利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

13 条记录 (耗时 0.028 秒)

    SMALL MOLECULE PRINTING
    2.
    发明申请
    SMALL MOLECULE PRINTING 审中-公开
    小分子印刷

    公开(公告)号：US20120021933A1

    公开(公告)日：2012-01-26

    申请号：US13094609

    申请日：2011-04-26

    申请人： Seung Bum Park ,  David Barnes-Seeman ,  Angela N. Koehler ,  Stuart L. Schreiber

    发明人： Seung Bum Park ,  David Barnes-Seeman ,  Angela N. Koehler ,  Stuart L. Schreiber

    IPC分类号： C40B30/04 ,  C40B50/18 ,  C40B60/08 ,  C40B40/04

    CPC分类号： C40B60/14 ,  B01J19/0046 ,  B01J2219/00387 ,  B01J2219/00454 ,  B01J2219/00459 ,  B01J2219/005 ,  B01J2219/00533 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/0072 ,  C07B2200/11 ,  C07C311/49 ,  C40B30/04 ,  C40B40/04 ,  C40B50/14 ,  G01N33/54353 ,  Y10S436/809

    摘要： The present invention provides compositions and methods to facilitate the identification of compounds that are capable of interacting with a biological macromolecule of interest. In one aspect, a composition is provided that comprises an array of one or more types of chemical compounds attached to a solid support, wherein the density of the array of compounds is at least 1000 spots per cm2. In particularly preferred embodiments, these compounds are attached to the solid support through a covalent interaction. In general, these inventive arrays are generated by: (1) providing a solid support, wherein said solid support is functionalized with a selected chemical moiety capable of interacting with a desired chemical compound to form an attachment; (2) providing one or more solutions of one or more types of compounds to be attached to the solid support; and (3) delivering said one or more types of compounds to the solid support, whereby an array is formed and the array of compounds has a density of at least 1000 spots per cm2. In another aspect, the present invention provides methods for utilizing these arrays to identify small molecule partners for biological macromolecules of interest comprising: (1) providing an array of compounds, wherein the array has a density of at least 1000 spots per cm2; (2) contacting the array with one of more types of biological macromolecules of interest; and (3) determining the interaction of specific small molecule-biological macromolecule partners.

    摘要翻译： 本发明提供了有助于鉴定能够与感兴趣的生物大分子相互作用的化合物的组合物和方法。 在一个方面，提供了包含连接到固体支持物上的一种或多种类型化学化合物的阵列的组合物，其中化合物阵列的密度为每cm 2至少1000个点。 在特别优选的实施方案中，这些化合物通过共价相互作用连接到固体支持物上。 通常，这些本发明的阵列通过以下方式产生：（1）提供固体支持物，其中所述固体支持物用能够与所需化学化合物相互作用以形成附着物的选定化学部分官能化; （2）提供待连接到固体支持物上的一种或多种类型化合物的一种或多种溶液; 和（3）将所述一种或多种类型的化合物递送到固体支持物，由此形成阵列，并且化合物阵列的密度至少为1000个点/ cm2。 在另一方面，本发明提供了利用这些阵列鉴定感兴趣的生物大分子的小分子伴侣的方法，包括：（1）提供化合物阵列，其中阵列的密度至少为1000个点/ cm2; （2）使阵列与感兴趣的多种生物大分子之一接触; 和（3）确定特定小分子 - 生物大分子伴侣的相互作用。

    NANOSOAP CONTAINING SILVER NANOPARTICLES
    4.
    发明申请
    NANOSOAP CONTAINING SILVER NANOPARTICLES 审中-公开
    包含银纳米粒子的纳米糖

    公开(公告)号：US20100056485A1

    公开(公告)日：2010-03-04

    申请号：US12200817

    申请日：2008-08-28

    申请人： Seung Bum Park

    发明人： Seung Bum Park

    IPC分类号： A61K31/661 ,  A61K31/555 ,  A61P31/04 ,  A61P31/12 ,  A61P31/10 ,  A61K31/28

    CPC分类号： A61K31/28 ,  A61K31/555 ,  A61K31/661 ,  A61K33/38 ,  A61K2300/00

    摘要： Disclosed herein is a silver nanoparticle based antimicrobial composition and methods for making the same. The antimicrobial composition comprises an amphiphilic molecule having at least one hydrophilic group and at least hydrophobic groups attached thereto; and an at least one silver nanoparticle in contact with the amphiphilic molecule. Also disclosed are uses for the antimicrobial composition such as for the treatment of skin disorders.

    摘要翻译： 本文公开了一种基于银纳米颗粒的抗微生物组合物及其制备方法。 抗微生物组合物包含具有至少一个亲水基团和至少与其连接的疏水基团的两亲分子; 和与两亲分子接触的至少一种银纳米颗粒。 还公开了用于抗微生物组合物的用途，例如用于治疗皮肤病症。

    Fluorescent dye-labeled glucose bioprobe, synthesis method and usage thereof
    7.
    发明授权
    Fluorescent dye-labeled glucose bioprobe, synthesis method and usage thereof 有权
    荧光染料标记的葡萄糖生物探针，其合成方法和用途

    公开(公告)号：US08772463B2

    公开(公告)日：2014-07-08

    申请号：US12876520

    申请日：2010-09-07

    申请人： Seung Bum Park ,  Hyang Yeon Lee ,  Jong Min Park

    发明人： Seung Bum Park ,  Hyang Yeon Lee ,  Jong Min Park

    IPC分类号： C07H17/02

    CPC分类号： C07H15/26

    摘要： Disclosed are a novel fluorescent glucose analogue, a method for the synthesis thereof and the use thereof. The novel fluorescent glucose analogue is labeled with fluorescent dye by O-1-glycosylation and via various linkers. The fluorescent glucose analogue can be applied to molecular bioimaging and a method for screening curative or preventive drugs for glucose metabolism-related diseases.

    摘要翻译： 公开了一种新型荧光葡萄糖类似物，其合成方法及其应用。 新型荧光葡萄糖类似物通过O-1-糖基化和通过各种接头用荧光染料标记。 荧光葡萄糖类似物可用于分子生物成像和用于筛选用于葡萄糖代谢相关疾病的治疗或预防药物的方法。

    Fluorescent dye-labeled glucose bioprobe, synthesis method and usage thereof
    8.
    发明授权
    Fluorescent dye-labeled glucose bioprobe, synthesis method and usage thereof 有权
    荧光染料标记的葡萄糖生物探针，其合成方法和用途

    公开(公告)号：US08679854B2

    公开(公告)日：2014-03-25

    申请号：US12532913

    申请日：2007-12-21

    申请人： Seung Bum Park ,  Myung Haing Cho ,  Hyang Yeon Lee ,  Jong Min Park

    发明人： Seung Bum Park ,  Myung Haing Cho ,  Hyang Yeon Lee ,  Jong Min Park

    IPC分类号： G01N21/76

    CPC分类号： C07H3/00

    摘要： The present invention relates to a fluorescent dye-labeled glucose analog, and a synthesis method and usage of the same, and more particularly, to novel glucose α and β anomers in which a fluorescent dye is labeled by O-1-glycosylation, an asymmetric synthesis method of the anomers, a molecular bioimaging method of the anomers, and a screening method of curing or preventing drugs for diseases related to glucose metabolism.

    摘要翻译： 荧光染料标记的葡萄糖类似物及其合成方法和用途本发明涉及荧光染料标记的葡萄糖类似物，更具体地说，涉及新型葡萄糖α和β- 荧光染料由O-1-糖基化标记的前体，前体的不对称合成方法，前体的分子生物成像方法，以及用于治疗或预防与葡萄糖代谢相关的疾病的药物的筛选方法。

    FLUORESCENT DYE-LABELED GLUCOSE BIOPROBE, SYNTHESIS METHOD AND USAGE THEREOF
    9.
    发明申请
    FLUORESCENT DYE-LABELED GLUCOSE BIOPROBE, SYNTHESIS METHOD AND USAGE THEREOF 有权
    荧光标记的葡萄糖生物色素，合成方法及其用途

    公开(公告)号：US20100105149A1

    公开(公告)日：2010-04-29

    申请号：US12532913

    申请日：2007-12-21

    申请人： Seung Bum Park ,  Myung Haing Cho ,  Hyang Yeon Lee ,  Jong Min Park

    发明人： Seung Bum Park ,  Myung Haing Cho ,  Hyang Yeon Lee ,  Jong Min Park

    IPC分类号： G01N21/76 ,  C07H15/04 ,  C07H17/02

    CPC分类号： C07H3/00

    摘要： The present invention relates to a fluorescent dye-labeled glucose analog, and a synthesis method and usage of the same, and more particularly, to novel glucose α and β anomers in which a fluorescent dye is labeled by O-1-glycosylation, an asymmetric synthesis method of the anomers, a molecular bioimaging method of the anomers, and a screening method of curing or preventing drugs for diseases related to glucose metabolism.

    摘要翻译： 荧光染料标记的葡萄糖类似物及其合成方法和用途本发明涉及荧光染料标记的葡萄糖类似物，更具体地说，涉及新型葡萄糖α和β- 荧光染料由O-1-糖基化标记的前体，前体的不对称合成方法，前体的分子生物成像方法，以及用于治疗或预防与葡萄糖代谢相关的疾病的药物的筛选方法。