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公开(公告)号：US20120288496A1
公开(公告)日：2012-11-15
申请号：US13472305
申请日：2012-05-15
申请人： Austin L. GURNEY , Timothy Charles Hoey , Edward Thein Htun van der Horst , Aaron Ken Sato , Yuan Ching Liu , Maureen Fitch Bruhns , John A. Lewicki
发明人： Austin L. GURNEY , Timothy Charles Hoey , Edward Thein Htun van der Horst , Aaron Ken Sato , Yuan Ching Liu , Maureen Fitch Bruhns , John A. Lewicki
IPC分类号： A61K39/395 , A61P35/00 , A61P9/00 , C12N5/09
CPC分类号： C07K16/22 , A61K31/337 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61N5/10 , C07H21/04 , C07K14/435 , C07K14/71 , C07K16/28 , C07K16/30 , C07K16/3046 , C07K16/462 , C07K16/464 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C12N5/0693 , C12N5/12 , C12N15/63 , C12N15/79 , C12N2501/998
摘要： The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides antibodies that specifically bind to a non-ligand binding region of the extracellular domain of one or more human Notch receptor, such as Notch2 and/or Notch3, and inhibit tumor growth. The present invention further provides methods of treating cancer, the methods comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.
摘要翻译： 本发明涉及Notch结合剂和Notch拮抗剂以及使用这些药剂和/或拮抗剂治疗诸如癌症的疾病的方法。 本发明提供了特异性结合一种或多种人Notch受体如Notch2和/或Notch3的细胞外结构域的非配体结合区并抑制肿瘤生长的抗体。 本发明还提供了治疗癌症的方法，所述方法包括施用治疗有效量的特异性结合人Notch受体蛋白的细胞外结构域的非配体结合区的抗体并抑制肿瘤生长。
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公开(公告)号：US08425903B2
公开(公告)日：2013-04-23
申请号：US13472305
申请日：2012-05-15
申请人： Austin L. Gurney , Timothy Charles Hoey , Edward Thein Htun van der Horst , Aaron Ken Sato , Yuan Ching Liu , Maureen Fitch Bruhns , John A. Lewicki
发明人： Austin L. Gurney , Timothy Charles Hoey , Edward Thein Htun van der Horst , Aaron Ken Sato , Yuan Ching Liu , Maureen Fitch Bruhns , John A. Lewicki
IPC分类号： A61K39/395 , A61P35/00 , C07K16/28
CPC分类号： C07K16/22 , A61K31/337 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61N5/10 , C07H21/04 , C07K14/435 , C07K14/71 , C07K16/28 , C07K16/30 , C07K16/3046 , C07K16/462 , C07K16/464 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C12N5/0693 , C12N5/12 , C12N15/63 , C12N15/79 , C12N2501/998
摘要： The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides antibodies that specifically bind to a non-ligand binding region of the extracellular domain of one or more human Notch receptor, such as Notch2 and/or Notch3, and inhibit tumor growth. The present invention further provides methods of treating cancer, the methods comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.
摘要翻译： 本发明涉及Notch结合剂和Notch拮抗剂以及使用这些药剂和/或拮抗剂治疗诸如癌症的疾病的方法。 本发明提供了特异性结合一种或多种人Notch受体如Notch2和/或Notch3的细胞外结构域的非配体结合区并抑制肿瘤生长的抗体。 本发明还提供了治疗癌症的方法，所述方法包括施用治疗有效量的特异性结合人Notch受体蛋白的细胞外结构域的非配体结合区的抗体并抑制肿瘤生长。
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公开(公告)号：US08226943B2
公开(公告)日：2012-07-24
申请号：US12499627
申请日：2009-07-08
申请人： Austin L. Gurney , Timothy Charles Hoey , Edward Thein Htun van der Horst , Aaron Ken Sato , Yuan Ching Liu , Maureen Fitch Bruhns , John A. Lewicki
发明人： Austin L. Gurney , Timothy Charles Hoey , Edward Thein Htun van der Horst , Aaron Ken Sato , Yuan Ching Liu , Maureen Fitch Bruhns , John A. Lewicki
IPC分类号： A61K39/395 , C07K16/28 , C07K14/705 , C12N5/00
CPC分类号： C07K16/22 , A61K31/337 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61N5/10 , C07H21/04 , C07K14/435 , C07K14/71 , C07K16/28 , C07K16/30 , C07K16/3046 , C07K16/462 , C07K16/464 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C12N5/0693 , C12N5/12 , C12N15/63 , C12N15/79 , C12N2501/998
摘要： The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides antibodies that specifically bind to a non-ligand binding region of the extracellular domain of one or more human Notch receptor, such as Notch2 and/or Notch3, and inhibit tumor growth. The present invention further provides methods of treating cancer, the methods comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.
摘要翻译： 本发明涉及Notch结合剂和Notch拮抗剂以及使用这些药剂和/或拮抗剂治疗诸如癌症的疾病的方法。 本发明提供了特异性结合一种或多种人Notch受体如Notch2和/或Notch3的细胞外结构域的非配体结合区并抑制肿瘤生长的抗体。 本发明还提供了治疗癌症的方法，所述方法包括施用治疗有效量的特异性结合人Notch受体蛋白的细胞外结构域的非配体结合区的抗体并抑制肿瘤生长。
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公开(公告)号：US20100111958A1
公开(公告)日：2010-05-06
申请号：US12499627
申请日：2009-07-08
申请人： Austin L. Gurney , Timothy Charles Hoey , Edward Thein Htun van der Horst , Aaron Ken Sato , Yuan Ching Liu , Maureen Fitch Bruhns , John A. Lewicki
发明人： Austin L. Gurney , Timothy Charles Hoey , Edward Thein Htun van der Horst , Aaron Ken Sato , Yuan Ching Liu , Maureen Fitch Bruhns , John A. Lewicki
IPC分类号： A61K39/395 , C07K16/18 , C07K16/28 , A61P35/04 , C12N5/00 , C12N5/02 , C07K14/435 , C07H21/04
CPC分类号： C07K16/22 , A61K31/337 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61N5/10 , C07H21/04 , C07K14/435 , C07K14/71 , C07K16/28 , C07K16/30 , C07K16/3046 , C07K16/462 , C07K16/464 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C12N5/0693 , C12N5/12 , C12N15/63 , C12N15/79 , C12N2501/998
摘要： The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides antibodies that specifically bind to a non-ligand binding region of the extracellular domain of one or more human Notch receptor, such as Notch2 and/or Notch3, and inhibit tumor growth. The present invention further provides methods of treating cancer, the methods comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.
摘要翻译： 本发明涉及Notch结合剂和Notch拮抗剂以及使用这些药剂和/或拮抗剂治疗诸如癌症的疾病的方法。 本发明提供了特异性结合一种或多种人Notch受体如Notch2和/或Notch3的细胞外结构域的非配体结合区并抑制肿瘤生长的抗体。 本发明还提供了治疗癌症的方法，所述方法包括施用治疗有效量的特异性结合人Notch受体蛋白的细胞外结构域的非配体结合区的抗体并抑制肿瘤生长。
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公开(公告)号：US20110183866A1
公开(公告)日：2011-07-28
申请号：US13077380
申请日：2011-03-31
CPC分类号： G01N33/6887 , C12N5/0693 , C12N5/0695 , C12N2501/58 , C12Q1/6886 , G01N33/57484 , G01N2333/705
摘要： The present invention relates to compositions and methods for treating, characterizing, and diagnosing cancer. In particular, the present invention provides gene expression profiles and signatures associated with solid tumor stem cells, as well as novel stem cell cancer markers useful for the diagnosis, characterization, prognosis and treatment of solid tumor stem cells. More particularly, the present invention identifies two profiles of cancer stem cells useful for the diagnosis, characterization, and treatment of cancer and cancer metastases. The invention also provides a variety of reagents such as stem cell gene signatures for use in the diagnosis and management of cancer.
摘要翻译： 本发明涉及用于治疗，表征和诊断癌症的组合物和方法。 特别地，本发明提供了与实体肿瘤干细胞相关的基因表达谱和特征，以及用于实体瘤干细胞的诊断，表征，预后和治疗的新型干细胞癌标记。 更具体地，本发明鉴定了可用于癌症和癌症转移的诊断，表征和治疗的癌症干细胞的两个概况。 本发明还提供用于诊断和治疗癌症的多种试剂如干细胞基因特征。
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公开(公告)号：US20100093556A1
公开(公告)日：2010-04-15
申请号：US12512655
申请日：2009-07-30
CPC分类号： G01N33/6887 , C12N5/0693 , C12N5/0695 , C12N2501/58 , C12Q1/6886 , G01N33/57484 , G01N2333/705
摘要： The present invention relates to compositions and methods for treating, characterizing, and diagnosing cancer. In particular, the present invention provides gene expression profiles and signatures associated with solid tumor stem cells, as well as novel stem cell cancer markers useful for the diagnosis, characterization, prognosis and treatment of solid tumor stem cells. More particularly, the present invention identifies two profiles of cancer stem cells useful for the diagnosis, characterization, and treatment of cancer and cancer metastases. The invention also provides a variety of reagents such as stem cell gene signatures for use in the diagnosis and management of cancer.
摘要翻译： 本发明涉及用于治疗，表征和诊断癌症的组合物和方法。 特别地，本发明提供了与实体肿瘤干细胞相关的基因表达谱和特征，以及用于实体瘤干细胞的诊断，表征，预后和治疗的新型干细胞癌标记。 更具体地，本发明鉴定了可用于癌症和癌症转移的诊断，表征和治疗的癌症干细胞的两个概况。 本发明还提供用于诊断和治疗癌症的多种试剂如干细胞基因特征。
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公开(公告)号：US07939263B2
公开(公告)日：2011-05-10
申请号：US12512655
申请日：2009-07-30
IPC分类号： C12Q1/68
CPC分类号： G01N33/6887 , C12N5/0693 , C12N5/0695 , C12N2501/58 , C12Q1/6886 , G01N33/57484 , G01N2333/705
摘要： The present invention relates to compositions and methods for treating, characterizing, and diagnosing cancer. In particular, the present invention provides gene expression profiles and signatures associated with solid tumor stem cells, as well as novel stem cell cancer markers useful for the diagnosis, characterization, prognosis and treatment of solid tumor stem cells. More particularly, the present invention identifies two profiles of cancer stem cells useful for the diagnosis, characterization, and treatment of cancer and cancer metastases. The invention also provides a variety of reagents such as stem cell gene signatures for use in the diagnosis and management of cancer.
摘要翻译： 本发明涉及用于治疗，表征和诊断癌症的组合物和方法。 特别地，本发明提供了与实体肿瘤干细胞相关的基因表达谱和特征，以及用于实体瘤干细胞的诊断，表征，预后和治疗的新型干细胞癌标记。 更具体地，本发明鉴定了可用于癌症和癌症转移的诊断，表征和治疗的癌症干细胞的两个概况。 本发明还提供用于诊断和治疗癌症的多种试剂如干细胞基因特征。
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8.发明授权公开(公告)号：US07833791B2
公开(公告)日：2010-11-16
申请号：US11938044
申请日：2007-11-09
IPC分类号： C12N15/00
CPC分类号： C07K14/335 , A61K35/747 , A61K38/164 , A61K38/1774 , C12N15/74
摘要： The present invention relates to Lactobacillus species recombinantly altered to express a biologically active protein. The invention also related to methods of providing the bacteria to the vagina.
摘要翻译： 本发明涉及重组改变以表达生物活性蛋白质的乳杆菌属物种。 本发明还涉及将细菌提供给阴道的方法。
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公开(公告)号：US07179790B2
公开(公告)日：2007-02-20
申请号：US11234424
申请日：2005-09-23
IPC分类号： A61K38/00
CPC分类号： C12P21/02 , A61K38/00 , C07K14/58 , C07K14/582 , C07K16/241 , C07K16/2803 , C07K2317/622 , G01N33/74
摘要： Peptides comprising the effective portion of human brain natriuretic peptide are provided in pharmaceutical compositions and methods to effect vasodilation and/or natriuresis.
摘要翻译： 包含人脑钠肽的有效部分的肽在药物组合物和方法中提供以实现血管舒张和/或利尿。
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公开(公告)号：US06541477B2
公开(公告)日：2003-04-01
申请号：US09796997
申请日：2001-02-28
申请人： R. Richard Goehring , Babu J. Mavunkel , David Y. Liu , George F. Schreiner , Gregory Leudtke , John A. Lewicki
发明人： R. Richard Goehring , Babu J. Mavunkel , David Y. Liu , George F. Schreiner , Gregory Leudtke , John A. Lewicki
IPC分类号： A61K31495
CPC分类号： C07D215/04 , A61K31/00 , A61K31/426 , A61K31/445 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/495 , A61K31/496 , A61K31/522 , A61K31/5377 , A61K45/06 , C07D209/08 , C07D211/14 , C07D211/16 , C07D215/06 , C07D235/06 , C07D277/52 , C07D295/192 , C07D307/68 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/06 , C07D471/04 , C07D471/10 , C07D473/06 , C07D495/04
摘要： The invention is directed to methods for treating conditions mediated by by P38&agr; kinase using compounds of the formula wherein Ar1 and Ph are limited to specific embodiments or wherein the compound of formula (3) is a compound set forth in FIGS. 1A-1T.
摘要翻译： 本发明涉及用于治疗由P38α激酶介导的病症的方法，其中使用化学式Ar1和Ph的化合物限于具体实施方案或其中式（3）化合物是图1和图2所示的化合物。 1A-1T。
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