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公开(公告)号：US20160076099A1
公开(公告)日：2016-03-17
申请号：US14848311
申请日：2015-09-08
Applicant: Bio-Rad Laboratories, Inc.
Inventor： John F. Regan , Serge Saxonov , Michael Y. Lucero , Benjamin J. Hindson , Phillip Belgrader , Simant Dube , Austin P. So , Jeffrey C. Mellen , Nicholas J. Heredia , Kevin D. Ness , Billy W. Colston, Jr.
IPC: C12Q1/68
CPC classification number: C12Q1/6883 , C12Q1/683 , C12Q1/6858 , C12Q2600/158 , C12Q2600/172 , C12Q2537/16 , C12Q2563/159 , C12Q2537/165
Abstract: Provided herein are improved methods, compositions, and kits for analysis of nucleic acids. The improved methods, compositions, and kits can enable copy number estimation of a nucleic acid in a sample. Also provided herein are methods, compositions, and kits for determining the linkage of two or more copies of a target nucleic acid in a sample (e.g. whether the two or more copies are on the same chromosome or different chromosomes) or for phasing alleles.
Abstract translation: 本文提供了用于分析核酸的改进的方法，组合物和试剂盒。 改进的方法，组合物和试剂盒可以使得样品中核酸的拷贝数估计可以进行。 本文还提供了用于确定样品中靶核酸的两个或多个拷贝（例如两个或多个拷贝是在同一染色体上还是在不同染色体上）或用于定相等位基因的连接的方法，组合物和试剂盒。
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公开(公告)号：US20170205345A9
公开(公告)日：2017-07-20
申请号：US14099750
申请日：2013-12-06
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Yann Jouvenot , Serge Saxonov , Simant Dube , John Frederick Regan
IPC: G01N21/64
CPC classification number: G01N21/64 , G01N21/6428 , G01N2021/6432 , G01N2021/6439 , G01N2021/6441 , G06F19/12 , G06F19/18
Abstract: System, including methods and apparatus, for performing a multiplexed digital assay.
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公开(公告)号：US11499181B2
公开(公告)日：2022-11-15
申请号：US16235996
申请日：2018-12-28
Applicant: Bio-Rad Laboratories, Inc.
Inventor： John F. Regan , Serge Saxonov , Michael Y. Lucero , Benjamin J. Hindson , Phillip Belgrader , Simant Dube , Austin P. So , Jeffrey C. Mellen , Nicholas J. Heredia , Kevin D. Ness , Billy W. Colston, Jr.
IPC: C12Q1/6858 , C12Q1/683 , C12Q1/6883 , C12Q1/6806 , C12Q1/6827 , C12Q1/686
Abstract: Method of haplotype analysis. In an exemplary method, an aqueous phase containing nucleic acid may be partitioned into a plurality of discrete volumes. At least one allele sequence may be amplified in the volumes from each of a first polymorphic locus and a second polymorphic locus that exhibit sequence variation in the nucleic acid. At least one measure of co-amplification of allele sequences from both loci in the same volumes may be determined. A haplotype of the first and second loci may be selected based on the at least one measure of co-amplification.
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Patent Agency Ranking
公开(公告)号：US20190241947A1
公开(公告)日：2019-08-08
申请号：US16235996
申请日：2018-12-28
Applicant: Bio-Rad Laboratories, Inc.
Inventor： John F. Regan , Serge Saxonov , Michael Y. Lucero , Benjamin J. Hindson , Phillip Belgrader , Simant Dube , Austin P. So , Jeffrey C. Mellen , Nicholas J. Heredia , Kevin D. Ness , Billy W. Colston, JR.
IPC: C12Q1/6858 , C12Q1/6806 , C12Q1/686 , C12Q1/6827
CPC classification number: C12Q1/6806 , C12Q1/6827 , C12Q1/683 , C12Q1/6858 , C12Q1/686 , C12Q1/6883 , C12Q2535/125 , C12Q2600/158 , C12Q2600/172 , C12Q2537/16 , C12Q2563/159 , C12Q2537/165
Abstract: Method of haplotype analysis. In an exemplary method, an aqueous phase containing nucleic acid may be partitioned into a plurality of discrete volumes. At least one allele sequence may be amplified in the volumes from each of a first polymorphic locus and a second polymorphic locus that exhibit sequence variation in the nucleic acid. At least one measure of co-amplification of allele sequences from both loci in the same volumes may be determined. A haplotype of the first and second loci may be selected based on the at least one measure of co-amplification.
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公开(公告)号：US10167509B2
公开(公告)日：2019-01-01
申请号：US14848311
申请日：2015-09-08
Applicant: Bio-Rad Laboratories, Inc.
Inventor： John F. Regan , Serge Saxonov , Michael Y. Lucero , Benjamin J. Hindson , Phillip Belgrader , Simant Dube , Austin P. So , Jeffrey C. Mellen , Nicholas J. Heredia , Kevin D. Ness , Billy W. Colston, Jr.
IPC: C12Q1/68 , C07H21/00 , C12Q1/6883 , C12Q1/683 , C12Q1/6858
Abstract: Provided herein are improved methods, compositions, and kits for analysis of nucleic acids. The improved methods, compositions, and kits can enable copy number estimation of a nucleic acid in a sample. Also provided herein are methods, compositions, and kits for determining the linkage of two or more copies of a target nucleic acid in a sample (e.g. whether the two or more copies are on the same chromosome or different chromosomes) or for phasing alleles.
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公开(公告)号：US09921154B2
公开(公告)日：2018-03-20
申请号：US14099750
申请日：2013-12-06
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Yann Jouvenot , Serge Saxonov , Simant Dube , John Frederick Regan
CPC classification number: G01N21/64 , G01N21/6428 , G01N2021/6432 , G01N2021/6439 , G01N2021/6441 , G06F19/12 , G06F19/18
Abstract: System, including methods and apparatus, for performing a multiplexed digital assay.
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公开(公告)号：US20160108464A1
公开(公告)日：2016-04-21
申请号：US14981134
申请日：2015-12-28
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Serge Saxonov , Simant Dube , Benjamin J. Hindson , Adam M. McCoy
IPC: C12Q1/68
CPC classification number: C12Q1/686 , C12Q1/6851 , G06F17/10 , G06F17/11 , G06F17/12 , G16B5/00 , G16B20/00 , G16B25/00 , C12Q2537/143 , C12Q2537/165 , C12Q2563/159
Abstract: System, including methods, apparatus, and compositions, for performing a multiplexed digital assay on a greater number of targets through combinatorial use of signals.
Abstract translation: 用于通过组合使用信号对更多数量目标进行多路复用数字测定的系统，包括方法，装置和组合物。
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公开(公告)号：US20140171341A1
公开(公告)日：2014-06-19
申请号：US14099750
申请日：2013-12-06
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Yann Jouvenot , Serge Saxonov , Simant Dube , John Frederick Regan
IPC: G01N21/64
CPC classification number: G01N21/64 , G01N21/6428 , G01N2021/6432 , G01N2021/6439 , G01N2021/6441 , G06F19/12 , G06F19/18
Abstract: System, including methods and apparatus, for performing a multiplexed digital assay.
Abstract translation: 用于执行多路复用数字测定的系统，包括方法和装置。
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