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公开(公告)号：US09709179B2
公开(公告)日：2017-07-18
申请号：US14834870
申请日：2015-08-25
IPC分类号： F16K11/065 , F16K11/16 , F16K7/16 , F16K27/00 , F16K31/524 , F16K99/00 , G01N35/00 , B01L3/00 , G01N35/10
CPC分类号： F16K11/065 , B01L3/502738 , B01L2300/0636 , B01L2300/0816 , B01L2300/123 , B01L2400/06 , B01L2400/0655 , B01L2400/0661 , B01L2400/082 , F16K7/16 , F16K11/161 , F16K27/003 , F16K31/52483 , F16K99/0001 , F16K99/0015 , F16K99/0042 , F16K2099/008 , F16K2099/0084 , G01N35/1097 , G01N2035/00158 , G01N2035/00237 , Y10T137/0396 , Y10T137/86445 , Y10T137/86919 , Y10T137/87
摘要： An array of valves are arranged in n columns and m lines and which are each designed to control a fluid flow in an associated flow channel in a lab-on-a-chip system. The array includes at least two valves, every column having not more than one valve and every line having from zero to n valves. A device is used for actuating the valves. The valves are pressure-actuated. To produce the device, the flow channels are arranged in accordance with the arrangement of the valves. Which valves are actuated being changeable by movement of projections relative to array of valves so as to change which valves the projections are pressed against.
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2.发明申请SYSTEM FOR OPERATING A SYSTEM FOR THE INTEGRATED AND AUTOMATED ANALYSIS OF DNA OR PROTEIN 审中-公开用于综合和自动分析DNA或蛋白质的系统的系统公开(公告)号：US20160047832A1
公开(公告)日：2016-02-18
申请号：US14828878
申请日：2015-08-18
发明人： Walter Gumbrecht , Peter Paulicka
CPC分类号： G01N35/00871 , B01L3/5027 , B01L3/502723 , B01L3/50273 , B01L3/502761 , B01L7/52 , B01L9/527 , B01L2200/027 , B01L2200/0668 , B01L2200/10 , B01L2200/143 , B01L2300/023 , B01L2300/0645 , B01L2300/0816 , B01L2300/1822 , B01L2300/1877 , B01L2400/0406 , C12Q1/686 , G01N35/00009 , G01N35/00584 , G01N35/00732 , G01N35/08 , G01N35/1002 , G01N2035/00019 , G01N2035/00346 , G01N2035/00376 , G01N2035/00841 , G01N2035/1034
摘要： A system for the integrated and automated analysis of DNA or protein, including a single-use cartridge, with an analysis device having a control device, and devices for capturing and processing signals, the control device carrying out a completely automatic process and evaluation of molecular diagnostic analysis via single-use cartridges (Lab-on-a-Chip). Controlling of an analysis process, which occurs in the cartridge, involves the subsequent displacement and thermostatisation of liquids with a first device, and with a second device the signals which are obtained during the analysis are processed. The first and the second devices are synchronized in such a manner that the analysis process of the sample can be carried out in a totally integrated manner thus producing an immediate result.
摘要翻译： 一种用于综合和自动分析DNA或蛋白质的系统，包括一次性盒，具有控制装置的分析装置，以及用于捕获和处理信号的装置，所述控制装置进行完全自动的过程并评估分子 通过一次性使用墨盒进行诊断分析（Lab-on-a-Chip）。 在盒中发生的分析过程的控制涉及随着第一装置的液体的随后位移和恒温化，并且与第二装置一起处理在分析期间获得的信号。 第一和第二装置以使得样品的分析过程可以完全集成的方式进行同步，从而产生立即的结果。
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3.发明授权公开(公告)号：US10816563B2
公开(公告)日：2020-10-27
申请号：US16059175
申请日：2018-08-09
发明人： Walter Gumbrecht , Peter Paulicka
摘要： A system for the integrated and automated analysis of DNA or protein, including a single-use cartridge, with an analysis device having a control device, and devices for capturing and processing signals, the control device carrying out a completely automatic process and evaluation of molecular diagnostic analysis via single-use cartridges (Lab-on-a-Chip). Controlling of an analysis process, which occurs in the cartridge, involves the subsequent displacement and thermostatisation of liquids with a first device, and with a second device the signals which are obtained during the analysis are processed. The first and the second devices are synchronized in such a manner that the analysis process of the sample can be carried out in a totally integrated manner thus producing an immediate result.
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4.发明授权公开(公告)号：US10184946B2
公开(公告)日：2019-01-22
申请号：US14828866
申请日：2015-08-18
发明人： Walter Gumbrecht , Peter Paulicka
IPC分类号： C12Q1/68 , C12M1/34 , C12M1/00 , G01N35/00 , B01L3/00 , B01L7/00 , B01L9/00 , G01N35/08 , C12Q1/686 , G01N35/10
摘要： A method for the integrated and automated analysis of DNA or protein, including a single-use cartridge, with an analysis device having a control device, and devices for capturing and processing signals, the control device carrying out a completely automatic process and evaluation of molecular diagnostic analysis via single-use cartridges (Lab-on-a-Chip). Controlling of an analysis process, which occurs in the cartridge, involve the subsequent displacement and thermostatisation of liquids with a first device, and with a second device the signals which are obtained during the analysis are processed. The first and the second devices are synchronized in such a manner that the analysis process of the sample can be carried out in a totally integrated manner thus producing an immediate result.
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5.发明申请METHOD FOR OPERATING A SYSTEM FOR THE INTEGRATED AND AUTOMATED ANALYSIS OF DNA OR PROTEIN 审中-公开用于操作DNA或蛋白质的综合和自动分析的系统的方法公开(公告)号：US20160041193A1
公开(公告)日：2016-02-11
申请号：US14828866
申请日：2015-08-18
发明人： Walter Gumbrecht , Peter Paulicka
CPC分类号： G01N35/00871 , B01L3/5027 , B01L3/502723 , B01L3/50273 , B01L3/502761 , B01L7/52 , B01L9/527 , B01L2200/027 , B01L2200/0668 , B01L2200/10 , B01L2200/143 , B01L2300/023 , B01L2300/0645 , B01L2300/0816 , B01L2300/1822 , B01L2300/1877 , B01L2400/0406 , C12Q1/686 , G01N35/00009 , G01N35/00584 , G01N35/00732 , G01N35/08 , G01N35/1002 , G01N2035/00019 , G01N2035/00346 , G01N2035/00376 , G01N2035/00841 , G01N2035/1034
摘要： A method for the integrated and automated analysis of DNA or protein, including a single-use cartridge, with an analysis device having a control device, and devices for capturing and processing signals, the control device carrying out a completely automatic process and evaluation of molecular diagnostic analysis via single-use cartridges (Lab-on-a-Chip). Controlling of an analysis process, which occurs in the cartridge, involve the subsequent displacement and thermostatisation of liquids with a first device, and with a second device the signals which are obtained during the analysis are processed. The first and the second devices are synchronized in such a manner that the analysis process of the sample can be carried out in a totally integrated manner thus producing an immediate result.
摘要翻译： 一种用于综合和自动分析DNA或蛋白质的方法，包括一次性使用的盒式磁带，具有控制装置的分析装置，以及用于捕获和处理信号的装置，所述控制装置进行完全自动的过程并评估分子 通过一次性使用墨盒进行诊断分析（Lab-on-a-Chip）。 在盒中发生的分析过程的控制涉及随着第一装置的液体的随后位移和恒温化，并且与第二装置一起处理在分析期间获得的信号。 第一和第二装置以使得样品的分析过程可以完全集成的方式进行同步，从而产生立即的结果。
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公开(公告)号：US09766196B2
公开(公告)日：2017-09-19
申请号：US14807035
申请日：2015-07-23
CPC分类号： G01N27/27 , G01N15/04 , G01N27/30 , G01N27/40 , G01N33/50 , G01N33/566 , Y10T436/143333
摘要： An apparatus for detecting liquids or substances from liquids in spatially separate reaction zones using a plug-in module or a chip card for rapid immunological tests, for example, with the help of a reading device. The liquids or substances from liquids are detected by a sensor array and on which at least one diaphragm is arranged. Individual sensors are spatially separated from each other on a plane by means of walls. The diaphragm is filled with liquid that is to be analyzed. Sealed reaction chambers are created when pressure is applied to the diaphragm. Pores in the diaphragm are completely closed in the zone of the walls while the pores are merely reduced in size and liquid can continue to be exchanged in zones directly above the sensors. No liquid can be exchanged between adjacent reaction chambers as long as pressure is applied to and compresses the diaphragm.
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公开(公告)号：US09347097B2
公开(公告)日：2016-05-24
申请号：US14220736
申请日：2014-03-20
发明人： Walter Gumbrecht , Jörn Mosner , Sebastian Schmidt
IPC分类号： C12M1/00 , C12M1/34 , C12M3/00 , C12Q1/68 , C12P19/34 , C12N9/00 , G01N27/00 , C40B40/06 , C07H21/02 , B01L3/00 , B01L7/00
CPC分类号： C12Q1/686 , B01L3/5027 , B01L7/52 , B01L2200/143 , B01L2200/16 , B01L2300/0645 , B01L2300/0816 , B01L2300/0867 , B01L2300/1822 , B01L2400/0487 , B01L2400/0633 , C12Q1/6851 , C12Q2565/629
摘要： An arrangement for determining the concentration of nucleic acids in a sample in a microfluidic device. In at least one embodiment, the arrangement having a) a first chamber into which a the sample is introduced, b) an element in the first chamber for carrying out a number of cycles of an amplification reaction to be carried out in cycles for amplifying nucleic acids, c) a second chamber, connectable to the first chamber by way of fluidic communication, equipped with an element to determine concentrations of amplified nucleic acids, d) a control unit to introduce a defined volume of a solution containing reagents for the amplification reaction into the first chamber and to transfer a defined volume from said first chamber to the second chamber.
摘要翻译： 用于确定微流体装置中样品中核酸浓度的装置。 在至少一个实施方案中，所述装置具有：a）第一室，其中导入样品; b）第一室中的元件，用于进行多个循环的扩增反应，以循环进行以扩增核酸 酸，c）通过流体连通可连接到第一室的第二室，其配备有用于确定扩增核酸浓度的元件，d）引入限定体积的含有扩增反应试剂的溶液的控制单元 并且将限定的体积从所述第一室转移到第二室。
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8.发明申请公开(公告)号：US20180356434A1
公开(公告)日：2018-12-13
申请号：US16059175
申请日：2018-08-09
发明人： Walter Gumbrecht , Peter Paulicka
摘要： A system for the integrated and automated analysis of DNA or protein, including a single-use cartridge, with an analysis device having a control device, and devices for capturing and processing signals, the control device carrying out a completely automatic process and evaluation of molecular diagnostic analysis via single-use cartridges (Lab-on-a-Chip). Controlling of an analysis process, which occurs in the cartridge, involves the subsequent displacement and thermostatisation of liquids with a first device, and with a second device the signals which are obtained during the analysis are processed. The first and the second devices are synchronized in such a manner that the analysis process of the sample can be carried out in a totally integrated manner thus producing an immediate result.
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9.发明授权公开(公告)号：US10073107B2
公开(公告)日：2018-09-11
申请号：US14828878
申请日：2015-08-18
发明人： Walter Gumbrecht , Peter Paulicka
IPC分类号： C12M1/34 , C12M3/00 , C12Q1/68 , G01N35/00 , B01L3/00 , B01L7/00 , B01L9/00 , G01N35/08 , C12Q1/686 , G01N35/10
CPC分类号： G01N35/00871 , B01L3/5027 , B01L3/502723 , B01L3/50273 , B01L3/502761 , B01L7/52 , B01L9/527 , B01L2200/027 , B01L2200/0668 , B01L2200/10 , B01L2200/143 , B01L2300/023 , B01L2300/0645 , B01L2300/0816 , B01L2300/1822 , B01L2300/1877 , B01L2400/0406 , C12Q1/686 , G01N35/00009 , G01N35/00584 , G01N35/00732 , G01N35/08 , G01N35/1002 , G01N2035/00019 , G01N2035/00346 , G01N2035/00376 , G01N2035/00841 , G01N2035/1034
摘要： A system for the integrated and automated analysis of DNA or protein, including a single-use cartridge, with an analysis device having a control device, and devices for capturing and processing signals, the control device carrying out a completely automatic process and evaluation of molecular diagnostic analysis via single-use cartridges (Lab-on-a-Chip). Controlling of an analysis process, which occurs in the cartridge, involves the subsequent displacement and thermostatization of liquids with a first device, and with a second device the signals which are obtained during the analysis are processed. The first and the second devices are synchronized in such a manner that the analysis process of the sample can be carried out in a totally integrated manner thus producing an immediate result.
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公开(公告)号：US09400278B2
公开(公告)日：2016-07-26
申请号：US14306401
申请日：2014-06-17
发明人： Walter Gumbrecht , Manfred Stanzel
IPC分类号： C12M1/34 , C12M1/00 , C12Q1/68 , C07H21/02 , G01N27/00 , B03C5/02 , G01N15/06 , G01N33/00 , C07H21/04 , G01N33/543 , G01N27/02
CPC分类号： C12M1/34 , G01N27/026 , G01N33/5438
摘要： A biochip includes a flat carrier and an array of spots containing catcher molecules which are arranged on the carrier. Each spot is associated with a microelectrode arrangement for impedance spectroscopic detection of binding events occurring between the catcher molecules and the target molecules applied via an analyte solution. In order to increase the sensitivity or the binding-specific measuring effects of the bio-chip, the electrode arrangement is at least partially embedded in a hydrophilic reaction layer containing catcher molecules and which is permeable to target molecules.
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