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37 条记录 (耗时 0.026 秒)

    Substituted N-benzylpiperidine amides
    1.
    发明授权
    Substituted N-benzylpiperidine amides 失效
    取代的N-苄基哌啶酰胺

    公开(公告)号：US5098915A

    公开(公告)日：1992-03-24

    申请号：US403205

    申请日：1989-09-05

    申请人： Bipinchandra N. Desai ,  Kerry W. Fowler ,  Alan E. Moormann

    发明人： Bipinchandra N. Desai ,  Kerry W. Fowler ,  Alan E. Moormann

    IPC分类号： C07D401/12 ,  C07D405/12

    CPC分类号： C07D401/12 ,  C07D405/12

    摘要： Substituted N-benzylpiperidine amides, which have activity as Class III antiarrhythmic agents, acting by prolonging cardiac action potential repolarization. The invention further provides for compositions incorporating the compunds and methods of their use, as well as providing for pharmaceutically acceptable salts of the compounds.

    摘要翻译： 取代的N-苄基哌啶酰胺，其具有作为III类抗心律失常药物的活性，通过延长心脏动作电位复极化起作用。 本发明还提供了掺入其组合物及其使用方法的组合物，以及提供化合物的药学上可接受的盐。

    Pharmaceutically useful meso-azacyclic amides of imidazopyridine carboxylic acids and analogs thereof
    2.
    发明授权
    Pharmaceutically useful meso-azacyclic amides of imidazopyridine carboxylic acids and analogs thereof 失效
    咪唑并吡啶羧酸及其类似物的药学有用的内消旋 - 氮杂环酰胺

    公开(公告)号：US5137893A

    公开(公告)日：1992-08-11

    申请号：US666278

    申请日：1991-03-07

    申请人： Daniel P. Becker ,  Daniel L. Flynn ,  Alan E. Moormann ,  Roger Nosal ,  Clara I. Villamil

    发明人： Daniel P. Becker ,  Daniel L. Flynn ,  Alan E. Moormann ,  Roger Nosal ,  Clara I. Villamil

    IPC分类号： C07D519/00

    CPC分类号： C07D519/00

    摘要： The imidazopyridines containing meso-azacycle side chains as described herein find utility as antagonists of the serotonin 5-HT.sub.3 receptor. As such they are useful for the treatment of humans and animals wherein antagonism of 5-HT.sub.3 receptors is benefical. Therapy is indicated for, but not limited to, the treatment of anxiety, psychoses, depression (especially depression accompanied by anxiety), cognitive disorders, substance abuse dependence and/or withdrawal, gastrointestinal motility disturbances (including esophageal reflux, dyspepsia, irritable bowel syndrome), emesis caused by chemotherapeutic agents, and visceral pain. Additionally, the compounds of the present invention may find utility as enhancers of nasal absorption of bioactive compounds.

    摘要翻译： 含有本文所述的内消旋 - 侧链侧链的咪唑并吡啶可用作5-羟色胺5-HT 3受体的拮抗剂。 因此，它们可用于治疗其中5-HT 3受体拮抗作用有益的人和动物。 治疗指示但不限于治疗焦虑症，精神病，抑郁症（特别是伴有焦虑的抑郁症），认知障碍，药物滥用依赖和/或戒断，胃肠蠕动障碍（包括食管反流，消化不良，肠易激综合征 ），由化疗药引起的呕吐和内脏痛。 此外，本发明的化合物可以用作生物活性化合物的鼻吸收增强剂。

    Benzimidazole compounds
    6.
    发明授权
    Benzimidazole compounds 失效
    苯并咪唑化合物

    公开(公告)号：US5280028A

    公开(公告)日：1994-01-18

    申请号：US903835

    申请日：1992-06-24

    申请人： Daniel L. Flynn ,  Alan E. Moormann

    发明人： Daniel L. Flynn ,  Alan E. Moormann

    IPC分类号： C07D403/12 ,  C07D471/18 ,  C07D487/04 ,  C07D487/08 ,  C07D451/00 ,  A61K31/41 ,  A61K31/435 ,  C07D471/00

    CPC分类号： C07D403/12 ,  C07D487/04 ,  C07D487/08

    摘要： This invention relates to compounds useful in treating HT.sub.4 and/or HT.sub.3 mediated conditions of the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein R.sub.1 and R.sub.2 are independently selected from the group consisting of hydrogen, alkoxy, halogen, amino, monoalkylamino, dialkylamino, acylamino and alkylsulfonylamino; R.sub.3 is selected from the group consisting of H, alkyl and cycloalkyl; X is NH or O; Z is selected from the group consisting of ##STR2## n and r are independently 1 or 2; p is 0 or 1; pharmaceutical compositions containing the compounds and a method for treating serotonin mediated condition with the compositions which act as 5-HT.sub.4 agonists or antagonists and/or 5-HT.sub.3 antagonists.

    摘要翻译： 本发明涉及可用于治疗HT4和/或HT3，介导的式（I）的条件或其药学上可接受的盐的化合物，其中R 1和R 2独立地选自氢，烷氧基，卤素，氨基，单烷基氨基，二烷基氨基 ，酰基氨基和烷基磺酰基氨基; R3选自H，烷基和环烷基; X是NH或O; Z选自（a），（b），（c），（d），（e），（f），（g），（h）和n和r独立地为1或2; p为0或1; q为0或1; 含有该化合物的药物组合物和用作为5-HT4，激动剂或拮抗剂和/或5-HT 3拮抗剂的组合物治疗血清素介导的病症的方法。

    Meso-azacyclic amides of imidazopyridine carboxylic acids and analogs thereof as pharmaceuticals
    7.
    发明授权
    Meso-azacyclic amides of imidazopyridine carboxylic acids and analogs thereof as pharmaceuticals 失效
    咪唑并吡啶羧酸的间 - 环氮杂酰胺及其类似物作为药物

    公开(公告)号：US5234921A

    公开(公告)日：1993-08-10

    申请号：US896244

    申请日：1992-06-10

    申请人： Daniel L. Flynn ,  Alan E. Moormann ,  Roger Nosal

    发明人： Daniel L. Flynn ,  Alan E. Moormann ,  Roger Nosal

    IPC分类号： C07D519/00

    CPC分类号： C07D519/00

    摘要： The imidazopyridines containing meso-azacycle side chains as described herein find utility as antagonists of the serotonin 5-HT.sub.3 receptor. As such they are useful for the treatment of humans and animals wherein antagonism of 5-HT.sub.3 receptors is beneficial. Therapy is indicated for, but not limited to, the treatment of anxiety, psychoses, depression (especially depression accompanied by anxiety), cognitive disorders, substance abuse dependence and/or withdrawal, gastrointestinal motility disturbancies (including esophageal reflux, dyspepsia, irritable bowel syndrome), emesis caused by chemotherapeutic agents, and visceral pain. Additionally, the compounds of the present invention may find utility as enhancers of nasal absorption of bioactive compounds.

    摘要翻译： 含有本文所述的内消旋 - 侧链侧链的咪唑并吡啶可用作5-羟色胺5-HT 3受体的拮抗剂。 因此，它们可用于治疗其中5-HT 3受体拮抗作用有益的人和动物。 治疗指示但不限于治疗焦虑症，精神病，抑郁症（特别是伴有焦虑症的抑郁症），认知障碍，药物滥用依赖和/或戒断，胃肠蠕动性窒息（包括食管反流，消化不良，肠易激综合征 ），由化疗药引起的呕吐和内脏痛。 此外，本发明的化合物可以用作生物活性化合物的鼻吸收增强剂。