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1.发明申请Methods and compositions to modulate adhesion and stress tolerance in bacteria 审中-公开调节细菌粘附和胁迫耐受性的方法和组合物公开(公告)号：US20060269998A1
公开(公告)日：2006-11-30
申请号：US11404436
申请日：2006-04-14
IPC分类号： C07K14/335 , C07H21/04 , C12P21/06 , C12N1/20 , C12N15/74
CPC分类号： C12R1/23 , A23L33/135 , A23V2002/00 , C12N1/20 , C12N1/36 , C12P9/00 , A23V2200/3204
摘要： Methods and compositions are provided which improve the adhesion of a bacteria to target substrates and/or improve the stress tolerance of a bacteria. Methods comprise exposing bacteria to adhesion adaptive conditions and thereby increasing the adhesion activity and/or stress tolerance of the bacteria. Further provided are bacteria having a modulated production of autoinducer-2. Compositions include recombinant bacteria expressing nucleic acid molecules involved in the pathway of autoinducer-2 production. Further provided are autoinducer-2-related fusion proteins, antigenic peptides, antibodies, and vectors. Methods of screening compounds or environmental conditions which will stimulate the production of autoinducer-2 and/or produce an adhesion adaptive response are further provided, as are various methods of use for the bacteria having increased adhesion and/or stress tolerance.
摘要翻译： 提供了提高细菌与靶基质的粘附性和/或提高细菌的胁迫耐受性的方法和组合物。 方法包括将细菌暴露于粘附适应条件，从而增加细菌的粘附活性和/或应激耐受性。 进一步提供了具有调节生产自动诱导剂-2的细菌。 组合物包括表达参与自动诱导剂-2生产途径的核酸分子的重组细菌。 还提供了自动诱导剂-2相关融合蛋白，抗原肽，抗体和载体。 还提供了筛选化合物或环境条件的方法，所述化合物或环境条件将刺激自体诱导剂-2的产生和/或产生粘附适应性应答，对于具有增加的粘附和/或应激耐受性的细菌的各种使用方法也是如此。
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2.发明授权Lactobacillus acidophilus nucleic acid sequences encoding stress-related proteins and uses therefor 失效编码胁迫相关蛋白质的嗜酸乳杆菌核酸序列及其用途公开(公告)号：US07608700B2
公开(公告)日：2009-10-27
申请号：US11074176
申请日：2005-03-07
申请人： Todd R. Klaenhammer , Eric Altermann , M. Andrea Azcarate-Peril , Olivia McAuliffe , W. Michael Russell
发明人： Todd R. Klaenhammer , Eric Altermann , M. Andrea Azcarate-Peril , Olivia McAuliffe , W. Michael Russell
CPC分类号： C07K14/335
摘要： Stress-related nucleic acid molecules and polypeptides and fragments and variants thereof are disclosed in the current invention. In addition, stress-related fusion proteins, antigenic peptides, and anti-stress-related antibodies are encompassed. The invention also provides recombinant expression vectors containing a nucleic acid molecule of the invention and host cells into which the expression vectors have been introduced. Methods for producing the polypeptides and methods of use for the polypeptides of the invention are further disclosed.
摘要翻译： 应激相关的核酸分子及其多肽及其片段和变体在本发明中公开。 此外，还包括与应激相关的融合蛋白，抗原肽和抗应激相关抗体。 本发明还提供了含有本发明的核酸分子的重组表达载体和已经引入表达载体的宿主细胞。 进一步公开了制备多肽的方法和本发明多肽的使用方法。
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3.发明申请LACTOBACILLUS ACIDOPHILUS NUCLEIC ACID SEQUENCES ENCODING STRESS-RELATED PROTEINS AND USES THEREFOR 审中-公开Lactobacillus ACIDOPHILUS核酸序列编码与应激相关的蛋白质及其用途公开(公告)号：US20100028945A1
公开(公告)日：2010-02-04
申请号：US12543838
申请日：2009-08-19
申请人： Todd R. Klaenhammer , Eric Altermann , M. Andrea Azcarate-Peril , Olivia McAuliffe , W. Michael Russell
发明人： Todd R. Klaenhammer , Eric Altermann , M. Andrea Azcarate-Peril , Olivia McAuliffe , W. Michael Russell
CPC分类号： C07K14/335
摘要： Stress-related nucleic acid molecules and polypeptides and fragments and variants thereof are disclosed in the current invention. In addition, stress-related fusion proteins, antigenic peptides, and anti-stress-related antibodies are encompassed. The invention also provides recombinant expression vectors containing a nucleic acid molecule of the invention and host cells into which the expression vectors have been introduced. Methods for producing the polypeptides and methods of use for the polypeptides of the invention are further disclosed.
摘要翻译： 应激相关的核酸分子及其多肽及其片段和变体在本发明中公开。 此外，还包括与应激相关的融合蛋白，抗原肽和抗应激相关抗体。 本发明还提供了含有本发明的核酸分子的重组表达载体和已经引入表达载体的宿主细胞。 进一步公开了制备多肽的方法和本发明多肽的使用方法。
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4.发明授权Lactobacillus acidophillus nucleic acid sequences encoding cell surface protein homologues and uses therefore 失效因此，编码细胞表面蛋白质同源物的酸乳酸乳杆菌核酸序列公开(公告)号：US07538209B2
公开(公告)日：2009-05-26
申请号：US11701335
申请日：2007-02-01
CPC分类号： A23L3/3526 , A23C9/123 , A23C19/0323 , A23L33/18 , A61K38/00 , C07K14/335
摘要： Cell wall, cell surface and secreted protein nucleic acid molecules and polypeptides and fragments and variants thereof are disclosed in the current invention. In addition, cell wall, cell surface and secreted fusion proteins, antigenic peptides, and anti-cell wall, cell surface and secreted antibodies are encompassed. The invention also provides recombinant expression vectors containing a nucleic acid molecule of the invention and host cells into which the expression vectors have been introduced. Methods for producing the polypeptides of the invention and methods for their use are further disclosed.
摘要翻译： 细胞壁，细胞表面和分泌的蛋白质核酸分子及其多肽及其片段和变体在本发明中公开。 此外，还包括细胞壁，细胞表面和分泌的融合蛋白，抗原肽和抗细胞壁，细胞表面和分泌的抗体。 本发明还提供了含有本发明的核酸分子的重组表达载体和已经引入表达载体的宿主细胞。 本发明的多肽的制备方法及其使用方法进一步公开。
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5.发明授权Lactobacillus acidophilus nucleic acid sequences encoding cell surface protein homologues and uses therefore 失效嗜酸乳酸乳杆菌核酸序列编码细胞表面蛋白质同源物并因此使用公开(公告)号：US07534876B2
公开(公告)日：2009-05-19
申请号：US11701319
申请日：2007-02-01
CPC分类号： A23L3/3526 , A23C9/123 , A23C19/0323 , A23L33/18 , A61K38/00 , C07K14/335
摘要： Cell wall, cell surface and secreted protein nucleic acid molecules and polypeptides and fragments and variants thereof are disclosed in the current invention. In addition, cell wall, cell surface and secreted fusion proteins, antigenic peptides, and anti-cell wall, cell surface and secreted antibodies are encompassed. The invention also provides recombinant expression vectors containing a nucleic acid molecule of the invention and host cells into which the expression vectors have been introduced. Methods for producing the polypeptides of the invention and methods for their use are further disclosed.
摘要翻译： 细胞壁，细胞表面和分泌的蛋白质核酸分子及其多肽及其片段和变体在本发明中公开。 此外，还包括细胞壁，细胞表面和分泌的融合蛋白，抗原肽和抗细胞壁，细胞表面和分泌的抗体。 本发明还提供了含有本发明的核酸分子的重组表达载体和已经引入表达载体的宿主细胞。 本发明的多肽的制备方法及其使用方法进一步公开。
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6.发明授权Lactobacillus acidophilus nucleic acid sequences encoding cell surface protein homologues and uses therefore 失效嗜酸乳酸乳杆菌核酸序列编码细胞表面蛋白质同源物并因此使用公开(公告)号：US07348420B2
公开(公告)日：2008-03-25
申请号：US10831070
申请日：2004-04-23
CPC分类号： A23L3/3526 , A23C9/123 , A23C19/0323 , A23L33/18 , A61K38/00 , C07K14/335
摘要： Cell wall, cell surface and secreted protein nucleic acid molecules and polypeptides and fragments and variants thereof are disclosed in the current invention. In addition, cell wall, cell surface and secreted fusion proteins, antigenic peptides, and anti-cell wall, cell surface and secreted antibodies are encompassed. The invention also provides recombinant expression vectors containing a nucleic acid molecule of the invention and host cells into which the expression vectors have been introduced. Methods for producing the polypeptides of the invention and methods for their use are further disclosed.
摘要翻译： 细胞壁，细胞表面和分泌的蛋白质核酸分子及其多肽及其片段和变体在本发明中公开。 此外，还包括细胞壁，细胞表面和分泌的融合蛋白，抗原肽和抗细胞壁，细胞表面和分泌的抗体。 本发明还提供了含有本发明的核酸分子的重组表达载体和已经引入表达载体的宿主细胞。 本发明的多肽的制备方法及其使用方法进一步公开。
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7.发明申请LACTOBACILLUS ACIDOPHILUS NUCLEIC ACID SEQUENCES ENCODING CELL SURFACE PROTEIN HOMOLOGUES AND USES THEREFORE 审中-公开Lactobacillus ACIDOPHILUS核酸序列编码细胞表面蛋白质成因及其用途公开(公告)号：US20120149590A1
公开(公告)日：2012-06-14
申请号：US11942295
申请日：2007-11-19
CPC分类号： A23L3/3526 , A23C9/123 , A23C19/0323 , A23L33/18 , A61K38/00 , C07K14/335
摘要： Cell wall, cell surface and secreted protein nucleic acid molecules and polypeptides and fragments and variants thereof are disclosed in the current invention. In addition, cell wall, cell surface and secreted fusion proteins, antigenic peptides, and anti-cell wall, cell surface and secreted antibodies are encompassed. The invention also provides recombinant expression vectors containing a nucleic acid molecule of the invention and host cells into which the expression vectors have been introduced. Methods for producing the polypeptides of the invention and methods for their use are further disclosed.
摘要翻译： 细胞壁，细胞表面和分泌的蛋白质核酸分子及其多肽及其片段和变体在本发明中公开。 此外，还包括细胞壁，细胞表面和分泌的融合蛋白，抗原肽和抗细胞壁，细胞表面和分泌的抗体。 本发明还提供了含有本发明的核酸分子的重组表达载体和已经引入表达载体的宿主细胞。 本发明的多肽的制备方法及其使用方法进一步公开。
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8.发明申请Lactobacillus acidophilus nucleic acid sequences encoding cell surface protein homologues and uses therefore 失效嗜酸乳酸乳杆菌核酸序列编码细胞表面蛋白质同源物并因此使用公开(公告)号：US20070172495A1
公开(公告)日：2007-07-26
申请号：US11701319
申请日：2007-02-01
申请人： Todd Klaenhammer , Eric Altermann , B. Buck , W. Michael Russell
发明人： Todd Klaenhammer , Eric Altermann , B. Buck , W. Michael Russell
IPC分类号： A61K48/00 , A61K39/02 , C12Q1/68 , G01N33/554 , C07H21/04 , C12P21/06 , C07K14/335
CPC分类号： A23L3/3526 , A23C9/123 , A23C19/0323 , A23L33/18 , A61K38/00 , C07K14/335
摘要： Cell wall, cell surface and secreted protein nucleic acid molecules and polypeptides and fragments and variants thereof are disclosed in the current invention. In addition, cell wall, cell surface and secreted fusion proteins, antigenic peptides, and anti-cell wall, cell surface and secreted antibodies are encompassed. The invention also provides recombinant expression vectors containing a nucleic acid molecule of the invention and host cells into which the expression vectors have been introduced. Methods for producing the polypeptides of the invention and methods for their use are further disclosed.
摘要翻译： 细胞壁，细胞表面和分泌的蛋白质核酸分子及其多肽及其片段和变体在本发明中公开。 此外，还包括细胞壁，细胞表面和分泌的融合蛋白，抗原肽和抗细胞壁，细胞表面和分泌的抗体。 本发明还提供了含有本发明的核酸分子的重组表达载体和已经引入表达载体的宿主细胞。 本发明的多肽的制备方法及其使用方法进一步公开。
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公开(公告)号：US07468182B2
公开(公告)日：2008-12-23
申请号：US11260843
申请日：2005-10-27
CPC分类号： C12N9/0044 , A23C9/1234 , A23C2220/202 , A23L33/135 , A61K35/747 , A61K38/00 , A61K2035/11 , C07K14/335 , C12N9/0008 , C12N9/1051 , C12N9/13 , C12N9/14 , C12N9/16 , C12N9/18 , C12N9/2471 , C12N9/80 , C12N9/88 , C12N9/90 , C12Q1/689 , C12Y302/01023
摘要： Lactobacillus acidophilus NCFM nucleic acid molecules, polypeptides, fragments and variants thereof are provided in the current invention. In addition, fusion proteins, antigenic peptides, and antibodies are encompassed. The invention also provides recombinant expression vectors containing a nucleic acid molecule of the invention and cells comprising the expression vectors. Methods for producing the polypeptides of the invention and methods for their use are further provided.
摘要翻译： 本发明提供了嗜酸乳杆菌NCFM核酸分子，多肽，其片段和变体。 此外，还包括融合蛋白，抗原肽和抗体。 本发明还提供含有本发明的核酸分子和包含表达载体的细胞的重组表达载体。 还提供了制备本发明多肽的方法及其使用方法。
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公开(公告)号：US20090155213A1
公开(公告)日：2009-06-18
申请号：US12253333
申请日：2008-10-17
IPC分类号： A61K45/00 , C07H21/04 , C12N1/20 , C07K14/00 , C07K16/00 , C12N15/74 , C12P21/06 , C12Q1/68 , G01N33/53 , A61P35/00
CPC分类号： C12N9/0044 , A23C9/1234 , A23C2220/202 , A23L33/135 , A61K35/747 , A61K38/00 , A61K2035/11 , C07K14/335 , C12N9/0008 , C12N9/1051 , C12N9/13 , C12N9/14 , C12N9/16 , C12N9/18 , C12N9/2471 , C12N9/80 , C12N9/88 , C12N9/90 , C12Q1/689 , C12Y302/01023
摘要： Lactobacillus acidophilus NCFM nucleic acid molecules, polypeptides, fragments and variants thereof are provided in the current invention. In addition, fusion proteins, antigenic peptides, and antibodies are encompassed. The invention also provides recombinant expression vectors containing a nucleic acid molecule of the invention and cells comprising the expression vectors. Methods for producing the polypeptides of the invention and methods for their use are further provided.
摘要翻译： 本发明提供了嗜酸乳杆菌NCFM核酸分子，多肽，其片段和变体。 此外，还包括融合蛋白，抗原肽和抗体。 本发明还提供含有本发明的核酸分子和包含表达载体的细胞的重组表达载体。 还提供了制备本发明多肽的方法及其使用方法。
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