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公开(公告)号：US20030070679A1
公开(公告)日：2003-04-17
申请号：US10159451
申请日：2002-05-31
IPC分类号： A61M013/00 , B05D007/14 , B65D083/06
CPC分类号： A61K9/0075 , A61K9/4816 , A61K9/4858 , A61K31/451 , A61K31/4523 , A61M11/003 , A61M15/0028 , A61M15/0033 , A61M2202/064
摘要： The invention relates to capsules for inhalation (inhalettes) made from specific capsule materials with a reduced moisture content, which contain the active substance tiotropium in the form of powdered preparations and are characterised by increased stability.
摘要翻译： 本发明涉及由具有降低的水分含量的特定胶囊材料制成的用于吸入（吸入剂）的胶囊，其含有粉末制剂形式的活性物质噻托溴铵，其特征在于增加的稳定性。
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公开(公告)号：US20030078551A1
公开(公告)日：2003-04-24
申请号：US10185949
申请日：2002-06-28
IPC分类号： A61M035/00
CPC分类号： B05B11/3091 , A61F9/0026 , A61H35/02 , A61M11/00 , A61M11/006 , A61M11/008 , A61M15/007 , A61M2210/0612 , B05B11/3001 , B05B11/308 , Y10T137/7909 , Y10T137/7916
摘要： The present invention relates to atomizers for administering liquids to the cornea or conjunctiva of the eye, special eye adapters for atomizers and the use of atomizers for ophthalmological administration. The atomizers according to the invention are free from propellant gas and have an energy reservoir for supplying the energy needed for the atomization process.
摘要翻译： 本发明涉及用于向眼睛的角膜或结膜施用液体的雾化器，用于雾化器的特殊眼睛适配器和用于眼科管理的雾化器的使用。 根据本发明的雾化器不含推进剂气体，并具有用于提供雾化过程所需的能量的能量储存器。
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3.发明申请Two-part capsule to accept pharmaceutical preparations for powder inhalers 审中-公开两部分胶囊用于接受粉末吸入器的药物制剂公开(公告)号：US20040131668A1
公开(公告)日：2004-07-08
申请号：US10740225
申请日：2003-12-18
发明人： Dieter Hochrainer , Josef Eckert
IPC分类号： A61K009/48
CPC分类号： A61M15/0028 , A61J3/071 , A61J3/072 , A61K9/0075 , A61K9/4816 , A61M15/003 , A61M2202/064
摘要： The present invention relates to capsules for holding pharmaceutical preparations for powder inhalers with increased drug safety and capsules for pharmaceutical preparations for powder inhalers with improved adaptation to their use in powder inhalers. The capsules consist of water-insoluble hydrophobic synthetic materials which do not significantly affect the pharmaceutical quality of the contents themselves, but which improve the usability of the filled capsules with regard to their function, their longevity and/or the geographic location of their use, and are advantageous at various stages from manufacture up to utilisation.
摘要翻译： 本发明涉及用于保持具有增加的药物安全性的粉末吸入器的药物制剂的胶囊和用于粉末吸入器的药物制剂的胶囊，其改进适用于其在粉末吸入器中的应用。 胶囊由不溶于水的疏水性合成材料组成，其不会显着影响内容物本身的药物质量，但改善填充胶囊的功能，使用寿命和/或使用地理位置的可用性， 并且在从制造到利用的各个阶段都是有利的。
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公开(公告)号：US20040010239A1
公开(公告)日：2004-01-15
申请号：US10601737
申请日：2003-06-23
IPC分类号： A61M035/00
CPC分类号： B05B11/3091 , A61F9/0026 , A61H35/02 , A61M11/00 , A61M11/006 , A61M11/008 , A61M15/007 , A61M2210/0612 , B05B11/3001 , B05B11/308 , Y10T137/7909 , Y10T137/7916
摘要： The present invention relates to atomizers for administering liquids to the cornea or conjunctiva of the eye, special eye adapters for atomizers and the use of atomizers for ophthalmological administration. The atomizers according to the invention are free from propellant gas and have an energy reservoir for supplying the energy needed for the atomization process.
摘要翻译： 本发明涉及用于向眼睛的角膜或结膜施用液体的雾化器，用于雾化器的特殊眼睛适配器和用于眼科管理的雾化器的使用。 根据本发明的雾化器不含推进剂气体，并具有用于提供雾化过程所需的能量的能量储存器。
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5.发明申请Closure-cap and container as a two-chamber cartridge for nebulisers for producing aerosols and active substance formulations, suitable for storage 有权封闭盖和容器作为用于产生气溶胶和活性物质制剂的雾化器的两室筒，适用于储存公开(公告)号：US20030066524A1
公开(公告)日：2003-04-10
申请号：US10256781
申请日：2002-09-27
IPC分类号： A61M011/00
CPC分类号： A61M15/0065 , A61K9/0078 , A61M15/0033 , A61M15/0036 , A61M2202/064
摘要： The invention relates to an apparatus comprising a closure-cap and a container in the form of a two-chamber cartridge in which an active ingredient and a solvent can be stored separately until the apparatus is used in a nebuliser, as well as an active substance concentrate in which the active-substance is present as a solution or suspension for storage purposes.
摘要翻译： 本发明涉及一种装置，其包括封闭盖和二室盒形式的容器，其中活性成分和溶剂可以分开储存，直到该装置用于雾化器，以及活性物质 浓缩物中存在活性物质作为溶液或悬浮液用于储存目的。
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公开(公告)号：US20030029558A1
公开(公告)日：2003-02-13
申请号：US10201443
申请日：2002-07-23
发明人： Dieter Hochrainer , Herbert Wachtel
IPC分类号： B29C065/16
CPC分类号： B29C66/65 , A61J3/072 , B29C65/10 , B29C65/103 , B29C65/1616 , B29C65/1638 , B29C65/1654 , B29C65/1677 , B29C65/58 , B29C66/003 , B29C66/1122 , B29C66/1142 , B29C66/1222 , B29C66/1224 , B29C66/12441 , B29C66/12821 , B29C66/1284 , B29C66/1312 , B29C66/54 , B29C66/5432 , B29C66/652 , B29C66/71 , B29C66/73115 , B29C66/73151 , B29C66/73321 , B29C66/7352 , B29C66/73921 , B29C66/836 , B29C66/9121 , B29C66/9141 , B29C66/9161 , B29C66/919 , B29C66/93451 , B29C66/939 , B29C66/961 , B29C2035/0216 , B29C2035/0822 , B29K2995/007 , B29K2995/0073 , B29L2031/7174 , Y10S53/90 , Y10T156/10 , Y10T428/13 , Y10T428/1352 , Y10T428/2982 , B29K2059/00 , B29K2055/02 , B29K2033/12 , B29K2027/06 , B29K2025/06 , B29K2023/12 , B29K2023/065 , B29K2023/0633
摘要： A method of sealing parts of a plastic capsule by forming a weld seam in an overlapping region of the parts of the capsule, wherein the capsule comprises a capsule cap having an open end and a capsule body having an open end, the method comprising: (a) holding the capsule cap and the capsule body in a capsule holder comprising a first holding part and a second holding part which can be guided synchronously with one another, wherein the first holding part interlockingly surrounds the capsule cap and the second holding part interlockingly surrounds the capsule body; (b) closing the capsule holder holding the capsule cap and the capsule body so that the open end of the capsule cap and the open end of the capsule body form a sealed cavity therebetween and form an overlapping region, wherein the overlapping region is not covered by the capsule holder, to obtain a closed capsule; and (c) welding the closed capsule using an energy beam of hot gas or laser light on the overlapping region by forming the weld seam thereon. The capsules produced by the process according to the invention are disposable capsules and preferably contain a single dose of a pharmaceutical formulation in the form of a powder or liquid suitable for inhalation and are suitable, by their form and function, for use in powder inhalers or liquid nebulizers for producing aerosols. Aerosols thus produced can be inhaled, for example, in order to administer a pharmaceutical formulation to the lungs.
摘要翻译： 一种通过在胶囊部分的重叠区域中形成焊缝来密封塑料胶囊的部件的方法，其中所述胶囊包括具有开口端的胶囊盖和具有开口端的胶囊主体，所述方法包括：（ a）将胶囊盖和胶囊体保持在胶囊保持器中，该胶囊保持器包括可彼此同步引导的第一保持部分和第二保持部分，其中第一保持部分互锁地围绕胶囊盖并且第二保持部分互锁地围绕 胶囊体; （b）关闭保持胶囊盖和胶囊主体的胶囊保持器，使得胶囊盖的开口端和胶囊主体的开口端在其间形成密封腔，并形成重叠区域，其中重叠区域不被覆盖 通过胶囊保持器获得封闭的胶囊; 和（c）通过在其上形成焊缝，在重叠区域上使用热气体或激光的能量束焊接封闭的胶囊。 通过根据本发明的方法制备的胶囊是一次性胶囊，并且优选含有单剂量的药物制剂，其形式和功能适用于粉末吸入器或粉末吸入器或粉末吸入器 用于生产气溶胶的液体喷雾器。 如此产生的气溶胶可以被吸入，例如为了向肺施用药物制剂。
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