公开(公告)号：US08431520B2

公开(公告)日：2013-04-30

申请号：US13616766

申请日：2012-09-14

申请人： Johan Smets ,  Hugo Robert Germain Denutte ,  An Pintens ,  David Thomas Stanton ,  Koen Van Aken ,  Inge Helena Hubert Laureyn ,  Bram Denolf ,  Freek Annie Camiel Vrielynck

发明人： Johan Smets ,  Hugo Robert Germain Denutte ,  An Pintens ,  David Thomas Stanton ,  Koen Van Aken ,  Inge Helena Hubert Laureyn ,  Bram Denolf ,  Freek Annie Camiel Vrielynck

IPC分类号： A61K8/34

CPC分类号： C11D3/50 ,  A61K8/732 ,  A61K8/84 ,  A61Q5/02 ,  A61Q13/00 ,  C07C33/05 ,  C07C33/14 ,  C07C49/203 ,  C07C49/213 ,  C07C49/217 ,  C07C49/225 ,  C07C49/255 ,  C07C49/293 ,  C07C49/557 ,  C07C49/792 ,  C07C49/794 ,  C07C57/03 ,  C07C69/007 ,  C07C255/07 ,  C07C255/33 ,  C07C2601/04 ,  C07C2601/16 ,  C11B9/003 ,  C11B9/0034 ,  C11B9/0061 ,  C11B9/0065

摘要： The present application relates to perfume raw materials, perfume delivery systems and consumer products comprising such perfume raw materials and/or such perfume delivery systems, as well as processes for making and using such perfume raw materials, perfume delivery systems and consumer products. Such perfume raw materials and compositions, including the delivery systems, disclosed herein expand the perfume communities options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles.

摘要翻译： 本申请涉及香水原料，香水输送系统和包含这种香料原料和/或这种香料输送系统的消费品，以及制造和使用这种香料原料，香水输送系统和消费品的方法。 本文公开的这种香料原料和组合物，包括递送系统，扩展了香水社区的选择，因为这样的香料原料可以提供特性的变化，并且这样的组合物可提供所需的气味分布。

公开(公告)号：US08987187B2

公开(公告)日：2015-03-24

申请号：US13166272

申请日：2011-06-22

申请人： Johan Smets ,  Hugo Robert Germain Denutte ,  An Pintens ,  Koen Van Aken ,  Freek Annie Camiel Vrielynck

发明人： Johan Smets ,  Hugo Robert Germain Denutte ,  An Pintens ,  Koen Van Aken ,  Freek Annie Camiel Vrielynck

IPC分类号： B08B3/00 ,  A61K8/84 ,  A61K8/73 ,  A61Q13/00 ,  C07C31/133 ,  C07C33/02 ,  C07C33/14 ,  C07C33/34 ,  C07C43/162 ,  C07C47/21 ,  C07C47/225 ,  C07C47/45 ,  C07C49/11 ,  C07C49/21 ,  C07C49/553 ,  C07C49/792 ,  C07C69/145 ,  C07C255/31 ,  C07C255/46 ,  C11B9/00 ,  C11D3/50 ,  A61Q5/02

CPC分类号： C11B9/0061 ,  A61K8/33 ,  A61K8/35 ,  A61K8/40 ,  A61K8/738 ,  A61K8/84 ,  A61Q5/02 ,  A61Q13/00 ,  C07C31/1333 ,  C07C33/02 ,  C07C33/14 ,  C07C33/34 ,  C07C43/162 ,  C07C47/21 ,  C07C47/225 ,  C07C47/45 ,  C07C49/11 ,  C07C49/21 ,  C07C49/553 ,  C07C49/792 ,  C07C69/145 ,  C07C255/31 ,  C07C255/46 ,  C07C2601/02 ,  C07C2601/16 ,  C07C2602/42 ,  C11B9/0015 ,  C11B9/0019 ,  C11B9/003 ,  C11B9/0034 ,  C11B9/0046 ,  C11D3/2068 ,  C11D3/2072 ,  C11D3/26 ,  C11D3/50 ,  C11D3/505 ,  C11D11/0017 ,  C11D11/0023

摘要： The present application relates to perfume raw materials, perfume delivery systems and consumer products comprising such perfume raw materials and/or such perfume delivery systems, as well as processes for making and using such perfume raw materials, perfume delivery systems and consumer products. Such perfume raw materials and compositions, including the delivery systems, disclosed herein expand the perfume communities' options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles.

摘要翻译： 本申请涉及香水原料，香水输送系统和包含这种香料原料和/或这种香料输送系统的消费品，以及制造和使用这种香料原料，香水输送系统和消费品的方法。 包括本文公开的这种香料原料和组合物包括递送系统扩展了香水社区的选择，因为这样的香料原料可以提供特性变化，并且这样的组合物可以提供所需的气味分布。

公开(公告)号：US20100137178A1

公开(公告)日：2010-06-03

申请号：US12628255

申请日：2009-12-01

申请人： Johan Smets ,  Hugo Robert Germain Denutte ,  An Pintens ,  David Thomas Stanton ,  Koen Van Aken ,  Inge Helena Hubert Laureyn ,  Bram Denolf ,  Freek Annie Camiel Vrielynck

发明人： Johan Smets ,  Hugo Robert Germain Denutte ,  An Pintens ,  David Thomas Stanton ,  Koen Van Aken ,  Inge Helena Hubert Laureyn ,  Bram Denolf ,  Freek Annie Camiel Vrielynck

IPC分类号： A61K8/11 ,  C07C49/00 ,  C07C49/20 ,  C07C49/213 ,  C07C49/21 ,  C07C69/74 ,  C07C69/52 ,  C07C255/06 ,  C07C255/33 ,  C07C255/00 ,  C07C35/04 ,  A61K8/34 ,  A61K8/35 ,  A61K8/36 ,  A61K8/37 ,  A61K8/40 ,  C11D3/50

CPC分类号： C11D3/50 ,  A61K8/732 ,  A61K8/84 ,  A61Q5/02 ,  A61Q13/00 ,  C07C33/05 ,  C07C33/14 ,  C07C49/203 ,  C07C49/213 ,  C07C49/217 ,  C07C49/225 ,  C07C49/255 ,  C07C49/293 ,  C07C49/557 ,  C07C49/792 ,  C07C49/794 ,  C07C57/03 ,  C07C69/007 ,  C07C255/07 ,  C07C255/33 ,  C07C2601/04 ,  C07C2601/16 ,  C11B9/003 ,  C11B9/0034 ,  C11B9/0061 ,  C11B9/0065

摘要： The present application relates to perfume raw materials, perfume delivery systems and consumer products comprising such perfume raw materials and/or such perfume delivery systems, as well as processes for making and using such perfume raw materials, perfume delivery systems and consumer products. Such perfume raw materials and compositions, including the delivery systems, disclosed herein expand the perfume communities options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles.

摘要翻译： 本申请涉及香水原料，香水输送系统和包含这种香料原料和/或这种香料输送系统的消费品，以及制造和使用这种香料原料，香水输送系统和消费品的方法。 本文公开的这种香料原料和组合物，包括递送系统，扩展了香水社区的选择，因为这样的香料原料可以提供特性的变化，并且这样的组合物可提供所需的气味分布。

公开(公告)号：US20130012422A1

公开(公告)日：2013-01-10

申请号：US13616766

申请日：2012-09-14

申请人： Johan SMETS ,  Hugo Robert Germain Denutte ,  An Pintens ,  David Thomas Stanton ,  Koen Van Aken ,  Inge Helena Hubert Laureyn ,  Bram Denolf ,  Freek Annie Camiel Vrielynck

发明人： Johan SMETS ,  Hugo Robert Germain Denutte ,  An Pintens ,  David Thomas Stanton ,  Koen Van Aken ,  Inge Helena Hubert Laureyn ,  Bram Denolf ,  Freek Annie Camiel Vrielynck

IPC分类号： A61K8/34 ,  C11D3/50 ,  A61Q13/00 ,  C07C33/05

CPC分类号： C11D3/50 ,  A61K8/732 ,  A61K8/84 ,  A61Q5/02 ,  A61Q13/00 ,  C07C33/05 ,  C07C33/14 ,  C07C49/203 ,  C07C49/213 ,  C07C49/217 ,  C07C49/225 ,  C07C49/255 ,  C07C49/293 ,  C07C49/557 ,  C07C49/792 ,  C07C49/794 ,  C07C57/03 ,  C07C69/007 ,  C07C255/07 ,  C07C255/33 ,  C07C2601/04 ,  C07C2601/16 ,  C11B9/003 ,  C11B9/0034 ,  C11B9/0061 ,  C11B9/0065

摘要： The present application relates to perfume raw materials, perfume delivery systems and consumer products comprising such perfume raw materials and/or such perfume delivery systems, as well as processes for making and using such perfume raw materials, perfume delivery systems and consumer products. Such perfume raw materials and compositions, including the delivery systems, disclosed herein expand the perfume communities options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles.

摘要翻译： 本申请涉及香水原料，香水输送系统和包含这种香料原料和/或这种香料输送系统的消费品，以及制造和使用这种香料原料，香水输送系统和消费品的方法。 本文公开的这种香料原料和组合物，包括递送系统，扩展了香水社区的选择，因为这样的香料原料可以提供特性的变化，并且这样的组合物可提供所需的气味分布。

公开(公告)号：US20110308556A1

公开(公告)日：2011-12-22

申请号：US13166272

申请日：2011-06-22

申请人： Johan Smets ,  Hugo Robert Germain Denutte ,  An Pintens ,  Koen Van Aken ,  Freek Annie Camiel Vrielynck

发明人： Johan Smets ,  Hugo Robert Germain Denutte ,  An Pintens ,  Koen Van Aken ,  Freek Annie Camiel Vrielynck

IPC分类号： B08B3/00 ,  C07C47/21 ,  C07C47/225 ,  C07C49/21 ,  A61K8/11 ,  C07C255/31 ,  A61K8/33 ,  A61K8/40 ,  A61Q13/00 ,  C11D3/50 ,  C07C43/162

CPC分类号： C11B9/0061 ,  A61K8/33 ,  A61K8/35 ,  A61K8/40 ,  A61K8/738 ,  A61K8/84 ,  A61Q5/02 ,  A61Q13/00 ,  C07C31/1333 ,  C07C33/02 ,  C07C33/14 ,  C07C33/34 ,  C07C43/162 ,  C07C47/21 ,  C07C47/225 ,  C07C47/45 ,  C07C49/11 ,  C07C49/21 ,  C07C49/553 ,  C07C49/792 ,  C07C69/145 ,  C07C255/31 ,  C07C255/46 ,  C07C2601/02 ,  C07C2601/16 ,  C07C2602/42 ,  C11B9/0015 ,  C11B9/0019 ,  C11B9/003 ,  C11B9/0034 ,  C11B9/0046 ,  C11D3/2068 ,  C11D3/2072 ,  C11D3/26 ,  C11D3/50 ,  C11D3/505 ,  C11D11/0017 ,  C11D11/0023

摘要： The present application relates to perfume raw materials, perfume delivery systems and consumer products comprising such perfume raw materials and/or such perfume delivery systems, as well as processes for making and using such perfume raw materials, perfume delivery systems and consumer products. Such perfume raw materials and compositions, including the delivery systems, disclosed herein expand the perfume communities' options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles.

摘要翻译： 本申请涉及香水原料，香水输送系统和包含这种香料原料和/或这种香料输送系统的消费品，以及制造和使用这种香料原料，香水输送系统和消费品的方法。 包括本文公开的这种香料原料和组合物包括递送系统扩展了香水社区的选择，因为这样的香料原料可以提供特性变化，并且这样的组合物可以提供所需的气味分布。

公开(公告)号：US08609603B2

公开(公告)日：2013-12-17

申请号：US13166263

申请日：2011-06-22

申请人： Johan Smets ,  Hugo Robert Germain Denutte ,  An Pintens ,  Koen Van Aken ,  Freek Annie Camiel Vrielynck

发明人： Johan Smets ,  Hugo Robert Germain Denutte ,  An Pintens ,  Koen Van Aken ,  Freek Annie Camiel Vrielynck

IPC分类号： A61Q13/00

CPC分类号： A61K8/738 ,  A61K8/84 ,  A61Q5/02 ,  A61Q13/00 ,  C11B9/0015 ,  C11B9/003 ,  C11B9/0034 ,  C11B9/0046 ,  C11B9/0061 ,  C11B9/0065 ,  C11B9/0076 ,  C11D3/50

摘要： The present application relates to perfume raw materials, perfume delivery systems and consumer products comprising such perfume raw materials and/or such perfume delivery systems, as well as processes for making and using such perfume raw materials, perfume delivery systems and consumer products. Such perfume raw materials and compositions, including the delivery systems, disclosed herein expand the perfume communities' options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles.

公开(公告)号：US20110308555A1

公开(公告)日：2011-12-22

申请号：US13166263

申请日：2011-06-22

申请人： Johan SMETS ,  Hugo Robert Germain Denutte ,  An Pintens ,  Koen Van Aken ,  Freek Annie Camiel Vrielynck

发明人： Johan SMETS ,  Hugo Robert Germain Denutte ,  An Pintens ,  Koen Van Aken ,  Freek Annie Camiel Vrielynck

IPC分类号： B08B3/00 ,  C07C49/213 ,  C07C49/21 ,  C07C49/11 ,  C07C33/20 ,  C07C31/133 ,  C07C251/16 ,  C07D317/12 ,  C07C47/11 ,  C07C255/33 ,  C07C69/96 ,  A61K8/34 ,  A61K8/35 ,  A61K8/37 ,  A61K8/40 ,  A61K8/49 ,  A61Q13/00 ,  C11D3/50

CPC分类号： A61K8/738 ,  A61K8/84 ,  A61Q5/02 ,  A61Q13/00 ,  C11B9/0015 ,  C11B9/003 ,  C11B9/0034 ,  C11B9/0046 ,  C11B9/0061 ,  C11B9/0065 ,  C11B9/0076 ,  C11D3/50

摘要： The present application relates to perfume raw materials, perfume delivery systems and consumer products comprising such perfume raw materials and/or such perfume delivery systems, as well as processes for making and using such perfume raw materials, perfume delivery systems and consumer products. Such perfume raw materials and compositions, including the delivery systems, disclosed herein expand the perfume communities' options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles.

公开(公告)号：US20050197354A1

公开(公告)日：2005-09-08

申请号：US11111358

申请日：2005-04-21

申请人： Koenraad Jozef Andries ,  Bart De Corte ,  Marc De Jonge ,  Jan Heeres ,  Chih Ho ,  Marcel Janssen ,  Paul Janssen ,  Lucien Koymans ,  Michael Kukla ,  Donald Ludovici ,  Koen Van Aken

发明人： Koenraad Jozef Andries ,  Bart De Corte ,  Marc De Jonge ,  Jan Heeres ,  Chih Ho ,  Marcel Janssen ,  Paul Janssen ,  Lucien Koymans ,  Michael Kukla ,  Donald Ludovici ,  Koen Van Aken

IPC分类号： C07D239/42 ,  C07D239/46 ,  C07D239/48 ,  C07D239/50 ,  C07D401/12 ,  A61K31/506 ,  C07D43/02

CPC分类号： C07D239/42 ,  C07D239/47 ,  C07D239/48 ,  C07D239/49 ,  C07D239/50 ,  C07D401/12

摘要： This invention concerns the use of the compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein A is CH, CR4 or N; n is 0 to 4; Q is hydrogen or —NR1R2; R1 and R2 are selected from hydrogen, hydroxy, C1-12alkyl, C1-12alkyloxy, C1-12alkylcarbonyl, C1-12alkyloxycarbonyl, aryl, amino, mono- or di(C1-12alkyl)-amino, mono- or di(C1-12alkyl)aminocarbonyl wherein each C1-12alkyl may optionally be substituted; or R1 and R2 taken together may form pyrrolidinyl, piperidinyl, morpholinyl, azido or mono- or di(C1-12alkyl)aminoC1-4alkylidene; R3 is hydrogen, aryl. C1-6alkylcarbonyl, optionally substituted C1-6alkyl, C1-6alkyloxy-carbonyl; and R4 is hydroxy, halo, optionally substituted C1-6alkyl, C1-6alkyloxy, cyano, aminocarbonyl, nitro, amino, trihalomethyl, trihalomethyloxy; R5 is hydrogen or C1-4alkyl; L is optionally substituted C1-10alkyl, C3-10alkenyl, C3-10alkynyl, C3-7cycloalkyl; or L is —X1—R6 or —X2-Alk-R7 wherein R6 and R7 are optionally substituted phenyl; X1 and X2 are —NR3—, —NH—NH—, —N═N—, —O—, —S—, —S(═O)— or —S(═O)2—; Alk is C1-4alkanediyl; aryl is potionally substituted phenyl; Het is an optionally substituted aliphatic or aromatic heterocyclic radical; for the manufacture of a medicine for the treatment of subjects suffering from HIV (Human Immunodeficiency Virus) infection. It further relates to new compounds being a subgroup of the compounds of formula (I), their preparation and compositions comprising them.

公开(公告)号：US20050277641A1

公开(公告)日：2005-12-15

申请号：US10649017

申请日：2003-08-27

申请人： Bart De Corte ,  Marc de Jonge ,  Jan Heeres ,  Paul Janssen ,  Robert Kavash ,  Lucien Koymans ,  Michael Kukla ,  Donald Ludovici ,  Koen Van Aken

发明人： Bart De Corte ,  Marc de Jonge ,  Jan Heeres ,  Paul Janssen ,  Robert Kavash ,  Lucien Koymans ,  Michael Kukla ,  Donald Ludovici ,  Koen Van Aken

IPC分类号： C07D251/46 ,  A61K9/14 ,  A61K31/53 ,  A61P31/18 ,  C07D251/16 ,  C07D251/18 ,  C07D251/48 ,  C07D43/02

CPC分类号： A61K9/146 ,  Y10S977/775 ,  Y10S977/915

摘要： This invention concerns the use of the compounds of formula the N-oxides, the pharmaceutically acceptable addition salts, quaternary amines and the stereochemically isomeric forms thereof, wherein −a1=a2−a3=a4—forms a phenyl, pyridinyl, pyrimidinyl, pyridazinyl or pyrazinyl with the attached vinyl group; n is 0 to 4; and where possible 5; R1 is hydrogen, aryl, formyl, C1-6alkylcarbonyl, C1-6alkyl, C1-6alkyloxycarbonyl or substituted C1-6alkyl; each R2 independently is hydroxy, halo, optionally substituted C1-6alkyl, C2-6alkenyl or C2-6alkynyl, C3-7cycloalkyl, C1-6alkyloxy, C1-6alkyloxycarbonyl, carboxyl, cyano, nitro, amino, mono- or di(C1-6alkyl)amino, polyhalomethyl, polyhalomethyloxy, polyhalomethylthio, —S(═O)pR4, —NH—S(═O)pR4, —C(═O)R4, —NHC(═O)H, —C(═O)NHNH2, —NHC(═O)R4, —C(═NH)R4 or a 5-membered heterocyclic ring; p is 1 or 2; L is optionally substituted C1-10alkyl, C2-10alkenyl, C2-10alkynyl or C3-7cycloalkyl; or L is —X—R3 wherein R3 is optionally substituted phenyl, pyridinyl, pyrimidinyl, pyrazinyl or pyridazinyl; X is —NR1—, —NH—NH—, —N═N—, —O—, —C(═O)—, —CHOH—, —S—, —S(═O)— or —S(═O)2—; aryl is optionally substituted phenyl; for the manufacture of a medicine for the treatment of subjects suffering from HIV (Human Immunodeficiency Virus) infection.

公开(公告)号：US20050192305A1

公开(公告)日：2005-09-01

申请号：US11111400

申请日：2005-04-21

申请人： Koenraad Jozef Andries ,  Bart De Corte ,  Marc De Jonge ,  Jan Heeres ,  Chih Ho ,  Marcel Janssen ,  Paul Janssen ,  Lucien Koymans ,  Michael Kukla ,  Donald Ludovici ,  Koen Van Aken

发明人： Koenraad Jozef Andries ,  Bart De Corte ,  Marc De Jonge ,  Jan Heeres ,  Chih Ho ,  Marcel Janssen ,  Paul Janssen ,  Lucien Koymans ,  Michael Kukla ,  Donald Ludovici ,  Koen Van Aken

IPC分类号： C07D239/42 ,  C07D239/46 ,  C07D239/48 ,  C07D239/50 ,  C07D401/12 ,  A61K31/506 ,  C07D43/14

CPC分类号： C07D239/42 ,  C07D239/47 ,  C07D239/48 ,  C07D239/49 ,  C07D239/50 ,  C07D401/12

摘要： This invention concerns the use of the compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein A is CH, CR4 or N; n is 0 to 4; Q is hydrogen or —NR1R2; R1 and R2 are selected from hydrogen, hydroxy, C1-12alkyl, C1-12alkyloxy, C1-12alkylcarbonyl, C1-12alkyloxycarbonyl, aryl, amino, mono- or di(C1-12alkyl)-amino, mono- or di(C1-12alkyl)aminocarbonyl wherein each C1-12alkyl may optionally be substituted: or R1 and R2 taken together may form pyrrolidinyl, piperidinyl, morpholinyl, azido or mono- or di(C1-12alkyl)aminoC1-4alkylidene; R3 is hydrogen, aryl, C1-6alkylcarbonyl, optionally substituted C1-6alkyl, C1-6alkyloxy-carbonyl,; and R4 is hydroxy, halo, optionally substituted C1-6alkyl, C1-6alkyloxy, cyano, aminocarbonyl, nitro, amino, trihalomethyl, trihalomethyloxy; R5 is hydrogen or C1-4alkyl; L is optionally substituted C1-10alkyl, C3-10alkenyl, C3-10alkynyl, C3-7cycloalkyl: or L is —X1—R6 or —X2-Alk-R7 wherein R6 and R7 are optionally substituted phenyl; X1 and X2 are —NR3—, —NH—NH—, —N═N—, —O—, —S—, —S(═O)— or —S(═O)2—; Alk is C1-4alkanediyl; aryl is potionally substituted phenyl; Het is an optionally substituted aliphatic or aromatic heterocyclic radical: for the manufacture of a medicine for the treatment of subjects suffering from HIV (Human Immunodeficiency Virus) infection. It further relates to new compounds being a subgroup of the compounds of formula (I), their preparation and compositions comprising them.