利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

35 条记录 (耗时 0.041 秒)

    Methods and compositions to modulate adhesion and stress tolerance in bacteria
    4.
    发明申请
    Methods and compositions to modulate adhesion and stress tolerance in bacteria 审中-公开
    调节细菌粘附和胁迫耐受性的方法和组合物

    公开(公告)号：US20060269998A1

    公开(公告)日：2006-11-30

    申请号：US11404436

    申请日：2006-04-14

    申请人： B. Logan Buck ,  M. Andrea Azcarate-Peril ,  Eric Altermann ,  Todd Klaenhammer

    发明人： B. Logan Buck ,  M. Andrea Azcarate-Peril ,  Eric Altermann ,  Todd Klaenhammer

    IPC分类号： C07K14/335 ,  C07H21/04 ,  C12P21/06 ,  C12N1/20 ,  C12N15/74

    CPC分类号： C12R1/23 ,  A23L33/135 ,  A23V2002/00 ,  C12N1/20 ,  C12N1/36 ,  C12P9/00 ,  A23V2200/3204

    摘要： Methods and compositions are provided which improve the adhesion of a bacteria to target substrates and/or improve the stress tolerance of a bacteria. Methods comprise exposing bacteria to adhesion adaptive conditions and thereby increasing the adhesion activity and/or stress tolerance of the bacteria. Further provided are bacteria having a modulated production of autoinducer-2. Compositions include recombinant bacteria expressing nucleic acid molecules involved in the pathway of autoinducer-2 production. Further provided are autoinducer-2-related fusion proteins, antigenic peptides, antibodies, and vectors. Methods of screening compounds or environmental conditions which will stimulate the production of autoinducer-2 and/or produce an adhesion adaptive response are further provided, as are various methods of use for the bacteria having increased adhesion and/or stress tolerance.

    摘要翻译： 提供了提高细菌与靶基质的粘附性和/或提高细菌的胁迫耐受性的方法和组合物。 方法包括将细菌暴露于粘附适应条件，从而增加细菌的粘附活性和/或应激耐受性。 进一步提供了具有调节生产自动诱导剂-2的细菌。 组合物包括表达参与自动诱导剂-2生产途径的核酸分子的重组细菌。 还提供了自动诱导剂-2相关融合蛋白，抗原肽，抗体和载体。 还提供了筛选化合物或环境条件的方法，所述化合物或环境条件将刺激自体诱导剂-2的产生和/或产生粘附适应性应答，对于具有增加的粘附和/或应激耐受性的细菌的各种使用方法也是如此。

    Lactobacillus acidophilus nucleic acid sequences encoding protease homologues and uses therefore
    6.
    发明申请
    Lactobacillus acidophilus nucleic acid sequences encoding protease homologues and uses therefore 失效
    因此，编码蛋白酶同源物的嗜酸乳杆菌核酸序列和用途

    公开(公告)号：US20070003667A1

    公开(公告)日：2007-01-04

    申请号：US11062665

    申请日：2005-02-22

    申请人： Todd Klaenhammer ,  Eric Altermann ,  W. Russell

    发明人： Todd Klaenhammer ,  Eric Altermann ,  W. Russell

    IPC分类号： A23C9/12 ,  C07H21/04 ,  C12N9/48 ,  C12N1/21 ,  C12N15/74

    CPC分类号： C12N9/50 ,  C07K14/335

    摘要： Protease-like nucleic acid molecules and polypeptides and fragments and variants thereof are disclosed in the current invention. In addition, protease-like fusion proteins, antigenic peptides, and anti-protease-like antibodies are encompassed. The invention also provides vectors containing a nucleic acid molecule of the invention and cells into which the vectors have been introduced. Methods for producing the polypeptides and methods of use for the polypeptides of the invention are further disclosed.

    摘要翻译： 蛋白酶样核酸分子及其多肽及其片段和变体在本发明中公开。 此外，还包括蛋白酶样融合蛋白，抗原肽和抗蛋白酶样抗体。 本发明还提供了含有本发明的核酸分子的载体和已经引入载体的细胞。 进一步公开了制备多肽的方法和本发明多肽的使用方法。

    Lactobacillus acidophilus nucleic acid sequences encoding carbohydrate utilization-related proteins and uses therefor
    9.
    发明申请
    Lactobacillus acidophilus nucleic acid sequences encoding carbohydrate utilization-related proteins and uses therefor 失效
    编码碳水化合物利用相关蛋白质的嗜酸乳酸乳杆菌核酸序列及其用途

    公开(公告)号：US20070003668A1

    公开(公告)日：2007-01-04

    申请号：US11074226

    申请日：2005-03-07

    申请人： Todd Klaenhammer ,  Eric Altermann ,  Rodolphe Barrangou ,  W. Russell ,  Tri Duong

    发明人： Todd Klaenhammer ,  Eric Altermann ,  Rodolphe Barrangou ,  W. Russell ,  Tri Duong

    IPC分类号： C07H21/04 ,  A23C9/12 ,  C12P21/06 ,  C12N9/24 ,  C12N15/74 ,  C12N1/21

    CPC分类号： C07K14/335

    摘要： Carbohydrate utilization-related and multidrug transporter nucleic acids and polypeptides, and fragments and variants thereof, are disclosed in the current invention. In addition, carbohydrate utilization-related and multidrug transporter fusion proteins, antigenic peptides, and anti-carbohydrate utilization-related and anti-multidrug transporter antibodies are encompassed. The invention also provides vectors containing a nucleic acid of the invention and cells into which the vector has been introduced. Methods for producing the polypeptides and methods of use for the polypeptides of the invention are further disclosed.

    摘要翻译： 碳水化合物利用相关和多药转运蛋白核酸和多肽及其片段和变体在本发明中公开。 此外，包括碳水化合物利用相关和多药转运蛋白融合蛋白，抗原肽和抗碳水化合物利用相关和抗多药转运体抗体。 本发明还提供了含有本发明的核酸的载体和载体已导入其中的载体。 进一步公开了制备多肽的方法和本发明多肽的使用方法。