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公开(公告)号：US08883159B2
公开(公告)日：2014-11-11
申请号：US12868849
申请日：2010-08-26
申请人： Birgit Bossenmaier , Georg Fertig , Hans-Willi Krell , Reiner Lammers , Alexander Lifke , Gerhard Niederfellner
发明人： Birgit Bossenmaier , Georg Fertig , Hans-Willi Krell , Reiner Lammers , Alexander Lifke , Gerhard Niederfellner
IPC分类号： A61K39/395 , A61P35/04 , C07K16/30 , C07K16/28 , C12N15/13 , C12N15/85 , C12N5/10 , A61K39/00
CPC分类号： C07K16/2896 , A61K2039/505 , C07K2317/24 , C07K2317/565 , C07K2317/73 , C07K2317/75 , C07K2317/76
摘要： The present invention relates to antibodies against human CDCP1 binding to the same epitope as CUB4 (Deposition No. DSM ACC2551) for the treatment of cancer.
摘要翻译： 本发明涉及抗CDCP1与CUB4（沉积号DSM ACC2551）相同表位的抗体用于治疗癌症的抗体。
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公开(公告)号：US20110070246A1
公开(公告)日：2011-03-24
申请号：US12868849
申请日：2010-08-26
申请人： Birgit Bossenmaier , Georg Fertig , Hans-Willi Krell , Reiner Lammers , Alexander Lifke , Gerhard Niederfellner
发明人： Birgit Bossenmaier , Georg Fertig , Hans-Willi Krell , Reiner Lammers , Alexander Lifke , Gerhard Niederfellner
CPC分类号： C07K16/2896 , A61K2039/505 , C07K2317/24 , C07K2317/565 , C07K2317/73 , C07K2317/75 , C07K2317/76
摘要： The present invention relates to antibodies against human CDCP1 binding to the same epitope as CUB4 (Deposition No. DSM ACC2551) for the treatment of cancer.
摘要翻译： 本发明涉及抗CDCP1与CUB4（沉积号DSM ACC2551）相同表位的抗体用于治疗癌症的抗体。
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公开(公告)号：US20110052582A1
公开(公告)日：2011-03-03
申请号：US12868845
申请日：2010-08-26
申请人： Johannes Auer , Birgit Bossenmaier , Guy Georges , Alexander Lifke , Ekkehard Moessner , Gerhard Niederfellner
发明人： Johannes Auer , Birgit Bossenmaier , Guy Georges , Alexander Lifke , Ekkehard Moessner , Gerhard Niederfellner
IPC分类号： A61K39/395 , C07K16/18 , C07H21/00 , C12N15/63 , C12N5/10 , C12N1/00 , C12P21/02 , A61P35/00
CPC分类号： C07K16/30 , C07K16/2896 , C07K2317/24 , C07K2317/41 , C07K2317/56 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/75 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to humanized antibodies against human CDCP1 (anti-CDCP1 antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及针对人CDCP1（抗CDCP1抗体）的人源化抗体，其制备方法，含有所述抗体的药物组合物及其用途。
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公开(公告)号：US08394928B2
公开(公告)日：2013-03-12
申请号：US12868845
申请日：2010-08-26
申请人： Johannes Auer , Birgit Bossenmaier , Guy Georges , Alexander Lifke , Ekkehard Moessner , Gerhard Niederfellner
发明人： Johannes Auer , Birgit Bossenmaier , Guy Georges , Alexander Lifke , Ekkehard Moessner , Gerhard Niederfellner
IPC分类号： C12P21/08
CPC分类号： C07K16/30 , C07K16/2896 , C07K2317/24 , C07K2317/41 , C07K2317/56 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/75 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to humanized antibodies against human CDCP1 (anti-CDCP1 antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及针对人CDCP1（抗CDCP1抗体）的人源化抗体，其制备方法，含有所述抗体的药物组合物及其用途。
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公开(公告)号：US20110306094A1
公开(公告)日：2011-12-15
申请号：US13202446
申请日：2010-02-18
CPC分类号： C12P21/005 , C07K16/00 , C07K2317/14 , C07K2317/21 , C07K2317/55 , C12P19/34 , C12Q1/6804 , C12Q1/6858 , C12Q1/6881 , C12Q2600/16 , C12Q2549/119 , C12Q2537/143
摘要： The current invention is directed to a method for obtaining a nucleic acid encoding an immunoglobulin variable domain from a single cell comprising the following steps:—performing a first polymerase chain reaction with three to six 5′-primer and one 3′-primer, performing with the product of the first polymerase chain reaction a second polymerase chain reaction with thirteen to sixteen 5′-primer and one 3′-primer, whereby the distance of the binding locations of the primer employed in the second polymerase chain reaction is reduced compared to the first polymerase chain reaction.
摘要翻译： 本发明涉及从单细胞获得编码免疫球蛋白可变结构域的核酸的方法，包括以下步骤： - 用3至6个5'-引物和1个3'-引物进行第一聚合酶链反应，进行 与第一聚合酶链反应的产物进行第二聚合酶链反应与十三至十六个5'-引物和一个3'-引物，由此在第二聚合酶链式反应中使用的引物的结合位置的距离比 第一次聚合酶链反应。
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公开(公告)号：US09399670B2
公开(公告)日：2016-07-26
申请号：US13202446
申请日：2010-02-18
CPC分类号： C12P21/005 , C07K16/00 , C07K2317/14 , C07K2317/21 , C07K2317/55 , C12P19/34 , C12Q1/6804 , C12Q1/6858 , C12Q1/6881 , C12Q2600/16 , C12Q2549/119 , C12Q2537/143
摘要： The current invention is directed to a method for obtaining a nucleic acid encoding an immunoglobulin variable domain from a single cell comprising the following steps: —performing a first polymerase chain reaction with three to six 5′-primer and one 3′-primer, performing with the product of the first polymerase chain reaction a second polymerase chain reaction with thirteen to sixteen 5′-primer and one 3′-primer, whereby the distance of the binding locations of the primer employed in the second polymerase chain reaction is reduced compared to the first polymerase chain reaction.
摘要翻译： 本发明涉及从单细胞获得编码免疫球蛋白可变结构域的核酸的方法，包括以下步骤： - 用3至6个5'-引物和1个3'-引物进行第一聚合酶链反应，进行 与第一聚合酶链反应的产物进行第二聚合酶链反应与十三至十六个5'-引物和一个3'-引物，由此在第二聚合酶链式反应中使用的引物的结合位置的距离比 第一次聚合酶链反应。
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公开(公告)号：US20070266448A1
公开(公告)日：2007-11-15
申请号：US11801614
申请日：2007-05-08
IPC分类号： A01K67/027 , C12P21/04
CPC分类号： C12P21/00 , C07K16/00 , C07K16/2866 , C07K16/32 , C12N5/0635
摘要： The current invention is related to a method for the production of a human monoclonal antibody from a immundeficient non-human animal, said method comprising contacting a new borne immunodeficient non-human animal with a human fetal liver stem cell (FL cell) to generate an immune transplanted non-human animal (reconstituted animal), subsequently contacting said reconstituted animal with a antigen, collecting from said reconstituted animal a human cell producing human antibody against said antigen, and isolating said antibody from said antibody producing cell.
摘要翻译： 本发明涉及一种从无限非人动物制备人单克隆抗体的方法，所述方法包括使新的免疫缺陷型非人动物与人胎肝干细胞（FL细胞）接触以产生 免疫移植的非人动物（重构动物），随后使所述重建的动物与抗原接触，从所述重建的动物收集产生针对所述抗原的人抗体的人细胞，并从所述抗体产生细胞中分离所述抗体。
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公开(公告)号：US20100105073A1
公开(公告)日：2010-04-29
申请号：US12603642
申请日：2009-10-22
IPC分类号： G01N33/53 , C12P21/08 , C12N5/0781
CPC分类号： C12P21/00 , C07K16/00 , C07K16/2866 , C07K16/32 , C12N5/0635
摘要： The current invention is related to a method for the production of a human monoclonal antibody from a immunodeficient non-human animal, said method comprising contacting a new borne immunodeficient non-human animal with a human fetal liver stem cell (FL cell) to generate an immune transplanted non-human animal (reconstituted animal), subsequently contacting said reconstituted animal with a antigen, collecting from said reconstituted animal a human cell producing human antibody against said antigen, and isolating said antibody from said antibody producing cell.
摘要翻译： 本发明涉及从免疫缺陷型非人动物制备人单克隆抗体的方法，所述方法包括使新的免疫缺陷型非人动物与人胎肝干细胞（FL细胞）接触以产生 免疫移植的非人动物（重构动物），随后使所述重建的动物与抗原接触，从所述重建的动物收集产生针对所述抗原的人抗体的人细胞，并从所述抗体产生细胞中分离所述抗体。
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公开(公告)号：US20120195903A1
公开(公告)日：2012-08-02
申请号：US13443917
申请日：2012-04-11
IPC分类号： A61K39/395 , C12N5/0781 , C12P21/08 , G01N33/577
CPC分类号： C12P21/00 , C07K16/00 , C07K16/2866 , C07K16/32 , C12N5/0635
摘要： The current invention is related to a method for the production of a human monoclonal antibody from a immundeficient non-human animal, said method comprising contacting a new borne immunodeficient non-human animal with a human fetal liver stem cell (FL cell) to generate an immune transplanted non-human animal (reconstituted animal), subsequently contacting said reconstituted animal with a antigen, collecting from said reconstituted animal a human cell producing human antibody against said antigen, and isolating said antibody from said antibody producing cell.
摘要翻译： 本发明涉及一种从无限非人动物制备人单克隆抗体的方法，所述方法包括使新的免疫缺陷型非人动物与人胎肝干细胞（FL细胞）接触以产生 免疫移植的非人动物（重构动物），随后使所述重建的动物与抗原接触，从所述重建的动物收集产生针对所述抗原的人抗体的人细胞，并从所述抗体产生细胞中分离所述抗体。
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