要翻译: 公开了嵌合锌指结构域的文库。 文库可以包括来自天然存在的蛋白质的两个或多个锌指结构域,例如哺乳动物蛋白质,特别是人类蛋白质。 可以从文库鉴定有用的嵌合锌指结构域。 还公开了识别特定位点的锌指结构域的氨基酸序列。
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