公开(公告)号：US20130050683A1

公开(公告)日：2013-02-28

申请号：US13641894

申请日：2011-04-11

申请人： Bernardus Hendrikus Wilhelmus Henrdiks ,  Gerhardus Wilhelmus Lucassen ,  Rami Nachabe ,  Nenad Mihajlovic ,  Adrien Emmanuel Desjardins ,  Jeroen Jan Lambertus Horikx ,  Marjolein Van Der Voort

发明人： Bernardus Hendrikus Wilhelmus Henrdiks ,  Gerhardus Wilhelmus Lucassen ,  Rami Nachabe ,  Nenad Mihajlovic ,  Adrien Emmanuel Desjardins ,  Jeroen Jan Lambertus Horikx ,  Marjolein Van Der Voort

IPC分类号： G01J3/42 ,  G01J3/443 ,  G01J3/44

CPC分类号： A61B5/0075 ,  A61B5/0062 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/6848

摘要： The present invention relates to a system for extending microscopy information, where the microscopy information is image information from a first region (118) of an associated sample, the first region being imaged with an imaging system. The extension of the microscopy information originates from probing a larger second region (116) by photons which are emitted at an exit position (128) and collected at en entry position (130). The exit position and the entry position are spatially separated so that so that average spectral information of photons emitted from the exit position and collected at the entry position, is dependent on the second region (116) of the associated sample, the second region (116) being larger than the first region (118).

摘要翻译： 本发明涉及用于扩展显微镜信息的系统，其中显微镜信息是来自相关样品的第一区域（118）的图像信息，第一区域用成像系统成像。 显微镜信息的延伸来自于在出口位置（128）处发射并在入口位置（130）收集的光子探测较大的第二区域（116）。 出口位置和入口位置在空间上分离，使得从出口位置发射并在入口位置收集的光子的平均光谱信息取决于相关样品的第二区域（116），第二区域（116） ）大于第一区域（118）。

公开(公告)号：US09468379B2

公开(公告)日：2016-10-18

申请号：US13641229

申请日：2011-04-18

申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Jeroen Jan Lambertus Horikx ,  Gerhardus Wilhelmus Lucassen ,  Rami Nachabe ,  Marjolein Van Der Voort

发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Jeroen Jan Lambertus Horikx ,  Gerhardus Wilhelmus Lucassen ,  Rami Nachabe ,  Marjolein Van Der Voort

IPC分类号： G01N21/359 ,  A61B5/00

CPC分类号： A61B5/0059 ,  A61B5/4869 ,  G01N21/359

摘要： The present invention relates to an apparatus, a method and a computer program for determining a lipid-water ratio and a scattering parameter of a sample. In particular, the invention relates to an apparatus comprising a light source and a detector arranged to measure an optical parameter at various wavelengths, where the wavelengths are selected so that at two of the wavelengths the absorption coefficients for both water and lipids are substantially identical. This enables determination of a scattering parameter. A further measurement at a third wavelength enables determination of a water-lipid ratio. According to a specific embodiment, the light source and the detector are arranged in relation to an interventional device, so as to be able to examine a tissue in terms of lipid-water ratio and scattering during an intervention.

摘要翻译： 本发明涉及一种用于确定样品的脂质 - 水比和散射参数的装置，方法和计算机程序。 具体地，本发明涉及一种包括光源和检测器的设备，其被布置成测量各种波长的光学参数，其中选择波长使得在两个波长处，水和脂质的吸收系数基本相同。 这使得能够确定散射参数。 在第三波长处的进一步测量使得能够测定水 - 油比。 根据具体实施例，光源和检测器相对于介入装置布置，以便能够在干预期间根据脂质 - 水比和散射来检查组织。

公开(公告)号：US20130026367A1

公开(公告)日：2013-01-31

申请号：US13641229

申请日：2011-04-18

申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Jeroen Jan Lambertus Horikx ,  Gerhardus Wilhelmus Lucassen ,  Rami Nachabe ,  Marjolein Van Der Voort

发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Jeroen Jan Lambertus Horikx ,  Gerhardus Wilhelmus Lucassen ,  Rami Nachabe ,  Marjolein Van Der Voort

IPC分类号： G01N21/59 ,  G01N21/49

CPC分类号： A61B5/0059 ,  A61B5/4869 ,  G01N21/359

摘要： The present invention relates to an apparatus, a method and a computer program for determining a lipid-water ratio and a scattering parameter of a sample. In particular, the invention relates to an apparatus comprising a light source and a detector arranged to measure an optical parameter at various wavelengths, where the wavelengths are selected so that at two of the wavelengths the absorption coefficients for both water and lipids are substantially identical. This enables determination of a scattering parameter. A further measurement at a third wavelength enables determination of a water-lipid ratio. According to a specific embodiment, the light source and the detector are arranged in relation to an interventional device, so as to be able to examine a tissue in terms of lipid-water ratio and scattering during an intervention.

摘要翻译： 本发明涉及一种用于确定样品的脂质 - 水比和散射参数的装置，方法和计算机程序。 具体地，本发明涉及一种包括光源和检测器的设备，其被布置成测量各种波长的光学参数，其中选择波长使得在两个波长处，水和脂质的吸收系数基本相同。 这使得能够确定散射参数。 在第三波长处的进一步测量使得能够测定水 - 油比。 根据具体实施例，光源和检测器相对于介入装置布置，以便能够在干预期间根据脂质 - 水比和散射来检查组织。

公开(公告)号：US20140117256A1

公开(公告)日：2014-05-01

申请号：US14127719

申请日：2012-06-21

申请人： Manfred Mueller ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Gerhardus Wilhelmus Lucassen ,  Jeroen Jan Lambertus Horikx ,  Rami Nachabe ,  Marjolein Van Der Voort

发明人： Manfred Mueller ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Gerhardus Wilhelmus Lucassen ,  Jeroen Jan Lambertus Horikx ,  Rami Nachabe ,  Marjolein Van Der Voort

IPC分类号： A61B5/00

CPC分类号： A61B5/0071 ,  A61B5/0075 ,  A61B5/0084

摘要： In order to improve fluorescence measurements, there is provided an apparatus and, a method and a computer program for optical analysis of an associated tissue sample, the apparatus comprising a spectrometer comprising an optical detector, a light source, a first light emitter 219 arranged for emitting photons into the associated tissue sample, a first light collector 221 arranged for receiving photons from the associated tissue sample, a second light emitter 223, a second light collector 225, wherein a reflectance spectrum is obtained via the first light emitter 219 and collector 221 and a fluorescence spectrum is obtained via the second light emitter 223 and collector 225, and where a first distance d1 between the first light emitter and collector is larger than a second distance d2 between the second light emitter and collector. By combining the data thus obtained, an intrinsic fluorescence spectrum may be obtained.

摘要翻译： 为了改进荧光测量，提供了一种用于相关组织样本的光学分析的装置和方法以及计算机程序，该装置包括光谱仪，该光谱仪包括光学检测器，光源，第一光发射器219， 将光子发射到相关联的组织样本中，布置成从相关联的组织样本接收光子的第一光收集器221，第二光发射器223，第二光收集器225，其中通过第一光发射器219和集电极221获得反射光谱 并且通过第二光发射器223和集电极225获得荧光光谱，并且其中第一光发射器和集电极之间的第一距离d1大于第二发光体和集电极之间的第二距离d2。 通过组合由此获得的数据，可以获得固有的荧光光谱。

公开(公告)号：US20140121538A1

公开(公告)日：2014-05-01

申请号：US14127692

申请日：2012-06-13

申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Gerhardus Wilhelmus Lucassen ,  Jeroen Jan Lambertus Horiks ,  Susanne Dorien Van Den Bergdams ,  Christian Reich ,  Stephan Voss ,  Axel Winkel ,  Rami Nachabe ,  Manfred Muller ,  Marjolein Van Der Voort

发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Gerhardus Wilhelmus Lucassen ,  Jeroen Jan Lambertus Horiks ,  Susanne Dorien Van Den Bergdams ,  Christian Reich ,  Stephan Voss ,  Axel Winkel ,  Rami Nachabe ,  Manfred Muller ,  Marjolein Van Der Voort

IPC分类号： A61B5/00 ,  A61B10/02 ,  A61B1/00 ,  A61B1/06 ,  A61B1/07

CPC分类号： A61B1/00009 ,  A61B1/0646 ,  A61B1/0684 ,  A61B1/07 ,  A61B5/0071 ,  A61B5/0073 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/6848 ,  A61B10/0233 ,  F04C2270/0421 ,  Y10T29/49826

摘要： A needle is proposed including a cannula or hollow shaft with a multilumen insert inside. The insert comprises at least two lumen. Both the insert as well as the cannula have bevelled ends. In the insert substantially straight cleaved fibers are present that may be connected at the proximal end to a console. At least one of the distal fiber ends in the insert may protrude more than half the fiber diameter out of the insert. Furthermore, the bevel angle of the insert is different from the bevel angle of the cannula such that combination cannula and insert is such that the fiber ends do not protrude the bevel surface of the cannula.

摘要翻译： 提出了一种针头，其中包括插入件或空心轴，其中具有多孔插入件。 插入件包括至少两个内腔。 插入件以及套管均具有倾斜端部。 在插入件中，存在基本上直的切割的纤维，其可以在近端连接到控制台。 插入件中的远端纤维端部中的至少一个可以突出超过插入件的纤维直径的一半以上。 此外，插入件的斜角与插管的斜角不同，使得组合插管和插入件使得纤维端部不突出套管的斜面。

公开(公告)号：US10105057B2

公开(公告)日：2018-10-23

申请号：US13995967

申请日：2011-12-22

申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Rami Nachabe ,  Gerhardus Wilhelmus Lucassen ,  Adrien Emmanuel Desjardins ,  Theodoor Jacques Marie Ruers

发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Rami Nachabe ,  Gerhardus Wilhelmus Lucassen ,  Adrien Emmanuel Desjardins ,  Theodoor Jacques Marie Ruers

IPC分类号： A61B6/00 ,  A61B5/00 ,  A61B1/00 ,  G01N21/25 ,  A61B18/18

摘要： The present invention relates to an apparatus 100 and, a method and a computer program for determining a parameter indicative of a tissue type of an associated tissue 116. In particular, the invention relates to an apparatus 100 comprising a spectrometer 102, which spectrometer comprises a light source 104 and a detector 106, 108 arranged to measure an optical spectrum. This enables determination of a first parameter being indicative of a bile concentration. As the inventors of the present invention have made the insight that bile concentration may serve as a discriminative feature for different tissue types, the apparatus is arranged to determine a second parameter indicative of a tissue type based on a concentration of bile. According to a specific embodiment, the apparatus further comprises an interventional device 112.

公开(公告)号：US20140200459A1

公开(公告)日：2014-07-17

申请号：US13995967

申请日：2011-12-22

申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Rami Nachabe ,  Gerhardus Wilhelmus Lucassen ,  Adrien Emmanuel Desjardins ,  Theodoor Jacques Marie Ruers

发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Rami Nachabe ,  Gerhardus Wilhelmus Lucassen ,  Adrien Emmanuel Desjardins ,  Theodoor Jacques Marie Ruers

IPC分类号： A61B5/00 ,  A61B18/18

CPC分类号： A61B5/0075 ,  A61B1/00 ,  A61B5/0084 ,  A61B5/4836 ,  A61B18/18 ,  G01N21/25

摘要： The present invention relates to an apparatus 100 and, a method and a computer program for determining a parameter indicative of a tissue type of an associated tissue 116. In particular, the invention relates to an apparatus 100 comprising a spectrometer 102, which spectrometer comprises a light source 104 and a detector 106, 108 arranged to measure an optical spectrum. This enables determination of a first parameter being indicative of a bile concentration. As the inventors of the present invention have made the insight that bile concentration may serve as a discriminative feature for different tissue types, the apparatus is arranged to determine a second parameter indicative of a tissue type based on a concentration of bile. According to a specific embodiment, the apparatus further comprises an interventional device 112.

摘要翻译： 本发明涉及一种用于确定指示相关组织116的组织类型的参数的装置100和方法和计算机程序。特别地，本发明涉及一种包括分光计102的装置100，该分光计包括： 光源104和被布置成测量光谱的检测器106,108。 这使得能够确定指示胆汁浓度的第一参数。 本发明的发明人已经认识到胆汁浓度可以用作不同组织类型的鉴别特征，该装置被设置为基于胆汁的浓度来确定指示组织类型的第二参数。 根据具体实施例，该装置还包括介入装置112。

公开(公告)号：US06609015B2

公开(公告)日：2003-08-19

申请号：US09912127

申请日：2001-07-24

申请人： Gerhardus Wilhelmus Lucassen ,  Gerwin Jan Puppels ,  Peter Jacobus Caspers ,  Marjolein Van Der Voort ,  Egbert Lenderink ,  Martinus Bernardus Van Der Mark ,  Robert Frans Maria Hendriks ,  Julius Simon Cohen

发明人： Gerhardus Wilhelmus Lucassen ,  Gerwin Jan Puppels ,  Peter Jacobus Caspers ,  Marjolein Van Der Voort ,  Egbert Lenderink ,  Martinus Bernardus Van Der Mark ,  Robert Frans Maria Hendriks ,  Julius Simon Cohen

IPC分类号： A61B500

CPC分类号： G01N21/65 ,  A61B5/0068 ,  A61B5/0075 ,  A61B5/489 ,  A61B5/6824 ,  A61B5/7207 ,  A61B2562/0242 ,  G01N2021/656 ,  G02B21/0024 ,  G02B21/008

摘要： An analysis apparatus including a spectroscopic analysis apparatus comprises an excitation system and a monitoring system. The excitation system emits an excitation beam to excite a target region during an excitation period. The monitoring system emits a monitoring beam to image the target region during a monitoring period. The excitation period and the monitoring period substantially overlap. Hence the target region is imaged together with the excitation, and an image is formed displaying both the target region and the excitation area. On the basis of this image, the excitation beam can be very accurately aimed at the target region.

公开(公告)号：US20140142563A1

公开(公告)日：2014-05-22

申请号：US14131518

申请日：2012-07-05

申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Nicolaas Jan Noordhoek ,  Gerhardus Wilhelmus Lucassen ,  Pieter Maria Mielekamp ,  Rami Nachabé ,  Marjolein Van Der Voort ,  Waltherus Cornelis Jozef Bierhoff

发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Nicolaas Jan Noordhoek ,  Gerhardus Wilhelmus Lucassen ,  Pieter Maria Mielekamp ,  Rami Nachabé ,  Marjolein Van Der Voort ,  Waltherus Cornelis Jozef Bierhoff

IPC分类号： A61B19/00 ,  A61B18/14

CPC分类号： A61B34/10 ,  A61B18/14 ,  A61B2018/00577 ,  A61B2034/101

摘要： The invention relates to an energy application planning apparatus for planning an application of energy to an object (3) like a tumor. An energy application element representation represents an energy application element (5) like an ablation needle including an energy application part for applying energy and a sensing part (7). An arrangement of the energy application element (5) with respect to the object (3) is determined depending on the positions of the energy application part and the sensing part (7) with respect to the energy application element (5) as defined by the energy application element representation and depending on the object representation. The application of energy can therefore not only be planned such that the application of energy is performed as desired, but also such that the object and/or a surrounding of the object are sensible as desired. In this way, the planning procedure can be improved.

摘要翻译： 本发明涉及一种能量应用计划装置，用于规划能量到诸如肿瘤的物体（3）的应用。 能量应用元件表示代表诸如包括用于施加能量的能量施加部分和感测部分（7）的消融针的能量施加元件（5）。 能量施加元件（5）相对于物体（3）的布置根据能量施加部分和感测部分（7）相对于能量施加元件（5）的位置来确定，如由 能量应用元素表示，并取决于对象表示。 因此，能量的施加不仅可以被规划，使得能量的应用按照需要执行，而且还使得物体和/或物体的周围是期望的。 这样可以提高规划程序。

公开(公告)号：US07453564B2

公开(公告)日：2008-11-18

申请号：US10595358

申请日：2004-10-15

申请人： Wouter Harry Rensen ,  Michael Cornelis Van Beek ,  Marjolein Van Der Voort ,  Bernardus Leonardus Bakker ,  Gerhardus Wilhelmus Lucassen ,  Teunis Willem Tukker

发明人： Wouter Harry Rensen ,  Michael Cornelis Van Beek ,  Marjolein Van Der Voort ,  Bernardus Leonardus Bakker ,  Gerhardus Wilhelmus Lucassen ,  Teunis Willem Tukker

IPC分类号： G01J3/00

CPC分类号： A61B5/0059 ,  A61B5/0068 ,  A61B5/489

摘要： A property of a fluid is determined spectroscopically, such as for the purposes of in vivo blood analysis. First the position of a volume of interest through which the fluid flows is determined by an optical detection step by making use of an objective. Preferably the optical detection step is an imaging step. Next the objective is moved to bring the focal point of the objective into coincidence with the volume of interest. In this position an optical spectroscopic step is performed. This has the advantage that the measurement beam for performing the optical spectroscopy travels along the optical axis for optimum efficiency.

摘要翻译： 光谱性质确定流体的性质，例如用于体内血液分析的目的。 首先，通过利用目标的光学检测步骤来确定流体流过的感兴趣体积的位置。 优选地，光学检测步骤是成像步骤。 接下来的目标是使目标的焦点与感兴趣的数量相吻合。 在该位置，进行光学分光步骤。 这具有以下优点：用于执行光学光谱的测量光束沿着光轴行进以获得最佳效率。