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公开(公告)号：US20110306094A1
公开(公告)日：2011-12-15
申请号：US13202446
申请日：2010-02-18
CPC分类号： C12P21/005 , C07K16/00 , C07K2317/14 , C07K2317/21 , C07K2317/55 , C12P19/34 , C12Q1/6804 , C12Q1/6858 , C12Q1/6881 , C12Q2600/16 , C12Q2549/119 , C12Q2537/143
摘要： The current invention is directed to a method for obtaining a nucleic acid encoding an immunoglobulin variable domain from a single cell comprising the following steps:—performing a first polymerase chain reaction with three to six 5′-primer and one 3′-primer, performing with the product of the first polymerase chain reaction a second polymerase chain reaction with thirteen to sixteen 5′-primer and one 3′-primer, whereby the distance of the binding locations of the primer employed in the second polymerase chain reaction is reduced compared to the first polymerase chain reaction.
摘要翻译： 本发明涉及从单细胞获得编码免疫球蛋白可变结构域的核酸的方法，包括以下步骤： - 用3至6个5'-引物和1个3'-引物进行第一聚合酶链反应，进行 与第一聚合酶链反应的产物进行第二聚合酶链反应与十三至十六个5'-引物和一个3'-引物，由此在第二聚合酶链式反应中使用的引物的结合位置的距离比 第一次聚合酶链反应。
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公开(公告)号：US09399670B2
公开(公告)日：2016-07-26
申请号：US13202446
申请日：2010-02-18
CPC分类号： C12P21/005 , C07K16/00 , C07K2317/14 , C07K2317/21 , C07K2317/55 , C12P19/34 , C12Q1/6804 , C12Q1/6858 , C12Q1/6881 , C12Q2600/16 , C12Q2549/119 , C12Q2537/143
摘要： The current invention is directed to a method for obtaining a nucleic acid encoding an immunoglobulin variable domain from a single cell comprising the following steps: —performing a first polymerase chain reaction with three to six 5′-primer and one 3′-primer, performing with the product of the first polymerase chain reaction a second polymerase chain reaction with thirteen to sixteen 5′-primer and one 3′-primer, whereby the distance of the binding locations of the primer employed in the second polymerase chain reaction is reduced compared to the first polymerase chain reaction.
摘要翻译： 本发明涉及从单细胞获得编码免疫球蛋白可变结构域的核酸的方法，包括以下步骤： - 用3至6个5'-引物和1个3'-引物进行第一聚合酶链反应，进行 与第一聚合酶链反应的产物进行第二聚合酶链反应与十三至十六个5'-引物和一个3'-引物，由此在第二聚合酶链式反应中使用的引物的结合位置的距离比 第一次聚合酶链反应。
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公开(公告)号：US08859737B2
公开(公告)日：2014-10-14
申请号：US12971300
申请日：2010-12-17
申请人： Birgit Bossenmaier , Nikolaos Dimoudis , Thomas Friess , Guy Georges , Irene Kolm , Hans-Willi Krell , Valeria Lifke , Ekkehard Moessner
发明人： Birgit Bossenmaier , Nikolaos Dimoudis , Thomas Friess , Guy Georges , Irene Kolm , Hans-Willi Krell , Valeria Lifke , Ekkehard Moessner
CPC分类号： C07K16/32 , A61K2039/505 , C07K16/40 , C07K2317/24 , C07K2317/41 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies binding to human HER3 (anti-HER3 antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及与人HER3（抗HER3抗体）结合的抗体，其制备方法，含有所述抗体的药物组合物及其用途。
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4.发明授权公开(公告)号：US08609097B2
公开(公告)日：2013-12-17
申请号：US12792810
申请日：2010-06-03
申请人： Bernd Bohrmann , Ulrich Goepfert , Fiona Grueninger , Walter Huber , Hans-Willi Krell , Valeria Lifke , Olaf Mundigl , Sonja Offner , Laurence Ozmen , Michael Schraeml
发明人： Bernd Bohrmann , Ulrich Goepfert , Fiona Grueninger , Walter Huber , Hans-Willi Krell , Valeria Lifke , Olaf Mundigl , Sonja Offner , Laurence Ozmen , Michael Schraeml
IPC分类号： A61K39/395
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/4711 , C07K16/3053 , C07K2317/622 , C07K2317/92 , C07K2317/94 , C07K2319/40 , C07K2319/55
摘要： An antibody binding to Tau that is phosphorylated at serine 422 (pS422), which specifically binds to phosphorylated Tau fragment of SEQ ID NO:9 and to Tau pS422, but does not bind to Tau and to phosphorylated MCAK fragment of SEQ ID NO:17. The antibody is useful in the treatment of a Tauopathy.
摘要翻译： 与在丝氨酸422（pS422）磷酸化，特异性结合SEQ ID NO：9的磷酸化Tau片段和Tau pS422但不结合Tau和SEQ ID NO：17的磷酸化MCAK片段的Tau结合的抗体 。 该抗体可用于治疗Tauopathy。
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公开(公告)号：US20110059093A1
公开(公告)日：2011-03-10
申请号：US12792810
申请日：2010-06-03
申请人： Bernd Bohrmann , Ulrich Goepfert , Fiona Grueninger , Walter Huber , Hans-Willi Krell , Valeria Lifke , Olaf Mundigl , Sonja Offner , Laurence Ozmen , Michael Schraeml
发明人： Bernd Bohrmann , Ulrich Goepfert , Fiona Grueninger , Walter Huber , Hans-Willi Krell , Valeria Lifke , Olaf Mundigl , Sonja Offner , Laurence Ozmen , Michael Schraeml
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/4711 , C07K16/3053 , C07K2317/622 , C07K2317/92 , C07K2317/94 , C07K2319/40 , C07K2319/55
摘要： An antibody binding to Tau that is phosphorylated at serine 422 (pS422), which specifically binds to phosphorylated Tau fragment of SEQ ID NO:9 and to Tau pS422, but does not bind to Tau and to phosphorylated MCAK fragment of SEQ ID NO:17. The antibody is useful in the treatment of a Tauopathy.
摘要翻译： 与在丝氨酸422（pS422）磷酸化，特异性结合SEQ ID NO：9的磷酸化Tau片段和Tau pS422但不结合Tau和SEQ ID NO：17的磷酸化MCAK片段的Tau结合的抗体 。 该抗体可用于治疗Tauopathy。
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公开(公告)号：US20110171222A1
公开(公告)日：2011-07-14
申请号：US12971300
申请日：2010-12-17
申请人： Birgit Bossenmaier , Nikolaos Dimoudis , Thomas Friess , Guy Georges , Irene Kolm , Hans-Willi Krell , Valeria Lifke , Ekkehard Moessner
发明人： Birgit Bossenmaier , Nikolaos Dimoudis , Thomas Friess , Guy Georges , Irene Kolm , Hans-Willi Krell , Valeria Lifke , Ekkehard Moessner
IPC分类号： A61K39/395 , C07K16/32 , C07H21/00 , C12N15/63 , C12N5/10 , C12N1/00 , C12P21/02 , A61P35/00
CPC分类号： C07K16/32 , A61K2039/505 , C07K16/40 , C07K2317/24 , C07K2317/41 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies binding to human HER3 (anti-HER3 antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及与人HER3（抗HER3抗体）结合的抗体，其制备方法，含有所述抗体的药物组合物及其用途。
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公开(公告)号：US20110070246A1
公开(公告)日：2011-03-24
申请号：US12868849
申请日：2010-08-26
申请人： Birgit Bossenmaier , Georg Fertig , Hans-Willi Krell , Reiner Lammers , Alexander Lifke , Gerhard Niederfellner
发明人： Birgit Bossenmaier , Georg Fertig , Hans-Willi Krell , Reiner Lammers , Alexander Lifke , Gerhard Niederfellner
CPC分类号： C07K16/2896 , A61K2039/505 , C07K2317/24 , C07K2317/565 , C07K2317/73 , C07K2317/75 , C07K2317/76
摘要： The present invention relates to antibodies against human CDCP1 binding to the same epitope as CUB4 (Deposition No. DSM ACC2551) for the treatment of cancer.
摘要翻译： 本发明涉及抗CDCP1与CUB4（沉积号DSM ACC2551）相同表位的抗体用于治疗癌症的抗体。
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公开(公告)号：US08883159B2
公开(公告)日：2014-11-11
申请号：US12868849
申请日：2010-08-26
申请人： Birgit Bossenmaier , Georg Fertig , Hans-Willi Krell , Reiner Lammers , Alexander Lifke , Gerhard Niederfellner
发明人： Birgit Bossenmaier , Georg Fertig , Hans-Willi Krell , Reiner Lammers , Alexander Lifke , Gerhard Niederfellner
IPC分类号： A61K39/395 , A61P35/04 , C07K16/30 , C07K16/28 , C12N15/13 , C12N15/85 , C12N5/10 , A61K39/00
CPC分类号： C07K16/2896 , A61K2039/505 , C07K2317/24 , C07K2317/565 , C07K2317/73 , C07K2317/75 , C07K2317/76
摘要： The present invention relates to antibodies against human CDCP1 binding to the same epitope as CUB4 (Deposition No. DSM ACC2551) for the treatment of cancer.
摘要翻译： 本发明涉及抗CDCP1与CUB4（沉积号DSM ACC2551）相同表位的抗体用于治疗癌症的抗体。
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公开(公告)号：US20060235013A1
公开(公告)日：2006-10-19
申请号：US11384058
申请日：2006-03-17
申请人： Guy Georges , Bernhard Goller , Hans-Willi Krell , Anja Limberg , Ulrike Reiff , Petra Rueger , Matthias Rueth
发明人： Guy Georges , Bernhard Goller , Hans-Willi Krell , Anja Limberg , Ulrike Reiff , Petra Rueger , Matthias Rueth
IPC分类号： A61K31/5377 , A61K31/4745 , A61K31/4188 , C07D487/04
CPC分类号： C07D487/04 , C07D519/00
摘要： The present invention relates to the compounds of formula I: their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of such compounds in the control or prevention of illnesses such as cancer.
摘要翻译： 本发明涉及式I化合物：其药学上可接受的盐或酯，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的药物组合物及其制备，以及这些化合物的用途 控制或预防癌症等疾病。
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公开(公告)号：US06506755B2
公开(公告)日：2003-01-14
申请号：US09767306
申请日：2001-01-23
IPC分类号： C07D27720
CPC分类号： C07D277/20 , C07D417/12 , C07D417/14
摘要： 5-Arylidene-4-oxo-2-thioxo-3-thiazolidinecarboxylic acids of formula I in which the symbols R1, R2, A, A1 and A2 have the significance given in the description as medicaments for the treatment of cancer diseases.
摘要翻译： 符号R1，R2，A，A1和A2具有在描述中给出的用于治疗癌症疾病的药物的含义的式Iin的5-亚芳基-4-氧代-2-硫代-3-噻唑烷羧酸。
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