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公开(公告)号：US20220364975A1
公开(公告)日：2022-11-17
申请号：US17872872
申请日：2022-07-25
发明人： Utkan Demirci , Waseem Asghar
摘要： A system and method for sorting sperm is provided. The system includes a housing and a microfluidic system supported by the housing. The system also includes an inlet providing access to the microfluidic system to deliver sperm to the microfluidic system and an outlet providing access to the microfluidic system to harvest sorted sperm from the microfluidic system. The microfluidic system provides a flow path for sperm from the inlet to the outlet and includes at least one channel extending from the inlet to the outlet to allow sperm delivered to the microfluidic system through the inlet to progress along the flow path toward the outlet. The microfluidic system also includes a filter including a first plurality of micropores arranged in the flow path between the inlet and the outlet to cause sperm traveling along the flow path to move against through the filter and gravity to reach the outlet.
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公开(公告)号：US20240344958A1
公开(公告)日：2024-10-17
申请号：US18628507
申请日：2024-04-05
发明人： Utkan Demirci , Waseem Asghar
CPC分类号： G01N15/10 , B01L3/502753 , C12N5/061 , C12N5/0612 , G01N1/4005 , G01N15/00 , C12M21/06 , G01N2001/4088 , G01N2015/0003 , G01N15/01 , G01N2015/1006 , G01N2015/1028 , G01N2800/367
摘要： A system and method for sorting sperm is provided. The system includes a housing and a microfluidic system supported by the housing. The system also includes an inlet providing access to the microfluidic system to deliver sperm to the microfluidic system and an outlet providing access to the microfluidic system to harvest sorted sperm from the microfluidic system. The microfluidic system provides a flow path for sperm from the inlet to the outlet and includes at least one channel extending from the inlet to the outlet to allow sperm delivered to the microfluidic system through the inlet to progress along the flow path toward the outlet. The microfluidic system also includes a filter including a first plurality of micropores arranged in the flow path between the inlet and the outlet to cause sperm traveling along the flow path to move against through the filter and gravity to reach the outlet.
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公开(公告)号：US11709122B2
公开(公告)日：2023-07-25
申请号：US17322464
申请日：2021-05-17
发明人： Utkan Demirci , Waseem Asghar
CPC分类号： G01N15/10 , B01L3/502753 , C12N5/061 , C12N5/0612 , G01N1/4005 , G01N15/00 , C12M21/06 , G01N2001/4088 , G01N2015/0003 , G01N2015/0065 , G01N2015/1006 , G01N2015/1081 , G01N2800/367
摘要： A system and method for sorting sperm is provided. The system includes a housing and a microfluidic system supported by the housing. The system also includes an inlet providing access to the microfluidic system to deliver sperm to the microfluidic system and an outlet providing access to the microfluidic system to harvest sorted sperm from the microfluidic system. The microfluidic system provides a flow path for sperm from the inlet to the outlet and includes at least one channel extending from the inlet to the outlet to allow sperm delivered to the microfluidic system through the inlet to progress along the flow path toward the outlet. The microfluidic system also includes a filter including a first plurality of micropores arranged in the flow path between the inlet and the outlet to cause sperm traveling along the flow path to move against through the filter and gravity to reach the outlet.
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公开(公告)号：US10769765B2
公开(公告)日：2020-09-08
申请号：US16409979
申请日：2019-05-13
摘要： Method and system for lensless, shadow optical imaging. Formation of a hologram shadow image having higher spatial resolution and lower noise level is accomplished by processing image information contained in multiple individual hologram shadow image frames acquired either under conditions of relative shift between point light source and the detector of the system or under stationary conditions, when system remains fixed in space and is devoid of any relative movement during the process of acquisition of individual image frames.
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公开(公告)号：US11946846B2
公开(公告)日：2024-04-02
申请号：US18367772
申请日：2023-09-13
发明人： Utkan Demirci , Waseem Asghar
CPC分类号： G01N15/10 , B01L3/502753 , C12N5/061 , C12N5/0612 , G01N1/4005 , G01N15/00 , C12M21/06 , G01N2001/4088 , G01N2015/0003 , G01N2015/0065 , G01N2015/1006 , G01N2015/1081 , G01N2800/367
摘要： A system and method for sorting sperm is provided. The system includes a housing and a microfluidic system supported by the housing. The system also includes an inlet providing access to the microfluidic system to deliver sperm to the microfluidic system and an outlet providing access to the microfluidic system to harvest sorted sperm from the microfluidic system. The microfluidic system provides a flow path for sperm from the inlet to the outlet and includes at least one channel extending from the inlet to the outlet to allow sperm delivered to the microfluidic system through the inlet to progress along the flow path toward the outlet. The microfluidic system also includes a filter including a first plurality of micropores arranged in the flow path between the inlet and the outlet to cause sperm traveling along the flow path to move against through the filter and gravity to reach the outlet.
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公开(公告)号：US11788943B2
公开(公告)日：2023-10-17
申请号：US17872872
申请日：2022-07-25
发明人： Utkan Demirci , Waseem Asghar
CPC分类号： G01N15/10 , B01L3/502753 , C12N5/061 , C12N5/0612 , G01N1/4005 , G01N15/00 , C12M21/06 , G01N2001/4088 , G01N2015/0003 , G01N2015/0065 , G01N2015/1006 , G01N2015/1081 , G01N2800/367
摘要： A system and method for sorting sperm is provided. The system includes a housing and a microfluidic system supported by the housing. The system also includes an inlet providing access to the microfluidic system to deliver sperm to the microfluidic system and an outlet providing access to the microfluidic system to harvest sorted sperm from the microfluidic system. The microfluidic system provides a flow path for sperm from the inlet to the outlet and includes at least one channel extending from the inlet to the outlet to allow sperm delivered to the microfluidic system through the inlet to progress along the flow path toward the outlet. The microfluidic system also includes a filter including a first plurality of micropores arranged in the flow path between the inlet and the outlet to cause sperm traveling along the flow path to move against through the filter and gravity to reach the outlet.
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公开(公告)号：US11009444B2
公开(公告)日：2021-05-18
申请号：US16544762
申请日：2019-08-19
发明人： Utkan Demirci , Waseem Asghar
摘要： A system and method for sorting sperm is provided. The system includes a housing and a microfluidic system supported by the housing. The system also includes an inlet providing access to the microfluidic system to deliver sperm to the microfluidic system and an outlet providing access to the microfluidic system to harvest sorted sperm from the microfluidic system. The microfluidic system provides a flow path for sperm from the inlet to the outlet and includes at least one channel extending from the inlet to the outlet to allow sperm delivered to the microfluidic system through the inlet to progress along the flow path toward the outlet. The microfluidic system also includes a filter including a first plurality of micropores arranged in the flow path between the inlet and the outlet to cause sperm traveling along the flow path to move against through the filter and gravity to reach the outlet.
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8.发明申请公开(公告)号：US20200222907A1
公开(公告)日：2020-07-16
申请号：US16824228
申请日：2020-03-19
申请人： DxNow, Inc. , The Brigham and Women's Hospital, Inc. , Board of Trustees of the Leland Stanford Junior University
发明人： Leonard Klevan , Fatih lnci , Utkan Demirci
摘要： Embodiments of the present disclosure relate to a magnetic bead platform for isolating sperm cells from biological samples. In some embodiments, such magnetic bead platforms integrate recognition reagents to its surface to bind target cells, such as sperm cells. Such embodiments provide the ability to at least one of rapidly isolate and quantitate sperm cells from biological samples as occur in sexual assault evidence, for example, thereby enhancing identification of suspects in these cases and contributing to the safety of society.
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公开(公告)号：US20190340736A1
公开(公告)日：2019-11-07
申请号：US16409979
申请日：2019-05-13
摘要： Method and system for lensless, shadow optical imaging. Formation of a hologram shadow image having higher spatial resolution and lower noise level is accomplished by processing image information contained in multiple individual hologram shadow image frames acquired either under conditions of relative shift between point light source and the detector of the system or under stationary conditions, when system remains fixed in space and is devoid of any relative movement during the process of acquisition of individual image frames.
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公开(公告)号：US20240361343A1
公开(公告)日：2024-10-31
申请号：US18771037
申请日：2024-07-12
申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , BETH ISRAEL DEACONESS MEDICAL CENTER
发明人： Utkan Demirci , Ionita Ghiran , Savas Tasoglu , Ronald W. Davis , Lars Steinmetz , Naside Gozde Durmus , Huseyin Cumhur Tekin
IPC分类号： G01N33/80 , B01L3/00 , B03C1/32 , C12N13/00 , C12Q1/18 , G01N15/00 , G01N15/06 , G01N15/10 , G01N15/1031 , G01N27/76 , G01N33/487 , G01N33/49 , G01N33/574
CPC分类号： G01N33/80 , B01L3/502715 , B01L3/502761 , B03C1/32 , C12N13/00 , C12Q1/18 , G01N15/0656 , G01N15/1031 , G01N27/76 , G01N33/487 , G01N33/491 , G01N33/574 , B01L2200/0647 , B01L2300/0654 , B01L2300/0838 , B01L2300/168 , B03C2201/18 , B03C2201/26 , G01N2015/0053 , G01N2015/1006 , G01N2500/10 , G01N2800/042 , G01N2800/26 , G01N2800/52 , G01N2800/7042
摘要： Magnetic cell levitation and cell monitoring systems and methods are disclosed. A method for separating a heterogeneous population of cells is performed by placing a microcapillary channel containing the heterogeneous population of cells in a magnetically-responsive medium in the disclosed levitation system and separating the cells by balancing magnetic and corrected gravitational forces on the individual cells. A levitation system is also disclosed, having a microscope on which the microcapillary channel is placed and a set of two magnets between which the microcapillary channel is placed. Additionally, a method for monitoring cellular processes in real-time using the levitation system is disclosed.
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