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    NMR probe for material analysis
    2.
    发明授权
    NMR probe for material analysis 有权
    NMR探针进行材料分析

    公开(公告)号：US07095230B2

    公开(公告)日：2006-08-22

    申请号：US10955416

    申请日：2004-09-30

    申请人： Bernhard Blümich ,  Michael Bruder ,  Martin Klein ,  Karl-Heinz Krause ,  Michael Rabkin ,  Jürgen Stangenberg ,  Vladimir Anferov ,  Sophia Anferova ,  Radu Fechete

    发明人： Bernhard Blümich ,  Michael Bruder ,  Martin Klein ,  Karl-Heinz Krause ,  Michael Rabkin ,  Jürgen Stangenberg ,  Vladimir Anferov ,  Sophia Anferova ,  Radu Fechete

    IPC分类号： G01V3/00

    CPC分类号： G01R33/3808 ,  G01N24/08 ,  G01R33/341 ,  G01R33/383

    摘要： In a unilateral NMR probe for the analysis of a material comprising at least one magnet for generating a constant time-invariant polarization field B0 in the material to be analyzed and current conductors forming a radio frequency oscillation circuit for generating a pulsed radio frequency magnetic excitation field B1 which is superimposed on the polarization field N0 in the material, the circuit conductors are so designed as to provide several adjacent excitation fields B0 with alternatingly oppositely oriented magnetic fields, whereby the current conductors generating each one of the excitation fields have a distance from each other which causes a certain penetration depth in the material to be analyzed and echoes received therefrom provide measurement values which are characteristic for the material being analyzed.

    摘要翻译： 在用于分析包括至少一个磁体的材料的单侧核磁探针中，用于在待分析的材料中产生恒定的时间不变极化场B 0 <0>和形成射频振荡电路的电流导体 产生叠加在材料中的偏振场N <0>上的脉冲射频磁激励场B 1，电路导体被设计成提供几个相邻的激励场 B <0>具有交替反向取向的磁场，由此产生每个激励场的电流导体彼此之间具有一定距离，这导致要分析的材料中的一定穿透深度，并且从其接收的回波提供 测量值是被分析材料的特征。

    Plaster containing an active agent
    3.
    发明授权
    Plaster containing an active agent 失效
    含有活性剂的石膏

    公开(公告)号：US07045144B2

    公开(公告)日：2006-05-16

    申请号：US10239041

    申请日：2001-02-23

    申请人： Werner Schunk ,  Michael Bruder ,  Konrad Giessmann ,  Karl-Heinz Krause ,  Gerhard Merkmann

    发明人： Werner Schunk ,  Michael Bruder ,  Konrad Giessmann ,  Karl-Heinz Krause ,  Gerhard Merkmann

    IPC分类号： A61K9/00 ,  A61K9/70 ,  A61F13/00

    CPC分类号： A61K9/7038

    摘要： The invention relates to a plaster containing an active agent, comprising at least one cover membrane and an active membrane which is based on a skin-compatible matrix containing a molecular sieve which is loaded with at least one active agent. The molecular sieve/active agent adduct releases the active agent when the active membrane comes into contact with the skin, in conjunction with the transpired water of the skin. The inventive plaster is characterised in that the molecular sieve/active agent adduct also contains water of crystallisation, to the extent that the molecular sieve is partially hydrated compared to a sufficient basic molar quantity (m) of water of crystallisation, the molecular sieve with the reduced molar quantity (m′) of water of crystallisation being loaded with the active agent (Z, Z1, Z2) so that when the active membrane comes into contact with the skin, water is absorbed and the active agent is desorbed, whereupon the water of crystallisation content of the molecular sieve increases. The invention also relates to various suitable embodiments of the plaster containing an active agent and to an advantageous method for producing the inventive plaster containing an active agent.

    摘要翻译： 本发明涉及含有活性剂的石膏，其包括至少一个覆盖膜和活性膜，其基于含有分子筛的皮肤相容性基质，所述分子筛装载有至少一种活性剂。 当活性膜与皮肤接触时，分子筛/活性剂加合物与皮肤的蒸发水结合释放活性剂。 本发明的石膏的特征在于，分子筛/活性剂加合物还含有结晶水，在分子筛与足够的碱性摩尔数（m）结晶水相比分子筛部分水合的程度上，分子筛具有 降低了结晶活性剂（Z，Z 1，Z 2）的结晶水的摩尔量（m'），使得当活性膜与 皮肤，水被吸收并且活性剂被解吸，于是分子筛结晶含量的水增加。 本发明还涉及含有活性剂的石膏的各种合适的实施方案以及用于生产含有活性剂的本发明的石膏的有利方法。

    Rail arrangement
    5.
    发明授权
    Rail arrangement 失效
    铁路安排

    公开(公告)号：US06471139B1

    公开(公告)日：2002-10-29

    申请号：US09445840

    申请日：1999-12-14

    申请人： Michael Bruder ,  Michail Rabkin ,  Karl-Heinz Krause ,  Edgar Böhm ,  Gerhard Merkmann ,  Peter Schwob ,  Klaus Tübel

    发明人： Michael Bruder ,  Michail Rabkin ,  Karl-Heinz Krause ,  Edgar Böhm ,  Gerhard Merkmann ,  Peter Schwob ,  Klaus Tübel

    IPC分类号： E01B900

    CPC分类号： E01B9/681 ,  E01B9/62 ,  E01B9/68 ,  E01B9/683 ,  E01B9/686

    摘要： The invention relates to a rail arrangement for a rail superstucture such as a fixed railroad, comprising an elastic intermediate plate (3) which is located between the rail foot and a hard support (6) in the form of a concrete tie and has two through holes for the screws (7) to fasten the rails. For series mounting, which is the solution of choice, the elastic intermediate plate (3) is combined with an elastic intermediate layer (1) in such a way that the additional intermediate layer rests above the intermediate plate directly below the rail foot, whereby the intermediate layer (1) is separated from the intermediate plate (3) by a metal base plate (2) which serves to fasten the rail. According to the invention, the intermediate plate (3) consists of a single-piece vulcanisate made of a rubber mixture and has three structural zones related to a novel arrangement of protrusions (active surfaces) and recesses (inactive surfaces), whereby the inactive surfaces in the central zone are deeper than those in the two side zones. The invention also relates to other constructional features of the elastic intermediate plate (3).

    摘要翻译： 本发明涉及一种用于轨道结构（例如固定铁路）的轨道装置，其包括弹性中间板（3），该弹性中间板位于轨道脚与混凝土结扎形式的硬支撑（6）之间，并具有两个通过 用于螺钉（7）的孔用于固定导轨。 对于作为选择的解决方案的串联安装，弹性中间板（3）与弹性中间层（1）结合，使得附加中间层位于轨道脚下方的中间板的上方，由此 中间层（1）通过用于固定轨道的金属基板（2）与中间板（3）分离。 根据本发明，中间板（3）由橡胶混合物制成的单片硫化橡胶组成，并具有与突起（活性表面）和凹部（非活性表面）的新颖布置相关的三个结构区域，由此使非活性表面 在中部地区比两侧地区更深。 本发明还涉及弹性中间板（3）的其它结构特征。

    NOVEL MEANS AND METHODS FOR THE TREATMENT OF HEARING LOSS AND PHANTOM HEARING
    6.
    发明申请
    NOVEL MEANS AND METHODS FOR THE TREATMENT OF HEARING LOSS AND PHANTOM HEARING 有权
    治疗听力损失和听觉听觉的新手段和方法

    公开(公告)号：US20120252868A1

    公开(公告)日：2012-10-04

    申请号：US13336147

    申请日：2011-12-23

    申请人： Karl-Heinz Krause ,  Botond Banfi

    发明人： Karl-Heinz Krause ,  Botond Banfi

    IPC分类号： A61K31/713 ,  A61P27/16

    CPC分类号： C12N15/1137 ,  A61K31/713 ,  A61K45/06 ,  A61K49/0008 ,  C12N2310/11 ,  C12N2320/31 ,  G01N33/5088 ,  G01N2333/90209 ,  G01N2800/14

    摘要： This invention relates to modulators of NADPH oxidase as a medicament for the treatment and/or prevention of hearing loss and/or phantom hearing. Such modulators preferably act by inhibiting NADPH oxidase activity, wherein the NADPH oxidase comprises or consists of the amino acid sequence of any one of SEQ ID NO: 1, 3 or 5, or (ii) is encoded by a nucleic acid comprising or consisting of the sequence of any one of SEQ ID NO: 2, 4, 6, 23 or 24, or (iii) is a fragment of the protein according to (i) or (ii) and exhibits NADPH oxidase activity, or (iv) has a sequence at least 75% identical with the protein according to (i) or (ii) or with the fragment according to (iii) and exhibits NADPH oxidase activity. Also provided are pharmaceutical compositions, medical uses and diagnostic uses of compounds of the invention.

    摘要翻译： 本发明涉及NADPH氧化酶的调节剂，其用作治疗和/或预防听力损失和/或幻影听觉的药物。 这种调节剂优选通过抑制NADPH氧化酶活性而起作用，其中NADPH氧化酶包含SEQ ID NO：1,3或5中任一个的氨基酸序列或由其组成，或（ii）由包含或由 SEQ ID NO：2,4,6,23或24中任一项的序列，或（iii）是根据（i）或（ii）的蛋白质的片段，并且表现出NADPH氧化酶活性，或（iv）具有 与根据（i）或（ii）的蛋白质或根据（iii）的片段至少75％相同的序列并显示NADPH氧化酶活性的序列。 还提供了本发明化合物的药物组合物，医疗用途和诊断用途。

    Rubber mixture for an elastic intermediate layer for a rail support
    9.
    发明授权
    Rubber mixture for an elastic intermediate layer for a rail support 失效
    用于轨道支撑的弹性中间层的橡胶混合物

    公开(公告)号：US5735457A

    公开(公告)日：1998-04-07

    申请号：US549844

    申请日：1996-02-26

    申请人： Edgar Bohm ,  Manfred Klerk ,  Karl-Heinz Krause ,  Gerhard Merkmann ,  Rolf Steinmuller ,  Klaus Tubel

    发明人： Edgar Bohm ,  Manfred Klerk ,  Karl-Heinz Krause ,  Gerhard Merkmann ,  Rolf Steinmuller ,  Klaus Tubel

    IPC分类号： C08L7/00 ,  C08L21/00 ,  E01B9/68 ,  F16F1/377 ,  E01B9/62

    CPC分类号： E01B9/683 ,  F16F1/377

    摘要： A rubber mixture is particularly based on natural rubber (NR), epoxidized natural rubber (E-NR), isoprene rubber (IR), butadiene rubber (BR), acrylate rubber (ACM), styrene-butadiene rubber (SBR), or blends of these types of rubber, particularly NR/SBR- blends or NR-BR- blends, as well as the usual mixing ingredients such as fillers, plasticizers, anti-aging media, as well as additional additives, if needed. This mixture produces a plate-like, elastic intermediate layer with low dynamic stiffening; high dynamic stressability; high specific volume resistivity; and low frequency-dependence of the dynamic stiffening. The intermediate layer is arranged particularly between the base of the rail and the top side of the tie in connection with high-speed rail tracks. The underside of the intermediate layer is provided with at least one recess, with formation of an edge extending all around, and facing the top side of the tie. The top side of the intermediate layer which is the surface supporting the base of the rail, is substantially planar shaped.

    摘要翻译： PCT No.PCT / DE95 / 00186 Sec。 371日期1996年2月26日 102（e）日期1996年2月26日PCT提交1995年2月15日PCT公布。 第WO95 / 22659号公报 日期1995年8月24日橡胶混合物特别是基于天然橡胶（NR），环氧化天然橡胶（E-NR），异戊二烯橡胶（IR），丁二烯橡胶（BR），丙烯酸酯橡胶（ACM），苯乙烯 - 丁二烯橡胶 SBR）或这些类型的橡胶，特别是NR / SBR-共混物或NR-BR-共混物的混合物，以及通常的混合成分例如填料，增塑剂，抗老化介质以及另外的添加剂（如果需要） 。 该混合物产生具有低动态硬化的板状弹性中间层; 高动态应力; 高比体积电阻率; 和动态硬化的低频依赖性。 中间层特别地布置在轨道的基部和与高速铁路轨道相关联的连接的顶侧之间。 中间层的下侧设置有至少一个凹部，其形成有围绕连接件的顶侧的四周延伸的边缘。 作为支撑轨道的基部的表面的中间层的顶侧基本上是平面形状。

    Neurons, astrocytes and oligodendrocytes differentiated from a mammalian pluripotent or neural stem cells exposed to a pyridine deriviative
    10.
    发明授权
    Neurons, astrocytes and oligodendrocytes differentiated from a mammalian pluripotent or neural stem cells exposed to a pyridine deriviative 有权
    从暴露于吡啶衍生物的哺乳动物多能或神经干细胞分化的神经元，星形胶质细胞和少突胶质细胞

    公开(公告)号：US08609413B2

    公开(公告)日：2013-12-17

    申请号：US12747116

    申请日：2008-12-11

    申请人： David M. Suter ,  Olivier Preynat-Seauve ,  Karl-Heinz Krause

    发明人： David M. Suter ,  Olivier Preynat-Seauve ,  Karl-Heinz Krause

    IPC分类号： C12N5/00

    CPC分类号： C12N5/0619 ,  C12N5/0623 ,  C12N5/0697 ,  C12N2501/115 ,  C12N2501/999 ,  C12N2506/02 ,  C12N2506/03 ,  C12N2533/32 ,  C12N2533/52

    摘要： A method of preparing neural precursor cells by exposing pluripotent stem cells or neural stem cells to a differentiation agent. The agent is a pyridine analog, which in preferred embodiments is a phenylethynyl-substituted or phenylazo-substituted pyridine. In other embodiments, a method of enhancing neural precursor cell survival is provided in which the survival is enhanced by exposure to the pyridine analog. In further embodiments, a method of preparing neuronal cells is provided in which pluripotent or neural stem cells exposed to the pyridine analog are then incubated without the pyridine analog, resulting in differentiation into neurons, astrocytes and oligodendrocytes. These methods may be used in toxicological screens, e.g., to evaluate the neurotoxicity of a test compound.

    摘要翻译： 通过将多能干细胞或神经干细胞暴露于分化剂来制备神经前体细胞的方法。 该试剂是吡啶类似物，其在优选的实施方案中是苯基乙炔基取代或苯​​偶氮取代的吡啶。 在其它实施方案中，提供增强神经前体细胞存活的方法，其中通过暴露于吡啶类似物来增加存活。 在另外的实施方案中，提供制备神经元细胞的方法，其中暴露于吡啶类似物的多能或神经干细胞然后在没有吡啶类似物的情况下孵育，导致分化成神经元，星形胶质细胞和少突胶质细胞。 这些方法可用于毒理学筛选，例如评估测试化合物的神经毒性。