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公开(公告)号：US20220364975A1
公开(公告)日：2022-11-17
申请号：US17872872
申请日：2022-07-25
发明人： Utkan Demirci , Waseem Asghar
摘要： A system and method for sorting sperm is provided. The system includes a housing and a microfluidic system supported by the housing. The system also includes an inlet providing access to the microfluidic system to deliver sperm to the microfluidic system and an outlet providing access to the microfluidic system to harvest sorted sperm from the microfluidic system. The microfluidic system provides a flow path for sperm from the inlet to the outlet and includes at least one channel extending from the inlet to the outlet to allow sperm delivered to the microfluidic system through the inlet to progress along the flow path toward the outlet. The microfluidic system also includes a filter including a first plurality of micropores arranged in the flow path between the inlet and the outlet to cause sperm traveling along the flow path to move against through the filter and gravity to reach the outlet.
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公开(公告)号：US10208282B2
公开(公告)日：2019-02-19
申请号：US15121635
申请日：2015-02-25
发明人： Utkan Demirci , Savas Tasoglu
摘要： In one aspect, the present disclosure provides a method for self-assembly of magnetic building blocks, including distributing a plurality of building blocks in a liquid medium, each of the plurality of building blocks having a plurality of stable radicals, establishing a magnetic field interacting with at least a portion of the plurality of building blocks, guiding with the magnetic field the portion of the plurality of building blocks from a first location in the liquid medium to a second location in the liquid medium, assembling into a first construct the portion of the plurality of building blocks proximate the second location, and treating the first construct with at least one antioxidant to neutralize at least in part the plurality of stable radicals.
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公开(公告)号：US20240344958A1
公开(公告)日：2024-10-17
申请号：US18628507
申请日：2024-04-05
发明人： Utkan Demirci , Waseem Asghar
CPC分类号： G01N15/10 , B01L3/502753 , C12N5/061 , C12N5/0612 , G01N1/4005 , G01N15/00 , C12M21/06 , G01N2001/4088 , G01N2015/0003 , G01N15/01 , G01N2015/1006 , G01N2015/1028 , G01N2800/367
摘要： A system and method for sorting sperm is provided. The system includes a housing and a microfluidic system supported by the housing. The system also includes an inlet providing access to the microfluidic system to deliver sperm to the microfluidic system and an outlet providing access to the microfluidic system to harvest sorted sperm from the microfluidic system. The microfluidic system provides a flow path for sperm from the inlet to the outlet and includes at least one channel extending from the inlet to the outlet to allow sperm delivered to the microfluidic system through the inlet to progress along the flow path toward the outlet. The microfluidic system also includes a filter including a first plurality of micropores arranged in the flow path between the inlet and the outlet to cause sperm traveling along the flow path to move against through the filter and gravity to reach the outlet.
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公开(公告)号：US11709122B2
公开(公告)日：2023-07-25
申请号：US17322464
申请日：2021-05-17
发明人： Utkan Demirci , Waseem Asghar
CPC分类号： G01N15/10 , B01L3/502753 , C12N5/061 , C12N5/0612 , G01N1/4005 , G01N15/00 , C12M21/06 , G01N2001/4088 , G01N2015/0003 , G01N2015/0065 , G01N2015/1006 , G01N2015/1081 , G01N2800/367
摘要： A system and method for sorting sperm is provided. The system includes a housing and a microfluidic system supported by the housing. The system also includes an inlet providing access to the microfluidic system to deliver sperm to the microfluidic system and an outlet providing access to the microfluidic system to harvest sorted sperm from the microfluidic system. The microfluidic system provides a flow path for sperm from the inlet to the outlet and includes at least one channel extending from the inlet to the outlet to allow sperm delivered to the microfluidic system through the inlet to progress along the flow path toward the outlet. The microfluidic system also includes a filter including a first plurality of micropores arranged in the flow path between the inlet and the outlet to cause sperm traveling along the flow path to move against through the filter and gravity to reach the outlet.
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公开(公告)号：US10769765B2
公开(公告)日：2020-09-08
申请号：US16409979
申请日：2019-05-13
摘要： Method and system for lensless, shadow optical imaging. Formation of a hologram shadow image having higher spatial resolution and lower noise level is accomplished by processing image information contained in multiple individual hologram shadow image frames acquired either under conditions of relative shift between point light source and the detector of the system or under stationary conditions, when system remains fixed in space and is devoid of any relative movement during the process of acquisition of individual image frames.
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公开(公告)号：US20170248592A1
公开(公告)日：2017-08-31
申请号：US15594863
申请日：2017-05-15
发明人： Shuqi Wang , Utkan Demirci , Bin Ye , Ragip Akbas
IPC分类号： G01N33/543 , G01N21/25 , G01N21/27 , G01N21/29 , G01N35/00 , G01N21/78 , G01N33/53 , G01N33/569 , G01N33/574 , C12Q1/00 , G01N21/64
CPC分类号： G01N33/54386 , C12Q1/00 , G01N21/253 , G01N21/274 , G01N21/29 , G01N21/6452 , G01N21/78 , G01N33/53 , G01N33/56916 , G01N33/56972 , G01N33/57449 , G01N35/00
摘要： A system and method for analyzing a biomarker in a biological sample is provided. A biological sample is loaded onto a microchip and an enzyme-linked immunosorbent assay specific to the biomarker is performed on the microchip. A color image of the microchip is generated using a mobile device and a color intensity of a selected portion of the color image is determined. The color intensity is correlated with a biomarker concentration using a baseline curve calculation and the concentration of the biomarker is then reported.
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公开(公告)号：US20160145566A1
公开(公告)日：2016-05-26
申请号：US14898297
申请日：2014-06-20
发明人： Pu Chen , Utkan Demirci
CPC分类号： C12N5/0062 , B01D43/00 , C12M21/08 , C12M35/04 , C12N13/00
摘要： A method manufactures a structure based on reconfigurable assembly with faraday wave-based templates. The method includes the steps of providing a chamber containing a gas-liquid interface or liquid-liquid interface and dispersing a plurality of floaters at the gas-liquid interface or liquid-liquid interface. The method further includes oscillating the chamber along an axis orthogonal to the gas-liquid interface or liquid-liquid interface, thereby generating a standing wave formed by a parametric instability on the surface of the liquid. After formation of the standing wave, the floaters are allowed to self-assemble, at which point the floaters can be linked together.
摘要翻译： 一种方法制造了基于法拉第波形模板的基于可重构装配的结构。 该方法包括以下步骤：提供容纳气 - 液界面或液 - 液界面的室，并将多个浮子分散在气 - 液界面或液 - 液界面处。 该方法还包括沿着与液 - 液界面或液 - 液界面正交的轴振荡室，由此产生在液体表面上由参数不稳定性形成的驻波。 在形成驻波之后，允许浮子自组装，此时浮子可以连接在一起。
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公开(公告)号：US11946846B2
公开(公告)日：2024-04-02
申请号：US18367772
申请日：2023-09-13
发明人： Utkan Demirci , Waseem Asghar
CPC分类号： G01N15/10 , B01L3/502753 , C12N5/061 , C12N5/0612 , G01N1/4005 , G01N15/00 , C12M21/06 , G01N2001/4088 , G01N2015/0003 , G01N2015/0065 , G01N2015/1006 , G01N2015/1081 , G01N2800/367
摘要： A system and method for sorting sperm is provided. The system includes a housing and a microfluidic system supported by the housing. The system also includes an inlet providing access to the microfluidic system to deliver sperm to the microfluidic system and an outlet providing access to the microfluidic system to harvest sorted sperm from the microfluidic system. The microfluidic system provides a flow path for sperm from the inlet to the outlet and includes at least one channel extending from the inlet to the outlet to allow sperm delivered to the microfluidic system through the inlet to progress along the flow path toward the outlet. The microfluidic system also includes a filter including a first plurality of micropores arranged in the flow path between the inlet and the outlet to cause sperm traveling along the flow path to move against through the filter and gravity to reach the outlet.
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公开(公告)号：US11788943B2
公开(公告)日：2023-10-17
申请号：US17872872
申请日：2022-07-25
发明人： Utkan Demirci , Waseem Asghar
CPC分类号： G01N15/10 , B01L3/502753 , C12N5/061 , C12N5/0612 , G01N1/4005 , G01N15/00 , C12M21/06 , G01N2001/4088 , G01N2015/0003 , G01N2015/0065 , G01N2015/1006 , G01N2015/1081 , G01N2800/367
摘要： A system and method for sorting sperm is provided. The system includes a housing and a microfluidic system supported by the housing. The system also includes an inlet providing access to the microfluidic system to deliver sperm to the microfluidic system and an outlet providing access to the microfluidic system to harvest sorted sperm from the microfluidic system. The microfluidic system provides a flow path for sperm from the inlet to the outlet and includes at least one channel extending from the inlet to the outlet to allow sperm delivered to the microfluidic system through the inlet to progress along the flow path toward the outlet. The microfluidic system also includes a filter including a first plurality of micropores arranged in the flow path between the inlet and the outlet to cause sperm traveling along the flow path to move against through the filter and gravity to reach the outlet.
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公开(公告)号：US11009444B2
公开(公告)日：2021-05-18
申请号：US16544762
申请日：2019-08-19
发明人： Utkan Demirci , Waseem Asghar
摘要： A system and method for sorting sperm is provided. The system includes a housing and a microfluidic system supported by the housing. The system also includes an inlet providing access to the microfluidic system to deliver sperm to the microfluidic system and an outlet providing access to the microfluidic system to harvest sorted sperm from the microfluidic system. The microfluidic system provides a flow path for sperm from the inlet to the outlet and includes at least one channel extending from the inlet to the outlet to allow sperm delivered to the microfluidic system through the inlet to progress along the flow path toward the outlet. The microfluidic system also includes a filter including a first plurality of micropores arranged in the flow path between the inlet and the outlet to cause sperm traveling along the flow path to move against through the filter and gravity to reach the outlet.
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