公开(公告)号：US20060009474A1

公开(公告)日：2006-01-12

申请号：US11225839

申请日：2005-09-13

申请人： Michael Kukla ,  Donald Ludovici ,  Robert Kavash ,  Bart De Corte ,  Jan Heeres ,  Paul Janssen ,  Lucien Koymans ,  Marc de Jonge ,  Koen Van Aken ,  Alain Krief

发明人： Michael Kukla ,  Donald Ludovici ,  Robert Kavash ,  Bart De Corte ,  Jan Heeres ,  Paul Janssen ,  Lucien Koymans ,  Marc de Jonge ,  Koen Van Aken ,  Alain Krief

IPC分类号： A61K31/519 ,  C07D487/02 ,  A61K31/506 ,  C07D239/42

CPC分类号： C07D239/47 ,  C07D239/48 ,  C07D401/12

摘要： The present invention concerns compounds of formula (A1)(A2)N—R1 (I), the N-oxide forms, the pharmaceutically acceptable addition salts, the quaternary amines and stereochemically isomeric forms thereof, wherein R1 is substituted C1-6alkyl; —S(═O)—R8; —S(═O)2—R8; C7-12alkylcarbonyl; optionally substituted C1-6alkyloxycarbonylC1-6alkylcarbonyl; with R8 being C1-6alkyl, aryl1 or Het1; (A1)(A2)N— is the covalently bonded form of the corresponding intermediate of formula (A1)(A2)N—H, which is a HIV replication inhibiting pyrimidine of formula

摘要翻译： 本发明涉及式（A 1 _{1）（A 2 N）NR 1（I）的化合物，N-氧化物形式，药学上 可接受的加成盐，季胺和其立体化学异构形式，其中R 1是取代的C 1-6烷基; -S（-O）-R 8; -S（-O）2 -R 8; C 12-12烷基羰基; 任选取代的C 1-6烷氧基羰基C 1-6烷基羰基; 其中R 8是C 1-6烷基，芳基1或Het 1; （A 1 N 2）（A 2 N）N-是式（A 1 SUB）的相应中间体的共价键合形式（A 2）NH，其是具有下式的HIV复制抑制性嘧啶}

公开(公告)号：US20050277641A1

公开(公告)日：2005-12-15

申请号：US10649017

申请日：2003-08-27

申请人： Bart De Corte ,  Marc de Jonge ,  Jan Heeres ,  Paul Janssen ,  Robert Kavash ,  Lucien Koymans ,  Michael Kukla ,  Donald Ludovici ,  Koen Van Aken

发明人： Bart De Corte ,  Marc de Jonge ,  Jan Heeres ,  Paul Janssen ,  Robert Kavash ,  Lucien Koymans ,  Michael Kukla ,  Donald Ludovici ,  Koen Van Aken

IPC分类号： C07D251/46 ,  A61K9/14 ,  A61K31/53 ,  A61P31/18 ,  C07D251/16 ,  C07D251/18 ,  C07D251/48 ,  C07D43/02

CPC分类号： A61K9/146 ,  Y10S977/775 ,  Y10S977/915

摘要： This invention concerns the use of the compounds of formula the N-oxides, the pharmaceutically acceptable addition salts, quaternary amines and the stereochemically isomeric forms thereof, wherein −a1=a2−a3=a4—forms a phenyl, pyridinyl, pyrimidinyl, pyridazinyl or pyrazinyl with the attached vinyl group; n is 0 to 4; and where possible 5; R1 is hydrogen, aryl, formyl, C1-6alkylcarbonyl, C1-6alkyl, C1-6alkyloxycarbonyl or substituted C1-6alkyl; each R2 independently is hydroxy, halo, optionally substituted C1-6alkyl, C2-6alkenyl or C2-6alkynyl, C3-7cycloalkyl, C1-6alkyloxy, C1-6alkyloxycarbonyl, carboxyl, cyano, nitro, amino, mono- or di(C1-6alkyl)amino, polyhalomethyl, polyhalomethyloxy, polyhalomethylthio, —S(═O)pR4, —NH—S(═O)pR4, —C(═O)R4, —NHC(═O)H, —C(═O)NHNH2, —NHC(═O)R4, —C(═NH)R4 or a 5-membered heterocyclic ring; p is 1 or 2; L is optionally substituted C1-10alkyl, C2-10alkenyl, C2-10alkynyl or C3-7cycloalkyl; or L is —X—R3 wherein R3 is optionally substituted phenyl, pyridinyl, pyrimidinyl, pyrazinyl or pyridazinyl; X is —NR1—, —NH—NH—, —N═N—, —O—, —C(═O)—, —CHOH—, —S—, —S(═O)— or —S(═O)2—; aryl is optionally substituted phenyl; for the manufacture of a medicine for the treatment of subjects suffering from HIV (Human Immunodeficiency Virus) infection.

公开(公告)号：US20050288278A1

公开(公告)日：2005-12-29

申请号：US11204513

申请日：2005-08-16

申请人： Bart De Corte ,  Marc De Jonge ,  Jan Heeres ,  Chih Ho ,  Paul Janssen ,  Robert Kavash ,  Lucien Koymans ,  Michael Kukla ,  Donald Ludovici ,  Koen Van Aken

发明人： Bart De Corte ,  Marc De Jonge ,  Jan Heeres ,  Chih Ho ,  Paul Janssen ,  Robert Kavash ,  Lucien Koymans ,  Michael Kukla ,  Donald Ludovici ,  Koen Van Aken

IPC分类号： C07D239/47 ,  A61K20060101 ,  A61K31/505 ,  A61K31/506 ,  A61K31/513 ,  A61K31/551 ,  A61K31/5513 ,  A61K31/675 ,  A61K31/715 ,  A61P31/18 ,  C07D20060101 ,  C07D239/42 ,  C07D239/46 ,  C07D239/48 ,  C07D239/50 ,  C07D239/80 ,  C07D401/12 ,  C07D403/12

CPC分类号： A61K31/505 ,  A61K31/5513

摘要： This invention concerns the use of compounds of formula the N-oxides, the pharmaceutically acceptable addition salts, quaternary amines and the stereochemically isomeric forms thereof, wherein -a1=a2-a3=a4- forms a phenyl, pyridinyl, pyrimidinyl, pyridazinyl or pyrazinyl with the attached vinyl group; n is 0 to 4; and where possible 5; R1 is hydrogen, aryl, formyl, C1-6alkylcarbonyl, C1-6alkyl, C1-6alkyloxy-carbonyl, substituted C1-6alkyl, or substituted C1-6alkyloxyC1-6alkylcarbonyl; each R2 independently is hydroxy, halo, optionally substituted C1-6alkyl, C2-6alkenyl or C2-6alkynyl, C3-7cycloalkyl, C1-6alkyloxy, C1-6alkyloxycarbonyl, carboxyl, cyano, nitro, amino, mono- or di(C1-6alkyl)amino, polyhalomethyl, polyhalomethyloxy, polyhalo-methylthio, —S(═O)pR6, —NH—S(═O)pR6, —C(═O)R6, —NHC(═O)H, —C(═O)NHNH2, —NHC(═O)R6, —C(═NH)R6 or a 5-membered heterocyclic ring; p is 1 or 2; L is optionally substituted C1-10alkyl, C2-10alkenyl, C2-10alkynyl or C3-7cycloalkyl; or L is —X—R3 wherein R3 is optionally substituted phenyl, pyridinyl, pyrimidinyl, pyrazinyl or pyridazinyl; X is —NR1—, —NH—NH—, —N═N—, —O—, —C(═O)—, —CHOH—, —S—, —S(═O)— or —S(═O)2—; Q is hydrogen, C1-6alkyl, halo, polyhalo-C1-6alkyl or an optionally substituted amino group; Y represents hydroxy, halo, C3-7cycloalkyl, optionally substituted C1-6alkyl, C2-6alkenyl or C2-6alkynyl, C1-6alkyloxy, C1-6alkyloxycarbonyl, carboxyl, cyano, nitro, amino, mono- or di(C1-6alkyl)amino, polyhalomethyl, polyhalomethyloxy, polyhalomethylthio, —S(═O)pR6, —NH—S(═O)pR6, —C(═O)R6, —NHC(═O)H, —C(═O)NHNH2, —NHC(═O)R6, —C(═NH)R6 or aryl; aryl is optionally substituted phenyl. Het is an optionally substituted heterocyclic radical; for the manufacture of a medicine for the treatment of subjects suffering from HIV (Human Immunodeficiency Virus) infection.

公开(公告)号：US20050192305A1

公开(公告)日：2005-09-01

申请号：US11111400

申请日：2005-04-21

申请人： Koenraad Jozef Andries ,  Bart De Corte ,  Marc De Jonge ,  Jan Heeres ,  Chih Ho ,  Marcel Janssen ,  Paul Janssen ,  Lucien Koymans ,  Michael Kukla ,  Donald Ludovici ,  Koen Van Aken

发明人： Koenraad Jozef Andries ,  Bart De Corte ,  Marc De Jonge ,  Jan Heeres ,  Chih Ho ,  Marcel Janssen ,  Paul Janssen ,  Lucien Koymans ,  Michael Kukla ,  Donald Ludovici ,  Koen Van Aken

IPC分类号： C07D239/42 ,  C07D239/46 ,  C07D239/48 ,  C07D239/50 ,  C07D401/12 ,  A61K31/506 ,  C07D43/14

CPC分类号： C07D239/42 ,  C07D239/47 ,  C07D239/48 ,  C07D239/49 ,  C07D239/50 ,  C07D401/12

摘要： This invention concerns the use of the compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein A is CH, CR4 or N; n is 0 to 4; Q is hydrogen or —NR1R2; R1 and R2 are selected from hydrogen, hydroxy, C1-12alkyl, C1-12alkyloxy, C1-12alkylcarbonyl, C1-12alkyloxycarbonyl, aryl, amino, mono- or di(C1-12alkyl)-amino, mono- or di(C1-12alkyl)aminocarbonyl wherein each C1-12alkyl may optionally be substituted: or R1 and R2 taken together may form pyrrolidinyl, piperidinyl, morpholinyl, azido or mono- or di(C1-12alkyl)aminoC1-4alkylidene; R3 is hydrogen, aryl, C1-6alkylcarbonyl, optionally substituted C1-6alkyl, C1-6alkyloxy-carbonyl,; and R4 is hydroxy, halo, optionally substituted C1-6alkyl, C1-6alkyloxy, cyano, aminocarbonyl, nitro, amino, trihalomethyl, trihalomethyloxy; R5 is hydrogen or C1-4alkyl; L is optionally substituted C1-10alkyl, C3-10alkenyl, C3-10alkynyl, C3-7cycloalkyl: or L is —X1—R6 or —X2-Alk-R7 wherein R6 and R7 are optionally substituted phenyl; X1 and X2 are —NR3—, —NH—NH—, —N═N—, —O—, —S—, —S(═O)— or —S(═O)2—; Alk is C1-4alkanediyl; aryl is potionally substituted phenyl; Het is an optionally substituted aliphatic or aromatic heterocyclic radical: for the manufacture of a medicine for the treatment of subjects suffering from HIV (Human Immunodeficiency Virus) infection. It further relates to new compounds being a subgroup of the compounds of formula (I), their preparation and compositions comprising them.

公开(公告)号：US20050197354A1

公开(公告)日：2005-09-08

申请号：US11111358

申请日：2005-04-21

申请人： Koenraad Jozef Andries ,  Bart De Corte ,  Marc De Jonge ,  Jan Heeres ,  Chih Ho ,  Marcel Janssen ,  Paul Janssen ,  Lucien Koymans ,  Michael Kukla ,  Donald Ludovici ,  Koen Van Aken

发明人： Koenraad Jozef Andries ,  Bart De Corte ,  Marc De Jonge ,  Jan Heeres ,  Chih Ho ,  Marcel Janssen ,  Paul Janssen ,  Lucien Koymans ,  Michael Kukla ,  Donald Ludovici ,  Koen Van Aken

IPC分类号： C07D239/42 ,  C07D239/46 ,  C07D239/48 ,  C07D239/50 ,  C07D401/12 ,  A61K31/506 ,  C07D43/02

CPC分类号： C07D239/42 ,  C07D239/47 ,  C07D239/48 ,  C07D239/49 ,  C07D239/50 ,  C07D401/12

摘要： This invention concerns the use of the compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein A is CH, CR4 or N; n is 0 to 4; Q is hydrogen or —NR1R2; R1 and R2 are selected from hydrogen, hydroxy, C1-12alkyl, C1-12alkyloxy, C1-12alkylcarbonyl, C1-12alkyloxycarbonyl, aryl, amino, mono- or di(C1-12alkyl)-amino, mono- or di(C1-12alkyl)aminocarbonyl wherein each C1-12alkyl may optionally be substituted; or R1 and R2 taken together may form pyrrolidinyl, piperidinyl, morpholinyl, azido or mono- or di(C1-12alkyl)aminoC1-4alkylidene; R3 is hydrogen, aryl. C1-6alkylcarbonyl, optionally substituted C1-6alkyl, C1-6alkyloxy-carbonyl; and R4 is hydroxy, halo, optionally substituted C1-6alkyl, C1-6alkyloxy, cyano, aminocarbonyl, nitro, amino, trihalomethyl, trihalomethyloxy; R5 is hydrogen or C1-4alkyl; L is optionally substituted C1-10alkyl, C3-10alkenyl, C3-10alkynyl, C3-7cycloalkyl; or L is —X1—R6 or —X2-Alk-R7 wherein R6 and R7 are optionally substituted phenyl; X1 and X2 are —NR3—, —NH—NH—, —N═N—, —O—, —S—, —S(═O)— or —S(═O)2—; Alk is C1-4alkanediyl; aryl is potionally substituted phenyl; Het is an optionally substituted aliphatic or aromatic heterocyclic radical; for the manufacture of a medicine for the treatment of subjects suffering from HIV (Human Immunodeficiency Virus) infection. It further relates to new compounds being a subgroup of the compounds of formula (I), their preparation and compositions comprising them.

公开(公告)号：US20050004125A1

公开(公告)日：2005-01-06

申请号：US10493452

申请日：2002-10-29

申请人： Eddy Jean Edgard Freyne ,  Peter Jacobus Buijnsters ,  Marc Willems ,  Werner Embrechts ,  Christopher Love ,  Paul Janssen ,  Paulus Lewi ,  Jan Heeres ,  Marc de Jonge ,  Lucien Koymans ,  Hendrik Vinkers ,  Koen Van Aken ,  Gaston Diels

发明人： Eddy Jean Edgard Freyne ,  Peter Jacobus Buijnsters ,  Marc Willems ,  Werner Embrechts ,  Christopher Love ,  Paul Janssen ,  Paulus Lewi ,  Jan Heeres ,  Marc de Jonge ,  Lucien Koymans ,  Hendrik Vinkers ,  Koen Van Aken ,  Gaston Diels

IPC分类号： A61K31/435 ,  A61K31/4406 ,  A61K31/50 ,  A61K31/501 ,  A61K31/505 ,  A61K31/506 ,  A61K31/5377 ,  A61P3/10 ,  A61P17/00 ,  A61P21/04 ,  A61P25/00 ,  A61P25/04 ,  A61P25/16 ,  A61P25/18 ,  A61P25/24 ,  A61P25/28 ,  A61P29/00 ,  A61P31/18 ,  A61P35/00 ,  A61P35/02 ,  C07D213/53 ,  C07D213/74 ,  C07D239/42 ,  C07D239/48 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  A61K31/4965

CPC分类号： C07D213/74 ,  C07D239/42 ,  C07D239/48 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12

摘要： This invention concerns a compound of formula a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein ring A is a 6-membered heterocycle; R1 is hydrogen; aryl; formyl; C1-6alkylcarbonyl; optionally substituted C1-6alkyl; C1-6alkyloxycarbonyl; optionally substituted C1-6alkyloxyC1-6alkylcarbonyl; X is a direct bond or a linker atom or group; Z is a direct bond or a linker atom or group; R2 is hydrogen, C1-10alkyl, C2-10alkenyl, C2-10alkynyl, a carbocycle or a heterocycle, each of said groups may optionally be substituted; R3 is hydrogen; hydroxy; halo; optionally substituted C1-6alkyl or C2-6alkenyl or C2-6alkynyl; C1-6alkyloxy; C1-6alkylthio; C1-6alkyloxycarbonyl; C1-6alkylcarbonyloxy; carboxyl; cyano; nitro; amino; mono- or di(C1-6alkyl)amino; polyhaloC1-6alkyl; polyhaloC1-6alkyloxy; polyhaloC1-6alkylthio; R21; R21—C1-6alkyl; R21—O—; R21—S—; R21—C(═O)—; R21—S(═O)p—; R7—S(═O)p—; R7—S(═O)p—NH—; R21—S(═O)p—NH—; R7—C(═O)—; —NHC(═O)H; —C(═O)NHNH2; R7—C(═O)—NH—; R21—C(═O)—NH—; —C(═NH)R7—C(═NH)R21; R4 is an optionally substituted heterocycle provided that —X—R2 and/or R3 is other than hydrogen; their use, pharmaceutical compositions comprising them and processes for their preparation.

摘要翻译： 本发明涉及式的化合物N-氧化物，药学上可接受的加成盐，季胺及其立体化学异构形式，其中环A是6-元杂环; R 1是氢; 芳基; 甲酰基 C 1-6烷基羰基; 任选取代的C 1-6烷基; C 1-6烷氧基羰基; 任选取代的C 1-6烷氧基C 1-6烷基羰基; X是直接键或连接原子或基团; Z是直接键或连接原子或基团; R 2是氢，C 1-10烷基，C 2-10烯基，C 2-10炔基，碳环或杂环，所述基团中的每一个可任选被取代; R 3是氢; 羟基; 光环; 任选取代的C 1-6烷基或C 2-6烯基或C 2-6炔基; C 1-6烷氧基; C 1-6烷硫基; C 1-6烷氧基羰基; C 1-6烷基羰基氧基; 羧基; 氰基; 硝基 氨基; 单或二（C 1-6烷基）氨基; 多卤代C 1-6烷基; 多卤代C 1-6烷氧基; 多卤代C 1-6烷硫基; R 21; R 21 -C 1-6烷基; R 21 -O- R 21 -S-; R 21 -C（= O） - ; R 21 -S（= O）p - ; R 7 -S（= O）p-; R 7 -S（= O）p-NH-; R 21 -S（= O）p -NH-; R 7 -C（= O） - ; -NHC（= O）H; -C（= O）NHNH 2; R 7 -C（= O）-NH-; R 21 -C（= O）-NH-; -C（= NH）R 7 -C（= NH）R 21; R 4是任选取代的杂环，条件是-X-R 2和/或R 3不是氢; 其用途，包含它们的药物组合物及其制备方法。

公开(公告)号：US20060252764A1

公开(公告)日：2006-11-09

申请号：US11474855

申请日：2006-06-26

申请人： Jerome Guillemont ,  Patrice Palandijian ,  Marc De Jonge ,  Lucien Koymans ,  Hendrik Vinkers ,  Frederik Daeyaert ,  Jan Heeres ,  Koen Van Aken ,  Paulus Lewi ,  Paul Janssen ,  Frank Xavier Arts

发明人： Jerome Guillemont ,  Patrice Palandijian ,  Marc De Jonge ,  Lucien Koymans ,  Hendrik Vinkers ,  Frederik Daeyaert ,  Jan Heeres ,  Koen Van Aken ,  Paulus Lewi ,  Paul Janssen ,  Frank Xavier Arts

IPC分类号： A61K31/506 ,  C07D403/02

CPC分类号： C07D239/48 ,  A61K31/505 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/551 ,  A61K45/06 ,  C07C255/42 ,  C07C257/12 ,  C07D239/47 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

摘要： This invention concerns HIV replication inhibitors of formula the N-oxides, the pharmaceutically acceptable addition salts, the quaternary amines and the stereochemically isomeric forms thereof, wherein the ring containing -a1=a2-a3=a4- and -b1=b2-b3=b4- represents phenyl, pyridyl, pyrimidinyl, pirazinyl, pyridazinyl;n is 0 to 5; m is 1 to 4; R1 is hydrogen; aryl; formyl; C1-6alkylcarbonyl; C1-6alkyl; C1-6alkyloxycarbonyl; substituted C1-6alkyl, C1-6alkylcarbonyl, C1-6alkyloxycarbonyl, C1-6alkylcarbonyloxy; substituted C1-6alkyloxyC1-6alkylcarbonyl; R2 is hydroxy, halo, optionally substituted C1-6alkyl, C3-7cycloalkyl, optionally substituted C2-6alkenyl, optionally substituted C2-6alkynyl, C1-6alkyloxy, C1-6alkyloxycarbonyl, carboxyl, cyano, nitro, amino, mono- or di(C1-6alkyl)amino, polyhalomethyl, polyhalomethyloxy, polyhalomethylthio, —S(═O)pR6, —NH—S(═O)pR6, —C(═O)R6, —NHC(═O)H, —C(═O)NHNH2, —NHC(═O)R6, —C(═NH)R6 or a 5-membered heterocycle; X1 is —NR5—, —NH—NH—, —N═N—, —O—, —C(═O)—, C1-4alkanediyl, —CHOH—, —S—, —S(═O)p—, —X2—C1-4alkanediyl- or —C1-4alkanediyl-X2—; R3 is NHR13; NR13R14; —C(═O)—NHR13; —C(═O)—NR13R14; —C(═O)—R15; —CH═N—NH—C(═O)—R16; substituted C1-6alkyl; optionally substituted C1-6alkyloxyC1-6alkyl; substituted C2-6alkenyl; substituted C2-6alkynyl; C1-6alkyl substituted with hydroxy and a second substituent; —C(═N—O—R8)—C1-4alkyl; R7; or —X3—R7; R4 is halo, hydroxy, C1-6alkyl, C3-7cycloalkyl, C1-6alkyloxy, cyano, nitro, polyhaloC1-6alkyl, polyhaloC1-6alkyloxy, aminocarbonyl, C1-6alkyloxycarbonyl, C1-6alkylcarbonyl, formyl, amino, mono- or di(C1-4alkyl)amino; their use as a medicine, their processes for preparation and pharmaceutical compositions comprising them.

公开(公告)号：US08987187B2

公开(公告)日：2015-03-24

申请号：US13166272

申请日：2011-06-22

申请人： Johan Smets ,  Hugo Robert Germain Denutte ,  An Pintens ,  Koen Van Aken ,  Freek Annie Camiel Vrielynck

发明人： Johan Smets ,  Hugo Robert Germain Denutte ,  An Pintens ,  Koen Van Aken ,  Freek Annie Camiel Vrielynck

IPC分类号： B08B3/00 ,  A61K8/84 ,  A61K8/73 ,  A61Q13/00 ,  C07C31/133 ,  C07C33/02 ,  C07C33/14 ,  C07C33/34 ,  C07C43/162 ,  C07C47/21 ,  C07C47/225 ,  C07C47/45 ,  C07C49/11 ,  C07C49/21 ,  C07C49/553 ,  C07C49/792 ,  C07C69/145 ,  C07C255/31 ,  C07C255/46 ,  C11B9/00 ,  C11D3/50 ,  A61Q5/02

CPC分类号： C11B9/0061 ,  A61K8/33 ,  A61K8/35 ,  A61K8/40 ,  A61K8/738 ,  A61K8/84 ,  A61Q5/02 ,  A61Q13/00 ,  C07C31/1333 ,  C07C33/02 ,  C07C33/14 ,  C07C33/34 ,  C07C43/162 ,  C07C47/21 ,  C07C47/225 ,  C07C47/45 ,  C07C49/11 ,  C07C49/21 ,  C07C49/553 ,  C07C49/792 ,  C07C69/145 ,  C07C255/31 ,  C07C255/46 ,  C07C2601/02 ,  C07C2601/16 ,  C07C2602/42 ,  C11B9/0015 ,  C11B9/0019 ,  C11B9/003 ,  C11B9/0034 ,  C11B9/0046 ,  C11D3/2068 ,  C11D3/2072 ,  C11D3/26 ,  C11D3/50 ,  C11D3/505 ,  C11D11/0017 ,  C11D11/0023

摘要： The present application relates to perfume raw materials, perfume delivery systems and consumer products comprising such perfume raw materials and/or such perfume delivery systems, as well as processes for making and using such perfume raw materials, perfume delivery systems and consumer products. Such perfume raw materials and compositions, including the delivery systems, disclosed herein expand the perfume communities' options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles.

摘要翻译： 本申请涉及香水原料，香水输送系统和包含这种香料原料和/或这种香料输送系统的消费品，以及制造和使用这种香料原料，香水输送系统和消费品的方法。 包括本文公开的这种香料原料和组合物包括递送系统扩展了香水社区的选择，因为这样的香料原料可以提供特性变化，并且这样的组合物可以提供所需的气味分布。

公开(公告)号：US20100137178A1

公开(公告)日：2010-06-03

申请号：US12628255

申请日：2009-12-01

申请人： Johan Smets ,  Hugo Robert Germain Denutte ,  An Pintens ,  David Thomas Stanton ,  Koen Van Aken ,  Inge Helena Hubert Laureyn ,  Bram Denolf ,  Freek Annie Camiel Vrielynck

发明人： Johan Smets ,  Hugo Robert Germain Denutte ,  An Pintens ,  David Thomas Stanton ,  Koen Van Aken ,  Inge Helena Hubert Laureyn ,  Bram Denolf ,  Freek Annie Camiel Vrielynck

IPC分类号： A61K8/11 ,  C07C49/00 ,  C07C49/20 ,  C07C49/213 ,  C07C49/21 ,  C07C69/74 ,  C07C69/52 ,  C07C255/06 ,  C07C255/33 ,  C07C255/00 ,  C07C35/04 ,  A61K8/34 ,  A61K8/35 ,  A61K8/36 ,  A61K8/37 ,  A61K8/40 ,  C11D3/50

CPC分类号： C11D3/50 ,  A61K8/732 ,  A61K8/84 ,  A61Q5/02 ,  A61Q13/00 ,  C07C33/05 ,  C07C33/14 ,  C07C49/203 ,  C07C49/213 ,  C07C49/217 ,  C07C49/225 ,  C07C49/255 ,  C07C49/293 ,  C07C49/557 ,  C07C49/792 ,  C07C49/794 ,  C07C57/03 ,  C07C69/007 ,  C07C255/07 ,  C07C255/33 ,  C07C2601/04 ,  C07C2601/16 ,  C11B9/003 ,  C11B9/0034 ,  C11B9/0061 ,  C11B9/0065

摘要： The present application relates to perfume raw materials, perfume delivery systems and consumer products comprising such perfume raw materials and/or such perfume delivery systems, as well as processes for making and using such perfume raw materials, perfume delivery systems and consumer products. Such perfume raw materials and compositions, including the delivery systems, disclosed herein expand the perfume communities options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles.

摘要翻译： 本申请涉及香水原料，香水输送系统和包含这种香料原料和/或这种香料输送系统的消费品，以及制造和使用这种香料原料，香水输送系统和消费品的方法。 本文公开的这种香料原料和组合物，包括递送系统，扩展了香水社区的选择，因为这样的香料原料可以提供特性的变化，并且这样的组合物可提供所需的气味分布。

公开(公告)号：US20110308556A1

公开(公告)日：2011-12-22

申请号：US13166272

申请日：2011-06-22

申请人： Johan Smets ,  Hugo Robert Germain Denutte ,  An Pintens ,  Koen Van Aken ,  Freek Annie Camiel Vrielynck

发明人： Johan Smets ,  Hugo Robert Germain Denutte ,  An Pintens ,  Koen Van Aken ,  Freek Annie Camiel Vrielynck

IPC分类号： B08B3/00 ,  C07C47/21 ,  C07C47/225 ,  C07C49/21 ,  A61K8/11 ,  C07C255/31 ,  A61K8/33 ,  A61K8/40 ,  A61Q13/00 ,  C11D3/50 ,  C07C43/162

CPC分类号： C11B9/0061 ,  A61K8/33 ,  A61K8/35 ,  A61K8/40 ,  A61K8/738 ,  A61K8/84 ,  A61Q5/02 ,  A61Q13/00 ,  C07C31/1333 ,  C07C33/02 ,  C07C33/14 ,  C07C33/34 ,  C07C43/162 ,  C07C47/21 ,  C07C47/225 ,  C07C47/45 ,  C07C49/11 ,  C07C49/21 ,  C07C49/553 ,  C07C49/792 ,  C07C69/145 ,  C07C255/31 ,  C07C255/46 ,  C07C2601/02 ,  C07C2601/16 ,  C07C2602/42 ,  C11B9/0015 ,  C11B9/0019 ,  C11B9/003 ,  C11B9/0034 ,  C11B9/0046 ,  C11D3/2068 ,  C11D3/2072 ,  C11D3/26 ,  C11D3/50 ,  C11D3/505 ,  C11D11/0017 ,  C11D11/0023

摘要： The present application relates to perfume raw materials, perfume delivery systems and consumer products comprising such perfume raw materials and/or such perfume delivery systems, as well as processes for making and using such perfume raw materials, perfume delivery systems and consumer products. Such perfume raw materials and compositions, including the delivery systems, disclosed herein expand the perfume communities' options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles.

摘要翻译： 本申请涉及香水原料，香水输送系统和包含这种香料原料和/或这种香料输送系统的消费品，以及制造和使用这种香料原料，香水输送系统和消费品的方法。 包括本文公开的这种香料原料和组合物包括递送系统扩展了香水社区的选择，因为这样的香料原料可以提供特性变化，并且这样的组合物可以提供所需的气味分布。