公开(公告)号：US20070179558A1

公开(公告)日：2007-08-02

申请号：US11344453

申请日：2006-01-30

申请人： Bradford Gliner ,  Jeffrey Balzer ,  Brad Fowler ,  Leif Sloan

发明人： Bradford Gliner ,  Jeffrey Balzer ,  Brad Fowler ,  Leif Sloan

IPC分类号： A61N1/18

CPC分类号： A61N1/36082 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/36017 ,  A61N1/36025 ,  A61N1/37247

摘要： Systems and methods for varying electromagnetic and adjunctive neural therapies are disclosed. A method in accordance with one embodiment includes applying electromagnetic signals to a target neural population of a patient over a first period of time in accordance with a first mode (e.g., including signal delivery to the central nervous system or peripheral nervous system, via implanted or non-implanted devices). The method can further include applying electromagnetic stimulation to the patient over a second period of time in accordance with a second mode different than the first mode. Varying the mode between the first period of time and second period of time can increase the efficacy and/or longevity of the stimulation. Systems in accordance with other embodiments can support multiple signal delivery devices.

摘要翻译： 公开了用于改变电磁和辅助神经疗法的系统和方法。 根据一个实施例的方法包括根据第一模式（例如，包括通过植入的或通过植入的中枢神经系统或周围神经系统的信号传递）向第一时间段的患者的目标神经群体施加电磁信号 非植入设备）。 该方法还可以包括根据与第一模式不同的第二模式在第二时间段内向患者施加电磁刺激。 改变第一时间段和第二时间段之间的模式可以增加刺激的功效和/或寿命。 根据其他实施例的系统可以支持多个信号传递装置。

公开(公告)号：US20060015153A1

公开(公告)日：2006-01-19

申请号：US11182713

申请日：2005-07-15

申请人： Bradford Gliner ,  Allen Wyler ,  Brad Fowler ,  W. Douglas Sheffield ,  Richard Kuntz ,  Kent Leyde ,  Leif Sloan

发明人： Bradford Gliner ,  Allen Wyler ,  Brad Fowler ,  W. Douglas Sheffield ,  Richard Kuntz ,  Kent Leyde ,  Leif Sloan

IPC分类号： A61N1/18

CPC分类号： H04L67/2842 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/3606 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/36103 ,  A61N1/36135 ,  A61N1/36146 ,  A61N1/37252 ,  G06F13/385 ,  H04L49/90 ,  H04L49/901 ,  H04L67/2823

摘要： Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy are disclosed. In one embodiment, a system and/or method may apply electromagnetic stimulation to a patient's nervous system over a first time domain according to a first set of stimulation parameters, and over a second time domain according to a second set of stimulation parameters. The first and second time domains may be sequential, simultaneous, or nested. Stimulation parameters may vary in accordance with one or more types of duty cycle, amplitude, pulse repetition frequency, pulse width, spatiotemporal, and/or polarity variations. Stimulation may be applied at subthreshold, threshold, and/or suprathreshold levels in one or more periodic, aperiodic (e.g., chaotic), and/or pseudo-random manners. In some embodiments stimulation may comprise a burst pattern having an interburst frequency corresponding to an intrinsic brainwave frequency, and regular and/or varying intraburst stimulation parameters. Stimulation signals providing reduced power consumption with at least adequate symptomatic relief may be applied prior to moderate or significant power source depletion.

公开(公告)号：US20080103548A1

公开(公告)日：2008-05-01

申请号：US11833217

申请日：2007-08-02

申请人： Brad Fowler ,  Bradford Gliner ,  W. Sheffield ,  Leif Sloan

发明人： Brad Fowler ,  Bradford Gliner ,  W. Sheffield ,  Leif Sloan

IPC分类号： A61N1/05

CPC分类号： A61N1/36082

摘要： Methods for treating neurological disorders, including neuropsychiatric and neuropsychological disorders, and associated systems are disclosed. One such method includes identifying one or more neural populations, including a cortical target neural population, associated with a neurological condition. The method can further include comparing a patient-specific measure of a characteristic parameter for a selected one of the neural populations with a target measure for the same parameter. If the patient-specific measure differs from the target measure by at least a target amount, the method can include selecting an electrical signal polarity, frequency, or both polarity and frequency based at least in part on the difference between the patient-specific measure and the target measure. The method can further include applying electrical signals to the target neural population at the selected signal polarity, frequency, or both polarity and frequency to reduce the difference between the patient-specific measure and the target measure.

摘要翻译： 公开了治疗神经系统疾病，包括神经精神和神经心理障碍以及相关系统的方法。 一种这样的方法包括鉴定与神经病症相关的一个或多个神经群体，包括皮质靶神经群体。 该方法还可以包括将针对所选择的一个神经群体的特征参数的患者特异性测量与相同参数的目标测量进行比较。 如果患者特异性测量与目标测量值不同至少目标量，则该方法可以包括至少部分地基于患者特异性测量值与患者特异性测量值之间的差异来选择电信号极性，频率或极性和频率两者 目标措施。 该方法可以进一步包括以选定的信号极性，频率或极性和频率将电信号施加到目标神经群体，以减少患者特异性测量与目标测量之间的差异。

公开(公告)号：US20070179534A1

公开(公告)日：2007-08-02

申请号：US11255187

申请日：2005-10-19

申请人： Andrew Firlik ,  Bradford Gliner ,  W. Sheffield ,  Leif Sloan

发明人： Andrew Firlik ,  Bradford Gliner ,  W. Sheffield ,  Leif Sloan

IPC分类号： A61N1/00 ,  A61M31/00

CPC分类号： A61N1/36067 ,  A61B5/16 ,  A61B5/18 ,  A61B5/7275 ,  A61F2002/704 ,  A61M5/14276 ,  A61M5/1723 ,  A61M2205/05 ,  A61M2205/50 ,  A61M2230/63 ,  A61N1/0531 ,  A61N1/36003 ,  A61N1/36014 ,  A61N1/36017 ,  A61N1/36025 ,  A61N1/36082 ,  A61N1/361 ,  A61N1/36103 ,  A61N1/36139 ,  A61N1/372 ,  G06F19/00 ,  G06F19/3481

摘要： Systems and methods for patient interactive neural stimulation and/or chemical substance delivery are disclosed. A method in accordance with one embodiment of the invention includes affecting a target neural population of the patient by providing to the patient at least one of an electromagnetic signal and a chemical substance. The method can further include detecting at least one characteristic of the patient, with the characteristic at least correlated with the patient's performance of an adjunctive therapy task that is performed in association with affecting the target neural population. The method can still further include controlling at least one parameter in accordance with which the target neural population is affected, based at least in part on the detected characteristic.

摘要翻译： 公开了用于患者交互神经刺激和/或化学物质递送的系统和方法。 根据本发明的一个实施例的方法包括通过向患者提供电磁信号和化学物质中的至少一个来影响患者的目标神经群体。 该方法还可以包括检测患者的至少一个特征，其特征至少与患者与影响目标神经群体相关联的辅助治疗任务的性能相关。 该方法还可以进一步包括至少部分地基于检测到的特征来控制至少一个参数，根据目标神经群体受到影响。

公开(公告)号：US20070288072A1

公开(公告)日：2007-12-13

申请号：US11697696

申请日：2007-04-06

申请人： Alvaro Pascual-Leone ,  Bradford Gliner ,  David Himes ,  Leif Sloan

发明人： Alvaro Pascual-Leone ,  Bradford Gliner ,  David Himes ,  Leif Sloan

IPC分类号： A61N5/00

CPC分类号： A61N1/36171 ,  A61N1/36082 ,  A61N1/36103 ,  A61N1/3615

摘要： Systems and methods for applying signals, including contralesional electromagnetic signals, to neural populations, are disclosed. A particular method can be directed to treating a patient having a subject neural population in a first (e.g., ipsilesional) hemisphere of the brain, with the subject neural population having, or previously having, a functionality capable of being improved. The method can include directing an application of electromagnetic signals at least proximate to a target neural population at a second (e.g., contralesional) hemisphere of the brain to at least constrain a functionality of the target neural population, which has transcallosal communication with the first hemisphere.

摘要翻译： 公开了将信号（包括对数电磁信号）应用于神经群体的系统和方法。 具体方法可以涉及在脑的第一（例如ipsilesional）半球中治疗具有受试者神经群体的患者，其中受试者神经群体具有或预先具有能够改善的功能。 该方法可以包括将电磁信号的应用引导至少接近于大脑的第二（例如，对照）半球处的目标神经群体，以至少约束目标神经群体的功能，该目标神经群体与第一半球具有蜕皮通讯 。

公开(公告)号：US20070088403A1

公开(公告)日：2007-04-19

申请号：US11254240

申请日：2005-10-19

申请人： Allen Wyler ,  Bradford Gliner ,  Leif Sloan

发明人： Allen Wyler ,  Bradford Gliner ,  Leif Sloan

IPC分类号： A61N1/18

CPC分类号： A61N1/36082 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0539

摘要： Methods and systems for establishing parameters for neural stimulation are disclosed. A method in accordance with one embodiment includes applying a first stimulus to a first neural population associated with a first neural function, using a first set of stimulation parameters. The method can further include detecting a response to the first stimulus at least proximate to the patient's central nervous system and, based at least in part on the response to the first stimulus and on the first set of stimulation parameters, applying a second stimulus to a second neural population. The second neural population can be associated with a second neural function different than the first neural function and can be stimulated using a second set of stimulation parameters. In a further embodiment, evidence of a neural activity can be detected at the patient's central nervous system, and electromagnetic stimulation of a target neural population at the patient's central nervous system can be automatically triggered, based at least in part on the detected evidence.

摘要翻译： 公开了建立神经刺激参数的方法和系统。 根据一个实施例的方法包括使用第一组刺激参数将第一刺激应用于与第一神经功能相关联的第一神经群体。 该方法还可以包括至少接近患者的中枢神经系统检测对第一刺激的响应，并且至少部分地基于对第一刺激的响应和第一组刺激参数，将第二刺激应用于 第二神经人群。 第二神经群体可以与不同于第一神经功能的第二神经功能相关联，并且可以使用第二组刺激参数来刺激。 在另一实施例中，可以在患者的中枢神经系统处检测到神经活动的证据，并且至少部分地基于检测到的证据，可以自动触发患者中枢神经系统上的目标神经群体的电磁刺激。

公开(公告)号：US20050070971A1

公开(公告)日：2005-03-31

申请号：US10910775

申请日：2004-08-02

申请人： Brad Fowler ,  Bradford Gliner

发明人： Brad Fowler ,  Bradford Gliner

IPC分类号： A61N20060101 ,  A61N1/05 ,  A61N1/18 ,  A61N1/36

CPC分类号： A61N1/36082 ,  A61N1/0531 ,  A61N1/0539

摘要： Systems and methods for neural stimulation may include a stimulus unit; a first electrode assembly having a first set of contacts; and a second set of contacts. The stimulus unit can be an implantable pulse generator including a first terminal that can be biased at a first signal polarity and a second terminal that can be biased at a second signal polarity. The first electrode assembly includes a support member configured to be placed at the stimulation site, the first set of contacts carried by the support member, and a first lead configured to be attached to the first terminal of the implantable pulse generator for biasing the surface contacts at the first polarity. The second set of contacts is detached from the surface electrode assembly. The second set of contacts can be one or more conductive elements fixed to or forming portions of the implantable pulse generator, or a separate electrode array.

摘要翻译： 用于神经刺激的系统和方法可以包括刺激单元; 具有第一组触点的第一电极组件; 和第二组联系人。 刺激单元可以是可植入脉冲发生器，其包括可以以第一信号极性偏置的第一端子和可以以第二信号极性偏置的第二端子。 第一电极组件包括被配置为放置在刺激部位的支撑构件，由支撑构件承载的第一组触点，以及构造成附接到可植入脉冲发生器的第一端子的第一引线，用于偏置表面触点 在第一极性。 第二组触点与表面电极组件脱离。 第二组触点可以是固定到可植入脉冲发生器的一部分或形成部分的一个或多个导电元件，或单独的电极阵列。

公开(公告)号：US20080039895A1

公开(公告)日：2008-02-14

申请号：US11697694

申请日：2007-04-06

申请人： Brad Fowler ,  Bradford Gliner ,  David Himes

发明人： Brad Fowler ,  Bradford Gliner ,  David Himes

IPC分类号： A61N1/00

CPC分类号： A61N2/006 ,  A61N1/36017 ,  A61N1/36025 ,  A61N1/36082

摘要： Electromagnetic signal delivery for tissue affected by neuronal dysfunction, degradation, damage, and/or necrosis, and associated systems and methods are disclosed. A method in accordance with one embodiment of the invention includes identifying an affected region, with the affected region including neuronal tissue that, at least during a pre-dysfunctional period, was in neural communication with neuronal tissue in a dysfunctional region. The affected tissue can be functionally adversely affected by neuronal dysfunction in the dysfunctional region. The method can further include applying electromagnetic signals to the neuronal tissue in the affected region. For example, the electromagnetic signals can be applied to a hypo-active neural region that is not physically damaged, and has been identified as likely to recover at least in part as a result of electromagnetic signals. Signals can be applied at sub-threshold levels to cortical and/or subcortical regions.

摘要翻译： 公开了由神经元功能障碍，降解，损伤和/或坏死以及相关系统和方法影响的组织的电磁信号传递。 根据本发明的一个实施例的方法包括识别受影响的区域，其中受影响的区域包括神经元组织，至少在功能失调之前期间，与功能障碍区域中的神经元组织进行神经交流。 受影响的组织可能在功能障碍区域的神经元功能障碍中受功能不良的影响。 该方法还可以包括将电磁信号应用于受影响区域中的神经元组织。 例如，电磁信号可以应用于没有物理损坏的低活性神经区域，并且已被鉴定为可能至少部分地由于电磁信号而恢复。 信号可以在亚阈值水平应用于皮层和/或皮质下区域。

公开(公告)号：US20080046035A1

公开(公告)日：2008-02-21

申请号：US11845006

申请日：2007-08-24

申请人： Brad Fowler ,  Bradford Gliner

发明人： Brad Fowler ,  Bradford Gliner

IPC分类号： A61N1/36

CPC分类号： A61N1/0529 ,  A61N1/0531 ,  A61N1/36017 ,  A61N1/36082

摘要： Electrode configurations for reducing invasiveness and/or enhancing neural stimulation efficacy, and associated methods, are disclosed. A method in accordance with one embodiment of the invention for treating a brain disorder includes identifying a target neural structure within a patient's skull and implanting an electrode device within the patient's skull so that an axis that is generally normal to the skull proximate to the electrode device and that passes through at least one electrical contact of the electrode device is offset from the target neural structure. The method further includes stimulating the target neural structure by applying an electrical signal to the at least one electrical contact. In particular embodiments, the electrode device can be positioned between, along, across, or adjacent to a fissure, recess, groove, and/or vascular structure of the patient's brain.

公开(公告)号：US20080033503A1

公开(公告)日：2008-02-07

申请号：US11845005

申请日：2007-08-24

申请人： Brad Fowler ,  Bradford Gliner

发明人： Brad Fowler ,  Bradford Gliner

IPC分类号： A61N1/04

CPC分类号： A61N1/0529 ,  A61N1/0531 ,  A61N1/36017 ,  A61N1/36082

摘要： Electrode configurations for reducing invasiveness and/or enhancing neural stimulation efficacy, and associated methods, are disclosed. A method in accordance with one embodiment of the invention for treating a brain disorder includes identifying a target neural structure within a patient's skull and implanting an electrode device within the patient's skull so that an axis that is generally normal to the skull proximate to the electrode device and that passes through at least one electrical contact of the electrode device is offset from the target neural structure. The method further includes stimulating the target neural structure by applying an electrical signal to the at least one electrical contact. In particular embodiments, the electrode device can be positioned between, along, across, or adjacent to a fissure, recess, groove, and/or vascular structure of the patient's brain.

摘要翻译： 公开了用于降低侵入性和/或增强神经刺激功效的电极配置及相关方法。 根据用于治疗脑疾病的本发明的一个实施例的方法包括识别患者颅骨内的目标神经结构并且在患者的颅骨内植入电极装置，使得通常垂直于颅骨的轴线靠近电极装置 并且通过电极装置的至少一个电接触偏离目标神经结构。 该方法还包括通过向至少一个电触点施加电信号来刺激目标神经结构。 在特定实施例中，电极装置可以位于患者大脑的裂缝，凹槽，凹槽和/或血管结构之间，沿着，横过或相邻。